Gene Symbol | SNCA |
Entrez ID | 6622 |
Uniprot ID | P37840 |
Description | synuclein alpha |
Chromosomal Location | chr4: 89,724,099-89,838,315 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
TAS |
BP |
GO:0001774 |
microglial cell activation |
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. |
TAS |
BP |
GO:0001921 |
positive regulation of receptor recycling |
Any process that activates or increases the frequency, rate or extent of receptor recycling. |
IDA |
BP |
GO:0001933 |
negative regulation of protein phosphorylation |
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. |
IEA |
BP |
GO:0001956 |
positive regulation of neurotransmitter secretion |
Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. |
IEA |
BP |
GO:0006631 |
fatty acid metabolic process |
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
IEA |
BP |
GO:0006638 |
neutral lipid metabolic process |
The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. |
IEA |
BP |
GO:0006644 |
phospholipid metabolic process |
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
IEA |
BP |
GO:0006915 |
apoptotic process |
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
IEA |
BP |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. |
IDA |
BP |
GO:0007006 |
mitochondrial membrane organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. |
IEA |
BP |
GO:0007568 |
aging |
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
IEA |
BP |
GO:0008344 |
adult locomotory behavior |
Locomotory behavior in a fully developed and mature organism. |
IEA |
BP |
GO:0010040 |
response to iron(II) ion |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. |
IDA |
BP |
GO:0010517 |
regulation of phospholipase activity |
Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. |
IDA |
BP |
GO:0010642 |
negative regulation of platelet-derived growth factor receptor signaling pathway |
Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. |
IDA |
BP |
GO:0014048 |
regulation of glutamate secretion |
Any process that modulates the frequency, rate or extent of the controlled release of glutamate. |
IEA |
BP |
GO:0014059 |
regulation of dopamine secretion |
Any process that modulates the frequency, rate or extent of the regulated release of dopamine. |
TAS |
BP |
GO:0031115 |
negative regulation of microtubule polymerization |
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. |
IDA |
BP |
GO:0031623 |
receptor internalization |
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. |
IDA |
BP |
GO:0031648 |
protein destabilization |
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. |
IDA |
BP |
GO:0032026 |
response to magnesium ion |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. |
IDA |
BP |
GO:0032410 |
negative regulation of transporter activity |
Any process that stops or reduces the activity of a transporter. |
IDA |
BP |
GO:0032496 |
response to lipopolysaccharide |
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
IDA |
BP |
GO:0032769 |
negative regulation of monooxygenase activity |
Any process that stops or reduces the activity of a monooxygenase. |
IDA |
BP |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
ISS |
BP |
GO:0034341 |
response to interferon-gamma |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. |
IDA |
BP |
GO:0034599 |
cellular response to oxidative stress |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
IC |
BP |
GO:0035067 |
negative regulation of histone acetylation |
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. |
