Protein Description

Gene Symbol RELA
Entrez ID 5970
Uniprot ID Q04206
Description v-rel avian reticuloendotheliosis viral oncogene homolog A
Chromosomal Location chr11: 65,653,596-65,663,094
Ontology GO ID GO Term Definition Evidence

BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA

BP

GO:0001889

liver development

The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.

IEA

BP

GO:0001942

hair follicle development

The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.

IEA

BP

GO:0002223

stimulatory C-type lectin receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.

TAS

BP

GO:0006117

acetaldehyde metabolic process

The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.

IEA

BP

GO:0006366

transcription from RNA polymerase II promoter

The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

IEA

BP

GO:0006954

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

IDA

BP

GO:0006968

cellular defense response

A defense response that is mediated by cells.

NAS

BP

GO:0007568

aging

A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).

IEA

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IDA

BP

GO:0009887

animal organ morphogenesis

Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

IEA

BP

GO:0010033

response to organic substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

IDA

BP

GO:0010224

response to UV-B

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.

IDA

BP

GO:0014040

positive regulation of Schwann cell differentiation

Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation.

IEA

BP

GO:0019221

cytokine-mediated signaling pathway

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IDA

BP

GO:0031293

membrane protein intracellular domain proteolysis

The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.

TAS

BP

GO:0032332

positive regulation of chondrocyte differentiation

Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.

IEA

BP

GO:0032481

positive regulation of type I interferon production

Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

TAS

BP

GO:0032495

response to muramyl dipeptide

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.

IEA

BP

GO:0032570

response to progesterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.

IEA

BP

GO:0032868

response to insulin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.

IEA

BP

GO:0033590

response to cobalamin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus.

IEA

BP

GO:0035729

cellular response to hepatocyte growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.

IEA

BP

GO:0035994

response to muscle stretch

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.

IEA

BP

GO:0038095

Fc-epsilon receptor signaling pathway

A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.

TAS

BP

GO:0042177

negative regulation of protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

IEA

BP

GO:0042493

response to drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

IEA

BP

GO:0043066

negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

IDA|TAS

BP

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

IEP

BP

GO:0043200

response to amino acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.

IEA

BP

GO:0043278

response to morphine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.

IEA

BP

GO:0045084

positive regulation of interleukin-12 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.

IEA

BP

GO:0045892

negative regulation of transcription, DNA-templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

IDA

BP

GO:0045893

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

IDA

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA|IMP

BP

GO:0046627

negative regulation of insulin receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.

IEA

BP

GO:0050727

regulation of inflammatory response

Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.

ISS

BP

GO:0050852

T cell receptor signaling pathway

A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

TAS

BP

GO:0051092

positive regulation of NF-kappaB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

IDA|TAS

BP

GO:0051591

response to cAMP

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.

IEA

BP

GO:0051607

defense response to virus

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

NAS

BP

GO:0070301

cellular response to hydrogen peroxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

IDA

BP

GO:0070431

nucleotide-binding oligomerization domain containing 2 signaling pathway

Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 2 (NOD2).

IDA

BP

GO:0070555

response to interleukin-1

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.

IGI

BP

GO:0071222

cellular response to lipopolysaccharide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

IEA

BP

GO:0071316

cellular response to nicotine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.

IMP

BP

GO:0071347

cellular response to interleukin-1

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.

IDA

BP

GO:0071354

cellular response to interleukin-6

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.

IMP

BP

GO:0071356

cellular response to tumor necrosis factor

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

IDA

BP

GO:0071375

cellular response to peptide hormone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.

IMP

BP

GO:1901223

negative regulation of NIK/NF-kappaB signaling

Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.

IMP

BP

GO:1902895

positive regulation of pri-miRNA transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter.

IMP

BP

GO:2000630

positive regulation of miRNA metabolic process

Any process that activates or increases the frequency, rate or extent of miRNA metabolic process.

IMP

BP

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.

IMP

CC

GO:0000790

nuclear chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

CC

GO:0005667

transcription factor complex

A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA|TAS

CC

GO:0033256

I-kappaB/NF-kappaB complex

A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm.

IBA

CC

GO:0071159

NF-kappaB complex

A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.

IEA

MF

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.

IDA

MF

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.

IDA

MF

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.

