Protein Description

Gene Symbol BCS1L
Entrez ID 617
Uniprot ID Q9Y276
Description BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Chromosomal Location chr2: 218,658,764-218,663,443
Ontology GO ID GO Term Definition Evidence

BP

GO:0007005

mitochondrion organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.

IMP

BP

GO:0032981

mitochondrial respiratory chain complex I assembly

The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.

IMP

BP

GO:0033617

mitochondrial respiratory chain complex IV assembly

The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane.

IMP

BP

GO:0034551

mitochondrial respiratory chain complex III assembly

The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane.

IMP

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IDA

CC

GO:0005750

mitochondrial respiratory chain complex III

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

Domain ID Description

IPR003593

AAA+ ATPase domain

IPR003959

ATPase, AAA-type, core

IPR003960

ATPase, AAA-type, conserved site

IPR014851

BCS1, N-terminal

IPR027243

Mitochondrial chaperone BCS1

IPR027417

P-loop containing nucleoside triphosphate hydrolase

No pathways found.

UMLS CUI UMLS Term

C0023264

Leigh Disease

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

colon

glandular cells

duodenum

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

liver

hepatocytes

lung

macrophages

ovary

follicle cells

pancreas

islets of Langerhans

placenta

trophoblastic cells

rectum

glandular cells

small intestine

glandular cells

stomach

glandular cells

testis

Leydig cells

No databases found.

Pubmed ID Author Year Title

22789864

Yan et al.

2012

Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation

Gene Symbol Entrez ID Uniprot ID Score

UQCRFS1

7386

P47985

0.49

AIFM1

9131

O95831

0.49

VAPA

9218

Q9P0L0

0.49

MRPL10

124995

Q7Z7H8

0.49

DNAJA1

3301

P31689

0.63

LETM1

3954

O95202

0.63

DDX24

57062

Q9GZR7

0.63

UCKL1

54963

Q9NWZ5

0.49

FUS

2521

P35637

0.63

TMEFF1

8577

Q8IYR6

0.63

UBD

10537

O15205

0.63

RBFOX2

23543

O43251

0.63

VPS26A

9559

O75436

0.72