Gene Symbol | SELL |
Entrez ID | 6402 |
Uniprot ID | P14151 |
Description | selectin L |
Chromosomal Location | chr1: 169,690,667-169,711,698 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007155 |
cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
IEA |
BP |
GO:0033198 |
response to ATP |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. |
IEA |
BP |
GO:0050776 |
regulation of immune response |
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
TAS |
BP |
GO:0050900 |
leukocyte migration |
The movement of a leukocyte within or between different tissues and organs of the body. |
TAS |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
CC |
GO:0005887 |
integral component of plasma membrane |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
TAS |
CC |
GO:0009897 |
external side of plasma membrane |
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
IEA |
MF |
GO:0002020 |
protease binding |
Interacting selectively and non-covalently with any protease or peptidase. |
IPI |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0008201 |
heparin binding |
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. |
TAS |
MF |
GO:0030246 |
carbohydrate binding |
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
IEA |
MF |
GO:0043208 |
glycosphingolipid binding |
Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. |
TAS |
MF |
GO:0050839 |
cell adhesion molecule binding |
Interacting selectively and non-covalently with a cell adhesion molecule. |
IEA |
Domain ID | Description |
---|---|
IPR000436 |
Sushi/SCR/CCP domain |
IPR000742 |
EGF-like domain |
IPR001304 |
C-type lectin-like |
IPR002396 |
Selectin superfamily |
IPR013032 |
EGF-like, conserved site |
IPR016186 |
C-type lectin-like/link domain |
IPR016187 |
C-type lectin fold |
IPR016348 |
L-selectin |
IPR018378 |
C-type lectin, conserved site |
IPR033991 |
Selectin, C-type lectin-like domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04514 |
Cell adhesion molecules (CAMs) |
KEGG |
h_granulocytesPathway |
Adhesion and Diapedesis of Granulocytes |
BioCarta |
h_lympathway |
Adhesion and Diapedesis of Lymphocytes |
BioCarta |
h_lymphocytePathway |
Adhesion Molecules on Lymphocyte |
BioCarta |
h_monocytePathway |
Monocyte and its Surface Molecules |
BioCarta |
h_neutrophilPathway |
Neutrophil and Its Surface Molecules |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0017661 |
Iga Glomerulonephritis |
C0027051 |
Myocardial Infarction |
Tissue | Cell Type |
---|---|
appendix |
lymphoid tissue |
bone marrow |
hematopoietic cells |
lymph node |
non-germinal center cells |
spleen |
cells in white pulp |
tonsil |
germinal center cells |
tonsil |
non-germinal center cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
25393639 |
Ambekar et al. |
2014 |
Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CD4 |
920 |
P01730 |
0.52 |
SELPLG |
6404 |
Q14242 |
0.55 |
PRKCQ |
5588 |
Q04759 |
0.56 |
GRB2 |
2885 |
P62993 |
0.73 |
PODXL |
5420 |
O00592 |
0.73 |
SELE |
6401 |
P16581 |
0.73 |
VCAN |
1462 |
P13611 |
0.75 |
CFH |
3075 |
P08603 |
0.75 |
MSN |
4478 |
P26038 |
0.75 |
EZR |
7430 |
P15311 |
0.75 |
PRKG1 |
5592 |
Q13976 |
0.52 |
PRKCA |
5578 |
P17252 |
0.70 |
EMCN |
51705 |
Q9ULC0 |
0.73 |
MUC7 |
4589 |
Q8TAX7 |
0.75 |
PODXL2 |
50512 |
Q9NZ53 |
0.75 |