| Gene Symbol | MAPK13 |
| Entrez ID | 5603 |
| Uniprot ID | O15264 |
| Description | mitogen-activated protein kinase 13 |
| Chromosomal Location | chr6: 36,127,809-36,144,524 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000165 |
MAPK cascade |
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
IEA |
|
BP |
GO:0006351 |
transcription, DNA-templated |
The cellular synthesis of RNA on a template of DNA. |
IEA |
|
BP |
GO:0006355 |
regulation of transcription, DNA-templated |
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
IEA |
|
BP |
GO:0006950 |
response to stress |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). |
IDA |
|
BP |
GO:0006970 |
response to osmotic stress |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. |
IDA |
|
BP |
GO:0007049 |
cell cycle |
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
IEA |
|
BP |
GO:0018105 |
peptidyl-serine phosphorylation |
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
IDA |
|
BP |
GO:0032755 |
positive regulation of interleukin-6 production |
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. |
IMP |
|
BP |
GO:0035556 |
intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
IDA |
|
BP |
GO:0048010 |
vascular endothelial growth factor receptor signaling pathway |
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
TAS |
|
BP |
GO:0050729 |
positive regulation of inflammatory response |
Any process that activates or increases the frequency, rate or extent of the inflammatory response. |
IC |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
MF |
GO:0004674 |
protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
IDA |
|
MF |
GO:0004707 |
MAP kinase activity |
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
IDA |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR000719 |
Protein kinase domain |
|
IPR003527 |
Mitogen-activated protein (MAP) kinase, conserved site |
|
IPR008352 |
Mitogen-activated protein (MAP) kinase, p38 |
|
IPR011009 |
Protein kinase-like domain |
|
IPR017441 |
Protein kinase, ATP binding site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa01522 |
Endocrine resistance |
KEGG |
|
hsa04010 |
MAPK signaling pathway |
KEGG |
|
hsa04015 |
Rap1 signaling pathway |
KEGG |
|
hsa04068 |
FoxO signaling pathway |
KEGG |
|
hsa04071 |
Sphingolipid signaling pathway |
KEGG |
|
hsa04261 |
Adrenergic signaling in cardiomyocytes |
KEGG |
|
hsa04370 |
VEGF signaling pathway |
KEGG |
|
hsa04380 |
Osteoclast differentiation |
KEGG |
|
hsa04550 |
Signaling pathways regulating pluripotency of stem cells |
KEGG |
|
hsa04611 |
Platelet activation |
KEGG |
|
hsa04620 |
Toll-like receptor signaling pathway |
KEGG |
|
hsa04621 |
NOD-like receptor signaling pathway |
KEGG |
|
hsa04622 |
RIG-I-like receptor signaling pathway |
KEGG |
|
hsa04657 |
IL-17 signaling pathway |
KEGG |
|
hsa04658 |
Th1 and Th2 cell differentiation |
KEGG |
|
hsa04659 |
Th17 cell differentiation |
KEGG |
|
hsa04660 |
T cell receptor signaling pathway |
KEGG |
|
hsa04664 |
Fc epsilon RI signaling pathway |
KEGG |
|
hsa04668 |
TNF signaling pathway |
KEGG |
|
hsa04670 |
Leukocyte transendothelial migration |
KEGG |
|
hsa04722 |
Neurotrophin signaling pathway |
KEGG |
|
hsa04723 |
Retrograde endocannabinoid signaling |
KEGG |
|
hsa04728 |
Dopaminergic synapse |
KEGG |
|
