Protein Description

Gene Symbol OPN1SW
Entrez ID 611
Uniprot ID P03999
Description opsin 1 (cone pigments), short-wave-sensitive
Chromosomal Location chr7: 128,772,491-128,775,790
Ontology GO ID GO Term Definition Evidence

BP

GO:0001523

retinoid metabolic process

The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.

TAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007186

G-protein coupled receptor signaling pathway

A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).

IBA

BP

GO:0007601

visual perception

The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

IEA

BP

GO:0007602

phototransduction

The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.

IEA

BP

GO:0009584

detection of visible light

The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.

IEA

BP

GO:0018298

protein-chromophore linkage

The covalent or noncovalent attachment of a chromophore to a protein.

IEA

BP

GO:0071482

cellular response to light stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.

IBA

CC

GO:0001750

photoreceptor outer segment

The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.

IBA

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

CC

GO:0042622

photoreceptor outer segment membrane

The membrane surrounding the outer segment of a vertebrate photoreceptor.

TAS

MF

GO:0004872

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

TAS

MF

GO:0008020

G-protein coupled photoreceptor activity

Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

IBA

Domain ID Description

IPR000276

G protein-coupled receptor, rhodopsin-like

IPR001521

Opsin, blue sensitive

IPR001760

Opsin

IPR017452

GPCR, rhodopsin-like, 7TM

IPR027430

Visual pigments (opsins) retinal binding site

Pathway ID Pathway Term Pathway Source

WP455

GPCRs, Class A Rhodopsin-like

WikiPathways

UMLS CUI UMLS Term

C0155017

Color Blindness, Blue

Tissue Cell Type

retina

cells in photoreceptor layer

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

No partners found.