BP

GO:0010466

negative regulation of peptidase activity

Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.

IDA

BP

GO:0010951

negative regulation of endopeptidase activity

Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

IEA

BP

GO:0030162

regulation of proteolysis

Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

NAS

BP

GO:0042270

protection from natural killer cell mediated cytotoxicity

The process of protecting a cell from natural killer cell mediated cytotoxicity.

IMP

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IBA

CC

GO:0005622

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0002020

protease binding

Interacting selectively and non-covalently with any protease or peptidase.

IPI

MF

GO:0004867

serine-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

IDA|NAS

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI