PCOSBase

Protein Description

Gene Symbol	RAD21
Entrez ID	5885
Uniprot ID	O60216
Description	RAD21 cohesin complex component
Chromosomal Location	chr8: 116,845,935-116,874,866

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006302	double-strand break repair	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.	TAS
BP	GO:0006310	DNA recombination	Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.	TAS
BP	GO:0006357	regulation of transcription from RNA polymerase II promoter	Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.	IDA
BP	GO:0006366	transcription from RNA polymerase II promoter	The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).	IEA
BP	GO:0006915	apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.	IEA
BP	GO:0007062	sister chromatid cohesion	The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.	TAS
BP	GO:0007064	mitotic sister chromatid cohesion	The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.	IBA
BP	GO:0007131	reciprocal meiotic recombination	The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.	TAS
BP	GO:0016925	protein sumoylation	The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.	TAS
BP	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	IEA
BP	GO:0051301	cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.	IEA
BP	GO:0051754	meiotic sister chromatid cohesion, centromeric	The cell cycle process in which centromeres of sister chromatids are joined during meiosis.	IBA
BP	GO:0071168	protein localization to chromatin	Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.	IMP
CC	GO:0000775	chromosome, centromeric region	The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.	TAS
CC	GO:0000785	chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.	IEA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA\|TAS
CC	GO:0005694	chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.	TAS
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0008278	cohesin complex	A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).	TAS
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0034991	nuclear meiotic cohesin complex	A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the meiotic cohesin complex.	IBA
MF	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.	IEA
MF	GO:0003682	chromatin binding	Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.	IBA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI

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Domain ID	Description
IPR006909	Rad21/Rec8-like protein, C-terminal, eukaryotic
IPR006910	Rad21/Rec8-like protein, N-terminal
IPR011991	Winged helix-turn-helix DNA-binding domain

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Pathway ID	Pathway Term	Pathway Source
hsa04110	Cell cycle	KEGG

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UMLS CUI	UMLS Term
C0023470	Myeloid Leukemia
C0270972	Cornelia De Lange Syndrome

