BP

GO:0006814

sodium ion transport

The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

TAS

BP

GO:0006954

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

IEA

BP

GO:0009636

response to toxic substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

IEA

BP

GO:0009791

post-embryonic development

The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.

IEA

BP

GO:0019228

neuronal action potential

An action potential that occurs in a neuron.

IBA

BP

GO:0019233

sensory perception of pain

The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.

IMP

BP

GO:0034765

regulation of ion transmembrane transport

Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

IEA

BP

GO:0035725

sodium ion transmembrane transport

A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

IDA

BP

GO:0048266

behavioral response to pain

Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.

IEA

BP

GO:0060078

regulation of postsynaptic membrane potential

Any process that modulates the potential difference across a post-synaptic membrane.

IEA

BP

GO:0086010

membrane depolarization during action potential

The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.

IBA

CC

GO:0001518

voltage-gated sodium channel complex

A sodium channel in a cell membrane whose opening is governed by the membrane potential.

IEA

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IMP

CC

GO:0042995

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

IEA

MF

GO:0005248

voltage-gated sodium channel activity

Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

IDA

MF

GO:0031402

sodium ion binding

Interacting selectively and non-covalently with sodium ions (Na+).

IEA