PCOSBase

Protein Description

Gene Symbol	MRPL12
Entrez ID	6182
Uniprot ID	P52815
Description	mitochondrial ribosomal protein L12
Chromosomal Location	chr17: 81,703,357-81,707,526

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006390	transcription from mitochondrial promoter	The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.	IDA
BP	GO:0045893	positive regulation of transcription, DNA-templated	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.	IDA
BP	GO:0070125	mitochondrial translational elongation	The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion.	TAS
BP	GO:0070126	mitochondrial translational termination	The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).	TAS
CC	GO:0005739	mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	IDA
CC	GO:0005743	mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.	TAS
CC	GO:0005762	mitochondrial large ribosomal subunit	The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).	IDA
MF	GO:0003723	RNA binding	Interacting selectively and non-covalently with an RNA molecule or a portion thereof.	TAS
MF	GO:0003735	structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.	IEA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI

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Domain ID	Description
IPR000206	Ribosomal protein L7/L12
IPR008932	Ribosomal protein L7/L12, oligomerisation
IPR013823	Ribosomal protein L7/L12, C-terminal
IPR014719	Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like

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Pathway ID	Pathway Term	Pathway Source
hsa03010	Ribosome	KEGG

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No diseases found.

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
bronchus	respiratory epithelial cells
caudate	neuronal cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	glandular cells
duodenum	glandular cells
endometrium	glandular cells
endometrium	cells in endometrial stroma
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
heart muscle	myocytes
hippocampus	glial cells
hippocampus	neuronal cells
kidney	cells in tubules
lung	macrophages
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	follicle cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skin	epidermal cells
small intestine	glandular cells
spleen	cells in red pulp
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol	Entrez ID	Uniprot ID	Score
MRPL23	6150	Q16540	0.49
XRCC1	7515	P18887	0.49
RNASET2	8635	O00584	0.49
SUCLG2	8801	Q96I99	0.49
SUCLA2	8803	Q9P2R7	0.49
MRPS28	28957	Q9Y2Q9	0.49
MRPL42	28977	Q9Y6G3	0.49
MRPL15	29088	Q9P015	0.49
MRPL37	51253	Q9BZE1	0.49
UFM1	51569	P61960	0.49
MRPS26	64949	Q9BYN8	0.49
MRPS9	64965	P82933	0.49
MRPL41	64975	Q8IXM3	0.49
MRPL52	122704	Q86TS9	0.49
TMEM9	252839	Q9P0T7	0.49
DAP3	7818	P51398	0.55
RPS2	6187	P15880	0.56
POLR1D	51082	Q9Y2S0	0.63
TMEM51	55092	Q9NW97	0.63
OLIG1	116448	Q8TAK6	0.63
MRPL3	11222	P09001	0.71
MRPL12	6182	P52815	0.77
ACOX1	51	Q15067	0.49
AK2	204	P54819	0.49
HNRNPD	3184	Q14103	0.49
ILF3	3609	Q12906	0.49
RBM3	5935	P98179	0.49
RPL7A	6130	P62424	0.49
RPL18	6141	Q07020	0.49
RPL19	6143	P84098	0.49
RPLP2	6181	P05387	0.49
RPL14	9045	P50914	0.49
PITRM1	10531	Q5JRX3	0.49
NIT2	56954	Q9NQR4	0.49
EPPK1	83481	P58107	0.49
GADD45GIP1	90480	Q8TAE8	0.49
MRPL10	124995	Q7Z7H8	0.49
PPP2R2B	5521	Q00005	0.56
RPL11	6135	P62913	0.56
RPL12	6136	P30050	0.56
RPL23	9349	P62829	0.56
MRPL11	65003	Q9Y3B7	0.56
ADRB2	154	P07550	0.63
C1QBP	708	Q07021	0.63
COX6A2	1339	Q02221	0.63
MDM2	4193	Q00987	0.63
MLLT1	4298	Q03111	0.63
NPM1	4869	P06748	0.63
YBX1	4904	P67809	0.63
PARK2	5071	O60260	0.63
RARG	5916	P13631	0.63
SOX2	6657	P48431	0.63
CUL3	8452	Q13618	0.63
CUL1	8454	Q13616	0.63
BTRC	8945	Q9Y297	0.63
IKBKE	9641	Q14164	0.63
KIAA0101	9768	Q15004	0.63
MRPS30	10884	Q9NP92	0.63
MRPS27	23107	Q92552	0.63
TARDBP	23435	Q13148	0.63
SRRM2	23524	Q9UQ35	0.63
CAND1	55832	Q86VP6	0.63
MRPL47	57129	Q9HD33	0.63
NOA1	84273	Q8NC60	0.63
RELA	5970	Q04206	0.72
MRPL50	54534	Q8N5N7	0.72
MRPL9	65005	Q9BYD2	0.82
MRPL1	65008	Q9BYD6	0.82
ICT1	3396	Q14197	0.85