| Gene Symbol | RAF1 |
| Entrez ID | 5894 |
| Uniprot ID | P04049 |
| Description | Raf-1 proto-oncogene, serine/threonine kinase |
| Chromosomal Location | chr3: 12,583,601-12,664,226 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000165 |
MAPK cascade |
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
TAS |
|
BP |
GO:0000186 |
activation of MAPKK activity |
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). |
IDA |
|
BP |
GO:0001666 |
response to hypoxia |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
IEA |
|
BP |
GO:0002223 |
stimulatory C-type lectin receptor signaling pathway |
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation. |
TAS |
|
BP |
GO:0006468 |
protein phosphorylation |
The process of introducing a phosphate group on to a protein. |
TAS |
|
BP |
GO:0006915 |
apoptotic process |
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
TAS |
|
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
|
BP |
GO:0007190 |
activation of adenylate cyclase activity |
Any process that initiates the activity of the inactive enzyme adenylate cyclase. |
NAS |
|
BP |
GO:0007507 |
heart development |
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
IEA |
|
BP |
GO:0008283 |
cell proliferation |
The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
TAS |
|
BP |
GO:0008285 |
negative regulation of cell proliferation |
Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
IDA |
|
BP |
GO:0030154 |
cell differentiation |
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
IEA |
|
BP |
GO:0030168 |
platelet activation |
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. |
TAS |
|
BP |
GO:0030878 |
thyroid gland development |
The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. |
IEA |
|
BP |
GO:0031333 |
negative regulation of protein complex assembly |
Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. |
IDA |
|
BP |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
IDA |
|
BP |
GO:0034220 |
ion transmembrane transport |
A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
TAS |
|
BP |
GO:0035019 |
somatic stem cell population maintenance |
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. |
IEA |
|
BP |
GO:0035023 |
regulation of Rho protein signal transduction |
Any process that modulates the frequency, rate or extent of Rho protein signal transduction. |
TAS |
|
BP |
GO:0035773 |
insulin secretion involved in cellular response to glucose stimulus |
The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus. |
IEA |
|
BP |
GO:0035994 |
response to muscle stretch |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. |
IEA |
|
BP |
GO:0042060 |
wound healing |
The series of events that restore integrity to a damaged tissue, following an injury. |
TAS |
|
BP |
GO:0042981 |
regulation of apoptotic process |