IDA

MF

GO:0000983

transcription factor activity, RNA polymerase II core promoter sequence-specific

Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

IMP

MF

GO:0001077

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.

IDA

MF

GO:0001078

transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA

MF

GO:0001205

transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding

Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.

IDA

MF

GO:0003677

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

IDA|IMP

MF

GO:0003682

chromatin binding

Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

IDA

MF

GO:0003700

transcription factor activity, sequence-specific DNA binding

Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

IDA

MF

GO:0003705

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008134

transcription factor binding

Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.

IPI

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IPI

MF

GO:0031490

chromatin DNA binding

Interacting selectively and non-covalently with DNA that is assembled into chromatin.

IDA

MF

GO:0031625

ubiquitin protein ligase binding

Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.

IPI

MF

GO:0032403

protein complex binding

Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IEA

MF

GO:0033613

activating transcription factor binding

Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.

IPI

MF

GO:0042301

phosphate ion binding

Interacting selectively and non-covalently with phosphate.

IDA

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IDA

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IDA

MF

GO:0042805

actinin binding

Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.

IPI

MF

GO:0042826

histone deacetylase binding

Interacting selectively and non-covalently with the enzyme histone deacetylase.

IPI

MF

GO:0044212

transcription regulatory region DNA binding

Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.

IDA

MF

GO:0046982

protein heterodimerization activity

Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

IDA

MF

GO:0047485

protein N-terminus binding

Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.

IPI

MF

GO:0051059

NF-kappaB binding

Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.

IPI

MF

GO:0070491

repressing transcription factor binding

Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.

IPI

MF

GO:0071532

ankyrin repeat binding

Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.

IEA

Domain ID Description

IPR000451

NF-kappa-B/Dorsal

IPR002909

IPT domain

IPR008967

p53-like transcription factor, DNA-binding

IPR011539

Rel homology domain (RHD), DNA-binding domain

IPR013783

Immunoglobulin-like fold

IPR014756

Immunoglobulin E-set

IPR030492

Rel homology domain, conserved site

IPR030495

Transcription factor RelA (p65)

IPR032397

Rel homology dimerisation domain

IPR033926

NFkappaB IPT domain

Pathway ID Pathway Term Pathway Source

hsa01523

Antifolate resistance

KEGG

hsa04010

MAPK signaling pathway

KEGG

hsa04014

Ras signaling pathway

KEGG

hsa04024

cAMP signaling pathway

KEGG

hsa04062

Chemokine signaling pathway

KEGG

hsa04064

NF-kappa B signaling pathway

KEGG

hsa04066

HIF-1 signaling pathway

KEGG

hsa04071

Sphingolipid signaling pathway

KEGG

hsa04137

Mitophagy - animal

KEGG

hsa04151

PI3K-Akt signaling pathway

KEGG

hsa04210

Apoptosis

KEGG

hsa04211

Longevity regulating pathway

KEGG

hsa04380

Osteoclast differentiation

KEGG

hsa04620

Toll-like receptor signaling pathway

KEGG

hsa04621

NOD-like receptor signaling pathway

KEGG

hsa04622

RIG-I-like receptor signaling pathway

KEGG

hsa04623

Cytosolic DNA-sensing pathway

KEGG

hsa04657

IL-17 signaling pathway

KEGG

hsa04658

Th1 and Th2 cell differentiation

KEGG

hsa04659

Th17 cell differentiation

KEGG

hsa04660

T cell receptor signaling pathway

KEGG

hsa04662

B cell receptor signaling pathway

KEGG

hsa04668

TNF signaling pathway

KEGG

hsa04722

Neurotrophin signaling pathway

KEGG

hsa04917

Prolactin signaling pathway

KEGG

hsa04920

Adipocytokine signaling pathway

KEGG

hsa04931

Insulin resistance

KEGG

hsa04932

Non-alcoholic fatty liver disease (NAFLD)

KEGG

hsa04933

AGE-RAGE signaling pathway in diabetic complications

KEGG

hsa05030

Cocaine addiction

KEGG

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

KEGG

hsa05131

Shigellosis

KEGG

hsa05132

Salmonella infection

KEGG

hsa05133

Pertussis

KEGG

hsa05134

Legionellosis

KEGG

hsa05140

Leishmaniasis

KEGG

hsa05142

Chagas disease (American trypanosomiasis)

