| Gene Symbol | PRKCSH |
| Entrez ID | 5589 |
| Uniprot ID | P14314 |
| Description | protein kinase C substrate 80K-H |
| Chromosomal Location | chr19: 11,435,288-11,450,968 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006457 |
protein folding |
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
TAS |
|
BP |
GO:0006491 |
N-glycan processing |
The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. |
IEA |
|
BP |
GO:0035556 |
intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
NAS |
|
CC |
GO:0005622 |
intracellular |
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. |
NAS |
|
CC |
GO:0005783 |
endoplasmic reticulum |
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
IDA |
|
CC |
GO:0005788 |
endoplasmic reticulum lumen |
The volume enclosed by the membranes of the endoplasmic reticulum. |
TAS |
|
MF |
GO:0005080 |
protein kinase C binding |
Interacting selectively and non-covalently with protein kinase C. |
IPI |
|
MF |
GO:0005509 |
calcium ion binding |
Interacting selectively and non-covalently with calcium ions (Ca2+). |
IEA |
|
MF |
GO:0044325 |
ion channel binding |
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. |
IPI |
|
MF |
GO:0051219 |
phosphoprotein binding |
Interacting selectively and non-covalently with a phosphorylated protein. |
IPI |
| Domain ID | Description |
|---|---|
|
IPR002048 |
EF-hand domain |
|
IPR002172 |
Low-density lipoprotein (LDL) receptor class A repeat |
|
IPR009011 |
Mannose-6-phosphate receptor binding domain |
|
IPR011992 |
EF-hand domain pair |
|
IPR018247 |
EF-Hand 1, calcium-binding site |
|
IPR026874 |
Glucosidase 2 subunit beta |
|
IPR028146 |
Glucosidase II beta subunit, N-terminal |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04141 |
Protein processing in endoplasmic reticulum |
KEGG |
| UMLS CUI | UMLS Term |
|---|---|
|
C0022680 |
Polycystic Kidney Diseases |
| Tissue | Cell Type |
|---|---|
|
appendix |
glandular cells |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
neuronal cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
epididymis |
glandular cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
hippocampus |
neuronal cells |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
thyroid gland |
glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
20426491 |
Choi et al. |
2010 |
The Apolipoprotein A-I Level Is Downregulated in the Granulosa Cells of Patients with Polycystic Ovary Syndrome and Affects Steroidogenesis |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
P4HB |
5034 |
P07237 |
0.49 |
|
NUP153 |
9972 |
P49790 |
0.49 |
|
IPO9 |
55705 |
Q96P70 |
0.49 |
|
PNPT1 |
87178 |
Q8TCS8 |
0.49 |
|
BBS1 |
582 |
Q8NFJ9 |
0.63 |
|
BUB1B |
701 |
O60566 |
0.63 |
|
DNA2 |
1763 |
P51530 |
0.63 |
|
FLNB |
2317 |
O75369 |
0.63 |
|
PEX14 |
5195 |
O75381 |
0.63 |
|
RPS6 |
6194 |
P62753 |
0.63 |
|
AURKA |
6790 |
O14965 |
0.63 |
|
TSC2 |
7249 |
P49815 |
0.63 |
|
VDR |
7421 |
P11473 |
0.63 |
|
TUBA1A |
7846 |
Q71U36 |
0.63 |
|
TUBB3 |
10381 |
Q13509 |
0.63 |
|
PITRM1 |
10531 |
Q5JRX3 |
0.63 |
|
PAICS |
10606 |
P22234 |
0.63 |
|
SLC27A2 |
11001 |
O14975 |
0.63 |
|
COPG1 |
22820 |
Q9Y678 |
0.63 |
|
INTS7 |
25896 |
Q9NVH2 |
0.63 |
|
RANBP6 |
26953 |
O60518 |
0.63 |
|
ANAPC7 |
51434 |
Q9UJX3 |
0.63 |
|
ARMCX3 |
51566 |
Q9UH62 |
0.63 |
|
GBA3 |
57733 |
Q9H227 |
0.63 |
|
FUK |
197258 |
Q8N0W3 |
0.63 |
|
DENND6A |
201627 |
Q8IWF6 |
0.63 |
|
CANX |
821 |
P27824 |
0.66 |
|
RGS2 |
5997 |
P41220 |
0.73 |
|
GANAB |
23193 |
Q14697 |
0.76 |
|
ACADM |
34 |
P11310 |
0.49 |
|
CALR |
811 |
P27797 |
0.49 |
|
EWSR1 |
2130 |
Q01844 |
0.49 |
|
DNAJA1 |
3301 |
P31689 |
0.49 |
|
LDHA |
3939 |
P00338 |
0.49 |
|
HSP90B1 |
7184 |
P14625 |
0.49 |
|
UQCRC2 |
7385 |
P22695 |
0.49 |
|
TCTN3 |
26123 |
Q6NUS6 |
0.49 |
|
ERLEC1 |
27248 |
Q96DZ1 |
0.49 |
|
SRRT |
51593 |
Q9BXP5 |
0.49 |
|
TCTN1 |
79600 |
Q2MV58 |
0.49 |
|
ARL4D |
379 |
P49703 |
0.63 |
|
ELF3 |
1999 |
P78545 |
0.63 |
|
ESR2 |
2100 |
Q92731 |
0.63 |
|
HSPA5 |
3309 |
P11021 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
NEDD8 |
4738 |
Q15843 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PARK2 |
5071 |
O60260 |
0.63 |
|
PTPRC |
5788 |
P08575 |
0.63 |
|
TRAF6 |
7189 |
Q9Y4K3 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
UBD |
10537 |
O15205 |
0.63 |
|
POP4 |
10775 |
O95707 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
GET4 |
51608 |
Q7L5D6 |
0.63 |
|
QRICH1 |
54870 |
Q2TAL8 |
0.63 |
|
OTUB1 |
55611 |
Q96FW1 |
0.63 |
|
H2AFX |
3014 |
P16104 |
0.72 |
|
ESR1 |
2099 |
P03372 |
0.78 |