| Gene Symbol | RFX5 |
| Entrez ID | 5993 |
| Uniprot ID | P48382 |
| Description | regulatory factor X5 |
| Chromosomal Location | chr1: 151,340,640-151,347,357 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IEA |
|
BP |
GO:0006351 |
transcription, DNA-templated |
The cellular synthesis of RNA on a template of DNA. |
IEA |
|
BP |
GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IBA |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IEA |
|
MF |
GO:0000978 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding |
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II. |
IBA |
|
MF |
GO:0003677 |
DNA binding |
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
TAS |
|
MF |
GO:0003700 |
transcription factor activity, sequence-specific DNA binding |
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
IBA |
| Domain ID | Description |
|---|---|
|
IPR003150 |
DNA-binding RFX-type winged-helix domain |
|
IPR011991 |
Winged helix-turn-helix DNA-binding domain |
|
IPR029298 |
RFX5, C-terminal |
|
IPR033486 |
DNA-binding protein RFX5 |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04612 |
Antigen processing and presentation |
KEGG |
|
hsa05152 |
Tuberculosis |
KEGG |
|
hsa05340 |
Primary immunodeficiency |
KEGG |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
adipocytes |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
adipocytes |
|
soft tissue |
fibroblasts |
|
soft tissue |
peripheral nerve |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
RPS19 |
6223 |
P39019 |
0.49 |
|
SRPRB |
58477 |
Q9Y5M8 |
0.49 |
|
SLIRP |
81892 |
Q9GZT3 |
0.49 |
|
MRPL53 |
116540 |
Q96EL3 |
0.49 |
|
PPARG |
5468 |
P37231 |
0.63 |
|
HDAC4 |
9759 |
P56524 |
0.63 |
|
SIN3B |
23309 |
O75182 |
0.63 |
|
GIGYF2 |
26058 |
Q6Y7W6 |
0.72 |
|
CDC73 |
79577 |
Q6P1J9 |
0.72 |
|
HDAC2 |
3066 |
Q92769 |
0.77 |
|
RFXAP |
5994 |
O00287 |
0.86 |
|
CIITA |
4261 |
P33076 |
0.89 |
|
EWSR1 |
2130 |
Q01844 |
0.49 |
|
NDUFA2 |
4695 |
O43678 |
0.49 |
|
NDUFA7 |
4701 |
O95182 |
0.49 |
|
RBMS1 |
5937 |
P29558 |
0.49 |
|
HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI |
8339 |
P62807 |
0.49 |
|
HIST1H3A |
8350 |
P68431 |
0.49 |
|
LSM7 |
51690 |
Q9UK45 |
0.49 |
|
CDV3 |
55573 |
Q9UKY7 |
0.49 |
|
APP |
351 |
P05067 |
0.56 |
|
CDC5L |
988 |
Q99459 |
0.63 |
|
MLLT1 |
4298 |
Q03111 |
0.63 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
ANKRA2 |
57763 |
Q9H9E1 |
0.73 |
|
RFXANK |
8625 |
O14593 |
0.89 |