KEGG

hsa05145

Toxoplasmosis

KEGG

hsa05146

Amoebiasis

KEGG

hsa05152

Tuberculosis

KEGG

hsa05160

Hepatitis C

KEGG

hsa05161

Hepatitis B

KEGG

hsa05162

Measles

KEGG

hsa05164

Influenza A

KEGG

hsa05166

HTLV-I infection

KEGG

hsa05168

Herpes simplex infection

KEGG

hsa05169

Epstein-Barr virus infection

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05202

Transcriptional misregulation in cancer

KEGG

hsa05203

Viral carcinogenesis

KEGG

hsa05212

Pancreatic cancer

KEGG

hsa05215

Prostate cancer

KEGG

hsa05220

Chronic myeloid leukemia

KEGG

hsa05221

Acute myeloid leukemia

KEGG

hsa05222

Small cell lung cancer

KEGG

hsa05321

Inflammatory bowel disease (IBD)

KEGG

hsa05418

Fluid shear stress and atherosclerosis

KEGG

WP23

B Cell Receptor Signaling Pathway

WikiPathways

WP1533

Vitamin B12 Metabolism

WikiPathways

WP195

IL-1 signaling pathway

WikiPathways

WP15

Selenium Micronutrient Network

WikiPathways

WP3929

Chemokine signaling pathway

WikiPathways

WP262

EBV LMP1 signaling

WikiPathways

WP2324

AGE/RAGE pathway

WikiPathways

WP75

Toll-like Receptor Signaling Pathway

WikiPathways

WP2355

Corticotropin-releasing hormone signaling pathway

WikiPathways

WP2036

TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway

WikiPathways

WP3303

Rac1/Pak1/p38/MMP-2 pathway

WikiPathways

WP2034

Leptin signaling pathway

WikiPathways

WP288

NLR Proteins

WikiPathways

WP3414

Initiation of transcription and translation elongation at the HIV-1 LTR

WikiPathways

WP3617

Photodynamic therapy-induced NF-kB survival signaling

WikiPathways

WP2637

Structural Pathway of Interleukin 1 (IL-1)

