Gene Symbol | SLC2A1 |
Entrez ID | 6513 |
Uniprot ID | P11166 |
Description | solute carrier family 2 (facilitated glucose transporter), member 1 |
Chromosomal Location | chr1: 42,925,375-42,959,173 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0005989 |
lactose biosynthetic process |
The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose. |
TAS |
BP |
GO:0006461 |
protein complex assembly |
The aggregation, arrangement and bonding together of a set of components to form a protein complex. |
IDA |
BP |
GO:0006970 |
response to osmotic stress |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. |
IEA |
BP |
GO:0015758 |
glucose transport |
The directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
IDA|TAS |
BP |
GO:0019852 |
L-ascorbic acid metabolic process |
The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. |
TAS |
BP |
GO:0042149 |
cellular response to glucose starvation |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. |
IEA |
BP |
GO:0042908 |
xenobiotic transport |
The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
IEA |
BP |
GO:0050796 |
regulation of insulin secretion |
Any process that modulates the frequency, rate or extent of the regulated release of insulin. |
TAS |
BP |
GO:0070837 |
dehydroascorbic acid transport |
The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C. |
IEA |
BP |
GO:1904659 |
glucose transmembrane transport |
The directed movement of glucose across a membrane. |
IMP |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
TAS |
CC |
GO:0001939 |
female pronucleus |
The pronucleus originating from the ovum that is being fertilized. |
IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IEA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA|TAS |
CC |
GO:0005887 |
integral component of plasma membrane |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IDA |
CC |
GO:0005901 |
caveola |
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. |
IEA |
CC |
GO:0005911 |
cell-cell junction |
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals. |
IEA |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
TAS |
CC |
GO:0016323 |
basolateral plasma membrane |
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
IEA |
CC |
GO:0016324 |
apical plasma membrane |
The region of the plasma membrane located at the apical end of the cell. |
IEA |
CC |
GO:0030496 |
midbody |
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
IDA |
CC |
GO:0030864 |
cortical actin cytoskeleton |
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. |
IDA |
CC |
GO:0042470 |
melanosome |
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
IEA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
CC |
GO:0072562 |
blood microparticle |
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. |
IDA |
MF |
GO:0005355 |
glucose transmembrane transporter activity |
Enables the transfer of the hexose monosaccharide glucose from one side of the membrane to the other. |
EXP|IDA|TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0019900 |
kinase binding |
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
IEA |
MF |
GO:0033300 |
dehydroascorbic acid transporter activity |
Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
EXP |
MF |
GO:0042910 |
xenobiotic transporter activity |
Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells. |
IEA |
MF |
GO:0043621 |
protein self-association |
Interacting selectively and non-covalently with a domain within the same polypeptide. |
IDA |
MF |
GO:0055056 |
D-glucose transmembrane transporter activity |
Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other. |
IMP |
Domain ID | Description |
---|---|
IPR002439 |
Glucose transporter, type 1 (GLUT1) |
IPR003663 |
Sugar/inositol transporter |
IPR005828 |
Major facilitator, sugar transporter-like |
IPR005829 |
Sugar transporter, conserved site |
IPR020846 |
Major facilitator superfamily domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04066 |
HIF-1 signaling pathway |
KEGG |
hsa04911 |
Insulin secretion |
KEGG |
hsa04919 |
Thyroid hormone signaling pathway |
KEGG |
hsa04920 |
Adipocytokine signaling pathway |
KEGG |
hsa04922 |
Glucagon signaling pathway |
KEGG |
hsa04931 |
Insulin resistance |
KEGG |
hsa04976 |
Bile secretion |
KEGG |
hsa05166 |
HTLV-I infection |
KEGG |
hsa05200 |
Pathways in cancer |
KEGG |
hsa05211 |
Renal cell carcinoma |
KEGG |
hsa05230 |
Central carbon metabolism in cancer |
KEGG |
WP3915 |
Angiopoietin Like Protein 8 Regulatory Pathway |
WikiPathways |
WP2884 |
NRF2 pathway |
WikiPathways |
WP534 |
Glycolysis and Gluconeogenesis |
WikiPathways |
WP481 |
Insulin Signaling |
WikiPathways |
WP1946 |
Cori Cycle |
WikiPathways |
WP3614 |
Photodynamic therapy-induced HIF-1 survival signaling |
WikiPathways |
WP3932 |
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
WikiPathways |
h_vitCBPathway |
Vitamin C in the Brain |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0004134 |
Ataxia |
C0007124 |
Noninfiltrating Intraductal Carcinoma |
C0007134 |
Renal Cell Carcinoma |
C0007621 |
Neoplastic Cell Transformation |
C0008073 |
Developmental Disabilities |
C0009375 |
Colonic Neoplasms |
C0011860 |
Diabetes Mellitus, Non-Insulin-Dependent |
C0025521 |
Inborn Errors Of Metabolism |
C0025958 |
Microcephaly |
C0027765 |
Nervous System Disorder |
C0029408 |
Degenerative Polyarthritis |
C0036572 |
Seizures |
C0919267 |
Ovarian Neoplasm |
C1176475 |
Ductal Carcinoma |
C1458155 |
Mammary Neoplasms |
C2239176 |
Liver Carcinoma |
C3714756 |
Intellectual Disability |
Tissue | Cell Type |
---|---|
cerebral cortex |
endothelial cells |
placenta |
trophoblastic cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
COPS6 |
10980 |
Q7L5N1 |
0.63 |
SLC2A1 |
6513 |
P11166 |
0.73 |
STOM |
2040 |
P27105 |
0.74 |
CALR |
811 |
P27797 |
0.78 |
CANX |
821 |
P27824 |
0.78 |
E2F3 |
1871 |
O00716 |
0.07 |
CD55 |
1604 |
P08174 |
0.49 |
SUMO1 |
7341 |
P63165 |
0.52 |
GAPDH |
2597 |
P04406 |
0.62 |
HSPB2 |
3316 |
Q16082 |
0.63 |
ITGA4 |
3676 |
P13612 |
0.63 |
TXNIP |
10628 |
Q9H3M7 |
0.63 |
VHL |
7428 |
P40337 |
0.68 |
ATF2 |
1386 |
P15336 |
0.72 |
ILK |
3611 |
Q13418 |
0.72 |
IRAK1 |
3654 |
P51617 |
0.72 |
JAK2 |
3717 |
O60674 |
0.72 |
TYK2 |
7297 |
P29597 |
0.72 |
STK17B |
9262 |
O94768 |
0.72 |
NCSTN |
23385 |
Q92542 |
0.72 |
NEIL3 |
55247 |
Q8TAT5 |
0.72 |
PTK2B |
2185 |
Q14289 |
0.73 |
SUMO2 |
6613 |
P61956 |
0.73 |
UBE2I |
7329 |
P63279 |
0.78 |
PDIA3 |
2923 |
P30101 |
0.82 |
VCAM1 |
7412 |
P19320 |
0.82 |
GIPC1 |
10755 |
O14908 |
0.87 |