PCOSBase

Protein Description

Gene Symbol	RAB2A
Entrez ID	5862
Uniprot ID	P61019
Description	RAB2A, member RAS oncogene family
Chromosomal Location	chr8: 60,516,857-60,623,627

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0007030	Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.	IMP
BP	GO:0007264	small GTPase mediated signal transduction	Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.	IEA
BP	GO:0015031	protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	IEA
CC	GO:0000139	Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.	TAS
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA
CC	GO:0005765	lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.	IDA
CC	GO:0005789	endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.	IEA
CC	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.	IEA
CC	GO:0042470	melanosome	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.	IEA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0003924	GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + phosphate.	IDA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0005525	GTP binding	Interacting selectively and non-covalently with GTP, guanosine triphosphate.	IDA
MF	GO:0019003	GDP binding	Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.	IDA

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Domain ID	Description
IPR001806	Small GTPase superfamily
IPR005225	Small GTP-binding protein domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

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Pathway ID	Pathway Term	Pathway Source
hsa04152	AMPK signaling pathway	KEGG
WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	WikiPathways
h_rabPathway	Rab GTPases Mark Targets In The Endocytotic Machinery	BioCarta

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No diseases found.

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
bone marrow	hematopoietic cells
bronchus	respiratory epithelial cells
colon	glandular cells
duodenum	glandular cells
gallbladder	glandular cells
kidney	cells in tubules
lung	macrophages
lymph node	non-germinal center cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
small intestine	glandular cells
stomach	glandular cells
testis	Leydig cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells

Database Name
DisGeNET

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Pubmed ID	Author	Year	Title
15598877	Wood et al.	2005	Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects
21411543	Savaris et al.	2011	Progesterone Resistance in PCOS Endometrium: A Microarray Analysis in Clomiphene Citrate-Treated and Artificial Menstrual Cycles
22789864	Yan et al.	2012	Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation

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Gene Symbol	Entrez ID	Uniprot ID	Score
ABCB7	22	O75027	0.49
ACADM	34	P11310	0.49
APRT	353	P07741	0.49
ATP1A1	476	P05023	0.49
CANX	821	P27824	0.49
GMDS	2762	O60547	0.49
HNRNPU	3192	Q00839	0.49
RAB6A	5870	P20340	0.49
RAC1	5879	P63000	0.49
SSR4	6748	P51571	0.49
RAB11A	8766	P62491	0.49
SUCLG2	8801	Q96I99	0.49
BCAP31	10134	P51572	0.49
HNRNPA0	10949	Q13151	0.49
TES	26136	Q9UGI8	0.49
RAB6B	51560	Q9NRW1	0.49
ARL8B	55207	Q9NVJ2	0.49
BCAP29	55973	Q9UHQ4	0.49
CAV1	857	Q03135	0.63
EEF1G	1937	P26641	0.63
STOM	2040	P27105	0.63
FAM114A1	92689	Q8IWE2	0.63
ACTB	60	P60709	0.72
ASS1	445	P00966	0.72
ATP6V1B2	526	P21281	0.72
COX6C	1345	P09669	0.72
SOAT1	6646	P35610	0.72
VDAC1	7416	P21796	0.72
AKAP12	9590	Q02952	0.72
FLOT1	10211	O75955	0.72
PHB2	11331	Q99623	0.72
PUF60	22827	Q9UHX1	0.72
CHMP2A	27243	O43633	0.72
CHCHD3	54927	Q9NX63	0.72
DOCK6	57572	Q96HP0	0.72
TMEM109	79073	Q9BVC6	0.72
PTRF	284119	Q6NZI2	0.72
FAM71C	196472	Q8NEG0	0.73
ATP6V1H	51606	Q9UI12	0.79
PHB	5245	P35232	0.82
GORASP2	26003	Q9H8Y8	0.86
ARF1	375	P84077	0.49
ATP6V1A	523	P38606	0.49
DCTN1	1639	Q14203	0.49
EEF1A1	1915	P68104	0.49
ETFA	2108	P13804	0.49
ILF3	3609	Q12906	0.49
MYL6	4637	P60660	0.49
CTSA	5476	P10619	0.49
PTBP1	5725	P26599	0.49
RAB1A	5861	P62820	0.49
RAB5A	5868	P20339	0.49
RAB5B	5869	P61020	0.49
RAB5C	5878	P51148	0.49
RPN1	6184	P04843	0.49
UBA52	7311	P62987	0.49
OFD1	8481	O75665	0.49
LAMTOR3	8649	Q9UHA4	0.49
SUCLA2	8803	Q9P2R7	0.49
IGF2BP1	10642	Q9NZI8	0.49
IGF2BP3	10643	O00425	0.49
CNTRL	11064	Q7Z7A1	0.49
FGFR1OP	11116	O95684	0.49
ERLIN2	11160	O94905	0.49
NIN	51199	Q8N4C6	0.49
CEP97	79598	Q8IW35	0.49
CEP290	80184	O15078	0.49
RAB1B	81876	Q9H0U4	0.49
FBF1	85302	Q8TES7	0.49
TMEM67	91147	Q5HYA8	0.49
CNTROB	116840	Q8N137	0.49
SCLT1	132320	Q96NL6	0.49
POC5	134359	Q8NA72	0.49
SPICE1	152185	Q8N0Z3	0.49
TMEM17	200728	Q86X19	0.49
RBSN	64145	Q9H1K0	0.52
GAPDH	2597	P04406	0.55
CBFB	865	Q13951	0.56
ATF6B	1388	Q99941	0.63
EPB41	2035	P11171	0.63
HLA-B	3106	P30480	0.63
HOXB5	3215	P09067	0.63
ICA1	3382	Q05084	0.63
MCC	4163	P23508	0.63
TBC1D25	4943	Q3MII6	0.63
MAPK6	5597	Q16659	0.63
RGS2	5997	P41220	0.63
RPA1	6117	P27694	0.63
RPA2	6118	P15927	0.63
RPA3	6119	P35244	0.63
SUMO2	6613	P61956	0.63
VHL	7428	P40337	0.63
MAPKAPK3	7867	Q16644	0.63
HAX1	10456	O00165	0.63
DNAAF2	55172	Q9NVR5	0.63
RNF26	79102	Q9BY78	0.63
TMEM185A	84548	Q8NFB2	0.63
SLC25A41	284427	Q8N5S1	0.63
PRKCI	5584	P41743	0.67
ATF2	1386	P15336	0.72
STAMBPL1	57559	Q96FJ0	0.73
BLZF1	8548	Q9H2G9	0.75
FLOT2	2319	Q14254	0.82
RAB7A	7879	P51149	0.82
ATP6V0D1	9114	P61421	0.82
GDI2	2665	P50395	0.85
GOLGA2	2801	Q08379	0.88