PCOSBase

Protein Description

Gene Symbol	ACTB
Entrez ID	60
Uniprot ID	P60709
Description	actin, beta
Chromosomal Location	chr7: 5,527,151-5,563,784

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0001895	retina homeostasis	A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.	IEP
BP	GO:0006928	movement of cell or subcellular component	The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.	TAS
BP	GO:0007010	cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.	IEA
BP	GO:0021762	substantia nigra development	The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).	IEP
BP	GO:0034329	cell junction assembly	A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.	TAS
BP	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.	TAS
BP	GO:0043044	ATP-dependent chromatin remodeling	Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors.	IDA
BP	GO:0045815	positive regulation of gene expression, epigenetic	Any epigenetic process that activates or increases the rate of gene expression.	TAS
BP	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.	TAS
BP	GO:0048013	ephrin receptor signaling pathway	The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.	TAS
BP	GO:0070527	platelet aggregation	The adhesion of one platelet to one or more other platelets via adhesion molecules.	IMP
CC	GO:0000790	nuclear chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.	IDA
CC	GO:0005615	extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.	IDA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	TAS
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	TAS
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0005856	cytoskeleton	Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.	ISS\|TAS
CC	GO:0005886	plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	ISS\|TAS
CC	GO:0005925	focal adhesion	Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.	IDA
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0030529	intracellular ribonucleoprotein complex	An intracellular macromolecular complex containing both protein and RNA molecules.	IDA
CC	GO:0030863	cortical cytoskeleton	The portion of the cytoskeleton that lies just beneath the plasma membrane.	IEA
CC	GO:0035267	NuA4 histone acetyltransferase complex	A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).	IDA
CC	GO:0036464	cytoplasmic ribonucleoprotein granule	A ribonucleoprotein granule located in the cytoplasm.	IDA
CC	GO:0043209	myelin sheath	An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.	IEA
CC	GO:0043234	protein complex	A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.	IDA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
CC	GO:0070688	MLL5-L complex	A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively.	IDA
CC	GO:0072562	blood microparticle	A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.	IDA
CC	GO:0097433	dense body	An electron dense body which may contain granules.	ISS
MF	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.	IDA
MF	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.	IDA
MF	GO:0005200	structural constituent of cytoskeleton	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.	TAS
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0005524	ATP binding	Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	IEA
MF	GO:0019894	kinesin binding	Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.	IPI
MF	GO:0030957	Tat protein binding	Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus.	IPI
MF	GO:0031492	nucleosomal DNA binding	Interacting selectively and non-covalently with the DNA portion of a nucleosome.	IDA
MF	GO:0042802	identical protein binding	Interacting selectively and non-covalently with an identical protein or proteins.	IPI
MF	GO:0050998	nitric-oxide synthase binding	Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.	IPI

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Domain ID	Description
IPR004000	Actin family
IPR004001	Actin, conserved site
IPR020902	Actin/actin-like conserved site

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Pathway ID	Pathway Term	Pathway Source
hsa04015	Rap1 signaling pathway	KEGG
hsa04145	Phagosome	KEGG
hsa04210	Apoptosis	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa04520	Adherens junction	KEGG
hsa04530	Tight junction	KEGG
hsa04611	Platelet activation	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04971	Gastric acid secretion	KEGG
hsa05100	Bacterial invasion of epithelial cells	KEGG
hsa05110	Vibrio cholerae infection	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
hsa05131	Shigellosis	KEGG
hsa05132	Salmonella infection	KEGG
hsa05164	Influenza A	KEGG
hsa05205	Proteoglycans in cancer	KEGG
hsa05410	Hypertrophic cardiomyopathy (HCM)	KEGG
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG
hsa05414	Dilated cardiomyopathy	KEGG
hsa05416	Viral myocarditis	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG
WP306	Focal Adhesion	WikiPathways
WP2118	Arrhythmogenic Right Ventricular Cardiomyopathy	WikiPathways
WP289	Myometrial Relaxation and Contraction Pathways	WikiPathways
WP51	Regulation of Actin Cytoskeleton	WikiPathways
WP2272	Pathogenic Escherichia coli infection	WikiPathways
WP2636	Common Pathways Underlying Drug Addiction	WikiPathways
WP314	Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation	WikiPathways
h_hSWI-SNFpathway	Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes	BioCarta

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UMLS CUI	UMLS Term
C0003130	Anoxia
C0009363	Congenital Ocular Coloboma (Disorder)
C0013393	Dysostoses
C0013421	Dystonia
C0014859	Esophageal Neoplasms
C0018784	Sensorineural Hearing Loss (Disorder)
C0024121	Lung Neoplasms
C0024667	Animal Mammary Neoplasms
C0024668	Mammary Neoplasms, Experimental
C0027626	Neoplasm Invasiveness
C0029408	Degenerative Polyarthritis
C0151744	Myocardial Ischemia
C0376634	Craniofacial Abnormalities
C0497552	Congenital Neurologic Anomalies
C2239176	Liver Carcinoma

