Gene Symbol | PRKX |
Entrez ID | 5613 |
Uniprot ID | P51817 |
Description | protein kinase, X-linked |
Chromosomal Location | chrX: 3,604,370-3,713,608 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001525 |
angiogenesis |
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
IMP |
BP |
GO:0001935 |
endothelial cell proliferation |
The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. |
IMP |
BP |
GO:0007155 |
cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
IMP |
BP |
GO:0018105 |
peptidyl-serine phosphorylation |
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
IDA |
BP |
GO:0030099 |
myeloid cell differentiation |
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. |
IDA |
BP |
GO:0030155 |
regulation of cell adhesion |
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. |
IDA |
BP |
GO:0030334 |
regulation of cell migration |
Any process that modulates the frequency, rate or extent of cell migration. |
IDA |
BP |
GO:0031589 |
cell-substrate adhesion |
The attachment of a cell to the underlying substrate via adhesion molecules. |
IMP |
BP |
GO:0043542 |
endothelial cell migration |
The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. |
IMP |
BP |
GO:0046777 |
protein autophosphorylation |
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
IDA |
BP |
GO:0060562 |
epithelial tube morphogenesis |
The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. |
IDA |
BP |
GO:0060993 |
kidney morphogenesis |
Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. |
IDA |
BP |
GO:2000696 |
regulation of epithelial cell differentiation involved in kidney development |
Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
MF |
GO:0004691 |
cAMP-dependent protein kinase activity |
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
Domain ID | Description |
---|---|
IPR000719 |
Protein kinase domain |
IPR000961 |
AGC-kinase, C-terminal |
IPR008271 |
Serine/threonine-protein kinase, active site |
IPR011009 |
Protein kinase-like domain |
IPR017441 |
Protein kinase, ATP binding site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP3929 |
Chemokine signaling pathway |
WikiPathways |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
appendix |
lymphoid tissue |
breast |
adipocytes |
breast |
glandular cells |
breast |
myoepithelial cells |
caudate |
glial cells |
cerebellum |
cells in granular layer |
cerebellum |
cells in molecular layer |
cerebellum |
Purkinje cells |
cerebral cortex |
glial cells |
cervix, uterine |
glandular cells |
cervix, uterine |
squamous epithelial cells |
colon |
endothelial cells |
colon |
glandular cells |
endometrium |
glandular cells |
epididymis |
glandular cells |
esophagus |
squamous epithelial cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
hippocampus |
glial cells |
hippocampus |
neuronal cells |
kidney |
cells in glomeruli |
kidney |
cells in tubules |
lung |
pneumocytes |
lymph node |
non-germinal center cells |
nasopharynx |
respiratory epithelial cells |
ovary |
follicle cells |
ovary |
ovarian stroma cells |
pancreas |
exocrine glandular cells |
parathyroid gland |
glandular cells |
placenta |
decidual cells |
placenta |
trophoblastic cells |
rectum |
glandular cells |
salivary gland |
glandular cells |
skeletal muscle |
myocytes |
skin |
fibroblasts |
skin |
keratinocytes |
skin |
Langerhans |
skin |
melanocytes |
skin |
epidermal cells |
small intestine |
glandular cells |
smooth muscle |
smooth muscle cells |
soft tissue |
adipocytes |
soft tissue |
fibroblasts |
soft tissue |
peripheral nerve |
spleen |
cells in red pulp |
spleen |
cells in white pulp |
stomach |
glandular cells |
testis |
Leydig cells |
thyroid gland |
glandular cells |
tonsil |
squamous epithelial cells |
vagina |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22789864 |
Yan et al. |
2012 |
Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
RYR2 |
6262 |
Q92736 |
0.00 |
TJP1 |
7082 |
Q07157 |
0.00 |
PRKAR2A |
5576 |
P13861 |
0.59 |
HSP90AB1 |
3326 |
P08238 |
0.63 |
DNTTIP2 |
30836 |
Q5QJE6 |
0.63 |
SMAD6 |
4091 |
O43541 |
0.78 |
PRKAR1A |
5573 |
P10644 |
0.88 |
ADCY1 |
107 |
Q08828 |
0.00 |
ADCY2 |
108 |
Q08462 |
0.00 |
ADCY7 |
113 |
P51828 |
0.00 |
ADCY8 |
114 |
P40145 |
0.00 |
BAD |
572 |
Q92934 |
0.00 |
CREBBP |
1387 |
Q92793 |
0.00 |
CTNNB1 |
1499 |
P35222 |
0.00 |
EP300 |
2033 |
Q09472 |
0.00 |
GJA1 |
2697 |
P17302 |
0.00 |
GLI2 |
2736 |
P10070 |
0.00 |
GRIA1 |
2890 |
P42261 |
0.00 |
GSK3B |
2932 |
P49841 |
0.00 |
IGF1R |
3480 |
P08069 |
0.00 |
LIPE |
3991 |
Q05469 |
0.00 |
PLN |
5350 |
P26678 |
0.00 |
PRKCG |
5582 |
P05129 |
0.00 |
MAPK3 |
5595 |
P27361 |
0.00 |
ADCY4 |
196883 |
Q8NFM4 |
0.00 |
NEDD4 |
4734 |
P46934 |
0.52 |
PKIA |
5569 |
P61925 |
0.52 |
NEDD4L |
23327 |
Q96PU5 |
0.52 |
HSP90AA1 |
3320 |
P07900 |
0.63 |
XPO1 |
7514 |
O14980 |
0.63 |
PRKAR2B |
5577 |
P31323 |
0.70 |
GPKOW |
27238 |
Q92917 |
0.72 |