Protein Description

Gene Symbol S100A10
Entrez ID 6281
Uniprot ID P60903
Description S100 calcium binding protein A10
Chromosomal Location chr1: 151,982,915-151,994,390
Ontology GO ID GO Term Definition Evidence

BP

GO:0001765

membrane raft assembly

The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.

IDA

BP

GO:0006900

membrane budding

The evagination of a membrane, resulting in formation of a vesicle.

IDA

BP

GO:0043547

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

IMP

BP

GO:0051099

positive regulation of binding

Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.

IEA

BP

GO:0051290

protein heterotetramerization

The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.

IDA

BP

GO:0051496

positive regulation of stress fiber assembly

Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.

IMP

BP

GO:0051894

positive regulation of focal adhesion assembly

Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.

IMP

BP

GO:0090002

establishment of protein localization to plasma membrane

The directed movement of a protein to a specific location in the plasma membrane.

IDA

BP

GO:1900026

positive regulation of substrate adhesion-dependent cell spreading

Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.

IMP

CC

GO:0019897

extrinsic component of plasma membrane

The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

IEA

CC

GO:0045121

membrane raft

Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IDA

MF

GO:0044325

ion channel binding

Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

IPI

Domain ID Description

IPR001751

S100/Calbindin-D9k, conserved site

IPR011992

EF-hand domain pair

IPR013787

S100/CaBP-9k-type, calcium binding, subdomain

IPR028476

Protein S100-A10

Pathway ID Pathway Term Pathway Source

WP98

Prostaglandin Synthesis and Regulation

WikiPathways

UMLS CUI UMLS Term

C0011581

Depressive Disorder

C0022548

Keloid

C0023467

Leukemia, Myelocytic, Acute

C0025149

Medulloblastoma

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

breast

glandular cells

bronchus

respiratory epithelial cells

cerebral cortex

endothelial cells

cervix, uterine

squamous epithelial cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

kidney

cells in glomeruli

lung

macrophages

lung

pneumocytes

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

ovary

ovarian stroma cells

pancreas

exocrine glandular cells

placenta

trophoblastic cells

prostate

glandular cells

rectum

glandular cells

seminal vesicle

glandular cells

skin

fibroblasts

skin

keratinocytes

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

soft tissue

fibroblasts

soft tissue

peripheral nerve

spleen

cells in red pulp

testis

Leydig cells

tonsil

squamous epithelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

ATP6V1E1

529

P36543

0.49

HDLBP

3069

Q00341

0.49

SIN3A

25942

Q96ST3

0.49

ZFR

51663

Q96KR1

0.49

UBAP2

55833

Q5T6F2

0.49

SRPRB

58477

Q9Y5M8

0.49

WDR92

116143

Q96MX6

0.49

TMEM65

157378

Q6PI78

0.49

SRP9

653226

P49458

0.49

SUPT6H

6830

Q7KZ85

0.63

SETDB1

9869

Q15047

0.63

DLC1

10395

Q96QB1

0.63

COPS6

10980

Q7L5N1

0.63

TRPV5

56302

Q9NQA5

0.77

S100A10

6281

P60903

0.90

CD55

1604

P08174

0.49

ELAVL1

1994

Q15717

0.49

RPL10A

4736

P62906

0.49

RPL12

6136

P30050

0.49

PPIF

10105

P30405

0.49

FLOT1

10211

O75955

0.49

ZMPSTE24

10269

O75844

0.49

FAF2

23197

Q96CS3

0.49

PHF5A

84844

Q7RTV0

0.49

RPL10L

140801

Q96L21

0.49

ANXA7

310

P20073

0.62

CD81

975

P60033

0.63

EEF1G

1937

P26641

0.63

ERBB3

2065

P21860

0.63

FSHR

2492

P23945

0.63

GDNF

2668

P39905

0.63

NPM1

4869

P06748

0.63

CDK16

5127

Q00536

0.63

PDYN

5173

P01213

0.63

PLA2G4A

5321

P47712

0.63

ABCE1

6059

P61221

0.63

UQCRB

7381

P14927

0.63

PLG

5340

P00747

0.65

HLTF

6596

Q14527

0.68

ATF2

1386

P15336

0.72

FLNA

2316

P21333

0.72

PLA2G4C

8605

Q9UP65

0.75

AHNAK

79026

Q09666

0.76

KCNK3

3777

O14649

0.78

TRPV6

55503

Q9H1D0

0.85

BAD

572

Q92934

0.87

CTSB

1508

P07858

0.87

ANXA2

302

P07355

0.90