hsa04750 |
Inflammatory mediator regulation of TRP channels |
KEGG |
|
hsa04912 |
GnRH signaling pathway |
KEGG |
|
hsa04914 |
Progesterone-mediated oocyte maturation |
KEGG |
|
hsa04917 |
Prolactin signaling pathway |
KEGG |
|
hsa04933 |
AGE-RAGE signaling pathway in diabetic complications |
KEGG |
|
hsa05014 |
Amyotrophic lateral sclerosis (ALS) |
KEGG |
|
hsa05120 |
Epithelial cell signaling in Helicobacter pylori infection |
KEGG |
|
hsa05131 |
Shigellosis |
KEGG |
|
hsa05132 |
Salmonella infection |
KEGG |
|
hsa05133 |
Pertussis |
KEGG |
|
hsa05140 |
Leishmaniasis |
KEGG |
|
hsa05142 |
Chagas disease (American trypanosomiasis) |
KEGG |
|
hsa05145 |
Toxoplasmosis |
KEGG |
|
hsa05152 |
Tuberculosis |
KEGG |
|
hsa05160 |
Hepatitis C |
KEGG |
|
hsa05164 |
Influenza A |
KEGG |
|
hsa05169 |
Epstein-Barr virus infection |
KEGG |
|
hsa05205 |
Proteoglycans in cancer |
KEGG |
|
hsa05418 |
Fluid shear stress and atherosclerosis |
KEGG |
|
WP3915 |
Angiopoietin Like Protein 8 Regulatory Pathway |
WikiPathways |
|
WP3941 |
Oxidative Damage |
WikiPathways |
|
WP75 |
Toll-like Receptor Signaling Pathway |
WikiPathways |
|
WP3611 |
Photodynamic therapy-induced AP-1 survival signaling. |
WikiPathways |
|
WP3303 |
Rac1/Pak1/p38/MMP-2 pathway |
WikiPathways |
|
WP2371 |
Parkinsons Disease Pathway |
WikiPathways |
|
WP481 |
Insulin Signaling |
WikiPathways |
|
WP1449 |
Regulation of toll-like receptor signaling pathway |
WikiPathways |
|
WP2643 |
Nanoparticle-mediated activation of receptor signaling |
WikiPathways |
|
WP3865 |
RIG-I-like Receptor Signaling |
WikiPathways |
|
WP382 |
MAPK Signaling Pathway |
WikiPathways |
|
WP2446 |
Retinoblastoma (RB) in Cancer |
WikiPathways |
|
WP3612 |
Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
WikiPathways |
|
h_keratinocytePathway |
Keratinocyte Differentiation |
BioCarta |
|
h_mapkPathway |
MAPKinase Signaling Pathway |
BioCarta |
|
h_stathminPathway |
Stathmin and breast cancer resistance to antimicrotubule agents |
BioCarta |
| UMLS CUI | UMLS Term |
|---|---|
|
C0008370 |
Cholestasis |
| Tissue | Cell Type |
|---|---|
|
appendix |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
bronchus |
respiratory epithelial cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
gallbladder |
glandular cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22789864 |
Yan et al. |
2012 |
Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
MAPK14 |
1432 |
Q16539 |
0.00 |
|
PPP2CA |
5515 |
P67775 |
0.00 |
|
PPP2CB |
5516 |
P62714 |
0.00 |
|
PTPN7 |
5778 |
P35236 |
0.00 |
|
PTPRR |
5801 |
Q15256 |
0.00 |
|
TP53 |
7157 |
P04637 |
0.00 |
|
RIPK2 |
8767 |
O43353 |
0.00 |
|
PTPN5 |
84867 |
P54829 |
0.00 |
|
MAPT |
4137 |
P10636 |
0.52 |
|
SQSTM1 |
8878 |
Q13501 |
0.52 |
|
HTRA2 |
27429 |
O43464 |
0.52 |
|
APP |
351 |
P05067 |
0.56 |
|
PARP1 |
142 |
P09874 |
0.63 |
|
AHCY |
191 |
P23526 |
0.63 |
|
ALDOA |
226 |
P04075 |
0.63 |
|
ARF3 |
377 |
P61204 |
0.63 |
|
ATP5A1 |
498 |
P25705 |
0.63 |
|
CANX |
821 |
P27824 |
0.63 |
|
CBR1 |
873 |
P16152 |
0.63 |
|
CCT6A |
908 |
P40227 |
0.63 |
|
CKB |
1152 |
P12277 |
0.63 |
|
CLTC |
1213 |
Q00610 |
0.63 |
|
DDX1 |
1653 |
Q92499 |
0.63 |
|
DDX3X |
1654 |
O00571 |
0.63 |
|
DHX9 |
1660 |
Q08211 |
0.63 |
|
EEF1A1 |
1915 |
P68104 |
0.63 |
|
EEF1B2 |
1933 |
P24534 |
0.63 |
|
EEF1D |
1936 |