WikiPathways

WP3926

ApoE and miR-146 in inflammation and atherosclerosis

WikiPathways

WP28

Selenium Metabolism and Selenoproteins

WikiPathways

WP1449

Regulation of toll-like receptor signaling pathway

WikiPathways

WP2112

IL17 signaling pathway

WikiPathways

WP2374

Oncostatin M Signaling Pathway

WikiPathways

WP3858

Toll-like Receptor Signaling

WikiPathways

WP3865

RIG-I-like Receptor Signaling

WikiPathways

WP2037

Prolactin Signaling Pathway

WikiPathways

WP1434

Osteopontin Signaling

WikiPathways

WP176

Folate Metabolism

WikiPathways

WP254

Apoptosis

WikiPathways

WP2586

Aryl Hydrocarbon Receptor

WikiPathways

WP2018

RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway

WikiPathways

WP2380

Brain-Derived Neurotrophic Factor (BDNF) signaling pathway

WikiPathways

WP1433

Nucleotide-binding Oligomerization Domain (NOD) pathway

WikiPathways

WP138

Androgen receptor signaling pathway

WikiPathways

WP2332

Interleukin-11 Signaling Pathway

WikiPathways

WP395

IL-4 Signaling Pathway

WikiPathways

WP69

T-Cell antigen Receptor (TCR) Signaling Pathway

WikiPathways

WP3888

VEGFA-VEGFR2 Signaling Pathway

WikiPathways

h_RELAPathway

Acetylation and Deacetylation of RelA in The Nucleus

BioCarta

h_pkcPathway

Activation of PKC through G protein coupled receptor

BioCarta

h_aktPathway

AKT Signaling Pathway

BioCarta

h_atmPathway

ATM Signaling Pathway

BioCarta

h_ranklPathway

Bone Remodelling

BioCarta

h_cdMacPathway

Cadmium induces DNA synthesis and proliferation in macrophages

BioCarta

h_cd40Pathway

CD40L Signaling Pathway

BioCarta

h_ceramidePathway

Ceramide Signaling Pathway

BioCarta

h_tidPathway

Chaperones modulate interferon Signaling Pathway

BioCarta

h_gcrPathway

Corticosteroids and cardioprotection

BioCarta

h_cxcr4Pathway

CXCR4 Signaling Pathway

BioCarta

h_rnaPathway

Double Stranded RNA Induced Gene Expression

BioCarta

h_eponfkbPathway

Erythropoietin mediated neuroprotection through NF-kB

BioCarta

h_fMLPpathway

fMLP induced chemokine gene expression in HMC-1 cells

BioCarta

h_freePathway

Free Radical Induced Apoptosis

BioCarta

h_HivnefPathway

HIV-I Nef: negative effector of Fas and TNF

BioCarta

h_hcmvPathway

Human Cytomegalovirus and Map Kinase Pathways

BioCarta

h_gsk3Pathway

Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages

BioCarta

h_deathPathway

Induction of apoptosis through DR3 and DR4/5 Death Receptors

BioCarta

h_RacCycDPathway

Influence of Ras and Rho proteins on G1 to S Transition

BioCarta

h_keratinocytePathway

Keratinocyte Differentiation

BioCarta

h_mapkPathway

MAPKinase Signaling Pathway

BioCarta

h_pparaPathway

Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

BioCarta

h_vipPathway

Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells

BioCarta

h_nthiPathway

NFkB activation by Nontypeable Hemophilus influenzae

BioCarta

h_nfkbPathway

NF-kB Signaling Pathway

BioCarta

h_rasPathway

Ras Signaling Pathway

BioCarta

h_cardiacegfPathway

Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy

BioCarta

h_il1rPathway

Signal transduction through IL1R

BioCarta

h_tcrPathway

T Cell Receptor Signaling Pathway

BioCarta

h_tall1Pathway

TACI and BCMA stimulation of B cell immune responses

BioCarta

h_41bbPathway

The 4-1BB-dependent immune response

BioCarta

h_pcafpathway

The information-processing pathway at the IFN-beta enhancer

BioCarta

h_stressPathway

TNF/Stress Related Signaling

BioCarta

h_tnfr2Pathway

TNFR2 Signaling Pathway

BioCarta

h_tollPathway

Toll-Like Receptor Pathway

BioCarta

UMLS CUI UMLS Term

C0004763

Barrett Esophagus

C0006118

Brain Neoplasms

C0007134

Renal Cell Carcinoma

C0007621

Neoplastic Cell Transformation

C0007786

Brain Ischemia

C0008370

Cholestasis

C0009319

Colitis

C0009324

Ulcerative Colitis

C0009375

Colonic Neoplasms

C0010692

Cystitis

C0011853

Diabetes Mellitus, Experimental

C0011860

Diabetes Mellitus, Non-Insulin-Dependent

C0011881

Diabetic Nephropathy

C0014474

Ependymoma

C0018843

Heat Stroke

C0020538

Hypertensive Disease

C0022661

Kidney Failure, Chronic

C0023891

Liver Cirrhosis, Alcoholic

C0027626

Neoplasm Invasiveness

C0027659

Neoplasms, Experimental

C0035126

Reperfusion Injury

C0036346

Schizophrenia, Childhood

C0037286

Skin Neoplasms

C0236733

Amphetamine-Related Disorders

C1458155

Mammary Neoplasms

Tissue Cell Type

appendix

lymphoid tissue

bone marrow

hematopoietic cells

breast

glandular cells

breast

myoepithelial cells

cervix, uterine

glandular cells

colon

glandular cells

endometrium

glandular cells

epididymis

glandular cells

fallopian tube

glandular cells

gallbladder

glandular cells

lung

macrophages

lymph node

germinal center cells

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

ovary

follicle cells

parathyroid gland

glandular cells

placenta

trophoblastic cells

rectum

glandular cells

spleen

cells in white pulp

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

non-germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

15598877

Wood et al.

