BP

GO:0000045

autophagosome assembly

The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.

IMP

BP

GO:0006888

ER to Golgi vesicle-mediated transport

The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.

IGI|IMP|TAS

BP

GO:0006890

retrograde vesicle-mediated transport, Golgi to ER

The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

TAS

BP

GO:0006897

endocytosis

A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.

IMP

BP

GO:0006914

autophagy

The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.

IMP

BP

GO:0007030

Golgi organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.

IMP

BP

GO:0007264

small GTPase mediated signal transduction

Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.

IEA

BP

GO:0016192

vesicle-mediated transport

A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

TAS

BP

GO:0016477

cell migration

The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.

IMP

BP

GO:0019068

virion assembly

A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed.

IGI|IMP

BP

GO:0030252

growth hormone secretion

The regulated release of growth hormone from secretory granules into the blood.

IMP

BP

GO:0032402

melanosome transport

The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IEA

BP

GO:0034446

substrate adhesion-dependent cell spreading

The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

IEA

BP

GO:0042742

defense response to bacterium

Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

IMP

BP

GO:0047496

vesicle transport along microtubule

The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.

IMP

BP

GO:0048208

COPII vesicle coating

The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.

TAS

BP

GO:0072606

interleukin-8 secretion

The regulated release of interleukin-8 from a cell.

IMP

BP

GO:0090110

cargo loading into COPII-coated vesicle

The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi.

IMP

BP

GO:0098609

cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules.

IEA

BP

GO:1903020

positive regulation of glycoprotein metabolic process

Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process.

IGI

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IBA|TAS

CC

GO:0005769

early endosome

A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.

IEA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

IBA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0042470

melanosome

A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0003924

GTPase activity

Catalysis of the reaction: GTP + H2O = GDP + phosphate.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005525

GTP binding

Interacting selectively and non-covalently with GTP, guanosine triphosphate.

IEA

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA