PCOSBase

Protein Description

Gene Symbol	RPS6KA1
Entrez ID	6195
Uniprot ID	Q15418
Description	ribosomal protein S6 kinase, 90kDa, polypeptide 1
Chromosomal Location	chr1: 26,529,761-26,575,030

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006468	protein phosphorylation	The process of introducing a phosphate group on to a protein.	IEA
BP	GO:0006915	apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.	IEA
BP	GO:0007049	cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.	IEA
BP	GO:0007165	signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.	TAS
BP	GO:0030307	positive regulation of cell growth	Any process that activates or increases the frequency, rate, extent or direction of cell growth.	TAS
BP	GO:0035556	intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.	IBA
BP	GO:0043066	negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.	IMP
BP	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.	IDA
BP	GO:0043555	regulation of translation in response to stress	Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).	TAS
BP	GO:0043620	regulation of DNA-templated transcription in response to stress	Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).	TAS
BP	GO:0045597	positive regulation of cell differentiation	Any process that activates or increases the frequency, rate or extent of cell differentiation.	TAS
BP	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	IMP
BP	GO:0072574	hepatocyte proliferation	The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.	ISS
BP	GO:2000491	positive regulation of hepatic stellate cell activation	Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.	IMP
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IBA\|IDA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	TAS
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IBA\|IDA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
MF	GO:0000287	magnesium ion binding	Interacting selectively and non-covalently with magnesium (Mg) ions.	IEA
MF	GO:0004674	protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.	IDA\|TAS
MF	GO:0004712	protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.	IDA
MF	GO:0005524	ATP binding	Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	IEA
MF	GO:0016301	kinase activity	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.	TAS
MF	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.	IDA

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Domain ID	Description
IPR000719	Protein kinase domain
IPR000961	AGC-kinase, C-terminal
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain
IPR016239	Ribosomal protein S6 kinase II
IPR017441	Protein kinase, ATP binding site
IPR017892	Protein kinase, C-terminal

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Pathway ID	Pathway Term	Pathway Source
hsa04010	MAPK signaling pathway	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04720	Long-term potentiation	KEGG
hsa04722	Neurotrophin signaling pathway	KEGG
hsa04914	Progesterone-mediated oocyte maturation	KEGG
hsa04931	Insulin resistance	KEGG
WP23	B Cell Receptor Signaling Pathway	WikiPathways
WP437	EGF/EGFR Signaling Pathway	WikiPathways
WP3915	Angiopoietin Like Protein 8 Regulatory Pathway	WikiPathways
WP304	Kit receptor signaling pathway	WikiPathways
WP127	IL-5 Signaling Pathway	WikiPathways
WP481	Insulin Signaling	WikiPathways
WP2034	Leptin signaling pathway	WikiPathways
WP477	Cytoplasmic Ribosomal Proteins	WikiPathways
WP3945	TYROBP Causal Network	WikiPathways
WP3676	BDNF-TrkB Signaling	WikiPathways
WP2032	Human Thyroid Stimulating Hormone (TSH) signaling pathway	WikiPathways
WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway	WikiPathways
WP2332	Interleukin-11 Signaling Pathway	WikiPathways
h_g2Pathway	Cell Cycle: G2/M Checkpoint	BioCarta
h_erkPathway	Erk1/Erk2 Mapk Signaling pathway	BioCarta
h_ghPathway	Growth Hormone Signaling Pathway	BioCarta
h_mPRPathway	How Progesterone Initiates the Oocyte Maturation	BioCarta
h_mapkPathway	MAPKinase Signaling Pathway	BioCarta
h_melanocytepathway	Melanocyte Development and Pigmentation Pathway	BioCarta
h_igf1rPathway	Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation	BioCarta
h_badPathway	Regulation of BAD phosphorylation	BioCarta
h_erk5Pathway	Role of Erk5 in Neuronal Survival	BioCarta
h_crebPathway	Transcription factor CREB and its extracellular signals	BioCarta

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UMLS CUI	UMLS Term
C0036920	Sezary Syndrome