2005

Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects

Gene Symbol Entrez ID Uniprot ID Score

TRADD

8717

Q15628

0.00

ACTL6A

86

O96019

0.52

BTK

695

Q06187

0.52

IRF1

3659

P10914

0.52

CCL2

6347

P13500

0.52

SMARCA2

6595

P51531

0.52

STAT6

6778

P42226

0.52

AKAP8

10270

O43823

0.52

MED23

9439

Q9ULK4

0.56

MED7

9443

O43513

0.56

MED15

51586

Q96RN5

0.56

IRF3

3661

Q14653

0.59

ABCA1

19

O95477

0.63

ACTA1

58

P68133

0.63

ATF4

468

P18848

0.63

CCND1

595

P24385

0.63

CDK4

1019

P11802

0.63

CDKN2A

1029

P42771

0.63

COL2A1

1280

P02458

0.63

MAPK14

1432

Q16539

0.63

CSN3

1448

P07498

0.63

DDC

1644

P20711

0.63

HIF1A

3091

Q16665

0.63

IL1RN

3557

P18510

0.63

KRT5

3852

P13647

0.63

MUC3A

4584

Q02505

0.63

PEX1

5189

O43933

0.63

PLG

5340

P00747

0.63

RPL13

6137

P26373

0.63

SRSF7

6432

Q16629

0.63

SORD

6652

Q00796

0.63

SP3

6670

Q02447

0.63

TCF4

6925

P15884

0.63

TP53

7157

P04637

0.63

UBB

7314

P0CG47

0.63

GAN

8139

Q9H2C0

0.63

TCAP

8557

O15273

0.63

SOCS6

9306

O14544

0.63

CEBPZ

10153

Q03701

0.63

TUBB4A

10382

P04350

0.63

CNNM3

26505

Q8NE01

0.63

FKBP11

51303

Q9NYL4

0.63

REV1

51455

Q9UBZ9

0.63

GOPC

57120

Q9HD26

0.63

NSD1

64324

Q96L73

0.63

DCD

117159

P81605

0.63

DIS3L2

129563

Q8IYB7

0.63

PIWIL4

143689

Q7Z3Z4

0.63

POTEE

445582

Q6S8J3

0.63

POTEJ

653781

P0CG39

0.63

SPATA31A3

727830

Q5VYP0

0.63

ZBTB7B

100293130

O15156

0.63

MAP2K6

5608

P52564

0.65

STAT1

6772

P42224

0.65

MAP3K7

6885

O43318

0.65

TGM2

7052

P21980

0.65

USP7

7874

Q93009

0.65

KDM2A

22992

Q9Y2K7

0.65

PIN1

5300

Q13526

0.67

FAF1

11124

Q9UNN5

0.67

EZH2

2146

Q15910

0.68

BRMS1

25855

Q9HCU9

0.68

CDK5RAP3

80279

Q96JB5

0.68

ACTG1

71

P63261

0.72

SLC25A5

292

P05141

0.72

SLC25A6

293

P12236

0.72

ATP5A1

498

P25705

0.72

CAD

790

P27708

0.72

CLTC

1213

Q00610

0.72

KLF6

1316

Q99612

0.72

EEF1A2

1917

Q05639

0.72

EPRS

2058

P07814

0.72

FBL

2091

P22087

0.72

HNRNPU

3192

Q00839

0.72

DNAJA1

3301

P31689

0.72

HSPA9

3313

P38646

0.72

HSP90AA1

3320

P07900

0.72

HSP90AB1

3326

P08238

0.72

ILF2

3608

Q12905

0.72

KPNA4

3839

O00629

0.72

LGALS3BP

3959

Q08380

0.72

MARS

4141

P56192

0.72

MYH10

4628

P35580

0.72

HNRNPM

4670

P52272

0.72

NCL

4691

P19338

0.72

PCNA

5111

P12004

0.72

PHB

5245

P35232

0.72

RPL7

6129

P18124

0.72

RPL18

6141

Q07020

0.72

RPL27

6155

P61353

0.72

MRPL12

6182

P52815

0.72

RPS13

6207

P62277

0.72

RPS14

6208

P62263

0.72

SFPQ

6421

P23246

0.72

TCP1

6950

P17987

0.72

VIM