IDA |
BP |
GO:0040012 |
regulation of locomotion |
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. |
IEA |
BP |
GO:0042416 |
dopamine biosynthetic process |
The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
TAS |
BP |
GO:0042493 |
response to drug |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
IEA |
BP |
GO:0042775 |
mitochondrial ATP synthesis coupled electron transport |
The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane. |
IEA |
BP |
GO:0043030 |
regulation of macrophage activation |
Any process that modulates the frequency or rate of macrophage activation. |
IEA |
BP |
GO:0043065 |
positive regulation of apoptotic process |
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
TAS |
BP |
GO:0043066 |
negative regulation of apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
IMP |
BP |
GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. |
IMP |
BP |
GO:0043206 |
extracellular fibril organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins. |
TAS |
BP |
GO:0043524 |
negative regulation of neuron apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
IEA |
BP |
GO:0044267 |
cellular protein metabolic process |
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification. |
TAS |
BP |
GO:0044344 |
cellular response to fibroblast growth factor stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus. |
IEA |
BP |
GO:0045807 |
positive regulation of endocytosis |
Any process that activates or increases the frequency, rate or extent of endocytosis. |
IDA |
BP |
GO:0045920 |
negative regulation of exocytosis |
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. |
IMP |
BP |
GO:0045963 |
negative regulation of dopamine metabolic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine. |
IEA |
BP |
GO:0048148 |
behavioral response to cocaine |
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. |
IEA |
BP |
GO:0048169 |
regulation of long-term neuronal synaptic plasticity |
A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. |
IEA |
BP |
GO:0048488 |
synaptic vesicle endocytosis |
Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished. |
ISS |
BP |
GO:0050808 |
synapse organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
IEA |
BP |
GO:0050812 |
regulation of acyl-CoA biosynthetic process |
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. |
IEA |
BP |
GO:0051281 |
positive regulation of release of sequestered calcium ion into cytosol |
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. |
IDA |
BP |
GO:0051583 |
dopamine uptake involved in synaptic transmission |
The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
TAS |
BP |
GO:0051585 |
negative regulation of dopamine uptake involved in synaptic transmission |
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell. |
IDA |
BP |
GO:0051612 |
negative regulation of serotonin uptake |
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell. |
IDA |
BP |
GO:0051622 |
negative regulation of norepinephrine uptake |
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. |
IDA |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IDA |
BP |
GO:0060079 |
excitatory postsynaptic potential |
A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
IEA |
BP |
GO:0060291 |
long-term synaptic potentiation |
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. |
IEA |
BP |
GO:0060732 |
positive regulation of inositol phosphate biosynthetic process |
Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. |
IDA |
