PCOSBase

Protein Description

Gene Symbol	RPL5
Entrez ID	6125
Uniprot ID	P46777
Description	ribosomal protein L5
Chromosomal Location	chr1: 92,832,025-92,841,924

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000027	ribosomal large subunit assembly	The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.	IBA
BP	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.	TAS
BP	GO:0006364	rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.	IMP\|TAS
BP	GO:0006412	translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.	NAS
BP	GO:0006413	translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.	TAS
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.	TAS
BP	GO:0019083	viral transcription	The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.	TAS
BP	GO:0042273	ribosomal large subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.	IMP
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA
CC	GO:0005730	nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.	IDA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0005925	focal adhesion	Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.	IDA
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0022625	cytosolic large ribosomal subunit	The large subunit of a ribosome located in the cytosol.	IDA
CC	GO:0030529	intracellular ribonucleoprotein complex	An intracellular macromolecular complex containing both protein and RNA molecules.	IDA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0003723	RNA binding	Interacting selectively and non-covalently with an RNA molecule or a portion thereof.	TAS
MF	GO:0003735	structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.	NAS
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0008097	5S rRNA binding	Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome.	IBA
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR005485	Ribosomal protein L5 eukaryotic/L18 archaeal
IPR025607	Ribosomal protein L5 eukaryotic/L18 archaeal, C-terminal

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Pathway ID	Pathway Term	Pathway Source
hsa03010	Ribosome	KEGG
WP477	Cytoplasmic Ribosomal Proteins	WikiPathways

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UMLS CUI	UMLS Term
C0029927	Ovarian Cysts
C1260899	Anemia, Diamond-Blackfan
C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
breast	glandular cells
bronchus	respiratory epithelial cells
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
hippocampus	neuronal cells
lung	macrophages
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
placenta	decidual cells
placenta	trophoblastic cells
rectum	glandular cells
seminal vesicle	glandular cells
small intestine	glandular cells
stomach	glandular cells
testis	cells in seminiferous ducts
thyroid gland	glandular cells
tonsil	squamous epithelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
19141577	Kim et al.	2009	Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome
26459919	Lan et al.	2015	Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