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	adipocytes
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	glial cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebral cortex	endothelial cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	endothelial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	cells in endometrial stroma
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	glial cells
kidney	cells in tubules
lung	macrophages
lung	pneumocytes
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	ovarian stroma cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skeletal muscle	myocytes
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	epidermal cells
small intestine	glandular cells
soft tissue	adipocytes
soft tissue	chondrocytes
soft tissue	fibroblasts
soft tissue	peripheral nerve
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
SF3A3	10946	Q12874	0.49
NUMA1	4926	Q14980	0.52
CHD3	1107	Q12873	0.55
SMARCA5	8467	O60264	0.58
RPS17	6218	P08708	0.63
CCDC7	79741	Q96M83	0.63
ACAT1	38	P24752	0.63
ACO2	50	Q99798	0.63
AMPD3	272	Q01432	0.63
ARG1	383	P05089	0.63
AZU1	566	P20160	0.63
C1QBP	708	Q07021	0.63
C3	718	P01024	0.63
CAD	790	P27708	0.63
CALML3	810	P27482	0.63
CBR1	873	P16152	0.63
CDK9	1025	P50750	0.63
CFL1	1072	P23528	0.63
CHD4	1108	Q14839	0.63
CLU	1191	P10909	0.63
CP	1356	P00450	0.63
CPS1	1373	P31327	0.63
CSTA	1475	P01040	0.63
CSTB	1476	P04080	0.63
CTPS1	1503	P17812	0.63
CTSG	1511	P08311	0.63
DDX3X	1654	O00571	0.63
DHX9	1660	Q08211	0.63
SEPT1	1731	Q8WYJ6	0.63
EEF1D	1936	P29692	0.63
EIF2S1	1965	P05198	0.63
EIF2S3	1968	P41091	0.63
EIF4A1	1973	P60842	0.63
EIF4G1	1981	Q04637	0.63
SERPINB1	1992	P30740	0.63
CTTN	2017	Q14247	0.63
EVX1	2128	P49640	0.63
EWSR1	2130	Q01844	0.63
FASN	2194	P49327	0.63
FEN1	2237	P39748	0.63
GNL1	2794	P36915	0.63
HIST1H1D	3007	P16402	0.63
HIST1H1B	3009	P16401	0.63
HNRNPH2	3188	P55795	0.63
HNRNPU	3192	Q00839	0.63
HSP90AA1	3320	P07900	0.63
HSP90AB1	3326	P08238	0.63
IL7R	3575	P16871	0.63
ITGAM	3684	P11215	0.63
MCM2	4171	P49736	0.63
MCM3	4172	P25205	0.63
MPO	4353	P05164	0.63
MT-CO2	4513	P00403	0.63
NACA	4666	Q13765	0.63
NAP1L1	4673	P55209	0.63
NPAT	4863	Q14207	0.63
YBX1	4904	P67809	0.63
OSBP	5007	P22059	0.63
PFKL	5211	P17858	0.63
PGK1	5230	P00558	0.63
PIGR	5284	P01833	0.63
PSMC1	5700	P62191	0.63
PSMD2	5708	Q13200	0.63
RAN	5901	P62826	0.63
RFC3	5983	P40938	0.63
RNASE3	6037	P12724	0.63
RPL5	6125	P46777	0.63
RPL6	6128	Q02878	0.63
RPL10	6134	P27635	0.63
RPL11	6135	P62913	0.63
RPL13	6137	P26373	0.63
RPL17	6139	P18621	0.63
RPL22	6146	P35268	0.63
RPL23A	6147	P62750	0.63
RPL30	6156	P62888	0.63
RPL35A	6165	P18077	0.63
RPS2	6187	P15880	0.63
RPS3	6188	P23396	0.63
RPS3A	6189	P61247	0.63
RPS4X	6191	P62701	0.63
RPS5	6193	P46782	0.63
RPS6	6194	P62753	0.63
RPS7	6201	P62081	0.63
RPS10	6204	P46783	0.63
RPS11	6205	P62280	0.63
RPS13	6207	P62277	0.63
RPS14	6208	P62263	0.63
RPS15A	6210	P62244	0.63
RPS16	6217	P62249	0.63
RPS18	6222	P62269	0.63
RPS19	6223	P39019	0.63
RPS20	6224	P60866	0.63
RPS25	6230	P62851	0.63
RPS27A	6233	P62979	0.63
S100A9	6280	P06702	0.63
SFPQ	6421	P23246	0.63
TCF15	6939	Q12870	0.63
DYNLT1	6993	P63172	0.63
TMPO	7112	P42166	0.63
TMSB4X	7114	P62328	0.63
TOP3A	7156	Q13472	0.63
TPM3	7170	P06753	0.63
TPR	7175	P12270	0.63
CCT3	7203	P49368	0.63
UBA52	7311	P62987	0.63