Any process that modulates the occurrence or rate of cell death by apoptotic process. |
TAS |
|
BP |
GO:0043066 |
negative regulation of apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
IDA |
|
BP |
GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. |
TAS |
|
BP |
GO:0045104 |
intermediate filament cytoskeleton organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins. |
IEA |
|
BP |
GO:0045595 |
regulation of cell differentiation |
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. |
TAS |
|
BP |
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IEA |
|
BP |
GO:0048011 |
neurotrophin TRK receptor signaling pathway |
A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. |
IEA |
|
BP |
GO:0048538 |
thymus development |
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. |
IEA |
|
BP |
GO:0060324 |
face development |
The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. |
IEA |
|
BP |
GO:0071550 |
death-inducing signaling complex assembly |
A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway. |
IEA |
|
BP |
GO:1902042 |
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. |
IEA |
|
BP |
GO:2000145 |
regulation of cell motility |
Any process that modulates the frequency, rate or extent of cell motility. |
TAS |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IEA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA|ISS |
|
CC |
GO:0005741 |
mitochondrial outer membrane |
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
TAS |
|
CC |
GO:0005794 |
Golgi apparatus |
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. |
IPI |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IDA|TAS |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA|TAS |
|
CC |
GO:0031143 |
pseudopodium |
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. |
IEA |
|
MF |
GO:0004672 |
protein kinase activity |
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
TAS |
|
MF |
GO:0004674 |
protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
IDA |
|
MF |
GO:0004709 |
MAP kinase kinase kinase activity |
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
IEA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
|
MF |
GO:0016301 |
kinase activity |
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
TAS |
|
MF |
GO:0031434 |
mitogen-activated protein kinase kinase binding |
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. |
IEA |
|
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
|
MF |
GO:0046982 |
protein heterodimerization activity |
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR000719 |
Protein kinase domain |
|
IPR001245 |
Serine-threonine/tyrosine-protein kinase, catalytic domain |
|
IPR002219 |
Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
|
IPR003116 |
Raf-like Ras-binding |
|
IPR008271 |
Serine/threonine-protein kinase, active site |
|
