Protein Description

Gene Symbol SNCA
Entrez ID 6622
Uniprot ID P37840
Description synuclein alpha
Chromosomal Location chr4: 89,724,099-89,838,315
Ontology GO ID GO Term Definition Evidence

BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

TAS

BP

GO:0001774

microglial cell activation

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

TAS

BP

GO:0001921

positive regulation of receptor recycling

Any process that activates or increases the frequency, rate or extent of receptor recycling.

IDA

BP

GO:0001933

negative regulation of protein phosphorylation

Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.

IEA

BP

GO:0001956

positive regulation of neurotransmitter secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.

IEA

BP

GO:0006631

fatty acid metabolic process

The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.

IEA

BP

GO:0006638

neutral lipid metabolic process

The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.

IEA

BP

GO:0006644

phospholipid metabolic process

The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.

IEA

BP

GO:0006915

apoptotic process

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

IEA

BP

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.

IDA

BP

GO:0007006

mitochondrial membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.

IEA

BP

GO:0007568

aging

A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).

IEA

BP

GO:0008344

adult locomotory behavior

Locomotory behavior in a fully developed and mature organism.

IEA

BP

GO:0010040

response to iron(II) ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus.

IDA

BP

GO:0010517

regulation of phospholipase activity

Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.

IDA

BP

GO:0010642

negative regulation of platelet-derived growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.

IDA

BP

GO:0014048

regulation of glutamate secretion

Any process that modulates the frequency, rate or extent of the controlled release of glutamate.

IEA

BP

GO:0014059

regulation of dopamine secretion

Any process that modulates the frequency, rate or extent of the regulated release of dopamine.

TAS

BP

GO:0031115

negative regulation of microtubule polymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.

IDA

BP

GO:0031623

receptor internalization

A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.

IDA

BP

GO:0031648

protein destabilization

Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.

IDA

BP

GO:0032026

response to magnesium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.

IDA

BP

GO:0032410

negative regulation of transporter activity

Any process that stops or reduces the activity of a transporter.

IDA

BP

GO:0032496

response to lipopolysaccharide

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

IDA

BP

GO:0032769

negative regulation of monooxygenase activity

Any process that stops or reduces the activity of a monooxygenase.

IDA

BP

GO:0033138

positive regulation of peptidyl-serine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.

ISS

BP

GO:0034341

response to interferon-gamma

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.

IDA

BP

GO:0034599

cellular response to oxidative stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

IC

BP

GO:0035067

negative regulation of histone acetylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.

IDA

BP

GO:0040012

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

IEA

BP

GO:0042416

dopamine biosynthetic process

The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

TAS

BP

GO:0042493

response to drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

IEA

BP

GO:0042775

mitochondrial ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.

IEA

BP

GO:0043030

regulation of macrophage activation

Any process that modulates the frequency or rate of macrophage activation.

IEA

BP

GO:0043065

positive regulation of apoptotic process

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.

TAS

BP

GO:0043066

negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

IMP

BP

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.

IMP

BP

GO:0043206

extracellular fibril organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins.

TAS

BP

GO:0043524

negative regulation of neuron apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.

IEA

BP

GO:0044267

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.

TAS

BP

GO:0044344

cellular response to fibroblast growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.

IEA

BP

GO:0045807

positive regulation of endocytosis

Any process that activates or increases the frequency, rate or extent of endocytosis.

IDA

BP

GO:0045920

negative regulation of exocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.

IMP

BP

GO:0045963

negative regulation of dopamine metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.

IEA

BP

GO:0048148

behavioral response to cocaine

Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.

IEA

BP

GO:0048169

regulation of long-term neuronal synaptic plasticity

A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.

IEA

BP

GO:0048488

synaptic vesicle endocytosis

Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished.

ISS

BP

GO:0050808

synapse organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

IEA

BP

GO:0050812

regulation of acyl-CoA biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA.

IEA

BP

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.

IDA

BP

GO:0051583

dopamine uptake involved in synaptic transmission

The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

TAS

BP

GO:0051585

negative regulation of dopamine uptake involved in synaptic transmission

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell.

IDA

BP

GO:0051612

negative regulation of serotonin uptake

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell.

IDA

BP

GO:0051622

negative regulation of norepinephrine uptake

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.

IDA

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IDA

BP

GO:0060079

excitatory postsynaptic potential

A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.

IEA

BP

GO:0060291

long-term synaptic potentiation

A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.

IEA

BP

GO:0060732

positive regulation of inositol phosphate biosynthetic process

Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.

IDA

BP

GO:0070495

negative regulation of thrombin receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands.

IDA

BP

GO:0070555

response to interleukin-1

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.

IDA

BP

GO:0071280

cellular response to copper ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.

IDA

BP

GO:0071872

cellular response to epinephrine stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.

