PCOSBase

Protein Description

Gene Symbol	ACTG1
Entrez ID	71
Uniprot ID	P63261
Description	actin gamma 1
Chromosomal Location	chr17: 81,509,971-81,523,847

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0001895	retina homeostasis	A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.	IEP
BP	GO:0006928	movement of cell or subcellular component	The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.	TAS
BP	GO:0034329	cell junction assembly	A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.	TAS
BP	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.	TAS
BP	GO:0045214	sarcomere organization	The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.	IEA
BP	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.	TAS
BP	GO:0048013	ephrin receptor signaling pathway	The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.	TAS
BP	GO:0070527	platelet aggregation	The adhesion of one platelet to one or more other platelets via adhesion molecules.	IMP
CC	GO:0005615	extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.	IDA
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0005856	cytoskeleton	Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.	ISS\|TAS
CC	GO:0005886	plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	ISS\|TAS
CC	GO:0005925	focal adhesion	Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.	ISS
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0030016	myofibril	The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.	IEA
CC	GO:0031012	extracellular matrix	A structure lying external to one or more cells, which provides structural support for cells or tissues.	IDA
CC	GO:0031941	filamentous actin	A two-stranded helical polymer of the protein actin.	IEA
CC	GO:0043209	myelin sheath	An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.	IEA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
CC	GO:0072562	blood microparticle	A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.	IDA
CC	GO:0097433	dense body	An electron dense body which may contain granules.	ISS
MF	GO:0005200	structural constituent of cytoskeleton	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.	IC
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0005524	ATP binding	Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	IEA
MF	GO:0031625	ubiquitin protein ligase binding	Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.	IPI

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Domain ID	Description
IPR004000	Actin family
IPR004001	Actin, conserved site
IPR020902	Actin/actin-like conserved site

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Pathway ID	Pathway Term	Pathway Source
hsa04015	Rap1 signaling pathway	KEGG
hsa04145	Phagosome	KEGG
hsa04210	Apoptosis	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa04520	Adherens junction	KEGG
hsa04530	Tight junction	KEGG
hsa04611	Platelet activation	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa05100	Bacterial invasion of epithelial cells	KEGG
hsa05110	Vibrio cholerae infection	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
hsa05131	Shigellosis	KEGG
hsa05132	Salmonella infection	KEGG
hsa05164	Influenza A	KEGG
hsa05205	Proteoglycans in cancer	KEGG
hsa05410	Hypertrophic cardiomyopathy (HCM)	KEGG
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG
hsa05414	Dilated cardiomyopathy	KEGG
hsa05416	Viral myocarditis	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG
WP306	Focal Adhesion	WikiPathways
WP2118	Arrhythmogenic Right Ventricular Cardiomyopathy	WikiPathways
WP289	Myometrial Relaxation and Contraction Pathways	WikiPathways
WP51	Regulation of Actin Cytoskeleton	WikiPathways
WP383	Striated Muscle Contraction	WikiPathways
WP2272	Pathogenic Escherichia coli infection	WikiPathways
WP2636	Common Pathways Underlying Drug Addiction	WikiPathways
WP314	Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation	WikiPathways
h_HivnefPathway	HIV-I Nef: negative effector of Fas and TNF	BioCarta

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UMLS CUI	UMLS Term
C0007621	Neoplastic Cell Transformation
C0009363	Congenital Ocular Coloboma (Disorder)
C0024667	Animal Mammary Neoplasms
C0024668	Mammary Neoplasms, Experimental
C0029456	Osteoporosis
C0376634	Craniofacial Abnormalities
C0497552	Congenital Neurologic Anomalies
C0948089	Acute Coronary Syndrome

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Tissue	Cell Type
appendix	lymphoid tissue
breast	myoepithelial cells
colon	endothelial cells
duodenum	glandular cells
epididymis	glandular cells
gallbladder	glandular cells
lymph node	germinal center cells
lymph node	non-germinal center cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
spleen	cells in white pulp
stomach	glandular cells
tonsil	non-germinal center cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome
23824412	Piltonen et al.	2013	Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

