| Gene Symbol | MRPL12 |
| Entrez ID | 6182 |
| Uniprot ID | P52815 |
| Description | mitochondrial ribosomal protein L12 |
| Chromosomal Location | chr17: 81,703,357-81,707,526 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006390 |
transcription from mitochondrial promoter |
The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. |
IDA |
|
BP |
GO:0045893 |
positive regulation of transcription, DNA-templated |
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
IDA |
|
BP |
GO:0070125 |
mitochondrial translational elongation |
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion. |
TAS |
|
BP |
GO:0070126 |
mitochondrial translational termination |
The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa). |
TAS |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
|
CC |
GO:0005743 |
mitochondrial inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
TAS |
|
CC |
GO:0005762 |
mitochondrial large ribosomal subunit |
The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). |
IDA |
|
MF |
GO:0003723 |
RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
TAS |
|
MF |
GO:0003735 |
structural constituent of ribosome |
The action of a molecule that contributes to the structural integrity of the ribosome. |
IEA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
| Domain ID | Description |
|---|---|
|
IPR000206 |
Ribosomal protein L7/L12 |
|
IPR008932 |
Ribosomal protein L7/L12, oligomerisation |
|
IPR013823 |
Ribosomal protein L7/L12, C-terminal |
|
IPR014719 |
Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03010 |
Ribosome |
KEGG |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in tubules |
|
lung |
macrophages |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
MRPL23 |
6150 |
Q16540 |
0.49 |
|
XRCC1 |
7515 |
P18887 |
0.49 |
|
RNASET2 |
8635 |
O00584 |
0.49 |
|
SUCLG2 |
8801 |
Q96I99 |
0.49 |
|
SUCLA2 |
8803 |
Q9P2R7 |
0.49 |
|
MRPS28 |
28957 |
Q9Y2Q9 |
0.49 |
|
MRPL42 |
28977 |
Q9Y6G3 |
0.49 |
|
MRPL15 |
29088 |
Q9P015 |
0.49 |
|
MRPL37 |
51253 |
Q9BZE1 |
0.49 |
|
UFM1 |
51569 |
P61960 |
0.49 |
|
MRPS26 |
64949 |
Q9BYN8 |
0.49 |
|
MRPS9 |
64965 |
P82933 |
0.49 |
|
MRPL41 |
64975 |
Q8IXM3 |
0.49 |
|
MRPL52 |
122704 |
Q86TS9 |
0.49 |
|
TMEM9 |
252839 |
Q9P0T7 |
0.49 |
|
DAP3 |
7818 |
P51398 |
0.55 |
|
RPS2 |
6187 |
P15880 |
0.56 |
|
POLR1D |
51082 |
Q9Y2S0 |
0.63 |
|
TMEM51 |
55092 |
Q9NW97 |
0.63 |
|
OLIG1 |
116448 |
Q8TAK6 |
0.63 |
|
MRPL3 |
11222 |
P09001 |
0.71 |
|
MRPL12 |
6182 |
P52815 |
0.77 |
|
ACOX1 |
51 |
Q15067 |
0.49 |
|
AK2 |
204 |
P54819 |
0.49 |
|
HNRNPD |
3184 |
Q14103 |
0.49 |
|
ILF3 |
3609 |
Q12906 |
0.49 |
|
RBM3 |
5935 |
P98179 |
0.49 |
|
RPL7A |
6130 |
P62424 |
0.49 |
|
RPL18 |
6141 |
Q07020 |
0.49 |
|
RPL19 |
6143 |
P84098 |
0.49 |
|
RPLP2 |
6181 |
P05387 |
0.49 |
|
RPL14 |
9045 |
P50914 |
0.49 |
|
PITRM1 |
10531 |
Q5JRX3 |
0.49 |
|
NIT2 |
56954 |
Q9NQR4 |
0.49 |
|
EPPK1 |
83481 |
P58107 |
0.49 |
|
GADD45GIP1 |
90480 |
Q8TAE8 |
0.49 |
|
MRPL10 |
124995 |
Q7Z7H8 |
0.49 |
|
PPP2R2B |
5521 |
Q00005 |
0.56 |
|
RPL11 |
6135 |
P62913 |
0.56 |
|
RPL12 |
6136 |
P30050 |
0.56 |
|
RPL23 |
9349 |
P62829 |
0.56 |
|
MRPL11 |
65003 |
Q9Y3B7 |
0.56 |
|
ADRB2 |
154 |
P07550 |
0.63 |
|
C1QBP |
708 |
Q07021 |
0.63 |
|
COX6A2 |
1339 |
Q02221 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
MLLT1 |
4298 |
Q03111 |
0.63 |
|
NPM1 |
4869 |
P06748 |
0.63 |
|
YBX1 |
4904 |
P67809 |
0.63 |
|
PARK2 |
5071 |
O60260 |
0.63 |
|
RARG |
5916 |
P13631 |
0.63 |
|
SOX2 |
6657 |
P48431 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
BTRC |
8945 |
Q9Y297 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
MRPS30 |
10884 |
Q9NP92 |
0.63 |
|
MRPS27 |
23107 |
Q92552 |
0.63 |
|
TARDBP |
23435 |
Q13148 |
0.63 |
|
SRRM2 |
23524 |
Q9UQ35 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
MRPL47 |
57129 |
Q9HD33 |
0.63 |
|
NOA1 |
84273 |
Q8NC60 |
0.63 |
|
RELA |
5970 |
Q04206 |
0.72 |
|
MRPL50 |
54534 |
Q8N5N7 |
0.72 |
|
MRPL9 |
65005 |
Q9BYD2 |
0.82 |
|
MRPL1 |
65008 |
Q9BYD6 |
0.82 |
|
ICT1 |
3396 |
Q14197 |
0.85 |