| Gene Symbol | TRA2B |
| Entrez ID | 6434 |
| Uniprot ID | P62995 |
| Description | transformer 2 beta homolog (Drosophila) |
| Chromosomal Location | chr3: 185,915,906-185,938,136 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000375 |
RNA splicing, via transesterification reactions |
Splicing of RNA via a series of two transesterification reactions. |
TAS |
|
BP |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. |
IDA |
|
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
IDA|TAS |
|
BP |
GO:0021796 |
cerebral cortex regionalization |
The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops. |
IEA |
|
BP |
GO:0048025 |
negative regulation of mRNA splicing, via spliceosome |
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. |
IEA |
|
BP |
GO:0048026 |
positive regulation of mRNA splicing, via spliceosome |
Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. |
IDA |
|
BP |
GO:1990403 |
embryonic brain development |
The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure. |
IEA |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
|
CC |
GO:0005637 |
nuclear inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
IEA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
|
MF |
GO:0000166 |
nucleotide binding |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
IEA |
|
MF |
GO:0003729 |
mRNA binding |
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0036002 |
pre-mRNA binding |
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. |
IEA |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
|
MF |
GO:0070717 |
poly-purine tract binding |
Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR000504 |
RNA recognition motif domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03040 |
Spliceosome |
KEGG |
|
WP411 |
mRNA Processing |
WikiPathways |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
chondrocytes |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
SLC3A2 |
6520 |
P08195 |
0.49 |
|
EIF3I |
8668 |
Q13347 |
0.49 |
|
DDX47 |
51202 |
Q9H0S4 |
0.49 |
|
NGFR |
4804 |
P08138 |
0.52 |
|
TIAL1 |
7073 |
Q01085 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
IVNS1ABP |
10625 |
Q9Y6Y0 |
0.63 |
|
SRSF10 |
10772 |
O75494 |
0.63 |
|
SRSF9 |
8683 |
Q13242 |
0.66 |
|
RBMY1A1 |
5940 |
P0DJD3 |
0.67 |
|
SRPK1 |
6732 |
Q96SB4 |
0.70 |
|
SRPK2 |
6733 |
P78362 |
0.80 |
|
RBMX |
27316 |
P38159 |
0.84 |
|
SEPT7 |
989 |
Q16181 |
0.49 |
|
EWSR1 |
2130 |
Q01844 |
0.49 |
|
FLNA |
2316 |
P21333 |
0.49 |
|
HNRNPU |
3192 |
Q00839 |
0.49 |
|
DNAJA1 |
3301 |
P31689 |
0.49 |
|
ILF2 |
3608 |
Q12905 |
0.49 |
|
ILF3 |
3609 |
Q12906 |
0.49 |
|
SEPT2 |
4735 |
Q15019 |
0.49 |
|
NFIA |
4774 |
Q12857 |
0.49 |
|
SNU13 |
4809 |
P55769 |
0.49 |
|
PRKDC |
5591 |
P78527 |
0.49 |
|
RAN |
5901 |
P62826 |
0.49 |
|
RBMS2 |
5939 |
Q15434 |
0.49 |
|
S100A9 |
6280 |
P06702 |
0.49 |
|
EIF4H |
7458 |
Q15056 |
0.49 |
|
ZRANB2 |
9406 |
O95218 |
0.49 |
|
HIPK3 |
10114 |
Q9H422 |
0.49 |
|
GCN1 |
10985 |
Q92616 |
0.49 |
|
PSIP1 |
11168 |
O75475 |
0.49 |
|
CEP164 |
22897 |
Q9UPV0 |
0.49 |
|
FAF2 |
23197 |
Q96CS3 |
0.49 |
|
SF3B1 |
23451 |
O75533 |
0.49 |
|
PPP4R2 |
151987 |
Q9NY27 |
0.49 |
|
SPICE1 |
152185 |
Q8N0Z3 |
0.49 |
|
CLK1 |
1195 |
P49759 |
0.52 |
|
SRSF1 |
6426 |
Q07955 |
0.59 |
|
SRSF5 |
6430 |
Q13243 |
0.59 |
|
SRSF7 |
6432 |
Q16629 |
0.59 |
|
BARD1 |
580 |
Q99728 |
0.63 |
|
CEBPA |
1050 |
P49715 |
0.63 |
|
HNRNPA1 |
3178 |
P09651 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
LUM |
4060 |
P51884 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
POU5F1 |
5460 |
Q01860 |
0.63 |
|
SRSF2 |
6427 |
Q01130 |
0.63 |
|
SRSF4 |
6429 |
Q08170 |
0.63 |
|
SUMO3 |
6612 |
P55854 |
0.63 |
|
TADA2A |
6871 |
O75478 |
0.63 |
|
YWHAE |
7531 |
P62258 |
0.63 |
|
CUL5 |
8065 |
Q93034 |
0.63 |
|
SF3A2 |
8175 |
Q15428 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL2 |
8453 |
Q13617 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
EED |
8726 |
O75530 |
0.63 |
|
BANF1 |
8815 |
O75531 |
0.63 |
|
MED23 |
9439 |
Q9ULK4 |
0.63 |
|
MED20 |
9477 |
Q9H944 |
0.63 |
|
RBM39 |
9584 |
Q14498 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
COPS5 |
10987 |
Q92905 |
0.63 |
|
PAXIP1 |
22976 |
Q6ZW49 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
TNPO3 |
23534 |
Q9Y5L0 |
0.63 |
|
HINFP |
25988 |
Q9BQA5 |
0.63 |
|
TRA2A |
29896 |
Q13595 |
0.63 |
|
DDX41 |
51428 |
Q9UJV9 |
0.63 |
|
LUC7L2 |
51631 |
Q9Y383 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
SNIP1 |
79753 |
Q8TAD8 |
0.63 |
|
CCDC8 |
83987 |
Q9H0W5 |
0.63 |
|
UNK |
85451 |
Q9C0B0 |
0.63 |
|
SREK1 |
140890 |
Q8WXA9 |
0.63 |
|
CDK6 |
1021 |
Q00534 |
0.70 |
|
MAGOH |
4116 |
P61326 |
0.72 |
|
EIF4A3 |
9775 |
P38919 |
0.72 |
|
SRSF6 |
6431 |
Q13247 |
0.73 |
|
SUMO2 |
6613 |
P61956 |
0.73 |
|
SRSF3 |
6428 |
P84103 |
0.74 |
|
YTHDC1 |
91746 |
Q96MU7 |
0.75 |
|
CLK3 |
1198 |
P49761 |
0.79 |
|
YWHAG |
7532 |
P61981 |
0.86 |
|
YWHAZ |
7534 |
P63104 |
0.88 |
|
RNPS1 |
10921 |
Q15287 |
0.89 |