PCOSBase

Protein Description

Gene Symbol	PRKCA
Entrez ID	5578
Uniprot ID	P17252
Description	protein kinase C, alpha
Chromosomal Location	chr17: 66,302,636-66,810,743

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0001525	angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.	IEA
BP	GO:0001938	positive regulation of endothelial cell proliferation	Any process that activates or increases the rate or extent of endothelial cell proliferation.	IMP
BP	GO:0002159	desmosome assembly	A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.	IMP
BP	GO:0006468	protein phosphorylation	The process of introducing a phosphate group on to a protein.	IDA
BP	GO:0007077	mitotic nuclear envelope disassembly	The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs.	TAS
BP	GO:0007155	cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.	IEA
BP	GO:0007190	activation of adenylate cyclase activity	Any process that initiates the activity of the inactive enzyme adenylate cyclase.	ISS
BP	GO:0007194	negative regulation of adenylate cyclase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.	ISS
BP	GO:0010595	positive regulation of endothelial cell migration	Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.	IMP
BP	GO:0010613	positive regulation of cardiac muscle hypertrophy	Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.	ISS
BP	GO:0018105	peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.	IBA
BP	GO:0030168	platelet activation	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.	TAS
BP	GO:0030335	positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.	IMP
BP	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.	IMP
BP	GO:0034351	negative regulation of glial cell apoptotic process	Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.	IMP
BP	GO:0035408	histone H3-T6 phosphorylation	The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone.	IDA
BP	GO:0035556	intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.	IBA
BP	GO:0043488	regulation of mRNA stability	Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.	TAS
BP	GO:0043536	positive regulation of blood vessel endothelial cell migration	Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.	IDA
BP	GO:0045651	positive regulation of macrophage differentiation	Any process that activates or increases the frequency, rate or extent of macrophage differentiation.	ISS
BP	GO:0045766	positive regulation of angiogenesis	Any process that activates or increases angiogenesis.	IMP
BP	GO:0045785	positive regulation of cell adhesion	Any process that activates or increases the frequency, rate or extent of cell adhesion.	IMP
BP	GO:0045931	positive regulation of mitotic cell cycle	Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.	IMP
BP	GO:0050796	regulation of insulin secretion	Any process that modulates the frequency, rate or extent of the regulated release of insulin.	TAS
BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.	ISS
BP	GO:0070555	response to interleukin-1	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.	IMP