BP |
GO:0070495 |
negative regulation of thrombin receptor signaling pathway |
Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands. |
IDA |
BP |
GO:0070555 |
response to interleukin-1 |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. |
IDA |
BP |
GO:0071280 |
cellular response to copper ion |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. |
IDA |
BP |
GO:0071872 |
cellular response to epinephrine stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. |
TAS |
BP |
GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. |
IDA |
BP |
GO:1901215 |
negative regulation of neuron death |
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. |
IDA |
BP |
GO:1902957 |
negative regulation of mitochondrial electron transport, NADH to ubiquinone |
Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. |
TAS |
BP |
GO:1903284 |
positive regulation of glutathione peroxidase activity |
Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity. |
IDA |
BP |
GO:1903285 |
positive regulation of hydrogen peroxide catabolic process |
Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process. |
IDA |
BP |
GO:1903421 |
regulation of synaptic vesicle recycling |
Any process that modulates the frequency, rate or extent of synaptic vesicle recycling. |
TAS |
BP |
GO:1903426 |
regulation of reactive oxygen species biosynthetic process |
Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. |
TAS |
BP |
GO:1904715 |
negative regulation of chaperone-mediated autophagy |
Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy. |
IMP |
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
IDA|TAS |
CC |
GO:0005615 |
extracellular space |
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005640 |
nuclear outer membrane |
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. |
IEA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
TAS |
CC |
GO:0005747 |
mitochondrial respiratory chain complex I |
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. |
TAS |
CC |
GO:0005764 |
lysosome |
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
TAS |
CC |
GO:0005791 |
rough endoplasmic reticulum |
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. |
IEA |
CC |
GO:0005794 |
Golgi apparatus |
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. |
IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IDA|TAS |
CC |
GO:0005840 |
ribosome |
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. |
IEA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA |
CC |
GO:0005938 |
cell cortex |
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
IDA |
CC |
GO:0008021 |
synaptic vesicle |
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
IEA |
CC |
GO:0015629 |
actin cytoskeleton |
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
IDA |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
CC |
GO:0016234 |
inclusion body |
A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. |
IDA |
CC |
GO:0030054 |
cell junction |
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. |
IEA |
CC |
GO:0030424 |
axon |
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
IDA |
CC |
GO:0030426 |
growth cone |
The migrating motile tip of a growing nerve cell axon or dendrite. |
IDA |
CC |
GO:0031092 |
platelet alpha granule membrane |
The lipid bilayer surrounding the platelet alpha granule. |
IDA |
CC |
GO:0043195 |
terminal bouton |
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. |
IEA |
CC |
GO:0043205 |
fibril |
