| Gene Symbol | BCS1L |
| Entrez ID | 617 |
| Uniprot ID | Q9Y276 |
| Description | BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone |
| Chromosomal Location | chr2: 218,658,764-218,663,443 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0007005 | mitochondrion organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. | IMP |
BP | GO:0032981 | mitochondrial respiratory chain complex I assembly |
The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. | IMP |
BP | GO:0033617 | mitochondrial respiratory chain complex IV assembly |
The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane. | IMP |
BP | GO:0034551 | mitochondrial respiratory chain complex III assembly |
The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane. | IMP |
CC | GO:0005739 | mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | IDA |
CC | GO:0005750 | mitochondrial respiratory chain complex III |
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. | TAS |
MF | GO:0005515 | protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | IPI |
MF | GO:0005524 | ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | IEA |
| Domain ID | Description |
|---|---|
IPR003593 | AAA+ ATPase domain |
IPR003959 | ATPase, AAA-type, core |
IPR003960 | ATPase, AAA-type, conserved site |
IPR014851 | BCS1, N-terminal |
IPR027243 | Mitochondrial chaperone BCS1 |
IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| UMLS CUI | UMLS Term |
|---|---|
C0023264 | Leigh Disease |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | glandular cells |
colon | glandular cells |
duodenum | glandular cells |
esophagus | squamous epithelial cells |
fallopian tube | glandular cells |
gallbladder | glandular cells |
liver | hepatocytes |
lung | macrophages |
ovary | follicle cells |
pancreas | islets of Langerhans |
placenta | trophoblastic cells |
rectum | glandular cells |
small intestine | glandular cells |
stomach | glandular cells |
testis | Leydig cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22789864 | Yan et al. | 2012 | Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
UQCRFS1 | 7386 | P47985 | 0.49 |
AIFM1 | 9131 | O95831 | 0.49 |
VAPA | 9218 | Q9P0L0 | 0.49 |
MRPL10 | 124995 | Q7Z7H8 | 0.49 |
DNAJA1 | 3301 | P31689 | 0.63 |
LETM1 | 3954 | O95202 | 0.63 |
DDX24 | 57062 | Q9GZR7 | 0.63 |
UCKL1 | 54963 | Q9NWZ5 | 0.49 |
FUS | 2521 | P35637 | 0.63 |
TMEFF1 | 8577 | Q8IYR6 | 0.63 |
UBD | 10537 | O15205 | 0.63 |
RBFOX2 | 23543 | O43251 | 0.63 |
VPS26A | 9559 | O75436 | 0.72 |