Protein Description

Gene Symbol PRKX
Entrez ID 5613
Uniprot ID P51817
Description protein kinase, X-linked
Chromosomal Location chrX: 3,604,370-3,713,608
Ontology GO ID GO Term Definition Evidence

BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IMP

BP

GO:0001935

endothelial cell proliferation

The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

IMP

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IMP

BP

GO:0018105

peptidyl-serine phosphorylation

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

IDA

BP

GO:0030099

myeloid cell differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.

IDA

BP

GO:0030155

regulation of cell adhesion

Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.

IDA

BP

GO:0030334

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

IDA

BP

GO:0031589

cell-substrate adhesion

The attachment of a cell to the underlying substrate via adhesion molecules.

IMP

BP

GO:0043542

endothelial cell migration

The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

IMP

BP

GO:0046777

protein autophosphorylation

The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

IDA

BP

GO:0060562

epithelial tube morphogenesis

The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.

IDA

BP

GO:0060993

kidney morphogenesis

Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.

IDA

BP

GO:2000696

regulation of epithelial cell differentiation involved in kidney development

Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

MF

GO:0004691

cAMP-dependent protein kinase activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

Domain ID Description

IPR000719

Protein kinase domain

IPR000961

AGC-kinase, C-terminal

IPR008271

Serine/threonine-protein kinase, active site

IPR011009

Protein kinase-like domain

IPR017441

Protein kinase, ATP binding site

Pathway ID Pathway Term Pathway Source

WP3929

Chemokine signaling pathway

WikiPathways

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

appendix

lymphoid tissue

breast

adipocytes

breast

glandular cells

breast

myoepithelial cells

caudate

glial cells

cerebellum

cells in granular layer

cerebellum

cells in molecular layer

cerebellum

Purkinje cells

cerebral cortex

glial cells

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

colon

endothelial cells

colon

glandular cells

endometrium

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

hippocampus

glial cells

hippocampus

neuronal cells

kidney

cells in glomeruli

kidney

cells in tubules

lung

pneumocytes

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

ovary

follicle cells

ovary

ovarian stroma cells

pancreas

exocrine glandular cells

parathyroid gland

glandular cells

placenta

decidual cells

placenta

trophoblastic cells

rectum

glandular cells

salivary gland

glandular cells

skeletal muscle

myocytes

skin

fibroblasts

skin

keratinocytes

skin

Langerhans

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

smooth muscle

smooth muscle cells

soft tissue

adipocytes

soft tissue

fibroblasts

soft tissue

peripheral nerve

spleen

cells in red pulp

spleen

cells in white pulp

stomach

glandular cells

testis

Leydig cells

thyroid gland

glandular cells

tonsil

squamous epithelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22789864

Yan et al.

2012

Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

RYR2

6262

Q92736

0.00

TJP1

7082

Q07157

0.00

PRKAR2A

5576

P13861

0.59

HSP90AB1

3326

P08238

0.63

DNTTIP2

30836

Q5QJE6

0.63

SMAD6

4091

O43541

0.78

PRKAR1A

5573

P10644

0.88

ADCY1

107

Q08828

0.00

ADCY2

108

Q08462

0.00

ADCY7

113

P51828

0.00

ADCY8

114

P40145

0.00

BAD

572

Q92934

0.00

CREBBP

1387

Q92793

0.00

CTNNB1

1499

P35222

0.00

EP300

2033

Q09472

0.00

GJA1

2697

P17302

0.00

GLI2

2736

P10070

0.00

GRIA1

2890

P42261

0.00

GSK3B

2932

P49841

0.00

IGF1R

3480

P08069

0.00

LIPE

3991

Q05469

0.00

PLN

5350

P26678

0.00

PRKCG

5582

P05129

0.00

MAPK3

5595

P27361

0.00

ADCY4

196883

Q8NFM4

0.00

NEDD4

4734

P46934

0.52

PKIA

5569

P61925

0.52

NEDD4L

23327

Q96PU5

0.52

HSP90AA1

3320

P07900

0.63

XPO1

7514

O14980

0.63

PRKAR2B

5577

P31323

0.70

GPKOW

27238

Q92917

0.72