BP	GO:0090330	regulation of platelet aggregation	Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.	IDA
BP	GO:0097190	apoptotic signaling pathway	A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.	TAS
BP	GO:2000707	positive regulation of dense core granule biogenesis	Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis.	ISS
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	TAS
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0005739	mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	IDA
CC	GO:0005783	endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).	IDA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	IDA\|TAS
CC	GO:0005886	plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	IDA\|TAS
CC	GO:0031966	mitochondrial membrane	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.	IEA
CC	GO:0048471	perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.	ISS
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0004672	protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.	IDA
MF	GO:0004674	protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.	EXP\|TAS
MF	GO:0004697	protein kinase C activity	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.	ISS\|TAS
MF	GO:0004698	calcium-dependent protein kinase C activity	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium.	TAS
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0005524	ATP binding	Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	IEA
MF	GO:0008270	zinc ion binding	Interacting selectively and non-covalently with zinc (Zn) ions.	IEA
MF	GO:0019899	enzyme binding	Interacting selectively and non-covalently with any enzyme.	IDA
MF	GO:0035403	histone kinase activity (H3-T6 specific)	Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3.	IDA

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Domain ID	Description
IPR000008	C2 domain
IPR000719	Protein kinase domain
IPR000961	AGC-kinase, C-terminal
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain
IPR014375	Protein kinase C, alpha/beta/gamma types
IPR017441	Protein kinase, ATP binding site
IPR017892	Protein kinase, C-terminal
IPR020454	Diacylglycerol/phorbol-ester binding
IPR034663	Classical Protein Kinase C alpha, catalytic domain

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Pathway ID	Pathway Term	Pathway Source
hsa01521	EGFR tyrosine kinase inhibitor resistance	KEGG
hsa04010	MAPK signaling pathway	KEGG
hsa04012	ErbB signaling pathway	KEGG
hsa04014	Ras signaling pathway	KEGG
hsa04015	Rap1 signaling pathway	KEGG
hsa04020	Calcium signaling pathway	KEGG
hsa04066	HIF-1 signaling pathway	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04072	Phospholipase D signaling pathway	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04270	Vascular smooth muscle contraction	KEGG
hsa04310	Wnt signaling pathway	KEGG
hsa04360	Axon guidance	KEGG
hsa04370	VEGF signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa04540	Gap junction	KEGG
hsa04650	Natural killer cell mediated cytotoxicity	KEGG