Extracellular matrix material consisting of polysaccharides and protein. |
IDA |
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
IDA |
CC |
GO:0098794 |
postsynapse |
The part of a synapse that is part of the post-synaptic cell. |
IEA |
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IDA |
MF |
GO:0005507 |
copper ion binding |
Interacting selectively and non-covalently with copper (Cu) ions. |
IDA |
MF |
GO:0005509 |
calcium ion binding |
Interacting selectively and non-covalently with calcium ions (Ca2+). |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005543 |
phospholipid binding |
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. |
IDA |
MF |
GO:0008017 |
microtubule binding |
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
IEA |
MF |
GO:0008198 |
ferrous iron binding |
Interacting selectively and non-covalently with ferrous iron, Fe(II). |
IDA |
MF |
GO:0008270 |
zinc ion binding |
Interacting selectively and non-covalently with zinc (Zn) ions. |
IDA |
MF |
GO:0016491 |
oxidoreductase activity |
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
IDA |
MF |
GO:0019894 |
kinesin binding |
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. |
IPI |
MF |
GO:0019904 |
protein domain specific binding |
Interacting selectively and non-covalently with a specific domain of a protein. |
IEA |
MF |
GO:0042393 |
histone binding |
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. |
IDA |
MF |
GO:0042802 |
identical protein binding |
Interacting selectively and non-covalently with an identical protein or proteins. |
IDA|IPI |
MF |
GO:0043014 |
alpha-tubulin binding |
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. |
IPI |
MF |
GO:0043027 |
cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. |
IDA |
MF |
GO:0043274 |
phospholipase binding |
Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. |
IEA |
MF |
GO:0044212 |
transcription regulatory region DNA binding |
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
TAS |
MF |
GO:0045502 |
dynein binding |
Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules. |
IPI |
MF |
GO:0047485 |
protein N-terminus binding |
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
IEA |
MF |
GO:0048156 |
tau protein binding |
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. |
IDA |
MF |
GO:0048487 |
beta-tubulin binding |
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin. |
IEA |
MF |
GO:0051219 |
phosphoprotein binding |
Interacting selectively and non-covalently with a phosphorylated protein. |
IDA |
Domain ID | Description |
---|---|
IPR001058 |
Synuclein |
IPR002460 |
Alpha-synuclein |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa05010 |
Alzheimer's disease |
KEGG |
hsa05012 |
Parkinson's disease |
KEGG |
WP2059 |
Alzheimers Disease |
WikiPathways |
WP2371 |
Parkinsons Disease Pathway |
WikiPathways |
WP2858 |
Ectoderm Differentiation |
WikiPathways |
WP2359 |
Parkin-Ubiquitin Proteasomal System pathway |
WikiPathways |
h_ParkinsonsPathway |
Alpha-synuclein and Parkin-mediated proteolysis in Parkinson's disease |
BioCarta |
h_parkinPathway |
Role of Parkin in the Ubiquitin-Proteasomal Pathway |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0001973 |
Alcoholic Intoxication, Chronic |
C0017205 |
Gaucher Disease |
C0019202 |
Hepatolenticular Degeneration |
C0022976 |
Lameness, Animal |
C0027746 |
Nerve Degeneration |
C0030567 |
Parkinson Disease |
C0033941 |
Psychoses, Substance-Induced |
C0236733 |
Amphetamine-Related Disorders |
C0236736 |
Cocaine-Related Disorders |