IPR011009 |
Protein kinase-like domain |
|
IPR017441 |
Protein kinase, ATP binding site |
|
IPR020454 |
Diacylglycerol/phorbol-ester binding |
|
IPR029071 |
Ubiquitin-related domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa01521 |
EGFR tyrosine kinase inhibitor resistance |
KEGG |
|
hsa01522 |
Endocrine resistance |
KEGG |
|
hsa04010 |
MAPK signaling pathway |
KEGG |
|
hsa04012 |
ErbB signaling pathway |
KEGG |
|
hsa04014 |
Ras signaling pathway |
KEGG |
|
hsa04015 |
Rap1 signaling pathway |
KEGG |
|
hsa04022 |
cGMP-PKG signaling pathway |
KEGG |
|
hsa04024 |
cAMP signaling pathway |
KEGG |
|
hsa04062 |
Chemokine signaling pathway |
KEGG |
|
hsa04068 |
FoxO signaling pathway |
KEGG |
|
hsa04071 |
Sphingolipid signaling pathway |
KEGG |
|
hsa04072 |
Phospholipase D signaling pathway |
KEGG |
|
hsa04140 |
Autophagy - animal |
KEGG |
|
hsa04150 |
mTOR signaling pathway |
KEGG |
|
hsa04151 |
PI3K-Akt signaling pathway |
KEGG |
|
hsa04210 |
Apoptosis |
KEGG |
|
hsa04270 |
Vascular smooth muscle contraction |
KEGG |
|
hsa04360 |
Axon guidance |
KEGG |
|
hsa04370 |
VEGF signaling pathway |
KEGG |
|
hsa04371 |
Apelin signaling pathway |
KEGG |
|
hsa04510 |
Focal adhesion |
KEGG |
|
hsa04540 |
Gap junction |
KEGG |
|
hsa04550 |
Signaling pathways regulating pluripotency of stem cells |
KEGG |
|
hsa04630 |
Jak-STAT signaling pathway |
KEGG |
|
hsa04650 |
Natural killer cell mediated cytotoxicity |
KEGG |
|
hsa04660 |
T cell receptor signaling pathway |
KEGG |
|
hsa04662 |
B cell receptor signaling pathway |
KEGG |
|
hsa04664 |
Fc epsilon RI signaling pathway |
KEGG |
|
hsa04666 |
Fc gamma R-mediated phagocytosis |
KEGG |
|
hsa04720 |
Long-term potentiation |
KEGG |
|
hsa04722 |
Neurotrophin signaling pathway |
KEGG |
|
hsa04726 |
Serotonergic synapse |
KEGG |
|
hsa04730 |
Long-term depression |
KEGG |
|
hsa04810 |
Regulation of actin cytoskeleton |
KEGG |
|
hsa04910 |
Insulin signaling pathway |
KEGG |
|
hsa04912 |
GnRH signaling pathway |
KEGG |
|
hsa04914 |
Progesterone-mediated oocyte maturation |
KEGG |
|
hsa04915 |
Estrogen signaling pathway |
KEGG |
|
hsa04916 |
Melanogenesis |
KEGG |
|
hsa04917 |
Prolactin signaling pathway |
KEGG |
|
hsa04919 |
Thyroid hormone signaling pathway |
KEGG |
|
hsa04921 |
Oxytocin signaling pathway |
KEGG |
|
hsa05034 |
Alcoholism |
KEGG |
|
hsa05152 |
Tuberculosis |
KEGG |
|
hsa05160 |
Hepatitis C |
KEGG |
|
hsa05161 |
Hepatitis B |
KEGG |
|
hsa05164 |
Influenza A |
KEGG |
|
hsa05200 |
Pathways in cancer |
KEGG |
|
hsa05205 |
Proteoglycans in cancer |
KEGG |
|
hsa05206 |
MicroRNAs in cancer |
KEGG |
|
hsa05210 |
Colorectal cancer |
KEGG |
|
hsa05211 |
Renal cell carcinoma |
KEGG |
|
hsa05212 |
Pancreatic cancer |
KEGG |
|
hsa05213 |
Endometrial cancer |
KEGG |
|
hsa05214 |
Glioma |
KEGG |
|
hsa05215 |
Prostate cancer |
KEGG |
|
hsa05218 |