7431

P08670

0.72

TUBA1A

7846

Q71U36

0.72

IRS4

8471

O14654

0.72

OGT

8473

O15294

0.72

RUVBL1

8607

Q9Y265

0.72

AIFM1

9131

O95831

0.72

DDX21

9188

Q9NR30

0.72

EFTUD2

9343

Q15029

0.72

BAG2

9532

O95816

0.72

MATR3

9782

P43243

0.72

HAX1

10456

O00165

0.72

CCT4

10575

P50991

0.72

CCT8

10694

P50990

0.72

HSPH1

10808

Q92598

0.72

GCN1

10985

Q92616

0.72

PHB2

11331

Q99623

0.72

PYCR2

29920

Q96C36

0.72

ZBTB7A

51341

O95365

0.72

UBR5

51366

O95071

0.72

LARS

51520

Q9P2J5

0.72

CCAR2

57805

Q8N163

0.72

MTDH

92140

Q86UE4

0.72

TIMM50

92609

Q3ZCQ8

0.72

KCTD12

115207

Q96CX2

0.72

TUBB

203068

P07437

0.72

RPLP0P6

220717

Q8NHW5

0.72

TUBB2B

347733

Q9BVA1

0.72

TUBA3C; TUBA3D

113457

Q13748

0.72

BCL3

602

P20749

0.73

GFI1

2672

Q99684

0.73

PRMT5

10419

O14744

0.73

PPARGC1A

10891

Q9UBK2

0.73

SUZ12

23512

Q15022

0.73

SIN3A

25942

Q96ST3

0.73

PDCD4

27250

Q53EL6

0.73

CEBPD

1052

P49716

0.75

EGR1

1958

P18146

0.75

HSPA4

3308

P34932

0.75

IRF8

3394

Q02556

0.75

CXCL8

3576

P10145

0.75

PPP2CB

5516

P62714

0.75

IRF9

10379

Q00978

0.75

EHMT1

79813

Q9H9B1

0.75

UXT

8409

Q9UBK9

0.76

ATF3

467

P18847

0.77

SIRT6

51548

Q8N6T7

0.77

PSMD10

5716

O75832

0.78

IQGAP2

10788

Q13576

0.78

AKAP8L

26993

Q9ULX6

0.78

TNIP2

79155

Q8NFZ5

0.78

RFC1

5981

P35251

0.79

RPS16

6217

P62249

0.79

HSPA1L

3305

P34931

0.83

CALM2

805

P62158

0.84

CALM3

808

P62158

0.84

HMGB1

3146

P09429

0.84

CENPJ

55835

Q9HC77

0.84

IRF2

3660

P14316

0.85

PML

5371

P29590

0.85

TBK1

29110

Q9UHD2

0.85

HSPA5

3309

P11021

0.86

HSPA8

3312

P11142

0.86

NPM1

4869

P06748

0.86

PRKDC

5591

P78527

0.86

RPL23

9349

P62829

0.86

RUVBL2

10856

Q9Y230

0.86

SNAI1

6615

O95863

0.87

DNAJA3

9093

Q96EY1

0.87

KEAP1

9817

Q14145

0.87

FUS

2521

P35637

0.88

SETD6

79918

Q8TBK2

0.88

BRCA1

672

P38398

0.89

MAP3K8

1326

P41279

0.89

DHX9

1660

Q08211

0.89

PPP2CA

5515

P67775

0.89

RPS3

6188

P23396

0.89

SOCS1

8651

O15524

0.89

MEN1

4221

O00255

0.90

NFKBIE

4794

O00221

0.90

REL

5966

Q04864

0.90

RELB

5971

Q01201

0.90

STAT3

6774

P40763

0.90

BRD4

23476

O60885

0.90

SETD7

80854

Q8WTS6

0.90

PPARG

5468

P37231

0.93

RELA

5970

Q04206

0.96

NFKB2

4791

Q00653

0.97

NR3C1

2908

P04150

0.99

NFKBIA

4792

P25963

0.99

AKT1

207

P31749

0.00

AKT2

208

P31751

0.00

BIRC2

329

Q13490

0.00

BIRC3

330

Q13489

0.00

BCL2L1

598

Q07817

0.00

CASP8

841

Q14790

0.00

CSF2

1437

P04141

0.00

FCER2

2208

P06734

0.00

IL2

3558

P60568

0.00

IL6

3569

P05231

