Protein Description

Gene Symbol SLC22A3
Entrez ID 6581
Uniprot ID O75751
Description solute carrier family 22 (organic cation transporter), member 3
Chromosomal Location chr6: 160,348,268-160,452,581
Ontology GO ID GO Term Definition Evidence

BP

GO:0006855

drug transmembrane transport

The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

TAS

BP

GO:0015695

organic cation transport

The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.

IDA

BP

GO:0015697

quaternary ammonium group transport

The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.

IDA

BP

GO:0015872

dopamine transport

The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

IBA

BP

GO:0032098

regulation of appetite

Any process which modulates appetite, the desire or physical craving for food.

IEA

BP

GO:0051615

histamine uptake

The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.

IEA

BP

GO:1901998

toxin transport

The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

TAS

MF

GO:0005329

dopamine transmembrane transporter activity

Enables the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

IBA

MF

GO:0015101

organic cation transmembrane transporter activity

Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.

EXP|IDA|TAS

MF

GO:0015651

quaternary ammonium group transmembrane transporter activity

Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.

IDA

MF

GO:0019534

toxin transporter activity

Enables the directed movement of a toxin into, out of or within a cell, or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.

IEA

Domain ID Description

IPR004749

Organic cation transport protein/SVOP

IPR005829

Sugar transporter, conserved site

IPR011701

Major facilitator superfamily

IPR020846

Major facilitator superfamily domain

Pathway ID Pathway Term Pathway Source

hsa05231

Choline metabolism in cancer

KEGG

WP2267

Synaptic Vesicle Pathway

WikiPathways

UMLS CUI UMLS Term

C0010068

Coronary Heart Disease

C0010246

Coxsackievirus Infections

C0027059

Myocarditis

C0033578

Prostatic Neoplasms

C0236969

Substance-Related Disorders

C0376358

Malignant Neoplasm Of Prostate

C1527249

Colorectal Cancer

C1956346

Coronary Artery Disease

Tissue Cell Type

adrenal gland

glandular cells

breast

glandular cells

breast

myoepithelial cells

cerebellum

cells in granular layer

esophagus

squamous epithelial cells

kidney

cells in tubules

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

placenta

decidual cells

placenta

trophoblastic cells

prostate

glandular cells

rectum

glandular cells

skin

Langerhans

soft tissue

chondrocytes

spleen

cells in white pulp

testis

cells in seminiferous ducts

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

non-germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

NCK1

4690

P16333

0.63

ABL1

25

P00519

0.63

PDZD3

79849

Q86UT5

0.63