Melanoma |
KEGG |
|
hsa05219 |
Bladder cancer |
KEGG |
|
hsa05220 |
Chronic myeloid leukemia |
KEGG |
|
hsa05221 |
Acute myeloid leukemia |
KEGG |
|
hsa05223 |
Non-small cell lung cancer |
KEGG |
|
hsa05224 |
Breast cancer |
KEGG |
|
hsa05230 |
Central carbon metabolism in cancer |
KEGG |
|
hsa05231 |
Choline metabolism in cancer |
KEGG |
|
WP23 |
B Cell Receptor Signaling Pathway |
WikiPathways |
|
WP437 |
EGF/EGFR Signaling Pathway |
WikiPathways |
|
WP3915 |
Angiopoietin Like Protein 8 Regulatory Pathway |
WikiPathways |
|
WP304 |
Kit receptor signaling pathway |
WikiPathways |
|
WP313 |
Signaling of Hepatocyte Growth Factor Receptor |
WikiPathways |
|
WP127 |
IL-5 Signaling Pathway |
WikiPathways |
|
WP3929 |
Chemokine signaling pathway |
WikiPathways |
|
WP306 |
Focal Adhesion |
WikiPathways |
|
WP2324 |
AGE/RAGE pathway |
WikiPathways |
|
WP3863 |
T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
WikiPathways |
|
WP366 |
TGF-beta Signaling Pathway |
WikiPathways |
|
WP2355 |
Corticotropin-releasing hormone signaling pathway |
WikiPathways |
|
WP2036 |
TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
WikiPathways |
|
WP481 |
Insulin Signaling |
WikiPathways |
|
WP732 |
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling |
WikiPathways |
|
WP2034 |
Leptin signaling pathway |
WikiPathways |
|
WP2870 |
Extracellular vesicle-mediated signaling in recipient cells |
WikiPathways |
|
WP51 |
Regulation of Actin Cytoskeleton |
WikiPathways |
|
WP3931 |
ESC Pluripotency Pathways |
WikiPathways |
|
WP49 |
IL-2 Signaling Pathway |
WikiPathways |
|
WP3849 |
MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ |
WikiPathways |
|
WP2526 |
PDGF Pathway |
WikiPathways |
|
WP2374 |
Oncostatin M Signaling Pathway |
WikiPathways |
|
WP3853 |
ERK Pathway in Huntington's Disease |
WikiPathways |
|
WP2643 |
Nanoparticle-mediated activation of receptor signaling |
WikiPathways |
|
WP3879 |
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
WikiPathways |
|
WP185 |
Integrin-mediated Cell Adhesion |
WikiPathways |
|
WP422 |
MAPK Cascade |
WikiPathways |
|
WP382 |
MAPK Signaling Pathway |
WikiPathways |
|
WP2037 |
Prolactin Signaling Pathway |
WikiPathways |
|
WP2035 |
Follicle Stimulating Hormone (FSH) signaling pathway |
WikiPathways |
|
WP615 |
Senescence and Autophagy in Cancer |
WikiPathways |
|
WP1544 |
MicroRNAs in cardiomyocyte hypertrophy |
WikiPathways |
|
WP2261 |
Signaling Pathways in Glioblastoma |
WikiPathways |
|
WP3680 |
Association Between Physico-Chemical Features and Toxicity Associated Pathways |
WikiPathways |
|
WP2197 |
Endothelin Pathways |
WikiPathways |
|
WP2636 |
Common Pathways Underlying Drug Addiction |
WikiPathways |
|
WP2586 |
Aryl Hydrocarbon Receptor |
WikiPathways |
|
WP231 |
TNF alpha Signaling Pathway |
WikiPathways |
|
WP2446 |
Retinoblastoma (RB) in Cancer |
