| Gene Symbol | SNRPC |
| Entrez ID | 6631 |
| Uniprot ID | P09234 |
| Description | small nuclear ribonucleoprotein polypeptide C |
| Chromosomal Location | chr6: 34,757,406-34,773,794 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000387 |
spliceosomal snRNP assembly |
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. |
IDA |
|
BP |
GO:0000395 |
mRNA 5'-splice site recognition |
Recognition of the intron 5'-splice site by components of the assembling spliceosome. |
IBA |
|
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
IDA |
|
CC |
GO:0000243 |
commitment complex |
A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript. |
IBA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
|
CC |
GO:0005685 |
U1 snRNP |
A ribonucleoprotein complex that contains small nuclear RNA U1. |
IDA |
|
CC |
GO:0015030 |
Cajal body |
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. |
IDA |
|
CC |
GO:0071004 |
U2-type prespliceosome |
A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. |
IEA |
|
CC |
GO:0071010 |
prespliceosome |
A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. |
IBA |
|
MF |
GO:0003727 |
single-stranded RNA binding |
Interacting selectively and non-covalently with single-stranded RNA. |
IDA |
|
MF |
GO:0003729 |
mRNA binding |
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
IEA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0008270 |
zinc ion binding |
Interacting selectively and non-covalently with zinc (Zn) ions. |
IDA |
|
MF |
GO:0030627 |
pre-mRNA 5'-splice site binding |
Interacting selectively and non-covalently with the pre-mRNA 5' splice site sequence. |
IBA |
|
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
IPI |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
|
MF |
GO:1990446 |
U1 snRNP binding |
Interacting selectively and non-covalently with any part of a U1 small nuclear ribonucleoprotein particle. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR000690 |
Matrin/U1-C, C2H2-type zinc finger |
|
IPR003604 |
Matrin/U1-C-like, C2H2-type zinc finger |
|
IPR013085 |
U1-C, C2H2-type zinc finger |
|
IPR013087 |
Zinc finger C2H2-type |
|
IPR017340 |
U1 small nuclear ribonucleoprotein C |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03040 |
Spliceosome |
KEGG |
|
h_smPathway |
Spliceosomal Assembly |
BioCarta |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
adipocytes |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
endothelial cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
chondrocytes |
|
soft tissue |
fibroblasts |
|
soft tissue |
peripheral nerve |
|
soft tissue |
adipocytes |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
STOM |
2040 |
P27105 |
0.49 |
|
SNRPA1 |
6627 |
P09661 |
0.49 |
|
SNRPE |
6635 |
P62304 |
0.49 |
|
THY1 |
7070 |
P04216 |
0.49 |
|
TOMM40 |
10452 |
O96008 |
0.49 |
|
SF3A3 |
10946 |
Q12874 |
0.49 |
|
WRAP53 |
55135 |
Q9BUR4 |
0.49 |
|
SRPRB |
58477 |
Q9Y5M8 |
0.49 |
|
SLIRP |
81892 |
Q9GZT3 |
0.49 |
|
SARNP |
84324 |
P82979 |
0.49 |
|
CARM1 |
10498 |
Q86X55 |
0.56 |
|
HNRNPD |
3184 |
Q14103 |
0.63 |
|
HNRNPF |
3185 |
P52597 |
0.63 |
|
HNRNPH2 |
3188 |
P55795 |
0.63 |
|
ILF3 |
3609 |
Q12906 |
0.63 |
|
RBM4 |
5936 |
Q9BWF3 |
0.63 |
|
MAGED1 |
9500 |
Q9Y5V3 |
0.63 |
|
KHDRBS3 |
10656 |
O75525 |
0.63 |
|
RBPMS |
11030 |
Q93062 |
0.63 |
|
WWP2 |
11060 |
O00308 |
0.63 |
|
HNRNPUL1 |
11100 |
Q9BUJ2 |
0.63 |
|
DDX42 |
11325 |
Q86XP3 |
0.63 |
|
EXOSC8 |
11340 |
Q96B26 |
0.63 |
|
FAM168A |
23201 |
Q92567 |
0.63 |
|
RBFOX2 |
23543 |
O43251 |
0.63 |
|
SS18L1 |
26039 |
O75177 |
0.63 |
|
SPAG8 |
26206 |
Q99932 |
0.63 |
|
NCAPH2 |
29781 |
Q6IBW4 |
0.63 |
|
HSD17B14 |
51171 |
Q9BPX1 |
0.63 |
|
RBM11 |
54033 |
P57052 |
0.63 |
|
RNF31 |
55072 |
Q96EP0 |
0.63 |
|
AGGF1 |
55109 |
Q8N302 |
0.63 |
|
WDR77 |
79084 |
Q9BQA1 |
0.63 |
|
RFX6 |
222546 |
Q8HWS3 |
0.63 |
|
SNRPC |
6631 |
P09234 |
0.67 |
|
SNRNP70 |
6625 |
P08621 |
0.74 |
|
RBM10 |
8241 |
P98175 |
0.76 |
|
WDR83 |
84292 |
Q9BRX9 |
0.76 |
|
EWSR1 |
2130 |
Q01844 |
0.88 |
|
NDUFA2 |
4695 |
O43678 |
0.49 |
|
NDUFA7 |
4701 |
O95182 |
0.49 |
|
RBMS1 |
5937 |
P29558 |
0.49 |
|
SNRPB |
6628 |
P14678 |
0.49 |
|
PRPF3 |
9129 |
O43395 |
0.49 |
|
MATR3 |
9782 |
P43243 |
0.49 |
|
MRPL53 |
116540 |
Q96EL3 |
0.49 |
|
AES |
166 |
Q08117 |
0.63 |
|
BARD1 |
580 |
Q99728 |
0.63 |
|
CD81 |
975 |
P60033 |
0.63 |
|
GOLGA2 |
2801 |
Q08379 |
0.63 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
MYC |
4609 |
P01106 |
0.63 |
|
NEDD8 |
4738 |
Q15843 |
0.63 |
|
PSMA3 |
5684 |
P25788 |
0.63 |
|
CUL5 |
8065 |
Q93034 |
0.63 |
|
HIST1H3A |
8350 |
P68431 |
0.63 |
|
CUL4B |
8450 |
Q13620 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL2 |
8453 |
Q13617 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
SRRM1 |
10250 |
Q8IYB3 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
COPS6 |
10980 |
Q7L5N1 |
0.63 |
|
COPS5 |
10987 |
Q92905 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
|
GIGYF2 |
26058 |
Q6Y7W6 |
0.63 |
|
DCUN1D1 |
54165 |
Q96GG9 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
|
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
|
IFIT2 |
3433 |
P09913 |
0.72 |
|
IFIT1 |
3434 |
P09914 |
0.72 |
|
IFIT3 |
3437 |
O14879 |
0.72 |
|
SRPK2 |
6733 |
P78362 |
0.72 |
|
OFD1 |
8481 |
O75665 |
0.72 |
|
SRPK3 |
26576 |
Q9UPE1 |
0.72 |
|
SF3A2 |
8175 |
Q15428 |
0.73 |
|
SRRM2 |
23524 |
Q9UQ35 |
0.73 |