Protein Description

Gene Symbol SLC2A1
Entrez ID 6513
Uniprot ID P11166
Description solute carrier family 2 (facilitated glucose transporter), member 1
Chromosomal Location chr1: 42,925,375-42,959,173
Ontology GO ID GO Term Definition Evidence

BP

GO:0005989

lactose biosynthetic process

The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose.

TAS

BP

GO:0006461

protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a protein complex.

IDA

BP

GO:0006970

response to osmotic stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

IEA

BP

GO:0015758

glucose transport

The directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IDA|TAS

BP

GO:0019852

L-ascorbic acid metabolic process

The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.

TAS

BP

GO:0042149

cellular response to glucose starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.

IEA

BP

GO:0042908

xenobiotic transport

The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IEA

BP

GO:0050796

regulation of insulin secretion

Any process that modulates the frequency, rate or extent of the regulated release of insulin.

TAS

BP

GO:0070837

dehydroascorbic acid transport

The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C.

IEA

BP

GO:1904659

glucose transmembrane transport

The directed movement of glucose across a membrane.

IMP

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0001939

female pronucleus

The pronucleus originating from the ovum that is being fertilized.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IDA

CC

GO:0005901

caveola

A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.

IEA

CC

GO:0005911

cell-cell junction

A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.

IEA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

TAS

CC

GO:0016323

basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

IEA

CC

GO:0016324

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

IEA

CC

GO:0030496

midbody

A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.

IDA

CC

GO:0030864

cortical actin cytoskeleton

The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.

IDA

CC

GO:0042470

melanosome

A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:0072562

blood microparticle

A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.

IDA

MF

GO:0005355

glucose transmembrane transporter activity

Enables the transfer of the hexose monosaccharide glucose from one side of the membrane to the other.

EXP|IDA|TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0019900

kinase binding

Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.

IEA

MF

GO:0033300

dehydroascorbic acid transporter activity

Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

EXP

MF

GO:0042910

xenobiotic transporter activity

Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells.

IEA

MF

GO:0043621

protein self-association

Interacting selectively and non-covalently with a domain within the same polypeptide.

IDA

MF

GO:0055056

D-glucose transmembrane transporter activity

Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other.

IMP

Domain ID Description

IPR002439

Glucose transporter, type 1 (GLUT1)

IPR003663

Sugar/inositol transporter

IPR005828

Major facilitator, sugar transporter-like

IPR005829

Sugar transporter, conserved site

IPR020846

Major facilitator superfamily domain

Pathway ID Pathway Term Pathway Source

hsa04066

HIF-1 signaling pathway

KEGG

hsa04911

Insulin secretion

KEGG

hsa04919

Thyroid hormone signaling pathway

KEGG

hsa04920

Adipocytokine signaling pathway

KEGG

hsa04922

Glucagon signaling pathway

KEGG

hsa04931

Insulin resistance

KEGG

hsa04976

Bile secretion

KEGG

hsa05166

HTLV-I infection

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05211

Renal cell carcinoma

KEGG

hsa05230

Central carbon metabolism in cancer

KEGG

WP3915

Angiopoietin Like Protein 8 Regulatory Pathway

WikiPathways

WP2884

NRF2 pathway

WikiPathways

WP534

Glycolysis and Gluconeogenesis

WikiPathways

WP481

Insulin Signaling

WikiPathways

WP1946

Cori Cycle

WikiPathways

WP3614

Photodynamic therapy-induced HIF-1 survival signaling

WikiPathways

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

h_vitCBPathway

Vitamin C in the Brain

BioCarta

UMLS CUI UMLS Term

C0004134

Ataxia

C0007124

Noninfiltrating Intraductal Carcinoma

C0007134

Renal Cell Carcinoma

C0007621

Neoplastic Cell Transformation

C0008073

Developmental Disabilities

C0009375

Colonic Neoplasms

C0011860

Diabetes Mellitus, Non-Insulin-Dependent

C0025521

Inborn Errors Of Metabolism

C0025958

Microcephaly

C0027765

Nervous System Disorder

C0029408

Degenerative Polyarthritis

C0036572

Seizures

C0919267

Ovarian Neoplasm

C1176475

Ductal Carcinoma

C1458155

Mammary Neoplasms

C2239176

Liver Carcinoma

C3714756

Intellectual Disability

Tissue Cell Type

cerebral cortex

endothelial cells

placenta

trophoblastic cells

No databases found.

Pubmed ID Author Year Title

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

COPS6

10980

Q7L5N1

0.63

SLC2A1

6513

P11166

0.73

STOM

2040

P27105

0.74

CALR

811

P27797

0.78

CANX

821

P27824

0.78

E2F3

1871

O00716

0.07

CD55

1604

P08174

0.49

SUMO1

7341

P63165

0.52

GAPDH

2597

P04406

0.62

HSPB2

3316

Q16082

0.63

ITGA4

3676

P13612

0.63

TXNIP

10628

Q9H3M7

0.63

VHL

7428

P40337

0.68

ATF2

1386

P15336

0.72

ILK

3611

Q13418

0.72

IRAK1

3654

P51617

0.72

JAK2

3717

O60674

0.72

TYK2

7297

P29597

0.72

STK17B

9262

O94768

0.72

NCSTN

23385

Q92542

0.72

NEIL3

55247

Q8TAT5

0.72

PTK2B

2185

Q14289

0.73

SUMO2

6613

P61956

0.73

UBE2I

7329

P63279

0.78

PDIA3

2923

P30101

0.82

VCAM1

7412

P19320

0.82

GIPC1

10755

O14908

0.87