Gene Symbol | SLC22A3 |
Entrez ID | 6581 |
Uniprot ID | O75751 |
Description | solute carrier family 22 (organic cation transporter), member 3 |
Chromosomal Location | chr6: 160,348,268-160,452,581 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006855 |
drug transmembrane transport |
The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
TAS |
BP |
GO:0015695 |
organic cation transport |
The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. |
IDA |
BP |
GO:0015697 |
quaternary ammonium group transport |
The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. |
IDA |
BP |
GO:0015872 |
dopamine transport |
The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
IBA |
BP |
GO:0032098 |
regulation of appetite |
Any process which modulates appetite, the desire or physical craving for food. |
IEA |
BP |
GO:0051615 |
histamine uptake |
The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
IEA |
BP |
GO:1901998 |
toxin transport |
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
IEA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
CC |
GO:0005887 |
integral component of plasma membrane |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
TAS |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
TAS |
MF |
GO:0005329 |
dopamine transmembrane transporter activity |
Enables the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
IBA |
MF |
GO:0015101 |
organic cation transmembrane transporter activity |
Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. |
EXP|IDA|TAS |
MF |
GO:0015651 |
quaternary ammonium group transmembrane transporter activity |
Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. |
IDA |
MF |
GO:0019534 |
toxin transporter activity |
Enables the directed movement of a toxin into, out of or within a cell, or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. |
IEA |
Domain ID | Description |
---|---|
IPR004749 |
Organic cation transport protein/SVOP |
IPR005829 |
Sugar transporter, conserved site |
IPR011701 |
Major facilitator superfamily |
IPR020846 |
Major facilitator superfamily domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa05231 |
Choline metabolism in cancer |
KEGG |
WP2267 |
Synaptic Vesicle Pathway |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0010068 |
Coronary Heart Disease |
C0010246 |
Coxsackievirus Infections |
C0027059 |
Myocarditis |
C0033578 |
Prostatic Neoplasms |
C0236969 |
Substance-Related Disorders |
C0376358 |
Malignant Neoplasm Of Prostate |
C1527249 |
Colorectal Cancer |
C1956346 |
Coronary Artery Disease |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
breast |
glandular cells |
breast |
myoepithelial cells |
cerebellum |
cells in granular layer |
esophagus |
squamous epithelial cells |
kidney |
cells in tubules |
lymph node |
non-germinal center cells |
nasopharynx |
respiratory epithelial cells |
placenta |
decidual cells |
placenta |
trophoblastic cells |
prostate |
glandular cells |
rectum |
glandular cells |
skin |
Langerhans |
soft tissue |
chondrocytes |
spleen |
cells in white pulp |
testis |
cells in seminiferous ducts |
thyroid gland |
glandular cells |
tonsil |
germinal center cells |
tonsil |
non-germinal center cells |
tonsil |
squamous epithelial cells |
urinary bladder |
urothelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
NCK1 |
4690 |
P16333 |
0.63 |
ABL1 |
25 |
P00519 |
0.63 |
PDZD3 |
79849 |
Q86UT5 |
0.63 |