C0242422 |
Parkinsonian Disorders |
C0524851 |
Neurodegenerative Disorders |
C0677050 |
Manganese Poisoning |
C0752347 |
Lewy Body Disease |
Tissue | Cell Type |
---|---|
bone marrow |
hematopoietic cells |
cerebral cortex |
neuropil |
Pubmed ID | Author | Year | Title |
---|---|---|---|
18765015 |
Qiao et al. |
2008 |
Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ANXA6 |
309 |
P08133 |
0.49 |
FKBP4 |
2288 |
Q02790 |
0.49 |
HSD17B4 |
3295 |
P51659 |
0.49 |
KLC1 |
3831 |
Q07866 |
0.49 |
MT-CO1 |
4512 |
P00395 |
0.49 |
PRDX1 |
5052 |
Q06830 |
0.49 |
PFDN2 |
5202 |
Q9UHV9 |
0.49 |
SRI |
6717 |
P30626 |
0.49 |
ENC1 |
8507 |
O14682 |
0.49 |
PELP1 |
27043 |
Q8IZL8 |
0.49 |
SAP30BP |
29115 |
Q9UHR5 |
0.49 |
USP47 |
55031 |
Q96K76 |
0.49 |
BDH2 |
56898 |
Q9BUT1 |
0.49 |
ACTA1 |
58 |
P68133 |
0.56 |
CTNND1 |
1500 |
O60716 |
0.56 |
DMTN |
2039 |
Q08495 |
0.56 |
HSPB2 |
3316 |
Q16082 |
0.56 |
IARS |
3376 |
P41252 |
0.56 |
MEF2D |
4209 |
Q14814 |
0.56 |
PAK3 |
5063 |
O75914 |
0.56 |
PLCB2 |
5330 |
Q00722 |
0.56 |
RNF10 |
9921 |
Q8N5U6 |
0.56 |
CDC42EP2 |
10435 |
O14613 |
0.56 |
CDC42EP3 |
10602 |
Q9UKI2 |
0.56 |
ARPP19 |
10776 |
P56211 |
0.56 |
GABARAPL1 |
23710 |
Q9H0R8 |
0.56 |
HSPB8 |
26353 |
Q9UJY1 |
0.56 |
ADAP2 |
55803 |
Q9NPF8 |
0.56 |
ARHGAP15 |
55843 |
Q53QZ3 |
0.56 |
CDC42SE1 |
56882 |
Q9NRR8 |
0.56 |
KIAA1191 |
57179 |
Q96A73 |
0.56 |
HSPB6 |
126393 |
O14558 |
0.56 |
A1BG |
1 |
P04217 |
0.63 |
ACTB |
60 |
P60709 |
0.63 |
AP1B1 |
162 |
Q10567 |
0.63 |
APLP1 |
333 |
P51693 |
0.63 |
ARRB1 |
408 |
P49407 |
0.63 |
CDK4 |
1019 |
P11802 |
0.63 |
CLTC |
1213 |
Q00610 |
0.63 |
EEF1A1 |
1915 |
P68104 |
0.63 |
HPRT1 |
3251 |
P00492 |
0.63 |
DNAJB1 |
3337 |
P25685 |
0.63 |
LAMP2 |
3920 |
P13473 |
0.63 |
NDUFB6 |
4712 |
O95139 |
0.63 |
POLR2H |
5437 |
P52434 |
0.63 |
PRSS1 |
5644 |
P07477 |
0.63 |
RALGDS |
5900 |
Q12967 |
0.63 |
UQCRC2 |
7385 |
P22695 |
0.63 |
FXR1 |
8087 |
P51114 |
0.63 |
USP9X |
8239 |
Q93008 |
0.63 |
EIF3G |
8666 |
O75821 |
0.63 |
ATG5 |
9474 |
Q9H1Y0 |
0.63 |
PDE4DIP |
9659 |
Q5VU43 |
0.63 |
HERPUD1 |
9709 |
Q15011 |
0.63 |
SRRM1 |
10250 |
Q8IYB3 |
0.63 |
WDFY3 |
23001 |
Q8IZQ1 |
0.63 |
SGSM3 |
27352 |
Q96HU1 |
0.63 |
SDF4 |
51150 |
Q9BRK5 |
0.63 |
CHMP5 |
51510 |
Q9NZZ3 |
0.63 |
MPHOSPH8 |
54737 |
Q99549 |
0.63 |
TUBB1 |
81027 |
Q9H4B7 |
0.63 |
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
DOCK7 |
85440 |
Q96N67 |
0.63 |
TUBB |
203068 |
P07437 |
0.63 |
DYRK1A |
1859 |
Q13627 |
0.65 |
CYCS |
54205 |
P99999 |
0.65 |
ENSA |
2029 |
O43768 |
0.66 |
SUMO2 |
6613 |
P61956 |
0.68 |
VDAC2 |
7417 |
P45880 |
0.68 |
BAG5 |
9529 |
Q9UL15 |
0.68 |
AKT1 |
207 |
P31749 |
0.72 |
COL7A1 |
1294 |
Q02388 |
0.72 |
DHCR24 |
1718 |
Q15392 |
0.72 |
FMR1 |
2332 |
Q06787 |
0.72 |
HTT |
3064 |
P42858 |
0.72 |
HSPA1L |
3305 |
P34931 |
0.72 |
ILF3 |
3609 |
Q12906 |
0.72 |
MCM5 |
4174 |
P33992 |
0.72 |
NCBP1 |
4686 |
Q09161 |
0.72 |
POLR2L |
5441 |
P62875 |
0.72 |
MAPK3 |
5595 |
P27361 |
0.72 |
MAPK8 |
5599 |
P45983 |
0.72 |
RREB1 |
6239 |
Q92766 |
0.72 |
SRSF4 |
6429 |
Q08170 |
0.72 |
SSB |
6741 |
P05455 |
0.72 |
TAF7 |
6879 |
Q15545 |
0.72 |
TUBG1 |
7283 |
P23258 |
0.72 |
AKAP17A |
8227 |
Q02040 |
0.72 |
DYNLL1 |
8655 |
P63167 |
0.72 |
EFTUD2 |
9343 |
Q15029 |
0.72 |
FXR2 |
9513 |
P51116 |
0.72 |
NOS1AP |
9722 |
O75052 |
0.72 |
LCMT2 |
9836 |
O60294 |
0.72 |
INADL |
10207 |
Q8NI35 |
0.72 |
CGRRF1 |
10668 |
Q99675 |
0.72 |
PRDX3 |
10935 |
P30048 |
0.72 |
RRAS2 |
22800 |
P62070 |
0.72 |
NCBP2 |
22916 |
P52298 |
0.72 |
SNRNP200 |
23020 |