TAS

BP

GO:0071902

positive regulation of protein serine/threonine kinase activity

Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.

IDA

BP

GO:1901215

negative regulation of neuron death

Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.

IDA

BP

GO:1902957

negative regulation of mitochondrial electron transport, NADH to ubiquinone

Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone.

TAS

BP

GO:1903284

positive regulation of glutathione peroxidase activity

Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity.

IDA

BP

GO:1903285

positive regulation of hydrogen peroxide catabolic process

Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process.

IDA

BP

GO:1903421

regulation of synaptic vesicle recycling

Any process that modulates the frequency, rate or extent of synaptic vesicle recycling.

TAS

BP

GO:1903426

regulation of reactive oxygen species biosynthetic process

Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.

TAS

BP

GO:1904715

negative regulation of chaperone-mediated autophagy

Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy.

IMP

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

IDA|TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005640

nuclear outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

TAS

CC

GO:0005747

mitochondrial respiratory chain complex I

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

TAS

CC

GO:0005764

lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

TAS

CC

GO:0005791

rough endoplasmic reticulum

The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.

IEA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA|TAS

CC

GO:0005840

ribosome

An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0005938

cell cortex

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

IDA

CC

GO:0008021

synaptic vesicle

A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

IEA

CC

GO:0015629

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0016234

inclusion body

A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.

IDA

CC

GO:0030054

cell junction

A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

IEA

CC

GO:0030424

axon

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

IDA

CC

GO:0030426

growth cone

The migrating motile tip of a growing nerve cell axon or dendrite.

IDA

CC

GO:0031092

platelet alpha granule membrane

The lipid bilayer surrounding the platelet alpha granule.

IDA

CC

GO:0043195

terminal bouton

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.

IEA

CC

GO:0043205

fibril

Extracellular matrix material consisting of polysaccharides and protein.

IDA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IDA

CC

GO:0098794

postsynapse

The part of a synapse that is part of the post-synaptic cell.

IEA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IDA

MF

GO:0005507

copper ion binding

Interacting selectively and non-covalently with copper (Cu) ions.

IDA

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005543

phospholipid binding

Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.

IDA

MF

GO:0008017

microtubule binding

Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.

IEA

MF

GO:0008198

ferrous iron binding

Interacting selectively and non-covalently with ferrous iron, Fe(II).

IDA

MF

GO:0008270

zinc ion binding

Interacting selectively and non-covalently with zinc (Zn) ions.

IDA

MF

GO:0016491

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

IDA

MF

GO:0019894

kinesin binding

Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.

IPI

MF

GO:0019904

protein domain specific binding

Interacting selectively and non-covalently with a specific domain of a protein.

IEA

MF

GO:0042393

histone binding

Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.

IDA

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IDA|IPI

MF

GO:0043014

alpha-tubulin binding

Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.

IPI

MF

GO:0043027

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.

IDA

MF

GO:0043274

phospholipase binding

Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid.

IEA

MF

GO:0044212

transcription regulatory region DNA binding

Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.

TAS

MF

GO:0045502

dynein binding

Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules.

IPI

MF

GO:0047485

protein N-terminus binding

Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.

IEA

MF

GO:0048156

tau protein binding

Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.

IDA

MF

GO:0048487

beta-tubulin binding

Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.

IEA

MF

GO:0051219

phosphoprotein binding

Interacting selectively and non-covalently with a phosphorylated protein.

IDA

Domain ID Description

IPR001058

Synuclein

IPR002460

Alpha-synuclein

Pathway ID Pathway Term Pathway Source

hsa05010

Alzheimer's disease

KEGG

hsa05012

Parkinson's disease

KEGG

WP2059

Alzheimers Disease

WikiPathways

WP2371

Parkinsons Disease Pathway

WikiPathways

WP2858

Ectoderm Differentiation

WikiPathways

WP2359

Parkin-Ubiquitin Proteasomal System pathway

WikiPathways

h_ParkinsonsPathway

Alpha-synuclein and Parkin-mediated proteolysis in Parkinson's disease

BioCarta

h_parkinPathway

Role of Parkin in the Ubiquitin-Proteasomal Pathway

BioCarta

UMLS CUI UMLS Term

C0001973

Alcoholic Intoxication, Chronic

C0017205

Gaucher Disease

C0019202

Hepatolenticular Degeneration

C0022976

Lameness, Animal

C0027746

Nerve Degeneration

C0030567

Parkinson Disease

C0033941

Psychoses, Substance-Induced

C0236733

Amphetamine-Related Disorders

C0236736

Cocaine-Related Disorders

C0242422

Parkinsonian Disorders

C0524851

Neurodegenerative Disorders

C0677050

Manganese Poisoning

C0752347

Lewy Body Disease

Tissue Cell Type

bone marrow

hematopoietic cells

cerebral cortex

neuropil

No databases found.

