PCOSBase

Protein Description

Gene Symbol	RPS15A
Entrez ID	6210
Uniprot ID	P62244
Description	ribosomal protein S15a
Chromosomal Location	chr16: 18,781,295-18,790,383

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.	TAS
BP	GO:0006364	rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.	TAS
BP	GO:0006412	translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.	IC\|NAS
BP	GO:0006413	translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.	TAS
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.	TAS
BP	GO:0008284	positive regulation of cell proliferation	Any process that activates or increases the rate or extent of cell proliferation.	IDA
BP	GO:0009615	response to virus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.	IDA
BP	GO:0019083	viral transcription	The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.	TAS
BP	GO:0045787	positive regulation of cell cycle	Any process that activates or increases the rate or extent of progression through the cell cycle.	IDA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	TAS
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0005739	mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	IEA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0022627	cytosolic small ribosomal subunit	The small subunit of a ribosome located in the cytosol.	IDA
CC	GO:0031012	extracellular matrix	A structure lying external to one or more cells, which provides structural support for cells or tissues.	IDA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0003723	RNA binding	Interacting selectively and non-covalently with an RNA molecule or a portion thereof.	NAS
MF	GO:0003735	structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.	IDA\|NAS
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR000630	Ribosomal protein S8

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Pathway ID	Pathway Term	Pathway Source
hsa03010	Ribosome	KEGG
WP477	Cytoplasmic Ribosomal Proteins	WikiPathways

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No diseases found.

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Tissue	Cell Type
gallbladder	glandular cells
kidney	cells in tubules
liver	hepatocytes
pancreas	exocrine glandular cells
placenta	decidual cells
placenta	trophoblastic cells
small intestine	glandular cells
stomach	glandular cells

No databases found.

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Pubmed ID	Author	Year	Title
15291743	Diao et al.	2004	The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome
25393639	Ambekar et al.	2014	Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development

