| Gene Symbol | RPL17 |
| Entrez ID | 6139 |
| Uniprot ID | P18621 |
| Description | ribosomal protein L17 |
| Chromosomal Location | chr18: 49,488,453-49,492,523 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000184 |
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
TAS |
|
BP |
GO:0006364 |
rRNA processing |
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
TAS |
|
BP |
GO:0006412 |
translation |
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
NAS |
|
BP |
GO:0006413 |
translational initiation |
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
TAS |
|
BP |
GO:0006614 |
SRP-dependent cotranslational protein targeting to membrane |
The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
TAS |
|
BP |
GO:0019083 |
viral transcription |
The process by which a viral genome, or part of a viral genome, is transcribed within the host cell. |
TAS |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0022625 |
cytosolic large ribosomal subunit |
The large subunit of a ribosome located in the cytosol. |
IDA |
|
MF |
GO:0003735 |
structural constituent of ribosome |
The action of a molecule that contributes to the structural integrity of the ribosome. |
NAS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR001063 |
Ribosomal protein L22/L17 |
|
IPR005721 |
Ribosomal protein L22/L17, eukaryotic/archaeal |
|
IPR018260 |
Ribosomal protein L22/L17, conserved site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03010 |
Ribosome |
KEGG |
|
WP477 |
Cytoplasmic Ribosomal Proteins |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0151744 |
Myocardial Ischemia |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
neuronal cells |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
hippocampus |
neuronal cells |
|
nasopharynx |
respiratory epithelial cells |
|
pancreas |
exocrine glandular cells |
|
salivary gland |
glandular cells |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
soft tissue |
chondrocytes |
|
soft tissue |
fibroblasts |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
|
26459919 |
Lan et al. |
2015 |
Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
RPSA |
3921 |
P08865 |
0.49 |
|
RPL6 |
6128 |
Q02878 |
0.49 |
|
RPL18A |
6142 |
Q02543 |
0.49 |
|
RPL22 |
6146 |
P35268 |
0.49 |
|
RPL29 |
6159 |
P47914 |
0.49 |
|
RPL31 |
6160 |
P62899 |
0.49 |
|
RPL37A |
6168 |
P61513 |
0.49 |
|
RPL38 |
6169 |
P63173 |
0.49 |
|
RPLP0 |
6175 |
P05388 |
0.49 |
|
RPS12 |
6206 |
P25398 |
0.49 |