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Tissue	Cell Type
appendix	glandular cells
cervix, uterine	glandular cells
colon	glandular cells
duodenum	glandular cells
endometrium	glandular cells
rectum	glandular cells
salivary gland	glandular cells
small intestine	glandular cells
stomach	glandular cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
RPS6KA4	8986	O75676	0.00
RPS6KA5	9252	O75582	0.00
ILKAP	80895	Q9H0C8	0.49
EEF1D	1936	P29692	0.52
GSK3B	2932	P49841	0.52
METTL1	4234	Q9UBP6	0.52
NR4A2	4929	P43354	0.52
NR4A3	8013	Q92570	0.52
DLC1	10395	Q96QB1	0.52
PDCD4	27250	Q53EL6	0.52
RPTOR	57521	Q8N122	0.52
CEBPB	1051	P17676	0.55
GMFB	2764	P60983	0.55
L1CAM	3897	P32004	0.55
PPP1R3A	5506	Q16821	0.55
POLDIP3	84271	Q9BY77	0.59
FOS	2353	P01100	0.62
PARP1	142	P09874	0.63
SLC25A5	292	P05141	0.63
SLC25A6	293	P12236	0.63
ATP5A1	498	P25705	0.63
CAD	790	P27708	0.63
CFL1	1072	P23528	0.63
DDX3X	1654	O00571	0.63
DDX6	1656	P26196	0.63
DHX9	1660	Q08211	0.63
EEF1G	1937	P26641	0.63
EPRS	2058	P07814	0.63
FASN	2194	P49327	0.63
FUS	2521	P35637	0.63
GFAP	2670	P14136	0.63
GRSF1	2926	Q12849	0.63
HBA1 HBA2	3039	P69905	0.63
HNRNPA1	3178	P09651	0.63
HNRNPF	3185	P52597	0.63
HNRNPH1	3187	P31943	0.63
HNRNPK	3190	P61978	0.63
HNRNPU	3192	Q00839	0.63
HP	3240	P00738	0.63
DNAJA1	3301	P31689	0.63
HSPA1A	3303	P0DMV8	0.63
HSPA1B	3304	P0DMV9	0.63
HSPA1L	3305	P34931	0.63
HSPA4	3308	P34932	0.63
HSPA5	3309	P11021	0.63
HSPA8	3312	P11142	0.63
HSPA9	3313	P38646	0.63
HSPD1	3329	P10809	0.63
ITPKB	3707	P27987	0.63
ATXN3	4287	P54252	0.63
MPP1	4354	Q00013	0.63
NACA	4666	Q13765	0.63
NCL	4691	P19338	0.63
NF1	4763	P21359	0.63
NPM1	4869	P06748	0.63
PRDX1	5052	Q06830	0.63
PHKG1	5260	Q16816	0.63
PPM1G	5496	O15355	0.63
PPP2R1A	5518	P30153	0.63
PSMB2	5690	P49721	0.63
PSMC4	5704	P43686	0.63
PSMC5	5705	P62195	0.63
PSMC6	5706	P62333	0.63
PSMD1	5707	Q99460	0.63
PSMD2	5708	Q13200	0.63
PSMD11	5717	O00231	0.63
RARS	5917	P54136	0.63
RCN2	5955	Q14257	0.63
RPL5	6125	P46777	0.63
RPL11	6135	P62913	0.63
RPL12	6136	P30050	0.63
RPL13	6137	P26373	0.63
RPL17	6139	P18621	0.63
RPL18	6141	Q07020	0.63
RPL19	6143	P84098	0.63
RPL22	6146	P35268	0.63
RPL23A	6147	P62750	0.63
RPL24	6152	P83731	0.63
RPL26	6154	P61254	0.63
RPL27A	6157	P46776	0.63
RPL29	6159	P47914	0.63
RPL31	6160	P62899	0.63
RPL32	6161	P62910	0.63
RPL37A	6168	P61513	0.63
RPL38	6169	P63173	0.63
RPL36A	6173	P83881	0.63
RPLP1	6176	P05386	0.63
RPLP2	6181	P05387	0.63
RPS2	6187	P15880	0.63
RPS3	6188	P23396	0.63
RPS3A	6189	P61247	0.63
RPS4X	6191	P62701	0.63
RPS5	6193	P46782	0.63
RPS7	6201	P62081	0.63
RPS8	6202	P62241	0.63
RPS10	6204	P46783	0.63
RPS11	6205	P62280	0.63
RPS13	6207	P62277	0.63
RPS14	6208	P62263	0.63
RPS16	6217	P62249	0.63
RPS17	6218	P08708	0.63
RPS18	6222	P62269	0.63
RPS19	6223	P39019	0.63
RPS20	6224	P60866	0.63
RPS23	6228	P62266	0.63
RPS24	6229	P62847	0.63
RPS25	6230	P62851	0.63
RPS26	6231	P62854	0.63
RPS27	6232	P42677	0.63
RPS29	6235	P62273	0.63
SRSF5	6430	Q13243	0.63
SRP14	6727	P37108	0.63