WikiPathways |
|
WP3651 |
Pathways Affected in Adenoid Cystic Carcinoma |
WikiPathways |
|
WP2032 |
Human Thyroid Stimulating Hormone (TSH) signaling pathway |
WikiPathways |
|
WP2795 |
Cardiac Hypertrophic Response |
WikiPathways |
|
WP581 |
EPO Receptor Signaling |
WikiPathways |
|
WP2380 |
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
WikiPathways |
|
WP2332 |
Interleukin-11 Signaling Pathway |
WikiPathways |
|
WP3932 |
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
WikiPathways |
|
WP286 |
IL-3 Signaling Pathway |
WikiPathways |
|
WP69 |
T-Cell antigen Receptor (TCR) Signaling Pathway |
WikiPathways |
|
WP3888 |
VEGFA-VEGFR2 Signaling Pathway |
WikiPathways |
|
h_At1rPathway |
Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling |
BioCarta |
|
h_sppaPathway |
Aspirin Blocks Signaling Pathway Involved in Platelet Activation |
BioCarta |
|
h_bcrPathway |
BCR Signaling Pathway |
BioCarta |
|
h_biopeptidesPathway |
Bioactive Peptide Induced Signaling Pathway |
BioCarta |
|
h_cdMacPathway |
Cadmium induces DNA synthesis and proliferation in macrophages |
BioCarta |
|
h_CCR3Pathway |
CCR3 signaling in Eosinophils |
BioCarta |
|
h_ceramidePathway |
Ceramide Signaling Pathway |
BioCarta |
|
h_cxcr4Pathway |
CXCR4 Signaling Pathway |
BioCarta |
|
h_egfPathway |
EGF Signaling Pathway |
BioCarta |
|
h_epoPathway |
EPO Signaling Pathway |
BioCarta |
|
h_ecmPathway |
Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia |
BioCarta |
|
h_erkPathway |
Erk1/Erk2 Mapk Signaling pathway |
BioCarta |
|
h_fcer1Pathway |
Fc Epsilon Receptor I Signaling in Mast Cells |
BioCarta |
|
h_fMLPpathway |
fMLP induced chemokine gene expression in HMC-1 cells |
BioCarta |
|
h_ghPathway |
Growth Hormone Signaling Pathway |
BioCarta |
|
h_igf1Pathway |
IGF-1 Signaling Pathway |
BioCarta |
|
h_il2Pathway |
IL 2 signaling pathway |
BioCarta |
|
h_il3Pathway |
IL 3 signaling pathway |
BioCarta |
|
h_il6Pathway |
IL 6 signaling pathway |
BioCarta |
|
h_il2rbPathway |
IL-2 Receptor Beta Chain in T cell Activation |
BioCarta |
|
h_RacCycDPathway |
Influence of Ras and Rho proteins on G1 to S Transition |
BioCarta |
|
h_gleevecpathway |
Inhibition of Cellular Proliferation by Gleevec |
BioCarta |
|
h_insulinPathway |
Insulin Signaling Pathway |
BioCarta |
|
h_integrinPathway |
Integrin Signaling Pathway |
BioCarta |
|
h_keratinocytePathway |
Keratinocyte Differentiation |
BioCarta |
|
h_pyk2Pathway |
Links between Pyk2 and Map Kinases |
BioCarta |
|
h_mapkPathway |
MAPKinase Signaling Pathway |
BioCarta |
|
h_igf1rPathway |
Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation |
BioCarta |
|
h_ngfPathway |
Nerve growth factor pathway (NGF) |
BioCarta |
|
h_nfatPathway |
NFAT and Hypertrophy of the heart (Transcription in the broken heart) |
BioCarta |
|
h_pdgfPathway |