|
RPS16 |
6217 |
P62249 |
0.49 |
|
RPS18 |
6222 |
P62269 |
0.49 |
|
RPS19 |
6223 |
P39019 |
0.49 |
|
RPS24 |
6229 |
P62847 |
0.49 |
|
RPS25 |
6230 |
P62851 |
0.49 |
|
RPS26 |
6231 |
P62854 |
0.49 |
|
RPS27A |
6233 |
P62979 |
0.49 |
|
RPS28 |
6234 |
P62857 |
0.49 |
|
UBA52 |
7311 |
P62987 |
0.49 |
|
AHCYL2 |
23382 |
Q96HN2 |
0.49 |
|
RPS27L |
51065 |
Q71UM5 |
0.49 |
|
MRPS7 |
51081 |
Q9Y2R9 |
0.49 |
|
GFM2 |
84340 |
Q969S9 |
0.49 |
|
RPS10P5 |
93144 |
Q9NQ39 |
0.49 |
|
RPLP0P6 |
220717 |
Q8NHW5 |
0.49 |
|
RPS21 |
100291837 |
P63220 |
0.49 |
|
RPL7A |
6130 |
P62424 |
0.56 |
|
RPS15 |
6209 |
P62841 |
0.56 |
|
SEC61A1 |
29927 |
P61619 |
0.56 |
|
RPL3 |
6122 |
P39023 |
0.59 |
|
RPL4 |
6124 |
P36578 |
0.59 |
|
RPL7 |
6129 |
P18124 |
0.59 |
|
RPL18 |
6141 |
Q07020 |
0.59 |
|
RPL24 |
6152 |
P83731 |
0.59 |
|
RPS3A |
6189 |
P61247 |
0.59 |
|
RPS6 |
6194 |
P62753 |
0.59 |
|
RPS8 |
6202 |
P62241 |
0.59 |
|
RPS11 |
6205 |
P62280 |
0.59 |
|
RPS13 |
6207 |
P62277 |
0.59 |
|
RPS15A |
6210 |
P62244 |
0.59 |
|
RPL23 |
9349 |
P62829 |
0.59 |
|
RPL9; RPL9P7; RPL9P8; RPL9P9 |
6133 |
P32969 |
0.59 |
|
KARS |
3735 |
Q15046 |
0.63 |
|
PCYT1A |
5130 |
P49585 |
0.63 |
|
SNUPN |
10073 |
O95149 |
0.63 |
|
HIST1H2AB; HIST1H2AE |
3012 |
P04908 |
0.63 |
|
RPL5 |
6125 |
P46777 |
0.65 |
|
RPL8 |
6132 |
P62917 |
0.65 |
|
RPL19 |
6143 |
P84098 |
0.65 |
|
RPL23A |
6147 |
P62750 |
0.65 |
|
RPL32 |
6161 |
P62910 |
0.65 |
|
RPS2 |
6187 |
P15880 |
0.65 |
|
RPS3 |
6188 |
P23396 |
0.65 |
|
RPS4X |
6191 |
P62701 |
0.65 |
|
RPS5 |
6193 |
P46782 |
0.65 |
|
RPS20 |
6224 |
P60866 |
0.65 |
|
RPS23 |
6228 |
P62266 |
0.65 |
|
LRRK2 |
120892 |
Q5S007 |
0.68 |
|
RPL21 |
6144 |
P46778 |
0.73 |
|
ACTA2 |
59 |
P62736 |
0.49 |
|
ATP1B3 |
483 |
P54709 |
0.49 |
|
DES |
1674 |
P17661 |
0.49 |
|
FBL |
2091 |
P22087 |
0.49 |
|
HSP90AA1 |
3320 |
P07900 |
0.49 |
|
HSP90AB1 |
3326 |
P08238 |
0.49 |
|
ILF2 |
3608 |
Q12905 |
0.49 |
|
ILF3 |
3609 |
Q12906 |
0.49 |
|
EIF6 |
3692 |
P56537 |
0.49 |
|
RPL10A |
4736 |
P62906 |
0.49 |
|
RPL13 |
6137 |
P26373 |
0.49 |
|
RPL27A |
6157 |
P46776 |
0.49 |
|
RPL35A |
6165 |
P18077 |
0.49 |
|
RPS9 |
6203 |
P46781 |
0.49 |
|
RPS14 |
6208 |
P62263 |
0.49 |
|
SLC1A2 |
6506 |
P43004 |
0.49 |
|
TUFM |
7284 |
P49411 |
0.49 |
|
RPL14 |
9045 |
P50914 |
0.49 |
|
RPL13A |
23521 |
P40429 |
0.49 |
|
PABPC1 |
26986 |
P11940 |
0.49 |
|
MRPL4 |
51073 |
Q9BYD3 |
0.49 |
|
RPL26L1 |
51121 |
Q9UNX3 |
0.49 |
|
IMP3 |
55272 |
Q9NV31 |
0.49 |
|
MRPS5 |
64969 |