O75643 |
0.72 |
SKIV2L2 |
23517 |
P42285 |
0.72 |
KIAA1429 |
25962 |
Q69YN4 |
0.72 |
PRPF19 |
27339 |
Q9UMS4 |
0.72 |
HERC5 |
51191 |
Q9UII4 |
0.72 |
SRRT |
51593 |
Q9BXP5 |
0.72 |
PPIL3 |
53938 |
Q9H2H8 |
0.72 |
SMU1 |
55234 |
Q2TAY7 |
0.72 |
ZCCHC8 |
55596 |
Q6NZY4 |
0.72 |
P3H1 |
64175 |
Q32P28 |
0.72 |
C22orf65 |
85459 |
Q9C0D2 |
0.72 |
TGS1 |
96764 |
Q96RS0 |
0.72 |
CMBL |
134147 |
Q96DG6 |
0.72 |
LAMTOR4 |
389541 |
Q0VGL1 |
0.72 |
MT-CO3 |
4514 |
P00414 |
0.73 |
TUBA1B |
10376 |
P68363 |
0.74 |
SLC6A4 |
6532 |
P31645 |
0.75 |
MAP1B |
4131 |
P46821 |
0.76 |
GAPDH |
2597 |
P04406 |
0.78 |
GBA |
2629 |
P04062 |
0.78 |
HSPB1 |
3315 |
P04792 |
0.78 |
RABAC1 |
10567 |
Q9UI14 |
0.78 |
HSPA4 |
3308 |
P34932 |
0.79 |
HSPA8 |
3312 |
P11142 |
0.79 |
PSMC3 |
5702 |
P17980 |
0.79 |
SPTBN1 |
6711 |
Q01082 |
0.80 |
VDAC1 |
7416 |
P21796 |
0.80 |
DYNC1H1 |
1778 |
Q14204 |
0.82 |
BAX |
581 |
Q07812 |
0.85 |
CRYAB |
1410 |
P02511 |
0.85 |
LRRK2 |
120892 |
Q5S007 |
0.86 |
CALM2 |
805 |
P62158 |
0.87 |
CALM3 |
808 |
P62158 |
0.87 |
APP |
351 |
P05067 |
0.89 |
MAPT |
4137 |
P10636 |
0.89 |
SLC6A3 |
6531 |
Q01959 |
0.89 |
SNCA |
6622 |
P37840 |
0.90 |
PSAP |
5660 |
P07602 |
0.49 |
BCL2L1 |
598 |
Q07817 |
0.52 |
PLK3 |
1263 |
Q9H4B4 |
0.52 |
CTSD |
1509 |
P07339 |
0.52 |
PLK1 |
5347 |
P53350 |
0.52 |
PRKCE |
5581 |
Q02156 |
0.52 |
SRC |
6714 |
P12931 |
0.52 |
TGM1 |
7051 |
P22735 |
0.52 |
VIM |
7431 |
P08670 |
0.52 |
YWHAB |
7529 |
P31946 |
0.52 |
YWHAE |
7531 |
P62258 |
0.52 |
TUBA1A |
7846 |
Q71U36 |
0.52 |
MAPK8IP1 |
9479 |
Q9UQF2 |
0.52 |
NEDD4L |
23327 |
Q96PU5 |
0.52 |
MAP1LC3A |
84557 |
Q9H492 |
0.52 |
COL25A1 |
84570 |
Q9BXS0 |
0.52 |
KLK6 |
5653 |
Q92876 |
0.55 |
TH |
7054 |
P07101 |
0.55 |
CAV1 |
857 |
Q03135 |
0.56 |
GSK3B |
2932 |
P49841 |
0.56 |
HSP90AA1 |
3320 |
P07900 |
0.56 |
CSNK1A1 |
1452 |
P48729 |
0.62 |
PLK2 |
10769 |
Q9NYY3 |
0.62 |
DGUOK |
1716 |
Q16854 |
0.63 |
PRKCD |
5580 |
Q05655 |
0.63 |
RAB5A |
5868 |
P20339 |
0.63 |
TRAF6 |
7189 |
Q9Y4K3 |
0.63 |
CBX4 |
8535 |
O00257 |
0.63 |
HAX1 |
10456 |
O00165 |
0.63 |
YWHAQ |
10971 |
P27348 |
0.63 |
NUFIP1 |
26747 |
Q9UHK0 |
0.63 |
DNAAF2 |
55172 |
Q9NVR5 |
0.63 |
FBXW7 |
55294 |
Q969H0 |
0.63 |
FSD1 |
79187 |
Q9BTV5 |
0.63 |
CSNK2A2 |
1459 |
P19784 |
0.65 |
ELK1 |
2002 |
P19419 |
0.65 |
PIN1 |
5300 |
Q13526 |
0.65 |
GRK1 |
6011 |
Q15835 |
0.65 |
SQSTM1 |
8878 |
Q13501 |
0.65 |
HIST2H3A; HIST2H3C; HIST2H3D |
126961 |
Q71DI3 |
0.65 |
ADRBK1 |
156 |
P25098 |
0.66 |
PTK2B |
2185 |
Q14289 |
0.66 |
FGR |
2268 |
P09769 |
0.66 |
LYN |
4067 |
P07948 |
0.66 |
SYK |
6850 |
P43405 |
0.66 |
GRK6 |
2870 |
P43250 |
0.67 |
PINK1 |
65018 |
Q9BXM7 |
0.68 |
CSNK1D |
1453 |
P48730 |
0.71 |
SEPT2 |
4735 |
Q15019 |
0.72 |
RAB3A |
5864 |
P20336 |
0.73 |
SLC6A2 |
6530 |
P23975 |
0.73 |
SYN1 |
6853 |
P17600 |
0.73 |
PARK7 |
11315 |
Q99497 |
0.73 |
SNCB |
6620 |
Q16143 |
0.74 |
TOR1A |
1861 |
O14656 |
0.75 |
RAB8A |
4218 |
P61006 |
0.75 |
NEDD4 |
4734 |
P46934 |
0.75 |
STUB1 |
10273 |
Q9UNE7 |
0.75 |
SIAH2 |
6478 |
O43255 |
0.76 |
TPPP |
11076 |
O94811 |
0.77 |
ABL1 |
25 |
P00519 |
0.79 |
GRK5 |
2869 |
P34947 |
0.79 |
PLD1 |
5337 |
Q13393 |
0.79 |
FYN |
2534 |
P06241 |
0.80 |
SIAH1 |
6477 |
Q8IUQ4 |
0.81 |
SEPT4 |
5414 |
O43236 |
0.82 |
CSNK2A1 |
1457 |
P68400 |
0.83 |
PARK2 |
5071 |
O60260 |
0.84 |
MAPK1 |
5594 |
P28482 |
0.85 |
BAD |
572 |
Q92934 |
0.88 |
EGFR |
1956 |
P00533 |
0.88 |
HSPA1A |
3303 |
P0DMV8 |
0.88 |
HSPA1B |
3304 |
P0DMV9 |
0.88 |
SNCAIP |
9627 |
Q9Y6H5 |
0.90 |
YWHAH |
7533 |
Q04917 |
0.95 |