PDGF Signaling Pathway |
BioCarta |
|
h_cdk5Pathway |
Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway |
BioCarta |
|
h_rasPathway |
Ras Signaling Pathway |
BioCarta |
|
h_her2Pathway |
Role of ERBB2 in Signal Transduction and Oncology |
BioCarta |
|
h_barr-mapkPathway |
Role of ?-arrestins in the activation and targeting of MAP kinases |
BioCarta |
|
h_malPathway |
Role of MAL in Rho-Mediated Activation of SRF |
BioCarta |
|
h_bArrestin-srcPathway |
Roles of ?-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling |
BioCarta |
|
h_metPathway |
Signaling of Hepatocyte Growth Factor Receptor |
BioCarta |
|
h_gpcrPathway |
Signaling Pathway from G-Protein Families |
BioCarta |
|
h_spryPathway |
Sprouty regulation of tyrosine kinase signals |
BioCarta |
|
h_tcrPathway |
T Cell Receptor Signaling Pathway |
BioCarta |
|
h_TPOPathway |
TPO Signaling Pathway |
BioCarta |
| UMLS CUI | UMLS Term |
|---|---|
|
C0007131 |
Non-Small Cell Lung Carcinoma |
|
C0007193 |
Cardiomyopathy, Dilated |
|
C0007194 |
Hypertrophic Cardiomyopathy |
|
C0017638 |
Glioma |
|
C0020429 |
Hyperalgesia |
|
C0022665 |
Kidney Neoplasm |
|
C0023903 |
Liver Neoplasms |
|
C0024121 |
Lung Neoplasms |
|
C0028326 |
Noonan Syndrome |
|
C0175704 |
Leopard Syndrome |
|
C0334583 |
Pilocytic Astrocytoma |
|
C1383860 |
Cardiac Hypertrophy |
|
C1458155 |
Mammary Neoplasms |
| Tissue | Cell Type |
|---|---|
|
duodenum |
glandular cells |
|
kidney |
cells in tubules |
|
pancreas |
exocrine glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
19141487 |
Kenigsberg et al. |
2009 |
Gene expression microarray profiles of cumulus cells in lean and overweightobese polycystic ovary syndrome patients |
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22789864 |
Yan et al. |
2012 |
Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
RASA1 |
5921 |
P20936 |
0.00 |
|
SOS1 |
6654 |
Q07889 |
0.00 |
|
MLF1 |
4291 |
P58340 |
0.49 |
|
PSMD2 |
5708 |
Q13200 |
0.49 |
|
NUDCD3 |
23386 |
Q8IVD9 |
0.49 |
|
CACYBP |
27101 |
Q9HB71 |
0.49 |
|
FKBPL |
63943 |
Q9UIM3 |
0.49 |
|
BCL6 |
604 |
P41182 |
0.52 |
|
CDC25B |
994 |
P30305 |
0.52 |
|
INSR |
3643 |
P06213 |
0.52 |
|
PRKCD |
5580 |
Q05655 |
0.52 |
|
ERBB2IP |
55914 |
Q96RT1 |
0.52 |
|
MYBPC1 |
4604 |
Q00872 |
0.63 |
|
PHKA2 |
5256 |
P46019 |
0.63 |
|
PPP2R1A |
5518 |
P30153 |
0.63 |
|
PPP2R2B |
5521 |
Q00005 |
0.63 |
|
PRKAR1A |
5573 |
P10644 |
0.63 |
|
PRKG1 |
5592 |
Q13976 |
0.63 |
|
PURA |
5813 |
Q00577 |
0.63 |
|
RBBP8 |
5932 |
Q99708 |
0.63 |
|
SCNN1B |
6338 |
P51168 |
0.63 |
|
BRAP |
8315 |
Q7Z569 |
0.63 |
|
HUWE1 |
10075 |
Q7Z6Z7 |
0.63 |
|
PRPF6 |
24148 |
O94906 |
0.63 |
|
PACSIN3 |
29763 |
Q9UKS6 |
0.63 |
|
DCAF8 |
50717 |
Q5TAQ9 |
0.63 |
|
COPS7A |
50813 |
Q9UBW8 |
0.63 |
|
TMEM70 |
54968 |
Q9BUB7 |
0.63 |
|
NPLOC4 |
55666 |
Q8TAT6 |
0.63 |
|
FYCO1 |
79443 |
Q9BQS8 |
0.63 |
|