hsa04664	Fc epsilon RI signaling pathway	KEGG
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04713	Circadian entrainment	KEGG
hsa04720	Long-term potentiation	KEGG
hsa04723	Retrograde endocannabinoid signaling	KEGG
hsa04724	Glutamatergic synapse	KEGG
hsa04725	Cholinergic synapse	KEGG
hsa04726	Serotonergic synapse	KEGG
hsa04727	GABAergic synapse	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04730	Long-term depression	KEGG
hsa04750	Inflammatory mediator regulation of TRP channels	KEGG
hsa04911	Insulin secretion	KEGG
hsa04912	GnRH signaling pathway	KEGG
hsa04916	Melanogenesis	KEGG
hsa04918	Thyroid hormone synthesis	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04925	Aldosterone synthesis and secretion	KEGG
hsa04933	AGE-RAGE signaling pathway in diabetic complications	KEGG
hsa04960	Aldosterone-regulated sodium reabsorption	KEGG
hsa04961	Endocrine and other factor-regulated calcium reabsorption	KEGG
hsa04970	Salivary secretion	KEGG
hsa04971	Gastric acid secretion	KEGG
hsa04972	Pancreatic secretion	KEGG
hsa05031	Amphetamine addiction	KEGG
hsa05032	Morphine addiction	KEGG
hsa05110	Vibrio cholerae infection	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
hsa05143	African trypanosomiasis	KEGG
hsa05146	Amoebiasis	KEGG
hsa05161	Hepatitis B	KEGG
hsa05164	Influenza A	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05205	Proteoglycans in cancer	KEGG
hsa05206	MicroRNAs in cancer	KEGG
hsa05214	Glioma	KEGG
hsa05223	Non-small cell lung cancer	KEGG
hsa05231	Choline metabolism in cancer	KEGG
WP536	Calcium Regulation in the Cardiac Cell	WikiPathways
WP437	EGF/EGFR Signaling Pathway	WikiPathways
WP2431	Spinal Cord Injury	WikiPathways
WP304	Kit receptor signaling pathway	WikiPathways
WP399	Wnt Signaling Pathway and Pluripotency	WikiPathways
WP2012	miRs in Muscle Cell Differentiation	WikiPathways
WP3298	Melatonin metabolism and effects	WikiPathways
WP2324	AGE/RAGE pathway	WikiPathways
WP35	G Protein Signaling Pathways	WikiPathways
WP2355	Corticotropin-releasing hormone signaling pathway	WikiPathways
WP289	Myometrial Relaxation and Contraction Pathways	WikiPathways
WP481	Insulin Signaling	WikiPathways
WP3	Transcriptional activation by NRF2	WikiPathways
WP244	Alpha 6 Beta 4 signaling pathway	WikiPathways
WP2374	Oncostatin M Signaling Pathway	WikiPathways
WP2038	Regulation of Microtubule Cytoskeleton	WikiPathways
WP2035	Follicle Stimulating Hormone (FSH) signaling pathway	WikiPathways
WP2272	Pathogenic Escherichia coli infection	WikiPathways
WP2583	T-Cell Receptor and Co-stimulatory Signaling	WikiPathways
WP1471	Target Of Rapamycin (TOR) Signaling	WikiPathways
WP2261	Signaling Pathways in Glioblastoma	WikiPathways
WP2197	Endothelin Pathways	WikiPathways
WP2636	Common Pathways Underlying Drug Addiction	WikiPathways
WP428	Wnt Signaling Pathway	WikiPathways
WP2795	Cardiac Hypertrophic Response	WikiPathways
WP673	ErbB Signaling Pathway	WikiPathways
WP363	Wnt Signaling Pathway Netpath	WikiPathways
WP3888	VEGFA-VEGFR2 Signaling Pathway	WikiPathways