0.00

IL12A

3592

P29459

0.00

IL12B

3593

P29460

0.00

IRAK1

3654

P51617

0.00

MAP3K1

4214

Q13233

0.00

NGFR

4804

P08138

0.00

PIK3R1

5295

P27986

0.00

PITX2

5308

Q99697

0.00

PRKAA2

5563

P54646

0.00

PRKACG

5568

P22612

0.00

PRKCD

5580

Q05655

0.00

MAPK3

5595

P27361

0.00

CCL3

6348

P10147

0.00

CCL11

6356

P51671

0.00

AKT3

10000

Q9Y243

0.00

ALPL

249

P05186

0.49

MKS1

54903

Q9NXB0

0.49

ATM

472

Q13315

0.52

CDC34

997

P49427

0.52

TSC22D3

1831

Q99576

0.52

POLR2A

5430

P24928

0.52

PRTN3

5657

P24158

0.52

TP53BP1

7158

Q12888

0.52

UBE2D1

7321

P51668

0.52

UBE2D2

7322

P62837

0.52

UBE2D3

7323

P61077

0.52

UBE2E1

7324

P51965

0.52

UBE2H

7328

P62256

0.52

UBE2L3

7332

P68036

0.52

IKBKG

8517

Q9Y6K9

0.52

IKBKE

9641

Q14164

0.52

UBE2C

11065

O00762

0.52

IRAK1BP1

134728

Q5VVH5

0.52

MST1R

4486

Q04912

0.55

PPP2R1B

5519

P30154

0.55

PLK1

5347

P53350

0.56

PPP2R1A

5518

P30153

0.56

AK6

6880

Q9Y3D8

0.56

PDCD11

22984

Q14690

0.59

C1QB

713

P02746

0.63

CCNB1

891

P14635

0.63

CTNNB1

1499

P35222

0.63

DDX1

1653

Q92499

0.63

EEF1D

1936

P29692

0.63

GPS1

2873

Q13098

0.63

ISL1

3670

P61371

0.63

SMAD3

4088

P84022

0.63

SMAD4

4089

Q13485

0.63

MEOX2

4223

P50222

0.63

AFF1

4299

P51825

0.63

MX1

4599

P20591

0.63

NOV

4856

P48745

0.63

NTRK1

4914

P04629

0.63

PKM

5315

P14618

0.63

PLA2G4A

5321

P47712

0.63

PPARD

5467

Q03181

0.63

RAC3

5881

P60763

0.63

RNASE1

6035

P07998

0.63

RNF2

6045

Q99496

0.63

SAT1

6303

P21673

0.63

CCL5

6352

P13501

0.63

SUMO3

6612

P55854

0.63

SNRNP70

6625

P08621

0.63

SNRPD3

6634

P62318

0.63

TBL1X

6907

O60907

0.63

USF2

7392

Q15853

0.63

WAS

7454

P42768

0.63

XPO1

7514

O14980

0.63

MAFK

7975

O60675

0.63

DPF1

8193

Q92782

0.63

NME5

8382

P56597

0.63

TP63

8626

Q9H3D4

0.63

SOCS3

9021

O14543

0.63

REPS2

9185

Q8NFH8

0.63

KLF4

9314

O43474

0.63

NR1H4

9971

Q96RI1

0.63

ZBTB33

10009

Q86T24

0.63

STUB1

10273

Q9UNE7

0.63

MYBBP1A

10514

Q9BQG0

0.63

TXNIP

10628

Q9H3M7

0.63

SIRT5

23408

Q9NXA8

0.63

TXN2

25828

Q99757

0.63

AGO1

26523

Q9UL18

0.63

FOXP3

50943

Q9BZS1

0.63

BANP

54971

Q8N9N5

0.63

PHF10

55274

Q8WUB8

0.63

CHFR

55743

Q96EP1

0.63

RIOK2

55781

Q9BVS4

0.63

AKIP1

56672

Q9NQ31

0.63

USP31

57478

Q70CQ4

0.63

BATF2

116071

Q8N1L9

0.63

AR

367

P10275

0.65

CAMK4

814

Q16566

0.65

PIAS1

8554

O75925

0.65

CSNK1G1

53944

Q9HCP0

0.65

SNIP1

79753

Q8TAD8

0.66

CHEK1

1111

O14757

0.68

KAT2A

2648

Q92830

0.68

PRMT1

3276

Q99873

0.68

ASCC3

10973

Q8N3C0

0.68

COMMD5

28991

Q9GZQ3

0.68

COMMD2

51122

Q86X83

0.68

ECSIT

51295

Q9BQ95

0.68

COMMD10

51397

Q9Y6G5

0.68

COMMD4

54939

Q9H0A8

0.68

COMMD8

54951

Q9NX08

0.68

COMMD7

149951

Q86VX2

0.68

KAT2B

8850

Q92831

0.69

DPF3

8110

Q92784

0.70

ANXA1

301

P04083

0.72

BARD1

580

Q99728

0.72

GSK3B

2932

P49841

0.72

HIST1H1C

3006

P16403

0.72

IRF5

3663

Q13568

0.72

KAT5

10524

Q92993

0.72

PDLIM2

64236

Q96JY6

0.72

DAXX

1616

Q9UER7

0.73

NKX2-1

7080

P43699

0.73

FBXW11

23291

Q9UKB1

0.73

UNC5CL

222643

Q8IV45

0.73

TERT

7015

O14746

0.74

TRIB3

57761

Q96RU7

0.74

FOS

2353

P01100

0.75

LMO2

4005

P25791

0.75

PGR

5241

P06401

0.75

SRF

6722

P11831

0.75

TAF6

6878

P49848

0.75

TAF11

6882

Q15544

0.75

HMGA2

8091

P52926

0.75

IER3

8870

P46695

0.75

SIRT2

22933

Q8IXJ6

0.75

NCOA6

23054

Q14686

0.75

NKRF

55922

O15226

0.75

MAPK10

5602

P53779

0.76

TAF4B

6875

Q92750

0.76

APBA2

321

Q99767

0.77

CSNK2A2

1459

P19784

0.77

AATF

26574

Q9NY61

0.77

ASCC1

51008

Q8N9N2

0.77

ASCC2

84164

Q9H1I8

0.77

JUN

3725

P05412

0.78

DPF2

5977

Q92785

0.78

COMMD6

170622

Q7Z4G1

0.78

CDK9

1025

P50750

0.79

CSNK2A1

1457

P68400

0.79

CUL2

8453

Q13617

0.79

MTPN

136319

P58546

0.79

NCF1

653361

P14598

0.79

TRIP4

9325

Q15650

0.81

TLE1

7088

Q04724

0.82

CARM1

10498

Q86X55

0.82

ITGB3BP

23421

Q13352

0.82

AHR

196

P35869

0.83

ELF3

1999

P78545

0.83

NOTCH1

4851

P46531

0.83

NCOA3

8202

Q9Y6Q9

0.83

MDM2

4193

Q00987

0.84

MYC

4609

P01106

0.84

GTF2B

2959

Q00403

0.85

IKBKB

3551

O14920

0.85

PPARA

5465

Q07869

0.85

PRKACA

5566

P17612

0.85

TAF1

6872

P21675

0.85

UBC

7316

P0CG48

0.85

RPS6KA5

9252

O75582

0.85

HEXIM1

10614

O94992

0.85

ESR1

2099

P03372

0.86

HSPA1A

3303

P0DMV8

0.86

HSPA1B

3304

P0DMV9

0.86

PPP4C

5531

P60510

0.86

RXRA

6256

P19793

0.86

TWIST1

7291

Q15672

0.86

BTRC

8945

Q9Y297

0.86

POU2F1

5451

P14859

0.88

TP53BP2

7159

Q13625

0.88

HDAC3

8841

O15379

0.88

KPNA2

3838

P52292

0.89

PRKCZ

5590

Q05513

0.89

TBP

6908

P20226

0.89

PPP1R13L

10848

Q8WUF5

0.89

SIRT1

23411

Q96EB6

0.89

ETHE1

23474

O95571

0.89

RNF25

64320

Q96BH1

0.89

COMMD1

150684

Q8N668

0.89

PARP1

142

P09874

0.90

AES

166

Q08117

0.90

CEBPB

1051

P17676

0.90

CHUK

1147

O15111

0.90

EP300

2033

Q09472

0.90

HDAC2

3066

Q92769

0.90

SP1

6667

P08047

0.90

NCOR2

9612

Q9Y618

0.90

ING4

51147

Q9UNL4

0.90

PIAS3

10401

Q9Y6X2

0.96

CREBBP

1387

Q92793

0.97

HDAC1

3065

Q13547

0.97

NFKB1

4790

P19838

0.97

NFKBIB

4793

Q15653

0.97