UBA1	7317	P22314	0.63
WNT2B	7482	Q93097	0.63
ZNF80	7634	P51504	0.63
DEK	7913	P35659	0.63
HSD17B8	7923	Q92506	0.63
OR1E2	8388	P47887	0.63
CUL4A	8451	Q13619	0.63
PPM1D	8493	O15297	0.63
API5	8539	Q9BZZ5	0.63
EIF3A	8661	Q14152	0.63
EIF3B	8662	P55884	0.63
EIF3C	8663	Q99613	0.63
EIF3D	8664	O15371	0.63
EIF3F	8665	O00303	0.63
EIF3I	8668	Q13347	0.63
STX10	8677	O60499	0.63
TNFRSF14	8764	Q92956	0.63
UBE2L6	9246	O14933	0.63
RPL23	9349	P62829	0.63
KIF3B	9371	O15066	0.63
GTPBP1	9567	O00178	0.63
UBE3C	9690	Q15386	0.63
NCAPD2	9918	Q15021	0.63
SMC4	10051	Q9NTJ3	0.63
ACTR3	10096	P61158	0.63
LRPPRC	10128	P42704	0.63
TRAP1	10131	Q12931	0.63
G3BP1	10146	Q13283	0.63
ALYREF	10189	Q86V81	0.63
TRAIP	10293	Q9BWF2	0.63
TFG	10342	Q92734	0.63
TUBB4B	10383	P68371	0.63
SYNCRIP	10492	O60506	0.63
CCT7	10574	Q99832	0.63
CCT2	10576	P78371	0.63
CCT8	10694	P50990	0.63
SMR3B	10879	P02814	0.63
DNAJB4	11080	Q9UDY4	0.63
MSRB2	22921	Q9Y3D2	0.63
PDZD2	23037	O15018	0.63
CLASP2	23122	O75122	0.63
SKIV2L2	23517	P42285	0.63
GAPVD1	26130	Q14C86	0.63
OLA1	29789	Q9NTK5	0.63
ANAPC4	29945	Q9UJX5	0.63
AHSP	51327	Q9NZD4	0.63
EVL	51466	Q9UI08	0.63
CALML5	51806	Q9NZT1	0.63
FOCAD	54914	Q5VW36	0.63
SARS2	54938	Q9NP81	0.63
PSPC1	55269	Q8WXF1	0.63
CDKN2AIP	55602	Q9NXV6	0.63
YEATS2	55689	Q9ULM3	0.63
H2AFJ	55766	Q9BTM1	0.63
MTA3	57504	Q9BTC8	0.63
DIP2B	57609	Q9P265	0.63
CCAR2	57805	Q8N163	0.63
RNF123	63891	Q5XPI4	0.63
UBE2O	63893	Q9C0C9	0.63
NCAPG	64151	Q9BPX3	0.63
PHACTR4	65979	Q8IZ21	0.63
CCDC170	80129	Q8IYT3	0.63
NAA15	80155	Q9BXJ9	0.63
CTTNBP2	83992	Q8WZ74	0.63
SETD3	84193	Q86TU7	0.63
PPP1R15B	84919	Q5SWA1	0.63
HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4	121504	P62805	0.63
XIRP2	129446	A4UGR9	0.63
RPL22L1	200916	Q6P5R6	0.63
HNRNPA3	220988	P51991	0.63
THSD7A	221981	Q9UPZ6	0.63
RPL13P12	388344	N/A	0.63
RPS26P11	441502	Q5JNZ5	0.63
DDB1	100290337	Q16531	0.63
RPS21	100291837	P63220	0.63
ESPL1	9700	Q14674	0.68
KPNB1	3837	Q14974	0.70
CDC34	997	P49427	0.72
DAPK3	1613	O43293	0.72
CTCF	10664	P49711	0.72
PPP1R15A	23645	O75807	0.72
MIER1	57708	Q8N108	0.72
MUC16	94025	Q8WXI7	0.72
FLNB	2317	O75369	0.73
MCM4	4173	P33991	0.73
MCM7	4176	P33993	0.73
PRKDC	5591	P78527	0.73
DISC1	27185	Q9NRI5	0.73
CAPN1	823	P07384	0.75
PCNA	5111	P12004	0.80
APOB	338	P04114	0.82
FHL3	2275	Q13643	0.82
SMC3	9126	Q9UQE7	0.89
STAG1	10274	Q8WVM7	0.89
SMC1A	8243	Q14683	0.90
STAG2	10735	Q8N3U4	0.95
MSH6	2956	P52701	0.49
MEA1	4201	Q16626	0.49
MSH2	4436	P43246	0.49
PIN4	5303	Q9Y237	0.49
ANKRD28	23243	O15084	0.49
NIPBL	25836	Q6KC79	0.49
SMC1B	27127	Q8NDV3	0.49
CASP7	840	P55210	0.52
CENPC	1060	Q03188	0.52
BRCA1	672	P38398	0.63
NTRK1	4914	P04629	0.63
PSMC2	5701	P35998	0.63
RNF2	6045	Q99496	0.63
RPA2	6118	P15927	0.63
RPA3	6119	P35244	0.63
THBS3	7059	P49746	0.63
SUMO1	7341	P63165	0.63
HIST1H3A	8350	P68431	0.63
PIP5K1A	8394	Q99755	0.63
EED	8726	O75530	0.63
SRRM1	10250	Q8IYB3	0.63
SIRT7	51547	Q9NRC8	0.63
SIRT6	51548	Q8N6T7	0.63
HECW2	57520	Q9P2P5	0.63
UNK	85451	Q9C0B0	0.63
NSMCE2	286053	Q96MF7	0.65
RPA1	6117	P27694	0.70
AIRE	326	O43918	0.72
BRCA2	675	P51587	0.72
CHTF18	63922	Q8WVB6	0.72
SNW1	22938	Q13573	0.73
WFDC5	149708	Q8TCV5	0.73
SUMO2	6613	P61956	0.74
SSU72	29101	Q9NP77	0.79
SMC2	10592	O95347	0.82
CDCA5	113130	Q96FF9	0.85
PDS5B	23047	Q9NTI5	0.87
PDS5A	23244	Q29RF7	0.87
WAPL	23063	Q7Z5K2	0.89