BP

GO:0002576

platelet degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.

TAS

BP

GO:0006687

glycosphingolipid metabolic process

The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.

TAS

BP

GO:0006869

lipid transport

The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

TAS

BP

GO:0007193

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).

IBA

BP

GO:0010506

regulation of autophagy

Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

TAS

BP

GO:0019216

regulation of lipid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.

IBA

BP

GO:0043085

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

IEA

BP

GO:0043410

positive regulation of MAPK cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

IEA

BP

GO:0060736

prostate gland growth

The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state.

IBA

BP

GO:0060742

epithelial cell differentiation involved in prostate gland development

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland.

IBA

BP

GO:0071310

cellular response to organic substance

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

IEA

BP

GO:1903206

negative regulation of hydrogen peroxide-induced cell death

Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA|ISS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IBA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IEA

CC

GO:0005764

lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

IDA

CC

GO:0005765

lysosomal membrane

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

CC

GO:0043202

lysosomal lumen

The volume enclosed within the lysosomal membrane.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0001664

G-protein coupled receptor binding

Interacting selectively and non-covalently with a G-protein coupled receptor.

IBA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008047

enzyme activator activity

Binds to and increases the activity of an enzyme.

TAS

MF

GO:0008289

lipid binding

Interacting selectively and non-covalently with a lipid.

TAS