BP

GO:0000380

alternative mRNA splicing, via spliceosome

The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.

IDA

BP

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.

IDA|IMP

BP

GO:0000398

mRNA splicing, via spliceosome

The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

TAS

BP

GO:0006369

termination of RNA polymerase II transcription

The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.

TAS

BP

GO:0006376

mRNA splice site selection

Selection of a splice site by components of the assembling spliceosome.

IMP

BP

GO:0006405

RNA export from nucleus

The directed movement of RNA from the nucleus to the cytoplasm.

TAS

BP

GO:0006406

mRNA export from nucleus

The directed movement of mRNA from the nucleus to the cytoplasm.

TAS

BP

GO:0010837

regulation of keratinocyte proliferation

Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.

IMP

BP

GO:0031124

mRNA 3'-end processing

Any process involved in forming the mature 3' end of an mRNA molecule.

TAS

BP

GO:0032868

response to insulin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.

IEA

BP

GO:0045617

negative regulation of keratinocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.

IMP

BP

GO:0048025

negative regulation of mRNA splicing, via spliceosome

Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.

IDA

BP

GO:0060501

positive regulation of epithelial cell proliferation involved in lung morphogenesis

Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.

IDA

BP

GO:0060548

negative regulation of cell death

Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

IDA

BP

GO:0061041

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

IMP

BP

GO:2000675

negative regulation of type B pancreatic cell apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.

IEA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0016607

nuclear speck

A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.

IDA

MF

GO:0000166

nucleotide binding

Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

IEA

MF

GO:0003723

RNA binding

Interacting selectively and non-covalently with an RNA molecule or a portion thereof.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0036002

pre-mRNA binding

Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.

IDA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA