BP

GO:0002223

stimulatory C-type lectin receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.

TAS

BP

GO:0006468

protein phosphorylation

The process of introducing a phosphate group on to a protein.

IDA

BP

GO:0006915

apoptotic process

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

IDA

BP

GO:0006921

cellular component disassembly involved in execution phase of apoptosis

The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.

TAS

BP

GO:0007049

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007202

activation of phospholipase C activity

The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

TAS

BP

GO:0008631

intrinsic apoptotic signaling pathway in response to oxidative stress

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.

TAS

BP

GO:0010469

regulation of receptor activity

Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.

TAS

BP

GO:0016064

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

IEA

BP

GO:0016572

histone phosphorylation

The modification of histones by addition of phosphate groups.

IDA

BP

GO:0018105

peptidyl-serine phosphorylation

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

IDA

BP

GO:0018107

peptidyl-threonine phosphorylation

The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.

IDA

BP

GO:0018108

peptidyl-tyrosine phosphorylation

The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.

IEA

BP

GO:0023021

termination of signal transduction

The signaling process in which signal transduction is brought to an end rather than being reversibly modulated.

IMP

BP

GO:0030168

platelet activation

A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.

TAS

BP

GO:0030837

negative regulation of actin filament polymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.

ISS

BP

GO:0032079

positive regulation of endodeoxyribonuclease activity

Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.

IMP

BP

GO:0032091

negative regulation of protein binding

Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.

TAS

BP

GO:0032147

activation of protein kinase activity

Any process that initiates the activity of an inactive protein kinase.

IDA

BP

GO:0032613

interleukin-10 production

The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

IEA

BP

GO:0032615

interleukin-12 production

The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

IEA

BP

GO:0032930

positive regulation of superoxide anion generation

Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.

IMP

BP

GO:0032956

regulation of actin cytoskeleton organization

Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

IMP

BP

GO:0034351

negative regulation of glial cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.

IMP

BP

GO:0035307

positive regulation of protein dephosphorylation

Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.

IMP

BP

GO:0038096

Fc-gamma receptor signaling pathway involved in phagocytosis

An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.

TAS

BP

GO:0042100

B cell proliferation

The expansion of a B cell population by cell division. Follows B cell activation.

IEA

BP

GO:0042119

neutrophil activation

The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

IDA

BP

GO:0042307

positive regulation of protein import into nucleus

Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.

IMP

BP

GO:0042742

defense response to bacterium

Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

ISS

BP

GO:0043407

negative regulation of MAP kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.

IMP

BP

GO:0043488

regulation of mRNA stability

Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.

TAS

BP

GO:0046627

negative regulation of insulin receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.

ISS|TAS

BP

GO:0050728

negative regulation of inflammatory response

Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.

IC

BP

GO:0050732

negative regulation of peptidyl-tyrosine phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

ISS

BP

GO:0050821

protein stabilization

Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

NAS

BP

GO:0051490

negative regulation of filopodium assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

ISS

BP

GO:0060326

cell chemotaxis

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

IMP

BP

GO:0060333

interferon-gamma-mediated signaling pathway

A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.

TAS

BP

GO:0070301

cellular response to hydrogen peroxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

IDA

BP

GO:0071447

cellular response to hydroperoxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.

IDA

BP

GO:0090331

negative regulation of platelet aggregation

Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.

ISS

BP

GO:0090398

cellular senescence

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

IMP

BP

GO:1900163

positive regulation of phospholipid scramblase activity

Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity.

IMP

BP

GO:1904385

cellular response to angiotensin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.

IDA

BP

GO:2000304

positive regulation of ceramide biosynthetic process

Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process.

IMP

BP

GO:2000753

positive regulation of glucosylceramide catabolic process

Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process.

IMP

BP

GO:2000755

positive regulation of sphingomyelin catabolic process

Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process.

IMP

BP

GO:2001022

positive regulation of response to DNA damage stimulus

Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus.

IMP

BP

GO:2001235

positive regulation of apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005783

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA|TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005911

cell-cell junction

A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.

IEA

CC

GO:0016363

nuclear matrix

The dense fibrillar network lying on the inner side of the nuclear membrane.

IEA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0004672

protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

IDA

MF

GO:0004674

protein serine/threonine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

EXP|IDA|TAS

MF

GO:0004697

protein kinase C activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.

ISS|TAS

MF

GO:0004699

calcium-independent protein kinase C activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.

EXP|TAS

MF

GO:0004715

non-membrane spanning protein tyrosine kinase activity

Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0008047

enzyme activator activity

Binds to and increases the activity of an enzyme.

IDA

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IDA|IPI

MF

GO:0019900

kinase binding

Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.

IPI

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IPI

MF

GO:0043560

insulin receptor substrate binding

Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.

ISS

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA