Protein Description

Gene Symbol MRPS12
Entrez ID 6183
Uniprot ID O15235
Description mitochondrial ribosomal protein S12
Chromosomal Location chr19: 38,930,548-38,933,162
Ontology GO ID GO Term Definition Evidence

BP

GO:0006412

translation

The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.

IBA

BP

GO:0032543

mitochondrial translation

The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

ISS

BP

GO:0070125

mitochondrial translational elongation

The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion.

TAS

BP

GO:0070126

mitochondrial translational termination

The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).

TAS

CC

GO:0005743

mitochondrial inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

TAS

CC

GO:0005761

mitochondrial ribosome

A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.

TAS

CC

GO:0005763

mitochondrial small ribosomal subunit

The smaller of the two subunits of a mitochondrial ribosome.

ISS

MF

GO:0003735

structural constituent of ribosome

The action of a molecule that contributes to the structural integrity of the ribosome.

ISS

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR005679

Ribosomal protein S12, bacterial-type

IPR006032

Ribosomal protein S12/S23

IPR012340

Nucleic acid-binding, OB-fold

Pathway ID Pathway Term Pathway Source

hsa03010

Ribosome

KEGG

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

cerebellum

cells in granular layer

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

heart muscle

myocytes

hippocampus

neuronal cells

kidney

cells in tubules

liver

hepatocytes

nasopharynx

respiratory epithelial cells

parathyroid gland

glandular cells

placenta

decidual cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

small intestine

glandular cells

soft tissue

fibroblasts

stomach

glandular cells

testis

cells in seminiferous ducts

testis

Leydig cells

thyroid gland

glandular cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

19141487

Kenigsberg et al.

2009

Gene expression microarray profiles of cumulus cells in lean and overweightobese polycystic ovary syndrome patients

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

UNC119

9094

Q13432

0.63

C14orf1

11161

Q9UKR5

0.63

RIF1

55183

Q5UIP0

0.63

LRIF1

55791

Q5T3J3

0.63

RPS3

6188

P23396

0.56

CRMP1

1400

Q14194

0.63

RIOK2

55781

Q9BVS4

0.63

CNOT2

4848

Q9NZN8

0.72

CKAP5

9793

Q14008

0.72

MPHOSPH8

54737

Q99549

0.72

ZSCAN5A

79149

Q9BUG6

0.72

USP43

124739

Q70EL4

0.72

SPINK7

84651

P58062

0.73