h_pkcPathway	Activation of PKC through G protein coupled receptor	BioCarta
h_srcRPTPPathway	Activation of Src by Protein-tyrosine phosphatase alpha	BioCarta
h_At1rPathway	Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling	BioCarta
h_chemicalPathway	Apoptotic Signaling in Response to DNA Damage	BioCarta
h_sppaPathway	Aspirin Blocks Signaling Pathway Involved in Platelet Activation	BioCarta
h_agpcrPathway	Attenuation of GPCR Signaling	BioCarta
h_bcrPathway	BCR Signaling Pathway	BioCarta
h_biopeptidesPathway	Bioactive Peptide Induced Signaling Pathway	BioCarta
h_cdMacPathway	Cadmium induces DNA synthesis and proliferation in macrophages	BioCarta
h_cblPathway	CBL mediated ligand-induced downregulation of EGF receptors	BioCarta
h_CCR3Pathway	CCR3 signaling in Eosinophils	BioCarta
h_cxcr4Pathway	CXCR4 Signaling Pathway	BioCarta
h_calcineurinPathway	Effects of calcineurin in Keratinocyte Differentiation	BioCarta
h_egfPathway	EGF Signaling Pathway	BioCarta
h_ghPathway	Growth Hormone Signaling Pathway	BioCarta
h_erbB4pathway	g-Secretase mediated ErbB4 Signaling Pathway	BioCarta
h_ionPathway	Ion Channel and Phorbal Esters Signaling Pathway	BioCarta
h_keratinocytePathway	Keratinocyte Differentiation	BioCarta
h_pyk2Pathway	Links between Pyk2 and Map Kinases	BioCarta
h_pparaPathway	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	BioCarta
h_nos1Pathway	Nitric Oxide Signaling Pathway	BioCarta
h_arenrf2Pathway	Oxidative Stress Induced Gene Expression Via Nrf2	BioCarta
h_pdgfPathway	PDGF Signaling Pathway	BioCarta
h_Ccr5Pathway	Pertussis toxin-insensitive CCR5 Signaling in Macrophage	BioCarta
h_plcdPathway	Phospholipase C d1 in phospholipid associated cell signaling	BioCarta
h_plcPathway	Phospholipase C Signaling Pathway	BioCarta
h_edg1Pathway	Phospholipids as signalling intermediaries	BioCarta
h_myosinPathway	PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase	BioCarta
h_eif4Pathway	Regulation of eIF4e and p70 S6 Kinase	BioCarta
h_cardiacegfPathway	Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy	BioCarta
h_mef2dPathway	Role of MEF2D in T-cell Apoptosis	BioCarta
h_gpcrPathway	Signaling Pathway from G-Protein Families	BioCarta
h_tcrPathway	T Cell Receptor Signaling Pathway	BioCarta
h_telPathway	Telomeres, Telomerase, Cellular Aging, and Immortality	BioCarta
h_Par1Pathway	Thrombin signaling and protease-activated receptors	BioCarta
h_TPOPathway	TPO Signaling Pathway	BioCarta
h_crebPathway	Transcription factor CREB and its extracellular signals	BioCarta
h_trkaPathway	Trka Receptor Signaling Pathway	BioCarta
h_vegfPathway	VEGF, Hypoxia, and Angiogenesis	BioCarta

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UMLS CUI	UMLS Term
C0011853	Diabetes Mellitus, Experimental
C0018800	Cardiomegaly
C0021841	Intestinal Neoplasms
C0032617	Polyuria
C0162283	Nephrogenic Diabetes Insipidus

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Tissue	Cell Type
adrenal gland	glandular cells
hippocampus	neuronal cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol	Entrez ID	Uniprot ID	Score
