PCOSBase

Protein Description

Gene Symbol	RPL10
Entrez ID	6134
Uniprot ID	P27635
Description	ribosomal protein L10
Chromosomal Location	chrX: 154,389,955-154,409,168

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000027	ribosomal large subunit assembly	The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.	IBA
BP	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.	TAS
BP	GO:0006364	rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.	TAS
BP	GO:0006412	translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.	IBA\|IC\|NAS
BP	GO:0006413	translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.	TAS
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.	TAS
BP	GO:0019083	viral transcription	The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.	TAS
CC	GO:0005783	endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).	IDA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0022625	cytosolic large ribosomal subunit	The large subunit of a ribosome located in the cytosol.	IDA
MF	GO:0003735	structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.	IDA\|NAS
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR001197	Ribosomal protein L10e
IPR016180	Ribosomal protein L10e/L16
IPR018255	Ribosomal protein L10e, conserved site

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Pathway ID	Pathway Term	Pathway Source
hsa03010	Ribosome	KEGG
WP477	Cytoplasmic Ribosomal Proteins	WikiPathways

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UMLS CUI	UMLS Term
C0004352	Autistic Disorder
C0033578	Prostatic Neoplasms
C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	neuronal cells
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	neuronal cells
kidney	cells in tubules
liver	hepatocytes
lung	macrophages
lung	pneumocytes
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	ovarian stroma cells
pancreas	exocrine glandular cells
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skin	epidermal cells
small intestine	glandular cells
spleen	cells in white pulp
stomach	glandular cells
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
15291743	Diao et al.	2004	The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
RPL35A	6165	P18077	0.49
RPL37A	6168	P61513	0.49
RPLP1	6176	P05386	0.49
RPL26L1	51121	Q9UNX3	0.49
RPLP0P6	220717	Q8NHW5	0.49
RPL26	6154	P61254	0.56
RPS15	6209	P62841	0.56
RPL21	6144	P46778	0.59
FLNB	2317	O75369	0.63
FLNC	2318	Q14315	0.63
QARS	5859	P47897	0.63
ATXN2	6311	Q99700	0.63
EPM2A	7957	B3EWF7	0.63
EPM2A	7957	O95278	0.63
HIST1H3A	8350	P68431	0.63
EIF3F	8665	O00303	0.63
TBPL1	9519	P62380	0.63
RPP30	10556	P78346	0.63
IBTK	25998	Q9P2D0	0.63
