| Gene Symbol | SCD |
| Entrez ID | 6319 |
| Uniprot ID | O00767 |
| Description | stearoyl-CoA desaturase (delta-9-desaturase) |
| Chromosomal Location | chr10: 100,347,124-100,364,834 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006636 |
unsaturated fatty acid biosynthetic process |
The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. |
IDA |
|
BP |
GO:0035338 |
long-chain fatty-acyl-CoA biosynthetic process |
The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. |
TAS |
|
BP |
GO:0042759 |
long-chain fatty acid biosynthetic process |
The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22. |
IBA |
|
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
|
BP |
GO:1903966 |
monounsaturated fatty acid biosynthetic process |
The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid. |
IBA |
|
CC |
GO:0005783 |
endoplasmic reticulum |
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
IDA |
|
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
IDA|TAS |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IDA |
|
MF |
GO:0004768 |
stearoyl-CoA 9-desaturase activity |
Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O. |
IDA|TAS |
|
MF |
GO:0005506 |
iron ion binding |
Interacting selectively and non-covalently with iron (Fe) ions. |
IDA |
|
MF |
GO:0016491 |
oxidoreductase activity |
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR001522 |
Fatty acid desaturase type 1, conserved site |
|
IPR015876 |
Acyl-CoA desaturase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa01040 |
Biosynthesis of unsaturated fatty acids |
KEGG |
|
hsa01212 |
Fatty acid metabolism |
KEGG |
|
hsa03320 |
PPAR signaling pathway |
KEGG |
|
hsa04152 |
AMPK signaling pathway |
KEGG |
|
WP3915 |
Angiopoietin Like Protein 8 Regulatory Pathway |
WikiPathways |
|
WP1982 |
Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
WikiPathways |
|
WP357 |
Fatty Acid Biosynthesis |
WikiPathways |
|
WP236 |
Adipogenesis |
WikiPathways |
|
WP3942 |
PPAR signaling pathway |
WikiPathways |
|
WP2874 |
Liver X Receptor Pathway |
WikiPathways |
|
WP2011 |
SREBF and miR33 in cholesterol and lipid homeostasis |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0023794 |
Lipoidosis |
|
C0023903 |
Liver Neoplasms |
|
C0024667 |
Animal Mammary Neoplasms |
|
C0024668 |
Mammary Neoplasms, Experimental |
|
C0339143 |
Thyroid Associated Opthalmopathies |
|
C2239176 |
Liver Carcinoma |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
breast |
adipocytes |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
cells in molecular layer |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
liver |
bile duct cells |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
fibroblasts |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
soft tissue |
adipocytes |
|
stomach |
glandular cells |
|
testis |
Leydig cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
17062763 |
Corton et al. |
2007 |
Differential Gene Expression Profile in Omental Adipose Tissue in Women with Polycystic Ovary Syndrome |
|
22344199 |
Chazenbalk et al. |
2012 |
Abnormal Expression of Genes Involved in Inflammation, Lipid Metabolism, and Wnt Signaling in the Adipose Tissue of Polycystic Ovary Syndrome |
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
SSR4 |
6748 |
P51571 |
0.49 |
|
RPL14 |
9045 |
P50914 |
0.49 |
|
VAPB |
9217 |
O95292 |
0.49 |
|
NSUN5 |
55695 |
Q96P11 |
0.49 |
|
APP |
351 |
P05067 |
0.56 |
|
HSD17B12 |
51144 |
Q53GQ0 |
0.56 |
|
HDAC6 |
10013 |
Q9UBN7 |
0.63 |
|
VCP |
7415 |
P55072 |
0.73 |
|
PPARA |
5465 |
Q07869 |
0.00 |
|
E2F3 |
1871 |
O00716 |
0.07 |
|
MYC |
4609 |
P01106 |
0.49 |
|
SLC25A3 |
5250 |
Q00325 |
0.49 |
|
PPP2R1A |
5518 |
P30153 |
0.49 |
|
RPS3 |
6188 |
P23396 |
0.49 |
|
UQCRC2 |
7385 |
P22695 |
0.49 |
|
TCTN3 |
26123 |
Q6NUS6 |
0.49 |
|
TCTN2 |
79867 |
Q96GX1 |
0.49 |
|
CYB5A |
1528 |
P00167 |
0.52 |
|
NEDD4L |
23327 |
Q96PU5 |
0.56 |
|
EGFR |
1956 |
P00533 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
ILK |
3611 |
Q13418 |
0.63 |