P82675 |
0.49 |
|
MRPL24 |
79590 |
Q96A35 |
0.49 |
|
RPL10L |
140801 |
Q96L21 |
0.49 |
|
HSP90AA5P |
730211 |
Q58FG0 |
0.49 |
|
RPL11 |
6135 |
P62913 |
0.59 |
|
RPL12 |
6136 |
P30050 |
0.59 |
|
RPL15 |
6138 |
P61313 |
0.59 |
|
ADRBK1 |
156 |
P25098 |
0.63 |
|
CD81 |
975 |
P60033 |
0.63 |
|
CDK5 |
1020 |
Q00535 |
0.63 |
|
CSNK1A1 |
1452 |
P48729 |
0.63 |
|
CSNK1E |
1454 |
P49674 |
0.63 |
|
CSNK2A2 |
1459 |
P19784 |
0.63 |
|
CTBP2 |
1488 |
P56545 |
0.63 |
|
EGFR |
1956 |
P00533 |
0.63 |
|
FN1 |
2335 |
P02751 |
0.63 |
|
GALE |
2582 |
Q14376 |
0.63 |
|
SFN |
2810 |
P31947 |
0.63 |
|
HNRNPU |
3192 |
Q00839 |
0.63 |
|
ICAM1 |
3383 |
P05362 |
0.63 |
|
ILK |
3611 |
Q13418 |
0.63 |
|
ITGA4 |
3676 |
P13612 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
NAP1L1 |
4673 |
P55209 |
0.63 |
|
NFX1 |
4799 |
Q12986 |
0.63 |
|
NPM1 |
4869 |
P06748 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PHKG2 |
5261 |
P15735 |
0.63 |
|
PRKAA1 |
5562 |
Q13131 |
0.63 |
|
PRKACB |
5567 |
P22694 |
0.63 |
|
EIF2AK2 |
5610 |
P19525 |
0.63 |
|
RAD21 |
5885 |
O60216 |
0.63 |
|
RNF2 |
6045 |
Q99496 |
0.63 |
|
RPS6KA1 |
6195 |
Q15418 |
0.63 |
|
RPS6KB2 |
6199 |
Q9UBS0 |
0.63 |
|
STAU1 |
6780 |
O95793 |
0.63 |
|
TUBG1 |
7283 |
P23258 |
0.63 |
|
YWHAZ |
7534 |
P63104 |
0.63 |
|
HIST1H3A |
8350 |
P68431 |
0.63 |
|
STK24 |
8428 |
Q9Y6E0 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
AIMP1 |
9255 |
Q12904 |
0.63 |
|
PAN2 |
9924 |
Q504Q3 |
0.63 |
|
NOP56 |
10528 |
O00567 |
0.63 |
|
AHSA1 |
10598 |
O95433 |
0.63 |
|
COPS5 |
10987 |
Q92905 |
0.63 |
|
NUDT3 |
11165 |
O95989 |
0.63 |
|
TARDBP |
23435 |
Q13148 |
0.63 |
|
RPL36 |
25873 |
Q9Y3U8 |
0.63 |
|
AGO1 |
26523 |
Q9UL18 |
0.63 |
|
AGO2 |
27161 |
Q9UKV8 |
0.63 |
|
EEF2K |
29904 |
O00418 |
0.63 |
|
EXOSC1 |
51013 |
Q9Y3B2 |
0.63 |
|
STK26 |
51765 |
Q9P289 |
0.63 |
|
RIOK2 |
55781 |
Q9BVS4 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
SMURF1 |
57154 |
Q9HCE7 |
0.63 |
|
CEP76 |
79959 |
Q8TAP6 |
0.63 |
|
IGSF8 |
93185 |
Q969P0 |
0.63 |
|
TP53RK |
112858 |
Q96S44 |
0.63 |
|
EEF1A1 |
1915 |
P68104 |
0.65 |
|
ESR1 |
2099 |
P03372 |
0.67 |
|
ESR2 |
2100 |
Q92731 |
0.67 |
|
PPP2R2B |
5521 |
Q00005 |
0.68 |
|
RPL10 |
6134 |
P27635 |
0.70 |
|
HDGF |
3068 |
P51858 |
0.72 |
|
MAGOH |
4116 |
P61326 |
0.72 |
|
OXSR1 |
9943 |
O95747 |
0.73 |
|
SUMO1 |
7341 |
P63165 |
0.78 |
|
EIF4A3 |
9775 |
P38919 |
0.79 |
|
RPL35 |
11224 |
P42766 |
0.79 |
|
VCAM1 |
7412 |
P19320 |
0.82 |
|
RPL26 |
6154 |
P61254 |
0.89 |