BIRC7 |
79444 |
Q96CA5 |
0.63 |
|
WDR83 |
84292 |
Q9BRX9 |
0.63 |
|
ARRB2 |
409 |
P32121 |
0.65 |
|
TBXA2R |
6915 |
P21731 |
0.65 |
|
HSPA4 |
3308 |
P34932 |
0.67 |
|
BAD |
572 |
Q92934 |
0.69 |
|
ACOX1 |
51 |
Q15067 |
0.72 |
|
EMD |
2010 |
P50402 |
0.72 |
|
DNAJA1 |
3301 |
P31689 |
0.72 |
|
LTK |
4058 |
P29376 |
0.72 |
|
PCDH7 |
5099 |
O60245 |
0.72 |
|
EEF1E1 |
9521 |
O43324 |
0.72 |
|
CCT8 |
10694 |
P50990 |
0.72 |
|
COPS5 |
10987 |
Q92905 |
0.72 |
|
SS18L2 |
51188 |
Q9UHA2 |
0.72 |
|
JAK1 |
3716 |
P23458 |
0.73 |
|
VDAC1 |
7416 |
P21796 |
0.73 |
|
SPRY2 |
10253 |
O43597 |
0.73 |
|
RASD2 |
23551 |
Q96D21 |
0.75 |
|
HSPA5 |
3309 |
P11021 |
0.76 |
|
HSPA8 |
3312 |
P11142 |
0.77 |
|
MAP3K1 |
4214 |
Q13233 |
0.78 |
|
STUB1 |
10273 |
Q9UNE7 |
0.81 |
|
CALU |
813 |
O43852 |
0.82 |
|
STK3 |
6788 |
Q13188 |
0.82 |
|
RANBP9 |
10048 |
Q96S59 |
0.82 |
|
NR3C1 |
2908 |
P04150 |
0.83 |
|
HSP90AB1 |
3326 |
P08238 |
0.83 |
|
LCK |
3932 |
P06239 |
0.83 |
|
HSP90AA1 |
3320 |
P07900 |
0.84 |
|
BCL2L1 |
598 |
Q07817 |
0.85 |
|
RRAS |
6237 |
P10301 |
0.86 |
|
CDC37 |
11140 |
Q16543 |
0.87 |
|
RAF1 |
5894 |
P04049 |
0.88 |
|
XIAP |
331 |
P98170 |
0.89 |
|
FYN |
2534 |
P06241 |
0.89 |
|
YWHAH |
7533 |
Q04917 |
0.89 |
|
BCL2 |
596 |
P10415 |
0.90 |
|
MAP2K2 |
5605 |
P36507 |
0.95 |
|
MAP2K1 |
5604 |
Q02750 |
0.97 |
|
KRAS |
3845 |
P01116 |
0.99 |
|
CDC42 |
998 |
P60953 |
0.00 |
|
EGF |
1950 |
P01133 |
0.00 |
|
ETS2 |
2114 |
P15036 |
0.00 |
|
FOS |
2353 |
P01100 |
0.00 |
|
IGF1 |
3479 |
P05019 |
0.00 |
|
PRKCG |
5582 |
P05129 |
0.00 |
|
PRKCH |
5583 |
P24723 |
0.00 |
|
PAK6 |
56924 |
Q9NQU5 |
0.00 |
|
PAK7 |
57144 |
Q9P286 |
0.00 |
|
CRKL |
1399 |
P46109 |
0.49 |
|
BAG2 |
9532 |
O95816 |
0.49 |
|
STIP1 |
10963 |
P31948 |
0.49 |
|
AARSD1 |
80755 |
Q9BTE6 |
0.49 |
|
ADCY6 |
112 |
O43306 |
0.52 |
|
IL2RB |
3560 |
P14784 |
0.52 |
|
RSU1 |
6251 |
Q15404 |
0.52 |
|
KSR2 |
283455 |
Q6VAB6 |
0.52 |
|
KRT8 |
3856 |
P05787 |
0.55 |
|
PRKCA |
5578 |
P17252 |
0.55 |
|
PEX5L |
51555 |
Q8IYB4 |
0.55 |
|
RCAN1 |
1827 |
P53805 |
0.56 |
|
LOX |
4015 |
P28300 |
0.56 |
|
NEDD4 |
4734 |
P46934 |
0.56 |
|
DMPK |
1760 |
Q09013 |
0.62 |
|
CALM2 |
805 |
P62158 |
0.63 |
|
CALM3 |
808 |
P62158 |
0.63 |
|
CPS1 |
1373 |
P31327 |
0.63 |
|
EFEMP1 |
2202 |
Q12805 |
0.63 |
|
KRT19 |
3880 |
P08727 |
0.63 |
|
LRPAP1 |
4043 |
P30533 |
0.63 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
NFATC3 |
4775 |
Q12968 |
0.63 |
|
PPP2CB |
5516 |
P62714 |
0.63 |
|
MAPK8 |
5599 |
P45983 |
0.63 |
|
RAP2A |
5911 |
P10114 |
0.63 |
|
VCP |
7415 |
P55072 |
0.63 |
|
XPO1 |
7514 |
O14980 |
0.63 |
|
YY1 |
7528 |
P25490 |
0.63 |
|
COPS3 |
8533 |
Q9UNS2 |
0.63 |
|
HERC2 |
8924 |
O95714 |
0.63 |
|
LATS1 |
9113 |
O95835 |
0.63 |
|
MRC2 |
9902 |
Q9UBG0 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
OIP5 |
11339 |
O43482 |
0.63 |
|
NEDD4L |
23327 |
