| Gene Symbol | ATP5J |
| Entrez ID | 522 |
| Uniprot ID | P18859 |
| Description | ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 |
| Chromosomal Location | chr21: 25,716,503-25,735,673 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006754 |
ATP biosynthetic process |
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
TAS |
|
BP |
GO:0021762 |
substantia nigra development |
The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). |
IEP |
|
BP |
GO:0042776 |
mitochondrial ATP synthesis coupled proton transport |
The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. |
IC|TAS |
|
CC |
GO:0000276 |
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) |
All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. |
IEA |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
|
CC |
GO:0005743 |
mitochondrial inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
TAS |
|
CC |
GO:0005753 |
mitochondrial proton-transporting ATP synthase complex |
A proton-transporting ATP synthase complex found in the mitochondrial membrane. |
IDA |
|
MF |
GO:0005215 |
transporter activity |
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. |
NAS |
|
MF |
GO:0015078 |
hydrogen ion transmembrane transporter activity |
Enables the transfer of hydrogen ions from one side of a membrane to the other. |
IEA |
|
MF |
GO:0016887 |
ATPase activity |
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. |
IDA |
|
MF |
GO:0022857 |
transmembrane transporter activity |
Enables the transfer of a substance from one side of a membrane to the other. |
IC |
| Domain ID | Description |
|---|---|
|
IPR008387 |
ATP synthase-coupling factor 6, mitochondrial |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00190 |
Oxidative phosphorylation |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa05010 |
Alzheimer's disease |
KEGG |
|
hsa05012 |
Parkinson's disease |
KEGG |
|
hsa05016 |
Huntington's disease |
KEGG |
|
WP111 |
Electron Transport Chain |
WikiPathways |
|
WP623 |
Oxidative phosphorylation |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0018799 |
Heart Diseases |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cerebral cortex |
neuropil |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
15598877 |
Wood et al. |
2005 |
Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects |
|
20426491 |
Choi et al. |
2010 |
The Apolipoprotein A-I Level Is Downregulated in the Granulosa Cells of Patients with Polycystic Ovary Syndrome and Affects Steroidogenesis |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
FABP5 |
2171 |
Q01469 |
0.49 |
|
UQCRC2 |
7385 |
P22695 |
0.49 |
|
UQCRFS1 |
7386 |
P47985 |
0.49 |
|
GSTO1 |
9446 |
P78417 |
0.49 |
|
PRDX3 |
10935 |
P30048 |
0.49 |
|
PARK7 |
11315 |
Q99497 |
0.49 |
|
COA6 |
388753 |
Q5JTJ3 |
0.49 |
|
ATP5I |
521 |
P56385 |
0.56 |
|
ATP5J2 |
9551 |
P56134 |
0.56 |
|
ATP5O |
539 |
P48047 |
0.65 |
|
ACO2 |
50 |
Q99798 |
0.49 |
|
ALDOA |
226 |
P04075 |
0.49 |
|
ATP2B4 |
493 |
P23634 |
0.49 |
|
ATP5E |
514 |
P56381 |
0.49 |
|
ENO3 |
2027 |
P13929 |
0.49 |
|
NFKB1 |
4790 |
P19838 |
0.49 |
|
FKBP7 |
51661 |
Q9Y680 |
0.49 |
|
ATP5D |
513 |
P30049 |
0.56 |
|
NUP98 |
4928 |
P52948 |
0.63 |
|
MAPK6 |
5597 |
Q16659 |
0.63 |
|
RPS6KA3 |
6197 |
P51812 |
0.63 |
|
BANF1 |
8815 |
O75531 |
0.63 |
|
SLC38A2 |
54407 |
Q96QD8 |
0.63 |
|
SLC38A1 |
81539 |
Q9H2H9 |
0.63 |
|
SLC36A1 |
206358 |
Q7Z2H8 |
0.63 |
|
ATP5F1 |
515 |
P24539 |
0.64 |
|
BLK |
640 |
P51451 |
0.72 |
|
GBA |
2629 |
P04062 |
0.72 |
|
RALA |
5898 |
P11233 |
0.72 |
|
TFEB |
7942 |
P19484 |
0.72 |
|
CDC16 |
8881 |
Q13042 |
0.72 |
|
ITGB3BP |
23421 |
Q13352 |
0.72 |
|
GOLT1B |
51026 |
Q9Y3E0 |
0.72 |
|
NDUFA13 |
51079 |
Q9P0J0 |
0.72 |
|
FAM134A |
79137 |
Q8NC44 |
0.72 |
|
ENO1 |
2023 |
P06733 |
0.73 |