BP

GO:0001782

B cell homeostasis

The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

IEA

BP

GO:0001783

B cell apoptotic process

Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.

IEA

BP

GO:0002634

regulation of germinal center formation

Any process that modulates the frequency, rate, or extent of germinal center formation.

IEA

BP

GO:0002637

regulation of immunoglobulin production

Any process that modulates the frequency, rate, or extent of immunoglobulin production.

IEA

BP

GO:0003014

renal system process

A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).

IEA

BP

GO:0006351

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

IEA

BP

GO:0006357

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA|IMP

BP

GO:0006468

protein phosphorylation

The process of introducing a phosphate group on to a protein.

IDA

BP

GO:0006469

negative regulation of protein kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.

IEA

BP

GO:0006972

hyperosmotic response

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007257

activation of JUN kinase activity

The initiation of the activity of the inactive enzyme JUN kinase (JNK).

TAS

BP

GO:0010631

epithelial cell migration

The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.

IMP

BP

GO:0018105

peptidyl-serine phosphorylation

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

IBA

BP

GO:0030889

negative regulation of B cell proliferation

Any process that stops, prevents or reduces the rate or extent of B cell proliferation.

IEA

BP

GO:0035407

histone H3-T11 phosphorylation

The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone.

IDA

BP

GO:0048536

spleen development

The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.

IEA

BP

GO:2000145

regulation of cell motility

Any process that modulates the frequency, rate or extent of cell motility.

IMP

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005768

endosome

A vacuole to which materials ingested by endocytosis are delivered.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IEA

CC

GO:0016023

cytoplasmic, membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

IEA

CC

GO:0030496

midbody

A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.

IDA

CC

GO:0032154

cleavage furrow

The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.

IDA

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IEA

MF

GO:0003682

chromatin binding

Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

IDA

MF

GO:0004672

protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

TAS

MF

GO:0004674

protein serine/threonine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

EXP|IDA|TAS

MF

GO:0004697

protein kinase C activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.

IEA

MF

GO:0005080

protein kinase C binding

Interacting selectively and non-covalently with protein kinase C.

IPI

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0017049

GTP-Rho binding

Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.

IDA

MF

GO:0030374

ligand-dependent nuclear receptor transcription coactivator activity

The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.

IDA|IMP

MF

GO:0035402

histone kinase activity (H3-T11 specific)

Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3.

IDA

MF

GO:0042393

histone binding

Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.

IDA

MF

GO:0042826

histone deacetylase binding

Interacting selectively and non-covalently with the enzyme histone deacetylase.

IDA

MF

GO:0048365

Rac GTPase binding

Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.

IDA

MF

GO:0050681

androgen receptor binding

Interacting selectively and non-covalently with an androgen receptor.

IDA