P29692 |
0.63 |
|
EEF2 |
1938 |
P13639 |
0.63 |
|
EIF4A1 |
1973 |
P60842 |
0.63 |
|
ENO1 |
2023 |
P06733 |
0.63 |
|
EPRS |
2058 |
P07814 |
0.63 |
|
FASN |
2194 |
P49327 |
0.63 |
|
FUS |
2521 |
P35637 |
0.63 |
|
XRCC6 |
2547 |
P12956 |
0.63 |
|
GAPDH |
2597 |
P04406 |
0.63 |
|
GDI2 |
2665 |
P50395 |
0.63 |
|
PDIA3 |
2923 |
P30101 |
0.63 |
|
HIST1H1C |
3006 |
P16403 |
0.63 |
|
HIST1H1E |
3008 |
P10412 |
0.63 |
|
HNRNPA1 |
3178 |
P09651 |
0.63 |
|
HNRNPK |
3190 |
P61978 |
0.63 |
|
HSPA5 |
3309 |
P11021 |
0.63 |
|
ILF3 |
3609 |
Q12906 |
0.63 |
|
LDHA |
3939 |
P00338 |
0.63 |
|
LDHB |
3945 |
P07195 |
0.63 |
|
MARCKS |
4082 |
P29966 |
0.63 |
|
MDH2 |
4191 |
P40926 |
0.63 |
|
NAP1L4 |
4676 |
Q99733 |
0.63 |
|
NASP |
4678 |
P49321 |
0.63 |
|
NCL |
4691 |
P19338 |
0.63 |
|
NONO |
4841 |
Q15233 |
0.63 |
|
YBX1 |
4904 |
P67809 |
0.63 |
|
PFN1 |
5216 |
P07737 |
0.63 |
|
PGAM1 |
5223 |
P18669 |
0.63 |
|
PGK1 |
5230 |
P00558 |
0.63 |
|
PLS3 |
5358 |
P13797 |
0.63 |
|
PPA1 |
5464 |
Q15181 |
0.63 |
|
MAPK13 |
5603 |
O15264 |
0.63 |
|
RAN |
5901 |
P62826 |
0.63 |
|
RPLP2 |
6181 |
P05387 |
0.63 |
|
RPS3 |
6188 |
P23396 |
0.63 |
|
RPS14 |
6208 |
P62263 |
0.63 |
|
SFPQ |
6421 |
P23246 |
0.63 |
|
TMPO |
7112 |
P42166 |
0.63 |
|
HSP90B1 |
7184 |
P14625 |
0.63 |
|
CCT3 |
7203 |
P49368 |
0.63 |
|
UBA1 |
7317 |
P22314 |
0.63 |
|
YWHAB |
7529 |
P31946 |
0.63 |
|
YWHAZ |
7534 |
P63104 |
0.63 |
|
TAF15 |
8148 |
Q92804 |
0.63 |
|
TAGLN2 |
8407 |
P37802 |
0.63 |
|
IQGAP1 |
8826 |
P46940 |
0.63 |
|
PRDX6 |
9588 |
P30041 |
0.63 |
|
EIF5B |
9669 |
O60841 |
0.63 |
|
PDIA6 |
10130 |
Q15084 |
0.63 |
|
G3BP1 |
10146 |
Q13283 |
0.63 |
|
TFG |
10342 |
Q92734 |
0.63 |
|
CCT4 |
10575 |
P50991 |
0.63 |
|
CCT2 |
10576 |
P78371 |
0.63 |
|
PAICS |
10606 |
P22234 |
0.63 |
|
IGF2BP2 |
10644 |
Q9Y6M1 |
0.63 |
|
CCT8 |
10694 |
P50990 |
0.63 |
|
NUDC |
10726 |
Q9Y266 |
0.63 |
|
STIP1 |
10963 |
P31948 |
0.63 |
|
CCT5 |
22948 |
P48643 |
0.63 |
|
ANKLE2 |
23141 |
Q86XL3 |
0.63 |
|
GANAB |
23193 |
Q14697 |
0.63 |
|
SERBP1 |
26135 |
Q8NC51 |
0.63 |
|
PHGDH |
26227 |
O43175 |
0.63 |
|
PABPC1 |
26986 |
P11940 |
0.63 |
|
CACYBP |
27101 |
Q9HB71 |
0.63 |
|
GFM1 |
85476 |
Q96RP9 |
0.63 |
|
POTEF |
728378 |
A5A3E0 |
0.63 |
|
FGF12 |
2257 |
P61328 |
0.65 |
|
EEF2K |
29904 |
O00418 |
0.65 |
|
MBP |
4155 |
P02686 |
0.66 |
|
MAPKAPK3 |
7867 |
Q16644 |
0.66 |
|
MAP3K4 |
4216 |
Q9Y6R4 |
0.68 |
|
PRKD1 |
5587 |
Q15139 |
0.75 |
|
PKM |
5315 |
P14618 |
0.84 |
|
ATF2 |
1386 |
P15336 |
0.87 |
|
DDIT3 |
1649 |
P35638 |
0.00 |
|
DUSP1 |
1843 |
P28562 |
0.00 |
|
DUSP2 |
1844 |
Q05923 |
0.00 |
|
DUSP3 |
1845 |
P51452 |
0.00 |
|
DUSP4 |
1846 |
Q13115 |
0.00 |
|
DUSP5 |
1847 |
Q16690 |
0.00 |
|
DUSP6 |
1848 |
Q16828 |
0.00 |
|
DUSP7 |
1849 |
Q16829 |
0.00 |
|
DUSP8 |
1850 |
Q13202 |
0.00 |
|
DUSP9 |
1852 |
Q99956 |
0.00 |
|
JUNB |
3726 |
P17275 |
0.00 |
|
MAP3K7 |
6885 |
O43318 |
0.00 |
|
DUSP14 |
11072 |
O95147 |
0.00 |
|
DUSP10 |
11221 |
Q9Y6W6 |
0.00 |
|
DUSP16 |
80824 |
Q9BY84 |
0.00 |
|
DUSP22 |
56940 |
Q9NRW4 |
0.00 |
|
MAP2K6 |
5608 |
P52564 |
0.52 |
|
MAPKAPK5 |
8550 |
Q8IW41 |
0.55 |
|
GPX4 |
2879 |
P36969 |
0.63 |
|
MAPK12 |
6300 |
P53778 |
0.63 |
|
VCP |
7415 |
P55072 |
0.63 |
|
AKIP1 |
56672 |
Q9NQ31 |
0.63 |
|
FPR1 |
2357 |
P21462 |
0.72 |
|
SMAD4 |
4089 |
Q13485 |
0.73 |
|
MAPK8IP2 |
23542 |
Q13387 |
0.82 |