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Gene Symbol	Entrez ID	Uniprot ID	Score
FAU	2197	P62861	0.49
RPL27	6155	P61353	0.49
RPL28	6158	P46779	0.49
RPLP1	6176	P05386	0.49
RPS24	6229	P62847	0.49
RPS27	6232	P42677	0.49
RPS27A	6233	P62979	0.49
RPS28	6234	P62857	0.49
SSR3	6747	Q9UNL2	0.49
TUBA1A	7846	Q71U36	0.49
PABPC4	8761	Q13310	0.49
TUBA1B	10376	P68363	0.49
RACK1	10399	P63244	0.49
NSA2	10412	O95478	0.49
RPS27L	51065	Q71UM5	0.49
XRN1	54464	Q8IZH2	0.49
RPS10P5	93144	Q9NQ39	0.49
VASN	114990	Q6EMK4	0.49
FTSJ3	117246	Q8IY81	0.49
RPLP0P6	220717	Q8NHW5	0.49
RNA5S7	100169758	N/A	0.49
RPS21	100291837	P63220	0.49
KPNB1	3837	Q14974	0.52
IPO5	3843	O00410	0.52
RPL3L	6123	Q92901	0.56
RPS18	6222	P62269	0.56
ATP6V0D1	9114	P61421	0.56
PWP1	11137	Q13610	0.56
RRS1	23212	Q15050	0.56
RRP12	23223	Q5JTH9	0.56
SEC61A1	29927	P61619	0.56
DDX24	57062	Q9GZR7	0.56
RPL35	11224	P42766	0.58
TNPO1	3842	Q92973	0.59
RPSA	3921	P08865	0.59
RPL6	6128	Q02878	0.59
RPL7A	6130	P62424	0.59
RPLP2	6181	P05387	0.59
RPS3A	6189	P61247	0.59
RPS6	6194	P62753	0.59
RPS7	6201	P62081	0.59
RPS8	6202	P62241	0.59
RPS10	6204	P46783	0.59
RPS12	6206	P25398	0.59
RPS13	6207	P62277	0.59
RPS17	6218	P08708	0.59
RPS25	6230	P62851	0.59
RPS26	6231	P62854	0.59
FLNC	2318	Q14315	0.63
PML	5371	P29590	0.63
HARS	3035	P12081	0.65
RPS2	6187	P15880	0.65
RPS4X	6191	P62701	0.65
RPS5	6193	P46782	0.65
RPS9	6203	P46781	0.65
RPS11	6205	P62280	0.65
RPS14	6208	P62263	0.65
RPS15A	6210	P62244	0.65
RPS16	6217	P62249	0.65
RPS19	6223	P39019	0.65
RPS20	6224	P60866	0.65
RPL7	6129	P18124	0.68
RPL8	6132	P62917	0.68
RPLP0	6175	P05388	0.68
TP73	7161	O15350	0.68
RPL9; RPL9P7; RPL9P8; RPL9P9	6133	P32969	0.68
RPS3	6188	P23396	0.70
RPS23	6228	P62266	0.72
CSNK2B	1460	P67870	0.78
RPL5	6125	P46777	0.83
RPL11	6135	P62913	0.83
TP53	7157	P04637	0.83
CSNK2A1	1457	P68400	0.86
EIF5A	1984	P63241	0.89
MDM2	4193	Q00987	0.89
SLC25A5	292	P05141	0.49
CDC27	996	P30260	0.49
DHX9	1660	Q08211	0.49
EEF1G	1937	P26641	0.49
FBL	2091	P22087	0.49
GNL1	2794	P36915	0.49
ILF2	3608	Q12905	0.49
ILF3	3609	Q12906	0.49
HNRNPM	4670	P52272	0.49
NAP1L1	4673	P55209	0.49
SNU13	4809	P55769	0.49
NOP2	4839	P46087	0.49
PSMB1	5689	P20618	0.49
RPL29	6159	P47914	0.49
RPL34	6164	P49207	0.49
RPL35A	6165	P18077	0.49
SLC1A2	6506	P43004	0.49
DDX18	8886	Q9NVP1	0.49
PRPF4B	8899	Q13523	0.49
DDX21	9188	Q9NR30	0.49
VAPA	9218	Q9P0L0	0.49
NOLC1	9221	Q14978	0.49
CLINT1	9685	Q14677	0.49
MYBBP1A	10514	Q9BQG0	0.49
ARL6IP5	10550	O75915	0.49
EBNA1BP2	10969	Q99848	0.49
GNL3	26354	Q9BVP2	0.49
HP1BP3	50809	Q5SSJ5	0.49
RPL26L1	51121	Q9UNX3	0.49
DDX56	54606	Q9NY93	0.49
RBM28	55131	Q9NW13	0.49
NAT10	55226	Q9H0A0	0.49
DDX27	55661	Q96GQ7	0.49
IPO4	79711	Q8TEX9	0.49
NIFK	84365	Q9BYG3	0.49
HSP90AA5P	730211	Q58FG0	0.49
PARP1	142	P09874	0.52
CLK1	1195	P49759	0.52
TNIP1	10318	Q15025	0.52