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Gene Symbol	Entrez ID	Uniprot ID	Score
ACTN1	87	P12814	0.00
CTNNA1	1495	P35221	0.00
DIAPH1	1729	O60610	0.00
MLLT4	4301	P55196	0.00
MYH2	4620	Q9UKX2	0.00
MYH4	4622	Q9Y623	0.00
PFN1	5216	P07737	0.00
PRKCD	5580	Q05655	0.00
PRKCG	5582	P05129	0.00
PRKCH	5583	P24723	0.00
PRKCQ	5588	Q04759	0.00
PXN	5829	P49023	0.00
TJP1	7082	Q07157	0.00
ZYX	7791	Q15942	0.00
ARPC1B	10095	O15143	0.00
ARPC2	10109	O15144	0.00
WASF3	10810	Q9UPY6	0.00
CTNNA3	29119	Q9UI47	0.00
PARVB	29780	Q9HBI1	0.00
PARVG	64098	Q9HBI0	0.00
CAD	790	P27708	0.49
EEF1A1	1915	P68104	0.49
EEF1A2	1917	Q05639	0.49
YARS	8565	P54577	0.49
WASF1	8936	Q92558	0.55
RAN	5901	P62826	0.56
NCKAP1	10787	Q9Y2A7	0.56
NCF1	653361	P14598	0.62
ATP1A1	476	P05023	0.63
CTBP2	1488	P56545	0.63
EEF1G	1937	P26641	0.63
EHHADH	1962	Q08426	0.63
FLNC	2318	Q14315	0.63
EIF6	3692	P56537	0.63
PFN2	5217	P35080	0.63
PTPRO	5800	Q16827	0.63
ST3GAL3	6487	Q11203	0.63
TAGLN	6876	Q01995	0.63
GIT2	9815	Q14161	0.63
PRSS23	11098	O95084	0.63
CCDC22	28952	O60826	0.63
WDYHV1	55093	Q96HA8	0.63
ATF7IP	55729	Q6VMQ6	0.63
BRK1	55845	Q8WUW1	0.63
ACTBL2	345651	Q562R1	0.70
ACTA1	58	P68133	0.72
MYH9	4627	P35579	0.72
SH3GL2	6456	Q99962	0.73
DISC1	27185	Q9NRI5	0.73
WASL	8976	O00401	0.75
MLH1	4292	P40692	0.78
ACTB	60	P60709	0.80
CFL1	1072	P23528	0.80
VCL	7414	P18206	0.82
ACTG1	71	P63261	0.88
CFL2	1073	Q9Y281	0.94
CORO1C	23603	Q9ULV4	0.49
CORO1B	57175	Q9BR76	0.49
CYBB	1536	P04839	0.52
DNASE1	1773	P24855	0.52
FPR1	2357	P21462	0.52
GZMA	3001	P12544	0.52
GZMK	3003	P49863	0.52
ABLIM1	3983	O14639	0.52
LSP1	4046	P33241	0.52
MAP1A	4130	P78559	0.52
NR3C2	4306	P08235	0.52
MYO1A	4640	Q9UBC5	0.52
SRPK2	6733	P78362	0.52
DYNLL1	8655	P63167	0.52
TMSB4Y	9087	O14604	0.52
LGALS13	29124	Q9UHV8	0.52
SCIN	85477	Q9Y6U3	0.52
CAPZA3	93661	Q96KX2	0.52
CTTN	2017	Q14247	0.56
WIPF1	7456	O43516	0.56
COTL1	23406	Q14019	0.56
ANXA5	308	P08758	0.62
VIL1	7429	P09327	0.62
ADRB2	154	P07550	0.63
ANXA1	301	P04083	0.63
APOE	348	P02649	0.63
BMI1	648	P35226	0.63
BRCA1	672	P38398	0.63
CHUK	1147	O15111	0.63
EZH2	2146	Q15910	0.63
FN1	2335	P02751	0.63
SFN	2810	P31947	0.63
HSPB2	3316	Q16082	0.63
ILF3	3609	Q12906	0.63
ITGA4	3676	P13612	0.63
LIG4	3981	P49917	0.63
MCM2	4171	P49736	0.63
MDM2	4193	Q00987	0.63
MYOC	4653	Q99972	0.63
NFKB1	4790	P19838	0.63
NFKBIA	4792	P25963	0.63
NFKBIB	4793	Q15653	0.63
POU5F1	5460	Q01860	0.63