PRPF31	26121	Q8WWY3	0.63
TBL2	26608	Q9Y4P3	0.63
SPIN2A	54466	Q99865	0.63
DDX55	57696	Q8NHQ9	0.63
CMSS1	84319	Q9BQ75	0.63
IMP4	92856	Q96G21	0.63
H3F3C	440093	Q6NXT2	0.63
RPL17	6139	P18621	0.70
DDX24	57062	Q9GZR7	0.70
PARP1	142	P09874	0.72
BTF3	689	P20290	0.72
CHD1	1105	O14646	0.72
CHD3	1107	Q12873	0.72
DDX1	1653	Q92499	0.72
DDX5	1655	P17844	0.72
DHX9	1660	Q08211	0.72
DECR1	1666	Q16698	0.72
EIF2B1	1967	Q14232	0.72
ERCC6	2074	Q03468	0.72
FBL	2091	P22087	0.72
FMR1	2332	Q06787	0.72
GTF2B	2959	Q00403	0.72
GTF3C2	2976	Q8WUA4	0.72
HIST1H1B	3009	P16401	0.72
HNRNPU	3192	Q00839	0.72
IFI16	3428	Q16666	0.72
EIF3E	3646	P60228	0.72
KIF22	3835	Q14807	0.72
MKI67	4288	P46013	0.72
MLLT6	4302	P55198	0.72
MPG	4350	P29372	0.72
DRG1	4733	Q9Y295	0.72
NOP2	4839	P46087	0.72
NTHL1	4913	P78549	0.72
PA2G4	5036	Q9UQ80	0.72
POLRMT	5442	O00411	0.72
PPP1CC	5501	P36873	0.72
PSEN1	5663	P49768	0.72
RBM3	5935	P98179	0.72
RFC2	5982	P35250	0.72
RFC3	5983	P40938	0.72
RFC4	5984	P35249	0.72
RFC5	5985	P40937	0.72
RPL29	6159	P47914	0.72
RPL32	6161	P62910	0.72
RPS27A	6233	P62979	0.72
SKIV2L	6499	Q15477	0.72
SNRPB2	6629	P08579	0.72
SRP14	6727	P37108	0.72
SRP72	6731	O76094	0.72
SRPRA	6734	P08240	0.72
TOP2A	7153	P11388	0.72
TOP2B	7155	Q02880	0.72
UBTF	7343	P17480	0.72
DEK	7913	P35659	0.72
KAT6A	7994	Q92794	0.72
CHAF1B	8208	Q13112	0.72
PIP5K1A	8394	Q99755	0.72
SMARCA5	8467	O60264	0.72
EIF3A	8661	Q14152	0.72
EIF3C	8663	Q99613	0.72
EIF3G	8666	O75821	0.72
EIF3I	8668	Q13347	0.72
BANF1	8815	O75531	0.72
SGPL1	8879	O95470	0.72
DDX18	8886	Q9NVP1	0.72
EIF2B4	8890	Q9UI10	0.72
EIF2B2	8892	P49770	0.72
TOP3B	8940	O95985	0.72
H1FX	8971	Q92522	0.72
BAZ1B	9031	Q9UIG0	0.72
USP10	9100	Q14694	0.72
NEMF	9147	O60524	0.72
DDX21	9188	Q9NR30	0.72
TTC37	9652	Q6PGP7	0.72
JADE3	9767	Q92613	0.72
G3BP2	9908	Q9UN86	0.72
ABCF2	10061	Q9UG63	0.72
PDCD7	10081	Q8N8D1	0.72
G3BP1	10146	Q13283	0.72
ALYREF	10189	Q86V81	0.72
NPM3	10360	O75607	0.72
RACK1	10399	P63244	0.72
EMG1	10436	Q92979	0.72
NXF1	10482	Q9UBU9	0.72
MYBBP1A	10514	Q9BQG0	0.72
ZMYND11	10771	Q15326	0.72
POP4	10775	O95707	0.72
MORF4L1	10933	Q9UBU8	0.72
POP1	10940	Q99575	0.72
EBNA1BP2	10969	Q99848	0.72
PSIP1	11168	O75475	0.72
WDR6	11180	Q9NNW5	0.72
SUPT16H	11198	Q9Y5B9	0.72
PDAP1	11333	Q13442	0.72
DHX30	22907	Q7L2E3	0.72
MRPS27	23107	Q92552	0.72
LARP4B	23185	Q92615	0.72
PRRC2C	23215	Q9Y520	0.72
RRP12	23223	Q5JTH9	0.72
LARP1	23367	Q6PKG0	0.72
GTPBP4	23560	Q9BZE4	0.72
BRD1	23774	O95696	0.72
NIPBL	25836	Q6KC79	0.72
CNOT10	25904	Q9H9A5	0.72
ANKRD17	26057	O75179	0.72
SERBP1	26135	Q8NC51	0.72
GNL3	26354	Q9BVP2	0.72
AATF	26574	Q9NY61	0.72
MRPL46	26589	Q9H2W6	0.72
PABPC1	26986	P11940	0.72
PELP1	27043	Q8IZL8	0.72
SND1	27044	Q7KZF4	0.72