ANXA6	309	P08133	0.49
MAPK7	5598	Q13164	0.49
ACTA1	58	P68133	0.52
ADRA1B	147	P35368	0.52
RHOA	387	P61586	0.52
ATP2B1	490	P20020	0.52
ATP2B2	491	Q01814	0.52
BCL2	596	P10415	0.52
CD5	921	P06127	0.52
CDC42	998	P60953	0.52
CFTR	1080	P13569	0.52
CYP3A4	1576	P08684	0.52
DDX5	1655	P17844	0.52
DNM1	1759	Q05193	0.52
DVL2	1856	O14641	0.52
EEF1D	1936	P29692	0.52
EIF4EBP1	1978	Q13541	0.52
EP300	2033	Q09472	0.52
EWSR1	2130	Q01844	0.52
GABRG2	2566	P18507	0.52
GFPT1	2673	Q06210	0.52
GLI3	2737	P10071	0.52
GMFB	2764	P60983	0.52
GNA15	2769	P30679	0.52
GPM6A	2823	P51674	0.52
GRIN1	2902	Q05586	0.52
GRM1	2911	Q13255	0.52
HIST1H1C	3006	P16403	0.52
HIST1H1D	3007	P16402	0.52
HIST1H1E	3008	P10412	0.52
HIST1H1T	3010	P22492	0.52
HMGB1	3146	P09429	0.52
HMGA1	3159	P17096	0.52
HES1	3280	Q14469	0.52
ITPKB	3707	P27987	0.52
KCNE1	3753	P15382	0.52
KCNQ2	3785	O43526	0.52
MYOD1	4654	P15172	0.52
NFKBIA	4792	P25963	0.52
NRGN	4900	Q92686	0.52
OCLN	4950	Q16625	0.52
PAM	5066	P19021	0.52
PFKFB1	5207	P16118	0.52
PFKFB2	5208	O60825	0.52
PTPN6	5777	P29350	0.52
PTPN11	5781	Q06124	0.52
PTPN12	5782	Q05209	0.52
RARA	5914	P10276	0.52
RGS7	6000	P49802	0.52
SLC6A9	6536	P48067	0.52
SNAP25	6616	P60880	0.52
SPP1	6696	P10451	0.52
TNP1	7141	P09430	0.52
TNP2	7142	Q05952	0.52
TRPC3	7222	Q13507	0.52
NR1H2	7376	P55055	0.52
HMGA2	8091	P52926	0.52
HIST1H3A	8350	P68431	0.52
THOC5	8563	Q13769	0.52
PEA15	8682	Q15121	0.52
SNAP23	8773	O00161	0.52
CYTH2	9266	Q99418	0.52
NOXA1	10811	Q86UR1	0.52
ADAP1	11033	O75689	0.52
PLCB1	23236	Q9NQ66	0.52
SCRIB	23513	Q14160	0.52
HSPB8	26353	Q9UJY1	0.52
CACYBP	27101	Q9HB71	0.52
F11R	50848	Q9Y624	0.52
ADD3	120	Q9UEY8	0.55
ADRBK1	156	P25098	0.55
ANXA2	302	P07355	0.55
APLP2	334	Q06481	0.55
CASR	846	P41180	0.55
CREM	1390	Q03060	0.55
DLX3	1747	O60479	0.55
EIF4E	1977	P06730	0.55
GJB1	2705	P08034	0.55
GRIA1	2890	P42261	0.55
GRIA4	2893	P48058	0.55
GRIN2A	2903	Q12879	0.55
HLA-A	3105	P30443	0.55
HMGN2	3151	P05204	0.55
HSPA1A	3303	P0DMV8	0.55
HSPA1B	3304	P0DMV9	0.55
ITGB2	3689	P05107	0.55
KIT	3815	P10721	0.55
LCK	3932	P06239	0.55
OPRD1	4985	P41143	0.55
PA2G4	5036	Q9UQ80	0.55
PTGIR	5739	P43119	0.55
RAF1	5894	P04049	0.55
SDC2	6383	P34741	0.55
SHC1	6464	P29353	0.55
SPAG1	6674	Q07617	0.55
SRC	6714	P12931	0.55
VCL	7414	P18206	0.55
VTN	7448	P04004	0.55
DGKD	8527	Q16760	0.55
EDF1	8721	O60869	0.55
RALBP1	10928	Q15311	0.58
TRPV6	55503	Q9H1D0	0.58
GABRR1	2569	P24046	0.62
HIST1H1B	3009	P16401	0.62
INSR	3643	P06213	0.62
KRT18	3875	P05783	0.62
NFATC1	4772	O95644	0.62
NFE2L2	4780	Q16236	0.62
RPL10	6134	P27635	0.62
TBXA2R	6915	P21731	0.62
HIST3H3	8290	Q16695	0.62
RGS19	10287	P49795	0.62
CDKN2A	1029	P42771	0.63
FLNC	2318	Q14315	0.63
HIST1H1A	3024	Q02539	0.63
JAK1	3716	P23458	0.63
NOS1	4842	P29475	0.63
TNNI3	7137	P19429	0.63
TYK2	7297	P29597	0.63
UBC	7316	P0CG48	0.63
SACM1L	22908	Q9NTJ5	0.63
IBTK	25998	Q9P2D0	0.63
PPP1R14A	94274	Q96A00	0.64
ATP1A1	476	P05023	0.65
KLF5	688	Q13887	0.65
GSK3B	2932	P49841	0.65
ITPKA	3706	P23677	0.65
PEBP1	5037	P30086	0.65
RRAD	6236	P55042	0.65
DGKZ	8525	Q13574	0.65
RBCK1	10616	Q9BYM8	0.65
DDX58	23586	O95786	0.65