TCP1	6950	P17987	0.63
TTK	7272	P33981	0.63
TTN	7273	Q8WZ42	0.63
TUFM	7284	P49411	0.63
VCP	7415	P55072	0.63
VIM	7431	P08670	0.63
EIF4H	7458	Q15056	0.63
YWHAE	7531	P62258	0.63
CSDE1	7812	O75534	0.63
AIMP2	7965	Q13155	0.63
SLC25A11	8402	Q02978	0.63
IRS4	8471	O14654	0.63
EIF3A	8661	Q14152	0.63
H1FX	8971	Q92522	0.63
DDX21	9188	Q9NR30	0.63
RPL23	9349	P62829	0.63
BAG2	9532	O95816	0.63
MATR3	9782	P43243	0.63
G3BP2	9908	Q9UN86	0.63
G3BP1	10146	Q13283	0.63
SLC25A13	10165	Q9UJS0	0.63
HNRNPR	10236	O43390	0.63
DNAJA2	10294	O60884	0.63
TUBB4A	10382	P04350	0.63
TUBB4B	10383	P68371	0.63
SYNCRIP	10492	O60506	0.63
CCT7	10574	Q99832	0.63
CCT2	10576	P78371	0.63
PRPF8	10594	Q6P2Q9	0.63
TBR1	10716	Q16650	0.63
HSPH1	10808	Q92598	0.63
YWHAQ	10971	P27348	0.63
ATXN2L	11273	Q8WWM7	0.63
CCT5	22948	P48643	0.63
PDCD11	22984	Q14690	0.63
UBR4	23352	Q5T4S7	0.63
DDAH2	23564	O95865	0.63
CORO1C	23603	Q9ULV4	0.63
ZNF318	24149	Q5VUA4	0.63
SERBP1	26135	Q8NC51	0.63
PABPC1	26986	P11940	0.63
RPS27L	51065	Q71UM5	0.63
UBR5	51366	O95071	0.63
LARS	51520	Q9P2J5	0.63
C14orf166	51637	Q9Y224	0.63
GINS2	51659	Q9Y248	0.63
PHAX	51808	Q9H814	0.63
RIF1	55183	Q5UIP0	0.63
ENAH	55740	Q8N8S7	0.63
MCCC1	56922	Q96RQ3	0.63
NUFIP2	57532	Q7Z417	0.63
MCCC2	64087	Q9HCC0	0.63
TIMM50	92609	Q3ZCQ8	0.63
LSM12	124801	Q3MHD2	0.63
TUBB	203068	P07437	0.63
SKA3	221150	Q8IX90	0.63
ASPM	259266	Q8IZT6	0.63
HSP90AB2P	391634	Q58FF8	0.63
RPL9; RPL9P7; RPL9P8; RPL9P9	6133	P32969	0.63
CDKN1B	1027	P46527	0.65
ETV1	2115	P50549	0.66
SRF	6722	P11831	0.66
EIF4B	1975	P23588	0.68
ESR1	2099	P03372	0.69
MAPT	4137	P10636	0.70
RPL35	11224	P42766	0.70
ACACA	31	Q13085	0.72
CSNK2B	1460	P67870	0.72
GRN	2896	P28799	0.72
RPS6KA2	6196	Q15349	0.72
RPS6KA3	6197	P51812	0.72
TLK2	11011	Q86UE8	0.72
MASTL	84930	Q96GX5	0.72
CARHSP1	23589	Q9Y2V2	0.75
CREBBP	1387	Q92793	0.78
RPS6KA1	6195	Q15418	0.78
TOB1	10140	P50616	0.79
CREB1	1385	P16220	0.81
GBP2	2634	P32456	0.82
HSP90AA1	3320	P07900	0.82
HSP90AB1	3326	P08238	0.82
CCT4	10575	P50991	0.82
CDC37	11140	Q16543	0.82
BAD	572	Q92934	0.87
NFKBIA	4792	P25963	0.88
YWHAB	7529	P31946	0.88
EEF2K	29904	O00418	0.89
BUB1	699	O43683	0.00
IGF1	3479	P05019	0.00
INS	3630	P01308	0.00
MAPK7	5598	Q13164	0.00
PKMYT1	9088	Q99640	0.00
SCLT1	132320	Q96NL6	0.49
NR4A1	3164	P22736	0.52
SYK	6850	P43405	0.52
FGFR1	2260	P11362	0.55
GRB2	2885	P62993	0.55
MITF	4286	O75030	0.55
TOB2	10766	Q14106	0.55
CAPN1	823	P07384	0.63
CASP7	840	P55210	0.63
CSNK1E	1454	P49674	0.63
GNS	2799	P15586	0.63
GSR	2936	P00390	0.63
LDHA	3939	P00338	0.63
LDHB	3945	P07195	0.63
MVD	4597	P53602	0.63
NEDD8	4738	Q15843	0.63
NTRK1	4914	P04629	0.63
PEPD	5184	P12955	0.63
PGD	5226	P52209	0.63
KYNU	8942	Q16719	0.63
MAGI1	9223	Q96QZ7	0.63
NPEPPS	9520	P55786	0.63
CNDP2	55748	Q96KP4	0.63
YBX1	4904	P67809	0.65
PDPK1	5170	O15530	0.65
MXD1	4084	Q05195	0.70
TSC1	7248	Q92574	0.72
EEF2	1938	P13639	0.73
VASP	7408	P50552	0.75
RPS6	6194	P62753	0.84
TSC2	7249	P49815	0.88
MAPK3	5595	P27361	0.90
MAPK1	5594	P28482	0.99