Pubmed ID Author Year Title

18765015

Qiao et al.

2008

Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ANXA6

309

P08133

0.49

FKBP4

2288

Q02790

0.49

HSD17B4

3295

P51659

0.49

KLC1

3831

Q07866

0.49

MT-CO1

4512

P00395

0.49

PRDX1

5052

Q06830

0.49

PFDN2

5202

Q9UHV9

0.49

SRI

6717

P30626

0.49

ENC1

8507

O14682

0.49

PELP1

27043

Q8IZL8

0.49

SAP30BP

29115

Q9UHR5

0.49

USP47

55031

Q96K76

0.49

BDH2

56898

Q9BUT1

0.49

ACTA1

58

P68133

0.56

CTNND1

1500

O60716

0.56

DMTN

2039

Q08495

0.56

HSPB2

3316

Q16082

0.56

IARS

3376

P41252

0.56

MEF2D

4209

Q14814

0.56

PAK3

5063

O75914

0.56

PLCB2

5330

Q00722

0.56

RNF10

9921

Q8N5U6

0.56

CDC42EP2

10435

O14613

0.56

CDC42EP3

10602

Q9UKI2

0.56

ARPP19

10776

P56211

0.56

GABARAPL1

23710

Q9H0R8

0.56

HSPB8

26353

Q9UJY1

0.56

ADAP2

55803

Q9NPF8

0.56

ARHGAP15

55843

Q53QZ3

0.56

CDC42SE1

56882

Q9NRR8

0.56

KIAA1191

57179

Q96A73

0.56

HSPB6

126393

O14558

0.56

A1BG

1

P04217

0.63

ACTB

60

P60709

0.63

AP1B1

162

Q10567

0.63

APLP1

333

P51693

0.63

ARRB1

408

P49407

0.63

CDK4

1019

P11802

0.63

CLTC

1213

Q00610

0.63

EEF1A1

1915

P68104

0.63

HPRT1

3251

P00492

0.63

DNAJB1

3337

P25685

0.63

LAMP2

3920

P13473

0.63

NDUFB6

4712

O95139

0.63

POLR2H

5437

P52434

0.63

PRSS1

5644

P07477

0.63

RALGDS

5900

Q12967

0.63

UQCRC2

7385

P22695

0.63

FXR1

8087

P51114

0.63

USP9X

8239

Q93008

0.63

EIF3G

8666

O75821

0.63

ATG5

9474

Q9H1Y0

0.63

PDE4DIP

9659

Q5VU43

0.63

HERPUD1

9709

Q15011

0.63

SRRM1

10250

Q8IYB3

0.63

WDFY3

23001

Q8IZQ1

0.63

SGSM3

27352

Q96HU1

0.63

SDF4

51150

Q9BRK5

0.63

CHMP5

51510

Q9NZZ3

0.63

MPHOSPH8

54737

Q99549

0.63

TUBB1

81027

Q9H4B7

0.63

MAP1LC3B

81631

Q9GZQ8

0.63

DOCK7

85440

Q96N67

0.63

TUBB

203068

P07437

0.63

DYRK1A

1859

Q13627

0.65

CYCS

54205

P99999

0.65

ENSA

2029

O43768

0.66

SUMO2

6613

P61956

0.68

VDAC2

7417

P45880

0.68

BAG5

9529

Q9UL15

0.68

AKT1

207

P31749

0.72

COL7A1

1294

Q02388

0.72

DHCR24

1718

Q15392

0.72

FMR1

2332

Q06787

0.72

HTT

3064

P42858

0.72

HSPA1L

3305

P34931

0.72

ILF3

3609

Q12906

0.72

MCM5

4174

P33992

0.72

NCBP1

4686

Q09161

0.72

POLR2L

5441

P62875

0.72

MAPK3

5595

P27361

0.72

MAPK8

5599

P45983

0.72

RREB1

6239

Q92766

0.72

SRSF4

6429

Q08170

0.72

SSB

6741

P05455

0.72

TAF7

6879

Q15545

0.72

TUBG1

7283

P23258

0.72

AKAP17A

8227

Q02040

0.72

DYNLL1

8655

P63167

0.72

EFTUD2

9343

Q15029

0.72

FXR2

9513

P51116

0.72

NOS1AP

9722

O75052

0.72

LCMT2

9836

O60294

0.72

INADL

10207

Q8NI35

0.72

CGRRF1

10668

Q99675

0.72

PRDX3

10935

P30048

0.72

RRAS2

22800

P62070

0.72

NCBP2

22916

P52298

0.72

SNRNP200

23020

O75643

0.72

SKIV2L2

23517

P42285

0.72

KIAA1429

25962

Q69YN4

0.72

PRPF19

27339

Q9UMS4

0.72

HERC5

51191