DIMT1	27292	Q9UNQ2	0.72
APOBEC3C	27350	Q9NRW3	0.72
NOB1	28987	Q9ULX3	0.72
UHRF1	29128	Q96T88	0.72
PACSIN3	29763	Q9UKS6	0.72
GLTSCR2	29997	Q9NZM5	0.72
HP1BP3	50809	Q5SSJ5	0.72
RRP15	51018	Q9Y3B9	0.72
TFB1M	51106	Q8WVM0	0.72
HERC5	51191	Q9UII4	0.72
DDX47	51202	Q9H0S4	0.72
EIF3L	51386	Q9Y262	0.72
NIP7	51388	Q9Y221	0.72
NOL7	51406	Q9UMY1	0.72
YTHDF2	51441	Q9Y5A9	0.72
RTCB	51493	Q9Y3I0	0.72
TRMT112	51504	Q9UI30	0.72
NOP58	51602	Q9Y2X3	0.72
C14orf166	51637	Q9Y224	0.72
MRPL48	51642	Q96GC5	0.72
ZAK	51776	Q9NYL2	0.72
DHX29	54505	Q7Z478	0.72
GNL3L	54552	Q9NVN8	0.72
GTPBP2	54676	Q9BX10	0.72
TEX10	54881	Q9NXF1	0.72
NSUN2	54888	Q08J23	0.72
FOCAD	54914	Q5VW36	0.72
YTHDF1	54915	Q9BYJ9	0.72
PAK1IP1	55003	Q9NWT1	0.72
PHIP	55023	Q8WWQ0	0.72
RBM28	55131	Q9NW13	0.72
MTPAP	55149	Q9NVV4	0.72
MRM3	55178	Q9HC36	0.72
BRIX1	55299	Q8TDN6	0.72
TMA16	55319	Q96EY4	0.72
LSG1	55341	Q9H089	0.72
NOP10	55505	Q9NPE3	0.72
LYAR	55646	Q9NX58	0.72
DDX27	55661	Q96GQ7	0.72
TSR1	55720	Q2NL82	0.72
MEPCE	56257	Q7L2J0	0.72
BCCIP	56647	Q9P287	0.72
PNO1	56902	Q9NRX1	0.72
DHX33	56919	Q9H6R0	0.72
AVEN	57099	Q9NQS1	0.72
NUFIP2	57532	Q7Z417	0.72
USP36	57602	Q9P275	0.72
SCAF1	58506	Q9H7N4	0.72
MYO1G	64005	B0I1T2	0.72
MEAF6	64769	Q9HAF1	0.72
MRPL38	64978	Q96DV4	0.72
NOL6	65083	Q9H6R4	0.72
SPATS2	65244	Q86XZ4	0.72
DDX50	79009	Q9BQ39	0.72
SPATA5L1	79029	Q9BVQ7	0.72
DDX54	79039	Q8TDD1	0.72
CENPU	79682	Q71F23	0.72
NO66	79697	Q9H6W3	0.72
MUS81	80198	Q96NY9	0.72
TRMT1L	81627	Q7Z2T5	0.72
LAS1L	81887	Q9Y4W2	0.72
UTP23	84294	Q9BRU9	0.72
PHF6	84295	Q8IWS0	0.72
MINA	84864	Q8IUF8	0.72
GTPBP10	85865	A4D1E9	0.72
ZNF622	90441	Q969S3	0.72
ZNF598	90850	Q86UK7	0.72
DHX57	90957	Q6P158	0.72
LARP4	113251	Q71RC2	0.72
CCDC124	115098	Q96CT7	0.72
TSR3	115939	Q9UJK0	0.72
FTSJ3	117246	Q8IY81	0.72
DNAJC21	134218	Q5F1R6	0.72
CENPV	201161	Q7Z7K6	0.72
LEMD2	221496	Q8NC56	0.72
YTHDF3	253943	Q7Z739	0.72
RPS21	100291837	P63220	0.73
RPSA	3921	P08865	0.74
RPL19	6143	P84098	0.74
EIF1AX	1964	P47813	0.79
HDAC2	3066	Q92769	0.79
NACA	4666	Q13765	0.79
NVL	4931	O15381	0.79
RPS29	6235	P62273	0.79
GNL2	29889	Q13823	0.79
MRTO4	51154	Q9UKD2	0.79
NAT10	55226	Q9H0A0	0.79
RPL15	6138	P61313	0.82
RPS8	6202	P62241	0.82
RPS9	6203	P46781	0.82
RPS17	6218	P08708	0.82
RPS24	6229	P62847	0.82
RPS27	6232	P42677	0.82
RPL36	25873	Q9Y3U8	0.82
RPL6	6128	Q02878	0.83
RPL7	6129	P18124	0.83
RPL7A	6130	P62424	0.83
RPL30	6156	P62888	0.83
RPL31	6160	P62899	0.83
RPL38	6169	P63173	0.83
RPS3A	6189	P61247	0.83
RPS4X	6191	P62701	0.83
RPS7	6201	P62081	0.83
RPS10	6204	P46783	0.83
RPS13	6207	P62277	0.83
RPS26	6231	P62854	0.83
RPL14	9045	P50914	0.83
YES1	7525	P07947	0.87
RPL10A	4736	P62906	0.88
RPS3	6188	P23396	0.88
