| Gene Symbol | PTBP1 |
| Entrez ID | 5725 |
| Uniprot ID | P26599 |
| Description | polypyrimidine tract binding protein 1 |
| Chromosomal Location | chr19: 797,075-812,327 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000380 |
alternative mRNA splicing, via spliceosome |
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. |
IEA |
|
BP |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. |
IDA |
|
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
TAS |
|
BP |
GO:0006397 |
mRNA processing |
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
TAS |
|
BP |
GO:0008380 |
RNA splicing |
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
TAS |
|
BP |
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. |
TAS |
|
BP |
GO:0010467 |
gene expression |
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
TAS |
|
BP |
GO:0033119 |
negative regulation of RNA splicing |
Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. |
IDA |
|
BP |
GO:0048025 |
negative regulation of mRNA splicing, via spliceosome |
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. |
IDA |
|
BP |
GO:0051148 |
negative regulation of muscle cell differentiation |
Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. |
IDA |
|
BP |
GO:0075522 |
IRES-dependent viral translational initiation |
Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation. |
IMP |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
|
CC |
GO:0005730 |
nucleolus |
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
TAS |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0000166 |
nucleotide binding |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
IEA |
|
MF |
GO:0003723 |
RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
TAS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0008187 |
poly-pyrimidine tract binding |
Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. |
TAS |
|
MF |
GO:0036002 |
pre-mRNA binding |
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. |
IDA |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR000504 |
RNA recognition motif domain |
|
IPR006536 |
HnRNP-L/PTB |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP411 |
mRNA Processing |
WikiPathways |
|
WP3595 |
mir-124 predicted interactions with cell cycle and differentiation |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0024667 |
Animal Mammary Neoplasms |
|
C0024668 |
Mammary Neoplasms, Experimental |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
bronchus |
respiratory epithelial cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
|
25393639 |
Ambekar et al. |
2014 |
Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ACAT1 |
38 |
P24752 |
0.49 |
|
ATP5A1 |
498 |
P25705 |
0.49 |
|
ATP5B |
506 |
P06576 |
0.49 |
|
ATP5C1 |
509 |
P36542 |
0.49 |
|
CANX |
821 |
P27824 |
0.49 |
|
CCNH |
902 |
P51946 |
0.49 |
|
CHEK1 |
1111 |
O14757 |
0.49 |
|
HSD17B10 |
3028 |
Q99714 |
0.49 |
|
HSPA5 |
3309 |
P11021 |
0.49 |
|
HSPB1 |
3315 |
P04792 |
0.49 |
|
IL7R |
3575 |
P16871 |
0.49 |
|
PDHA1 |
5160 |
P08559 |
0.49 |
|
PDHB |
5162 |
P11177 |
0.49 |
|
PXN |
5829 |
P49023 |
0.49 |
|
RAB1A |
5861 |
P62820 |
0.49 |
|
RAB2A |
5862 |
P61019 |
0.49 |
|
RANGAP1 |
5905 |
P46060 |
0.49 |
|
RPS7 |
6201 |
P62081 |
0.49 |
|
SRSF5 |
6430 |
Q13243 |
0.49 |
|
SLC3A2 |
6520 |
P08195 |
0.49 |
|
TUFM |
7284 |
P49411 |
0.49 |
|
KHSRP |
8570 |
Q92945 |
0.49 |
|
TOMM70 |
9868 |
O94826 |
0.49 |
|
DDX17 |
10521 |
Q92841 |
0.49 |
|
HNRNPA0 |
10949 |
Q13151 |
0.49 |
|
RPL36 |
25873 |
Q9Y3U8 |
0.49 |
|
TIMM13 |
26517 |
Q9Y5L4 |
0.49 |
|
STOML2 |
30968 |
Q9UJZ1 |
0.49 |
|
SAR1A |
56681 |
Q9NR31 |
0.49 |
|
MARK4 |
57787 |
Q96L34 |
0.49 |
|
TMEM177 |
80775 |
Q53S58 |
0.49 |
|
AMIGO2 |
347902 |
Q86SJ2 |
0.49 |
|
APP |
351 |
P05067 |
0.56 |
|
HNRNPA3 |
220988 |
P51991 |
0.59 |
|
RPSA |
3921 |
P08865 |
0.63 |
|
SPTAN1 |
6709 |
Q13813 |
0.63 |
|
IQGAP1 |
8826 |
P46940 |
0.63 |