CORO1B	57175	Q9BR76	0.65
CHAT	1103	P28329	0.66
GFAP	2670	P14136	0.66
GRM5	2915	P41594	0.66
MARCKS	4082	P29966	0.66
MBP	4155	P02686	0.66
RHO	6010	P08100	0.66
TP53	7157	P04637	0.66
CD163	9332	Q86VB7	0.67
GRIN2B	2904	Q13224	0.69
GSK3A	2931	P49840	0.69
HMGN1	3150	P05114	0.69
MGMT	4255	P16455	0.69
STXBP1	6812	P61764	0.69
HAND1	9421	O96004	0.69
HABP4	22927	Q5JVS0	0.69
GRIA2	2891	P42262	0.7
SDC4	6385	P31431	0.7
SELL	6402	P14151	0.7
AVPR1B	553	P47901	0.72
AVPR2	554	P30518	0.72
CTNNB1	1499	P35222	0.72
GRM7	2917	Q14831	0.72
PPARG	5468	P37231	0.72
CD9	928	P21926	0.73
SLC1A1	6505	P43005	0.74
TOP2A	7153	P11388	0.74
EIF2S1	1965	P05198	0.75
TNNT2	7139	P45379	0.75
LMNA	4000	P02545	0.78
NCF1	653361	P14598	0.82
ITGB1	3688	P05556	0.83
EZR	7430	P15311	0.83
PLD1	5337	Q13393	0.84
CBL	867	P22681	0.85
HDAC6	10013	Q9UBN7	0.85
LMNB1	4001	P20700	0.86
PRKCA	5578	P17252	0.89
EGFR	1956	P00533	0.9
GJA1	2697	P17302	0.9
DSP	1832	P15924	0.49
HSP90AB1	3326	P08238	0.49
ACIN1	22985	Q9UKV3	0.49
ENTPD5	957	O75356	0.52
MTOR	2475	P42345	0.52
GABRR2	2570	P28476	0.52
MYLK	4638	Q15746	0.52
POLB	5423	P06746	0.52
PPARA	5465	Q07869	0.52
SCTR	6344	P47872	0.52
SYK	6850	P43405	0.52
XK	7504	P51811	0.52
SDPR	8436	O95810	0.52
ARHGEF1	9138	Q92888	0.52
KCNE4	23704	Q8WWG9	0.52
FBXO25	26260	Q8TCJ0	0.52
RNF31	55072	Q96EP0	0.52
ANXA7	310	P20073	0.55
GNA12	2768	Q03113	0.55
SEMG2	6407	Q02383	0.55
STXBP3	6814	O00186	0.55
TERT	7015	O14746	0.55
BTG2	7832	P78543	0.55
NUMB	8650	P49757	0.55
INADL	10207	Q8NI35	0.55
SLC9A3R2	9351	Q15599	0.56
SLC9A3R1	9368	O14745	0.56
CISH	1154	Q9NSE2	0.59
ADCY5	111	O95622	0.62
PDLIM7	9260	Q9NR12	0.62
BRAF	673	P15056	0.63
ITGB4	3691	P16144	0.63
MOV10	4343	Q9HCE1	0.63
NPM1	4869	P06748	0.63
NTRK1	4914	P04629	0.63
PLCG2	5336	P16885	0.63
PRKCE	5581	Q02156	0.63
PSMB4	5692	P28070	0.63
RPS6KA2	6196	Q15349	0.63
UQCRB	7381	P14927	0.63
SLC25A11	8402	Q02978	0.63
VPS4B	9525	O75351	0.63
NXF1	10482	Q9UBU9	0.63
GIPC1	10755	O14908	0.63
AKAP13	11214	Q12802	0.63
WWC1	23286	Q8IX03	0.63
TAS2R7	50837	Q9NYW3	0.63
WWC3	55841	Q9ULE0	0.63
MAPKAP1	79109	Q9BPZ7	0.63
WWC2	80014	Q6AWC2	0.63
CCNL2	81669	Q96S94	0.63
CCDC8	83987	Q9H0W5	0.63
TMEM185A	84548	Q8NFB2	0.63
LNX1	84708	Q8TBB1	0.63
JSRP1	126306	Q96MG2	0.63
LNX2	222484	Q8N448	0.63
SLC25A41	284427	Q8N5S1	0.63
FAS	355	P25445	0.65
BTK	695	Q06187	0.65
FLNA	2316	P21333	0.65
SEMG1	6406	P04279	0.65
TEP1	7011	Q99973	0.65
TRIM29	23650	Q14134	0.65
PRKCZ	5590	Q05513	0.66
CHUK	1147	O15111	0.68
RAC1	5879	P63000	0.68
RGS2	5997	P41220	0.69
TIAM1	7074	Q13009	0.69
HAND2	9464	P61296	0.69
IKBKB	3551	O14920	0.7
CD53	963	P19397	0.72
KIF2A	3796	O00139	0.72
KIF11	3832	P52732	0.72
AVPR1A	552	P37288	0.73
PLD2	5338	O14939	0.73
YWHAG	7532	P61981	0.73
AKAP12	9590	Q02952	0.73
RACK1	10399	P63244	0.73
GABRB3	2562	P28472	0.75
HSP90AA1	3320	P07900	0.75
RICTOR	253260	Q6R327	0.75
ELAVL1	1994	Q15717	0.76
AFAP1	60312	Q8N556	0.76
OGG1	4968	O15527	0.77
FSCN1	6624	Q16658	0.79
TRIM41	90933	Q8WV44	0.79
YWHAZ	7534	P63104	0.84
AKAP5	9495	P24588	0.85
C1QBP	708	Q07021	0.89
DLG4	1742	P78352	0.89
PICK1	9463	Q9NRD5	0.97