RPS5	6193	P46782	0.88
RPS14	6208	P62263	0.88
RPS18	6222	P62269	0.88
RPL3	6122	P39023	0.89
RPL12	6136	P30050	0.89
RPL18	6141	Q07020	0.89
RPL27A	6157	P46776	0.89
RPS2	6187	P15880	0.89
RPS15A	6210	P62244	0.89
RPS16	6217	P62249	0.89
RPS23	6228	P62266	0.89
RPLP0	6175	P05388	0.91
RPL4	6124	P36578	0.92
RPL5	6125	P46777	0.92
RPL8	6132	P62917	0.92
RPL11	6135	P62913	0.92
RPL23A	6147	P62750	0.92
RPL23	9349	P62829	0.92
RPL9; RPL9P7; RPL9P8; RPL9P9	6133	P32969	0.92
SLC25A6	293	P12236	0.49
ATP1B3	483	P54709	0.49
ILF2	3608	Q12905	0.49
MOV10	4343	Q9HCE1	0.49
HNRNPM	4670	P52272	0.49
RPLP2	6181	P05387	0.49
SYNCRIP	10492	O60506	0.49
GRB2	2885	P62993	0.56
SLC25A3	5250	Q00325	0.56
PRKCA	5578	P17252	0.62
CRY1	1407	Q16526	0.63
CRY2	1408	Q49AN0	0.63
FN1	2335	P02751	0.63
SFN	2810	P31947	0.63
HDGF	3068	P51858	0.63
ILF3	3609	Q12906	0.63
ILK	3611	Q13418	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
MCM2	4171	P49736	0.63
NEDD8	4738	Q15843	0.63
NTRK1	4914	P04629	0.63
PRKACA	5566	P17612	0.63
MAPK6	5597	Q16659	0.63
RAD21	5885	O60216	0.63
RNF2	6045	Q99496	0.63
SUMO1	7341	P63165	0.63
XRCC3	7517	O43542	0.63
YWHAZ	7534	P63104	0.63
UBL4A	8266	P11441	0.63
CUL3	8452	Q13618	0.63
DENR	8562	O43583	0.63
AURKB	9212	Q96GD4	0.63
BAG2	9532	O95816	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
PAN2	9924	Q504Q3	0.63
OXSR1	9943	O95747	0.63
TUBGCP3	10426	Q96CW5	0.63
TAB1	10454	Q15750	0.63
NOP56	10528	O00567	0.63
NES	10763	P48681	0.63
COPS5	10987	Q92905	0.63
AP4S1	11154	Q9Y587	0.63
CEP250	11190	Q9BV73	0.63
GABARAP	11337	O95166	0.63
GABARAPL2	11345	P60520	0.63
NCBP2	22916	P52298	0.63
WAPL	23063	Q7Z5K2	0.63
TARDBP	23435	Q13148	0.63
SF3B1	23451	O75533	0.63
PRAME	23532	P78395	0.63
AGO1	26523	Q9UL18	0.63
SUCO	51430	Q9UBS9	0.63
CTDSPL2	51496	Q05D32	0.63
SIRT7	51547	Q9NRC8	0.63
PHAX	51808	Q9H814	0.63
RIOK2	55781	Q9BVS4	0.63
CAND1	55832	Q86VP6	0.63
FOXRED2	80020	Q8IWF2	0.63
NAF1	92345	Q96HR8	0.63
CNTROB	116840	Q8N137	0.63
ENTHD2	146705	Q96N21	0.63
UBAC2	337867	Q8NBM4	0.63
SMN1; SMN2	6606	Q16637	0.63
ESR1	2099	P03372	0.67
MAGOH	4116	P61326	0.72
MAP3K1	4214	Q13233	0.72
MAP3K14	9020	Q99558	0.72
EIF4A3	9775	P38919	0.72
CBX8	57332	Q9HC52	0.72
AAMP	14	Q13685	0.73
STAU1	6780	O95793	0.73
FYN	2534	P06241	0.75
HCK	3055	P08631	0.75
LYN	4067	P07948	0.75
NPM1	4869	P06748	0.82
EIF2AK2	5610	P19525	0.82
RPL13	6137	P26373	0.82
RPL18A	6142	Q02543	0.82
RPL22	6146	P35268	0.82
RPL24	6152	P83731	0.82
RPL27	6155	P61353	0.82
RPS6	6194	P62753	0.82
RPS12	6206	P25398	0.82
RPS19	6223	P39019	0.82
RPS25	6230	P62851	0.82
VCAM1	7412	P19320	0.82
RPS11	6205	P62280	0.88
RPS20	6224	P60866	0.88
SRC	6714	P12931	0.88
RPL35	11224	P42766	0.91
RPL13A	23521	P40429	0.91