Protein Description

Gene Symbol PVR
Entrez ID 5817
Uniprot ID P15151
Description poliovirus receptor
Chromosomal Location chr19: 44,643,798-44,663,583
Ontology GO ID GO Term Definition Evidence

BP

GO:0002860

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.

IMP

BP

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.

IBA

BP

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.

IBA

BP

GO:0008037

cell recognition

The process in which a cell in an organism interprets its surroundings.

IBA

BP

GO:0034332

adherens junction organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.

TAS

BP

GO:0042271

susceptibility to natural killer cell mediated cytotoxicity

The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.

IMP

BP

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.

IMP

BP

GO:0046718

viral entry into host cell

The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.

IEA

BP

GO:0050776

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

TAS

BP

GO:0060370

susceptibility to T cell mediated cytotoxicity

The process of causing a cell to become susceptible to T cell mediated cytotoxicity.

IDA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IBA

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IBA

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0001618

virus receptor activity

Combining with a virus component and mediating entry of the virus into the cell.

IEA

MF

GO:0004872

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

TAS

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IBA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IBA

MF

GO:0050839

cell adhesion molecule binding

Interacting selectively and non-covalently with a cell adhesion molecule.

IPI

Domain ID Description

IPR003599

Immunoglobulin subtype

IPR007110

Immunoglobulin-like domain

IPR013106

Immunoglobulin V-set domain

IPR013162

CD80-like, immunoglobulin C2-set

IPR013783

Immunoglobulin-like fold

Pathway ID Pathway Term Pathway Source

hsa04514

Cell adhesion molecules (CAMs)

KEGG

UMLS CUI UMLS Term

C0026769

Multiple Sclerosis

C0032371

Poliomyelitis

Tissue Cell Type

heart muscle

myocytes

placenta

decidual cells

testis

Leydig cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ZC3HAV1

56829

Q7Z2W4

0.49

PVR

5817

P15151

0.52

TJP1

7082

Q07157

0.52

SLC30A2

7780

Q9BRI3

0.63

KRTAP10-7

386675

P60409

0.63

KRTAP10-9

386676

P60411

0.63

KRTAP10-8

386681

P60410

0.63

KRTAP10-3

386682

P60369

0.63

NOTCH2NL

388677

Q7Z3S9

0.63

DYNLT1

6993

P63172

0.76

CDH1

999

P12830

0.52

NECTIN1

5818

Q15223

0.52

TNFRSF12A

51330

Q9NP84

0.56

DYNLT3

6990

P51808

0.62

ELAVL1

1994

Q15717

0.63

PLA2G3

50487

Q9NZ20

0.63

WNK1

65125

Q9H4A3

0.63

TIGIT

201633

Q495A1

0.68

AP1M2

10053

Q9Y6Q5

0.75

CD96

10225

P40200

0.75

VTN

7448

P04004

0.85

NECTIN3

25945

Q9NQS3

0.85

CD226

10666

Q15762

0.87