Q96PU5 |
0.63 |
|
CDK20 |
23552 |
Q8IZL9 |
0.63 |
|
SH3KBP1 |
30011 |
Q96B97 |
0.63 |
|
FAM96B |
51647 |
Q9Y3D0 |
0.63 |
|
CASZ1 |
54897 |
Q86V15 |
0.63 |
|
INTS10 |
55174 |
Q9NVR2 |
0.63 |
|
PBK |
55872 |
Q96KB5 |
0.63 |
|
MMS19 |
64210 |
Q96T76 |
0.63 |
|
PDLIM2 |
64236 |
Q96JY6 |
0.63 |
|
GPRASP2 |
114928 |
Q96D09 |
0.63 |
|
HIPK4 |
147746 |
Q8NE63 |
0.63 |
|
NUDT14 |
256281 |
O95848 |
0.63 |
|
PKM |
5315 |
P14618 |
0.65 |
|
PPP1CC |
5501 |
P36873 |
0.65 |
|
UBE2D2 |
7322 |
P62837 |
0.65 |
|
KSR1 |
8844 |
Q8IVT5 |
0.65 |
|
PAK3 |
5063 |
O75914 |
0.66 |
|
PRKAA1 |
5562 |
Q13131 |
0.66 |
|
PRKACA |
5566 |
P17612 |
0.66 |
|
KRT18 |
3875 |
P05783 |
0.67 |
|
RFXANK |
8625 |
O14593 |
0.67 |
|
AR |
367 |
P10275 |
0.68 |
|
PPP2R5C |
5527 |
Q13362 |
0.68 |
|
ERAS |
3266 |
Q7Z444 |
0.72 |
|
MAD2L1 |
4085 |
Q13257 |
0.72 |
|
IRS4 |
8471 |
O14654 |
0.72 |
|
SYNPO |
11346 |
Q8N3V7 |
0.72 |
|
CNKSR2 |
22866 |
Q8WXI2 |
0.72 |
|
TMEM63B |
55362 |
Q5T3F8 |
0.72 |
|
PAQR3 |
152559 |
Q6TCH7 |
0.72 |
|
PRKCE |
5581 |
Q02156 |
0.73 |
|
SGK1 |
6446 |
O00141 |
0.73 |
|
SPRY4 |
81848 |
Q9C004 |
0.73 |
|
EEF1A1 |
1915 |
P68104 |
0.74 |
|
BIRC2 |
329 |
Q13490 |
0.75 |
|
BIRC3 |
330 |
Q13489 |
0.75 |
|
GNG4 |
2786 |
P50150 |
0.76 |
|
AGTR1 |
185 |
P30556 |
0.77 |
|
GNB2 |
2783 |
P62879 |
0.77 |
|
HSPD1 |
3329 |
P10809 |
0.77 |
|
CCT3 |
7203 |
P49368 |
0.77 |
|
STK26 |
51765 |
Q9P289 |
0.77 |
|
PAK2 |
5062 |
Q13177 |
0.78 |
|
MAP3K5 |
4217 |
Q99683 |
0.79 |
|
RBL2 |
5934 |
Q08999 |
0.79 |
|
PIN1 |
5300 |
Q13526 |
0.84 |
|
PPP2CA |
5515 |
P67775 |
0.84 |
|
VAV1 |
7409 |
P15498 |
0.84 |
|
SHOC2 |
8036 |
Q9UQ13 |
0.84 |
|
EGFR |
1956 |
P00533 |
0.86 |
|
PDGFRB |
5159 |
P09619 |
0.86 |
|
TIMM50 |
92609 |
Q3ZCQ8 |
0.86 |
|
BRAF |
673 |
P15056 |
0.87 |
|
ILK |
3611 |
Q13418 |
0.87 |
|
JAK2 |
3717 |
O60674 |
0.87 |
|
MRAS |
22808 |
O14807 |
0.87 |
|
MYC |
4609 |
P01106 |
0.88 |
|
PRKCZ |
5590 |
Q05513 |
0.88 |
|
MAPK7 |
5598 |
Q13164 |
0.88 |
|
CFLAR |
8837 |
O15519 |
0.88 |
|
CNKSR1 |
10256 |
Q969H4 |
0.88 |
|
MAPK8IP3 |
23162 |
Q9UPT6 |
0.88 |
|
AKT1 |
207 |
P31749 |
0.89 |
|
TSC22D3 |
1831 |
Q99576 |
0.89 |
|
GRB10 |
2887 |
Q13322 |
0.89 |
|
YWHAE |
7531 |
P62258 |
0.89 |
|
RRAS2 |
22800 |
P62070 |
0.89 |
|
PEBP4 |
157310 |
Q96S96 |
0.89 |
|
BAG1 |
573 |
Q99933 |
0.90 |
|
CDC25A |
993 |
P30304 |
0.90 |
|
SFN |
2810 |
P31947 |
0.90 |
|
PEBP1 |
5037 |
P30086 |
0.90 |
|
PAK1 |
5058 |
Q13153 |
0.90 |
|
PHB |
5245 |
P35232 |
0.90 |
|
RAP1A |
5906 |
P62834 |
0.90 |
|
RB1 |
5925 |
P06400 |
0.90 |
|
RHEB |
6009 |
Q15382 |
0.90 |
|
SRC |
6714 |
P12931 |
0.90 |
|
YWHAB |
7529 |
P31946 |
0.90 |
|
YWHAG |
7532 |
P61981 |
0.90 |
|
YWHAZ |
7534 |
P63104 |
0.90 |
|
YWHAQ |
10971 |
P27348 |
0.90 |
|
MAPK1 |
5594 |
P28482 |
0.92 |
|
MAPK3 |
5595 |
P27361 |
0.92 |
|
NRAS |
4893 |
P01111 |
0.96 |
|
HRAS |
3265 |
P01112 |
0.99 |