IPO7	10527	O95373	0.52
EEF2	1938	P13639	0.56
RPL26	6154	P61254	0.56
RPS15	6209	P62841	0.56
MRTO4	51154	Q9UKD2	0.56
NOP58	51602	Q9Y2X3	0.56
RPF1	80135	Q9H9Y2	0.56
RPL13A	23521	P40429	0.58
EEF1A1	1915	P68104	0.59
NCL	4691	P19338	0.59
RPL13	6137	P26373	0.59
RPL15	6138	P61313	0.59
RPL18A	6142	Q02543	0.59
RPL22	6146	P35268	0.59
RPL24	6152	P83731	0.59
RPL30	6156	P62888	0.59
RPL31	6160	P62899	0.59
RPL37A	6168	P61513	0.59
RPL38	6169	P63173	0.59
RPL14	9045	P50914	0.59
PABPC1	26986	P11940	0.59
BRIX1	55299	Q8TDN6	0.59
RPL10L	140801	Q96L21	0.59
ADRBK1	156	P25098	0.63
ATP5F1	515	P24539	0.63
CD81	975	P60033	0.63
CSNK1A1	1452	P48729	0.63
CSNK1E	1454	P49674	0.63
DHX8	1659	Q14562	0.63
ESR1	2099	P03372	0.63
MTOR	2475	P42345	0.63
HK2	3099	P52789	0.63
ICAM1	3383	P05362	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
MCM2	4171	P49736	0.63
NOS2	4843	P35228	0.63
NTRK1	4914	P04629	0.63
PRKAA1	5562	Q13131	0.63
EIF2AK2	5610	P19525	0.63
RAD21	5885	O60216	0.63
RPS6KA1	6195	Q15418	0.63
SUMO3	6612	P55854	0.63
SUMO2	6613	P61956	0.63
SPP1	6696	P10451	0.63
STAU1	6780	O95793	0.63
TUBG1	7283	P23258	0.63
XPO1	7514	O14980	0.63
CUL5	8065	Q93034	0.63
UBL4A	8266	P11441	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
TSC22D1	8848	Q15714	0.63
KIAA0101	9768	Q15004	0.63
PAN2	9924	Q504Q3	0.63
HDAC5	10014	Q9UQL6	0.63
HUWE1	10075	Q7Z6Z7	0.63
GCN1	10985	Q92616	0.63
COPS5	10987	Q92905	0.63
CEP250	11190	Q9BV73	0.63
GABARAP	11337	O95166	0.63
GABARAPL2	11345	P60520	0.63
FBXW11	23291	Q9UKB1	0.63
OBSL1	23363	O75147	0.63
TARDBP	23435	Q13148	0.63
GABARAPL1	23710	Q9H0R8	0.63
UPF2	26019	Q9HAU5	0.63
FBXO6	26270	Q9NRD1	0.63
EEF2K	29904	O00418	0.63
LRP12	29967	Q9Y561	0.63
SIRT7	51547	Q9NRC8	0.63
HAUS2	55142	Q9NVX0	0.63
LGR4	55366	Q9BXB1	0.63
RIOK2	55781	Q9BVS4	0.63
CAND1	55832	Q86VP6	0.63
RBM4B	83759	Q9BQ04	0.63
CCDC8	83987	Q9H0W5	0.63
MAP1LC3A	84557	Q9H492	0.63
IGSF8	93185	Q969P0	0.63
HIST3H2BB	128312	Q8N257	0.63
ZNF707	286075	Q96C28	0.63
EIF6	3692	P56537	0.65
RPL10A	4736	P62906	0.65
RPL3	6122	P39023	0.65
RPL12	6136	P30050	0.65
RPL17	6139	P18621	0.65
RPL18	6141	Q07020	0.65
RPL21	6144	P46778	0.65
RPL27A	6157	P46776	0.65
PPM1D	8493	O15297	0.65
RPL36	25873	Q9Y3U8	0.65
NVL	4931	O15381	0.67
RPL4	6124	P36578	0.68
RPL19	6143	P84098	0.68
RPL23A	6147	P62750	0.68
RPL32	6161	P62910	0.68
VHL	7428	P40337	0.68
SUMO1	7341	P63165	0.70
AMFR	267	Q9UKV5	0.72
FN1	2335	P02751	0.72
HSP90AB1	3326	P08238	0.72
KIF2C	11004	Q99661	0.72
RRP1B	23076	Q14684	0.72
CBX5	23468	P45973	0.72
HSP90AA1	3320	P07900	0.73
IPO13	9670	O94829	0.75
DCC	1630	P43146	0.77
HNRNPU	3192	Q00839	0.82
NEDD8	4738	Q15843	0.82
SURF2	6835	Q15527	0.82
VCAM1	7412	P19320	0.82
NPM1	4869	P06748	0.83
MAP3K14	9020	Q99558	0.83
RPL23	9349	P62829	0.83
NOP56	10528	O00567	0.83
YWHAZ	7534	P63104	0.84
PDCD4	27250	Q53EL6	0.87
RPL10	6134	P27635	0.92