|
AIMP1 |
9255 |
Q12904 |
0.63 |
|
RBFOX2 |
23543 |
O43251 |
0.63 |
|
PCBP3 |
54039 |
P57721 |
0.63 |
|
FUS |
2521 |
P35637 |
0.66 |
|
NPM1 |
4869 |
P06748 |
0.72 |
|
HNRNPA2B1 |
3181 |
P22626 |
0.73 |
|
CALCOCO2 |
10241 |
Q13137 |
0.73 |
|
QKI |
9444 |
Q96PU8 |
0.84 |
|
HNRNPK |
3190 |
P61978 |
0.88 |
|
PTBP1 |
5725 |
P26599 |
0.89 |
|
HSPA9 |
3313 |
P38646 |
0.49 |
|
NCL |
4691 |
P19338 |
0.49 |
|
HIST3H3 |
8290 |
Q16695 |
0.49 |
|
HNRNPDL |
9987 |
O14979 |
0.49 |
|
PHB2 |
11331 |
Q99623 |
0.49 |
|
HTATSF1 |
27336 |
O43719 |
0.49 |
|
PNPT1 |
87178 |
Q8TCS8 |
0.49 |
|
CASP3 |
836 |
P42574 |
0.55 |
|
PRKACA |
5566 |
P17612 |
0.55 |
|
GRB2 |
2885 |
P62993 |
0.56 |
|
NONO |
4841 |
Q15233 |
0.56 |
|
HMGA2 |
8091 |
P52926 |
0.56 |
|
MEX3C |
51320 |
Q5U5Q3 |
0.56 |
|
ABCF1 |
23 |
Q8NE71 |
0.63 |
|
BMI1 |
648 |
P35226 |
0.63 |
|
CDC5L |
988 |
Q99459 |
0.63 |
|
CDK2 |
1017 |
P24941 |
0.63 |
|
CRY1 |
1407 |
Q16526 |
0.63 |
|
EIF4G1 |
1981 |
Q04637 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
EPRS |
2058 |
P07814 |
0.63 |
|
ESR1 |
2099 |
P03372 |
0.63 |
|
FAU |
2197 |
P62861 |
0.63 |
|
FN1 |
2335 |
P02751 |
0.63 |
|
HNRNPAB |
3182 |
Q99729 |
0.63 |
|
ILF2 |
3608 |
Q12905 |
0.63 |
|
ITGA4 |
3676 |
P13612 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
MYC |
4609 |
P01106 |
0.63 |
|
NOS2 |
4843 |
P35228 |
0.63 |
|
NOTCH1 |
4851 |
P46531 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PSMA3 |
5684 |
P25788 |
0.63 |
|
QARS |
5859 |
P47897 |
0.63 |
|
RNF2 |
6045 |
Q99496 |
0.63 |
|
RORA |
6095 |
P35398 |
0.63 |
|
RPA1 |
6117 |
P27694 |
0.63 |
|
RPA2 |
6118 |
P15927 |
0.63 |
|
RPA3 |
6119 |
P35244 |
0.63 |
|
RPS27 |
6232 |
P42677 |
0.63 |
|
SUMO3 |
6612 |
P55854 |
0.63 |
|
STK4 |
6789 |
Q13043 |
0.63 |
|
WHSC1 |
7468 |
O96028 |
0.63 |
|
AIMP2 |
7965 |
Q13155 |
0.63 |
|
CUL5 |
8065 |
Q93034 |
0.63 |
|
RBM10 |
8241 |
P98175 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
YBX3 |
8531 |
P16989 |
0.63 |
|
EED |
8726 |
O75530 |
0.63 |
|
EIF2B2 |
8892 |
P49770 |
0.63 |
|
ISG15 |
9636 |
P05161 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
PTBP3 |
9991 |
O95758 |
0.63 |
|
HDAC5 |
10014 |
Q9UQL6 |
0.63 |
|
G3BP1 |
10146 |
Q13283 |
0.63 |
|
SRRM1 |
10250 |
Q8IYB3 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
COPS5 |
10987 |
Q92905 |
0.63 |
|
PARK7 |
11315 |
Q99497 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
SNW1 |
22938 |
Q13573 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
TARDBP |
23435 |
Q13148 |
0.63 |
|
SUZ12 |
23512 |
Q15022 |
0.63 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
|
NELFB |
25920 |
Q8WX92 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
DIMT1 |
27292 |
Q9UNQ2 |
0.63 |
|
DDX41 |
51428 |
Q9UJV9 |
0.63 |
|
LGR4 |
55366 |
Q9BXB1 |
0.63 |
|
MED29 |
55588 |
Q9NX70 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
SMARCAD1 |
56916 |
Q9H4L7 |
0.63 |
|
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
|
CCDC8 |
83987 |
Q9H0W5 |
0.63 |
|
MED10 |
84246 |
Q9BTT4 |
0.63 |
|
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
|
MED19 |
219541 |
A0JLT2 |
0.63 |
|
SCARNA22 |
677770 |
N/A |
0.63 |
|
SAP25 |
100316904 |
Q8TEE9 |
0.63 |
|
APBB1 |
322 |
O00213 |
0.68 |
|
YWHAZ |
7534 |
P63104 |
0.68 |
|
SRPK2 |
6733 |
P78362 |
0.70 |
|
RAVER2 |
55225 |
Q9HCJ3 |
0.70 |
|
ARRB2 |
409 |
P32121 |
0.72 |
|
MATR3 |
9782 |
P43243 |
0.72 |
|
HNRNPU |
3192 |
Q00839 |
0.73 |
|
MDM2 |
4193 |
Q00987 |
0.73 |
|
ZMYM2 |
7750 |
Q9UBW7 |
0.73 |
|
HNRNPA1 |
3178 |
P09651 |
0.74 |
|
SUMO2 |
6613 |
P61956 |
0.74 |
|
HMGA1 |
3159 |
P17096 |
0.75 |
|
RAVER1 |
125950 |
Q8IY67 |
0.75 |
|
SNRPA |
6626 |
P09012 |
0.79 |
|
SUMO1 |
7341 |
P63165 |
0.79 |
|
YBX1 |
4904 |
P67809 |
0.82 |
|
VCAM1 |
7412 |
P19320 |
0.82 |
|
HNRNPD |
3184 |
Q14103 |
0.83 |
|
PCBP1 |
5093 |
Q15365 |
0.84 |
|
HNRNPL |
3191 |
P14866 |
0.89 |
|
PCBP2 |
5094 |
Q15366 |
0.89 |
|
SFPQ |
6421 |
P23246 |
0.90 |