Q9UII4

0.72

SRRT

51593

Q9BXP5

0.72

PPIL3

53938

Q9H2H8

0.72

SMU1

55234

Q2TAY7

0.72

ZCCHC8

55596

Q6NZY4

0.72

P3H1

64175

Q32P28

0.72

C22orf65

85459

Q9C0D2

0.72

TGS1

96764

Q96RS0

0.72

CMBL

134147

Q96DG6

0.72

LAMTOR4

389541

Q0VGL1

0.72

MT-CO3

4514

P00414

0.73

TUBA1B

10376

P68363

0.74

SLC6A4

6532

P31645

0.75

MAP1B

4131

P46821

0.76

GAPDH

2597

P04406

0.78

GBA

2629

P04062

0.78

HSPB1

3315

P04792

0.78

RABAC1

10567

Q9UI14

0.78

HSPA4

3308

P34932

0.79

HSPA8

3312

P11142

0.79

PSMC3

5702

P17980

0.79

SPTBN1

6711

Q01082

0.80

VDAC1

7416

P21796

0.80

DYNC1H1

1778

Q14204

0.82

BAX

581

Q07812

0.85

CRYAB

1410

P02511

0.85

LRRK2

120892

Q5S007

0.86

CALM2

805

P62158

0.87

CALM3

808

P62158

0.87

APP

351

P05067

0.89

MAPT

4137

P10636

0.89

SLC6A3

6531

Q01959

0.89

SNCA

6622

P37840

0.90

PSAP

5660

P07602

0.49

BCL2L1

598

Q07817

0.52

PLK3

1263

Q9H4B4

0.52

CTSD

1509

P07339

0.52

PLK1

5347

P53350

0.52

PRKCE

5581

Q02156

0.52

SRC

6714

P12931

0.52

TGM1

7051

P22735

0.52

VIM

7431

P08670

0.52

YWHAB

7529

P31946

0.52

YWHAE

7531

P62258

0.52

TUBA1A

7846

Q71U36

0.52

MAPK8IP1

9479

Q9UQF2

0.52

NEDD4L

23327

Q96PU5

0.52

MAP1LC3A

84557

Q9H492

0.52

COL25A1

84570

Q9BXS0

0.52

KLK6

5653

Q92876

0.55

TH

7054

P07101

0.55

CAV1

857

Q03135

0.56

GSK3B

2932

P49841

0.56

HSP90AA1

3320

P07900

0.56

CSNK1A1

1452

P48729

0.62

PLK2

10769

Q9NYY3

0.62

DGUOK

1716

Q16854

0.63

PRKCD

5580

Q05655

0.63

RAB5A

5868

P20339

0.63

TRAF6

7189

Q9Y4K3

0.63

CBX4

8535

O00257

0.63

HAX1

10456

O00165

0.63

YWHAQ

10971

P27348

0.63

NUFIP1

26747

Q9UHK0

0.63

DNAAF2

55172

Q9NVR5

0.63

FBXW7

55294

Q969H0

0.63

FSD1

79187

Q9BTV5

0.63

CSNK2A2

1459

P19784

0.65

ELK1

2002

P19419

0.65

PIN1

5300

Q13526

0.65

GRK1

6011

Q15835

0.65

SQSTM1

8878

Q13501

0.65

HIST2H3A; HIST2H3C; HIST2H3D

126961

Q71DI3

0.65

ADRBK1

156

P25098

0.66

PTK2B

2185

Q14289

0.66

FGR

2268

P09769

0.66

LYN

4067

P07948

0.66

SYK

6850

P43405

0.66

GRK6

2870

P43250

0.67

PINK1

65018

Q9BXM7

0.68

CSNK1D

1453

P48730

0.71

SEPT2

4735

Q15019

0.72

RAB3A

5864

P20336

0.73

SLC6A2

6530

P23975

0.73

SYN1

6853

P17600

0.73

PARK7

11315

Q99497

0.73

SNCB

6620

Q16143

0.74

TOR1A

1861

O14656

0.75

RAB8A

4218

P61006

0.75

NEDD4

4734

P46934

0.75

STUB1

10273

Q9UNE7

0.75

SIAH2

6478

O43255

0.76

TPPP

11076

O94811

0.77

ABL1

25

P00519

0.79

GRK5

2869

P34947

0.79

PLD1

5337

Q13393

0.79

FYN

2534

P06241

0.80

SIAH1

6477

Q8IUQ4

0.81

SEPT4

5414

O43236

0.82

CSNK2A1

1457

P68400

0.83

PARK2

5071

O60260

0.84

MAPK1

5594

P28482

0.85

BAD

572

Q92934

0.88

EGFR

1956

P00533

0.88

HSPA1A

3303

P0DMV8

0.88

HSPA1B

3304

P0DMV9

0.88

SNCAIP

9627

Q9Y6H5

0.90

YWHAH

7533

Q04917

0.95