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Gene Symbol	Entrez ID	Uniprot ID	Score
RPL28	6158	P46779	0.49
RPL34	6164	P49207	0.49
RPL37	6167	P61927	0.49
UBA52	7311	P62987	0.49
UBA2	10054	Q9UBT2	0.49
MPHOSPH10	10199	O00566	0.49
TUBB4B	10383	P68371	0.49
RPL13A	23521	P40429	0.49
DIMT1	27292	Q9UNQ2	0.49
MRPL22	29093	Q9NWU5	0.49
MRPS7	51081	Q9Y2R9	0.49
MRPL16	54948	Q9NX20	0.49
IMP3	55272	Q9NV31	0.49
MRPL14	64928	Q6P1L8	0.49
TUBB	203068	P07437	0.49
TUBB2B	347733	Q9BVA1	0.49
RPL27A	6157	P46776	0.56
RPS27A	6233	P62979	0.56
RPL35	11224	P42766	0.56
RPS17	6218	P08708	0.59
MRPS14	63931	O60783	0.59
PSMC1	5700	P62191	0.63
PSMC6	5706	P62333	0.63
PSMD3	5709	O43242	0.63
PSMD11	5717	O00231	0.63
RPS15A	6210	P62244	0.63
RPS28	6234	P62857	0.63
RPSA	3921	P08865	0.65
RPS15	6209	P62841	0.68
TSR1	55720	Q2NL82	0.70
ELF5	2001	Q9UKW6	0.73
RPS24	6229	P62847	0.73
RPS21	100291837	P63220	0.73
RPS3A	6189	P61247	0.74
RPS6	6194	P62753	0.74
RPS7	6201	P62081	0.74
RPS8	6202	P62241	0.74
RPS16	6217	P62249	0.74
RPS19	6223	P39019	0.74
RPS23	6228	P62266	0.74
RPS26	6231	P62854	0.74
RPS2	6187	P15880	0.83
RPS3	6188	P23396	0.83
RPS4X	6191	P62701	0.83
RPS5	6193	P46782	0.83
RPS20	6224	P60866	0.83
ACTA2	59	P62736	0.49
SLC25A5	292	P05141	0.49
ATP5A1	498	P25705	0.49
EEF2	1938	P13639	0.49
GALNT2	2590	Q10471	0.49
HIST1H2AD	3013	P20671	0.49
HSPA8	3312	P11142	0.49
ILF2	3608	Q12905	0.49
ILF3	3609	Q12906	0.49
MOV10	4343	Q9HCE1	0.49
HNRNPM	4670	P52272	0.49
NOP2	4839	P46087	0.49
PSMB1	5689	P20618	0.49
RPL22	6146	P35268	0.49
RPL29	6159	P47914	0.49
RPL35A	6165	P18077	0.49
TUFM	7284	P49411	0.49
DDX18	8886	Q9NVP1	0.49
VAPA	9218	Q9P0L0	0.49
HNRNPA0	10949	Q13151	0.49
RPL36	25873	Q9Y3U8	0.49
NIFK	84365	Q9BYG3	0.49
RPL10L	140801	Q96L21	0.49
RPLP0P6	220717	Q8NHW5	0.49
CALM2	805	P62158	0.56
CALM3	808	P62158	0.56
EEF1A1	1915	P68104	0.56
FBL	2091	P22087	0.56
GRB2	2885	P62993	0.56
HSP90AA1	3320	P07900	0.56
PTEN	5728	P60484	0.56
RPL8	6132	P62917	0.56
UBE3A	7337	Q05086	0.56
NOP58	51602	Q9Y2X3	0.56
GNL1	2794	P36915	0.59
EIF6	3692	P56537	0.59
RPL10A	4736	P62906	0.59
SNU13	4809	P55769	0.59
RPL4	6124	P36578	0.59
RPL6	6128	Q02878	0.59
RPL7	6129	P18124	0.59
RPL7A	6130	P62424	0.59
RPL11	6135	P62913	0.59
RPL12	6136	P30050	0.59
RPL13	6137	P26373	0.59
RPL15	6138	P61313	0.59
RPL17	6139	P18621	0.59
RPL18	6141	Q07020	0.59
RPL18A	6142	Q02543	0.59
RPL21	6144	P46778	0.59
RPL24	6152	P83731	0.59
RPL27	6155	P61353	0.59
RPL30	6156	P62888	0.59
RPL31	6160	P62899	0.59
RPL37A	6168	P61513	0.59
RPL38	6169	P63173	0.59
RPLP0	6175	P05388	0.59
RPLP1	6176	P05386	0.59
RPLP2	6181	P05387	0.59
RPS11	6205	P62280	0.59
RPL14	9045	P50914	0.59
RPL23	9349	P62829	0.59
GNL3	26354	Q9BVP2	0.59
RPL9; RPL9P7; RPL9P8; RPL9P9	6133	P32969	0.59
CDK2	1017	P24941	0.63
CSNK1A1	1452	P48729	0.63
EGFR	1956	P00533	0.63
ESR1	2099	P03372	0.63
FN1	2335	P02751	0.63
SFN	2810	P31947	0.63
HTR7	3363	P34969	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
MCM2	4171	P49736	0.63
MGMT	4255	P16455	0.63
NFKB1	4790	P19838	0.63
PCK1	5105	P35558	0.63
PHKG2	5261	P15735	0.63
PRKAA1	5562	Q13131	0.63
EIF2AK2	5610	P19525	0.63
PSMD1	5707	Q99460	0.63
RAD21	5885	O60216	0.63
RNF2	6045	Q99496	0.63
RPS27	6232	P42677	0.63
RPS29	6235	P62273	0.63
TUBG1	7283	P23258	0.63
YWHAZ	7534	P63104	0.63
DDX39B	7919	Q13838	0.63
CUL5	8065	Q93034	0.63
UBL4A	8266	P11441	0.63
CUL4A	8451	Q13619	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
FEZ1	9638	Q99689	0.63
CEP57	9702	Q86XR8	0.63
KIAA0101	9768	Q15004	0.63
PAN2	9924	Q504Q3	0.63
HUWE1	10075	Q7Z6Z7	0.63
UBD	10537	O15205	0.63
AHSA1	10598	O95433	0.63
COPS6	10980	Q7L5N1	0.63
COPS5	10987	Q92905	0.63
CDC37	11140	Q16543	0.63
CEP250	11190	Q9BV73	0.63
GABARAP	11337	O95166	0.63
GABARAPL2	11345	P60520	0.63
ZBTB1	22890	Q9Y2K1	0.63
AGO1	26523	Q9UL18	0.63
AGO2	27161	Q9UKV8	0.63
RPS27L	51065	Q71UM5	0.63
RIOK2	55781	Q9BVS4	0.63
CAND1	55832	Q86VP6	0.63
PNO1	56902	Q9NRX1	0.63
SMURF1	57154	Q9HCE7	0.63
CEP76	79959	Q8TAP6	0.63
WDR26	80232	Q9H7D7	0.63
PYM1	84305	Q9BRP8	0.63
LRRK2	120892	Q5S007	0.63
RPL3	6122	P39023	0.65
RPL5	6125	P46777	0.65
RPL19	6143	P84098	0.65
RPL23A	6147	P62750	0.65
RPL32	6161	P62910	0.65
CSNK1E	1454	P49674	0.70
HDGF	3068	P51858	0.72
NFKB2	4791	Q00653	0.72
IKBKG	8517	Q9Y6K9	0.72
MAP3K14	9020	Q99558	0.72
EXOSC1	51013	Q9Y3B2	0.72
EWSR1	2130	Q01844	0.73
FAU	2197	P62861	0.73
RPS9	6203	P46781	0.73
RPS25	6230	P62851	0.73
RPS10	6204	P46783	0.74
RPS13	6207	P62277	0.74
RPS14	6208	P62263	0.74
VHL	7428	P40337	0.78
RPS18	6222	P62269	0.79
RPS12	6206	P25398	0.80
HNRNPU	3192	Q00839	0.82
NEDD8	4738	Q15843	0.82
VCAM1	7412	P19320	0.82
NOP56	10528	O00567	0.82
RPL10	6134	P27635	0.89