MAPK6	5597	Q16659	0.63
PSEN2	5664	P49810	0.63
REL	5966	Q04864	0.63
RNF2	6045	Q99496	0.63
RPS6KB2	6199	Q9UBS0	0.63
SUMO3	6612	P55854	0.63
SP1	6667	P08047	0.63
SUMO1	7341	P63165	0.63
GAN	8139	Q9H2C0	0.63
UBL4A	8266	P11441	0.63
HIST1H3A	8350	P68431	0.63
EED	8726	O75530	0.63
RPS6KA5	9252	O75582	0.63
UBD	10537	O15205	0.63
YWHAQ	10971	P27348	0.63
TOPBP1	11073	Q92547	0.63
TNIK	23043	Q9UKE5	0.63
FAF2	23197	Q96CS3	0.63
ITGB3BP	23421	Q13352	0.63
SUZ12	23512	Q15022	0.63
FBXO25	26260	Q8TCJ0	0.63
FBXO6	26270	Q9NRD1	0.63
UCHL5	51377	Q9Y5K5	0.63
LIMA1	51474	Q9UHB6	0.63
MRGBP	55257	Q9NV56	0.63
LGR4	55366	Q9BXB1	0.63
DMAP1	55929	Q9NPF5	0.63
AICDA	57379	Q9GZX7	0.63
TSGA10	80705	Q9BZW7	0.63
CCDC8	83987	Q9H0W5	0.63
UBE2Q2	92912	Q8WVN8	0.63
SGF29	112869	Q96ES7	0.63
PPP1R9A	55607	Q9ULJ8	0.65
SUMO4	387082	Q6EEV6	0.65
GRB2	2885	P62993	0.68
GSN	2934	P06396	0.68
VASP	7408	P50552	0.68
HSP90AA1	3320	P07900	0.70
MORF4L2	9643	Q15014	0.70
KAT5	10524	Q92993	0.70
MORF4L1	10933	Q9UBU8	0.70
PLD1	5337	Q13393	0.71
CAPZA2	830	P47755	0.72
CDH1	999	P12830	0.72
CDK2	1017	P24941	0.72
CTNND1	1500	O60716	0.72
DBN1	1627	Q16643	0.72
FLNA	2316	P21333	0.72
IKBKB	3551	O14920	0.72
MDK	4192	P21741	0.72
MAP3K1	4214	Q13233	0.72
MAP3K3	4215	Q99759	0.72
MYC	4609	P01106	0.72
MYO1C	4641	O00159	0.72
NFKB2	4791	Q00653	0.72
PPP1CB	5500	P62140	0.72
RELA	5970	Q04206	0.72
RELB	5971	Q01201	0.72
MAP3K7	6885	O43318	0.72
TNFRSF1A	7132	P19438	0.72
TNFRSF1B	7133	P20333	0.72
TRAF1	7185	Q13077	0.72
TRAF6	7189	Q9Y4K3	0.72
IKBKG	8517	Q9Y6K9	0.72
TRADD	8717	Q15628	0.72
RIPK1	8737	Q13546	0.72
RIPK2	8767	O43353	0.72
MAP3K14	9020	Q99558	0.72
PDLIM7	9260	Q9NR12	0.72
IKBKE	9641	Q14164	0.72
RBX1	9978	P62877	0.72
RIPK3	11035	Q9Y572	0.72
TAB2	23118	Q9NYJ8	0.72
TRAF3IP1	26146	Q8TDR0	0.72
ANLN	54443	Q9NQW6	0.72
EPS8L1	54869	Q8TE68	0.72
MEPCE	56257	Q7L2J0	0.72
EPS8L2	64787	Q9H6S3	0.72
EPS8L3	79574	Q8TE67	0.72
MYO19	80179	Q96H55	0.72
MYO18A	399687	Q92614	0.72
SUMO2	6613	P61956	0.73
NDRG1	10397	Q92597	0.73
CDKN2A	1029	P42771	0.78
HSP90AB1	3326	P08238	0.79
IQGAP1	8826	P46940	0.79
MYO5C	55930	Q9NQX4	0.79
YWHAZ	7534	P63104	0.82
RUVBL1	8607	Q9Y265	0.82
LRRK2	120892	Q5S007	0.82
TRAF2	7186	Q12933	0.83
BCAP31	10134	P51572	0.83
FHOD1	29109	Q9Y613	0.83
CAP1	10487	Q01518	0.85
PPP1CC	5501	P36873	0.86
FEZ1	9638	Q99689	0.86
RUVBL2	10856	Q9Y230	0.88
TMSB4X	7114	P62328	0.90
DSTN	11034	P60981	0.92
CAP2	10486	P40123	0.96