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Tissue	Cell Type
appendix	lymphoid tissue
breast	myoepithelial cells
colon	endothelial cells
duodenum	glandular cells
epididymis	glandular cells
gallbladder	glandular cells
lymph node	germinal center cells
lymph node	non-germinal center cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
spleen	cells in white pulp
stomach	glandular cells
tonsil	non-germinal center cells

Database Name
DisGeNET

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Pubmed ID	Author	Year	Title
18156650	Corton et al.	2008	Proteomic analysis of human omental adipose tissue in the polycystic ovary syndrome using two-dimensional difference gel electrophoresis and mass spectrometry
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome
23824412	Piltonen et al.	2013	Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

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Gene Symbol	Entrez ID	Uniprot ID	Score
ACTN4	81	O43707	0.00
ACTN1	87	P12814	0.00
CTNNA1	1495	P35221	0.00
DIAPH1	1729	O60610	0.00
MLLT4	4301	P55196	0.00
MYH2	4620	Q9UKX2	0.00
MYH4	4622	Q9Y623	0.00
MYH10	4628	P35580	0.00
MYL2	4633	P10916	0.00
PRKCG	5582	P05129	0.00
PRKCH	5583	P24723	0.00
PRKCQ	5588	Q04759	0.00
PXN	5829	P49023	0.00
VASP	7408	P50552	0.00
VCL	7414	P18206	0.00
ZYX	7791	Q15942	0.00
WASL	8976	O00401	0.00
ARPC5	10092	O15511	0.00
ARPC3	10094	O15145	0.00
ARPC2	10109	O15144	0.00
PLA2R1	22925	Q13018	0.00
PIP5K1C	23396	O60331	0.00
CTNNA3	29119	Q9UI47	0.00
PARVB	29780	Q9HBI1	0.00
PARVA	55742	Q9NVD7	0.00
PARVG	64098	Q9HBI0	0.00
EEF1A2	1917	Q05639	0.49
HMMR	3161	O75330	0.49
MYH11	4629	P35749	0.49
YARS	8565	P54577	0.49
NCF1C	654817	A8MVU1	0.49
DNASE1	1773	P24855	0.52
FLOT2	2319	Q14254	0.52
SRC	6714	P12931	0.52
BCAR1	9564	P56945	0.52
SORBS1	10580	Q9BX66	0.52
RAB35	11021	Q15286	0.52
MYO1G	64005	B0I1T2	0.52
SRCIN1	80725	Q9C0H9	0.52
ANXA1	301	P04083	0.55
ANXA2	302	P07355	0.55
ANXA6	309	P08133	0.55
CD4	920	P01730	0.55
DDX3X	1654	O00571	0.55
DDX5	1655	P17844	0.55
EEF1B2	1933	P24534	0.55
EIF4A2	1974	Q14240	0.55
ENO1	2023	P06733	0.55
EPB41L2	2037	O43491	0.55
FBL	2091	P22087	0.55
GNAI2	2771	P04899	0.55
HNRNPA2B1	3181	P22626	0.55
HNRNPH1	3187	P31943	0.55
HSP90AA1	3320	P07900	0.55
EIF3E	3646	P60228	0.55
KPNB1	3837	Q14974	0.55
TNPO1	3842	Q92973	0.55
LCK	3932	P06239	0.55
MME	4311	P08473	0.55
MYL6	4637	P60660	0.55
NCL	4691	P19338	0.55
NPM1	4869	P06748	0.55
YBX1	4904	P67809	0.55
RPL7	6129	P18124	0.55
RPL7A	6130	P62424	0.55
RPL11	6135	P62913	0.55
RPL18	6141	Q07020	0.55
RPL22	6146	P35268	0.55
RPLP0	6175	P05388	0.55
RPLP1	6176	P05386	0.55
RPS3A	6189	P61247	0.55
RPS4X	6191	P62701	0.55
RPS7	6201	P62081	0.55
RPS8	6202	P62241	0.55
RPS9	6203	P46781	0.55
RPS10	6204	P46783	0.55
RPS12	6206	P25398	0.55
RPS13	6207	P62277	0.55
RPS18	6222	P62269	0.55
RPS19	6223	P39019	0.55
RPS24	6229	P62847	0.55
SSRP1	6749	Q08945	0.55
UBB	7314	P0CG47	0.55
VDAC1	7416	P21796	0.55
VDAC2	7417	P45880	0.55
VDAC3	7419	Q9Y277	0.55
VIM	7431	P08670	0.55
TUBA1A	7846	Q71U36	0.55
HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI	8339	P62807	0.55
EIF3B	8662	P55884	0.55
EIF3C	8663	Q99613	0.55
EIF3D	8664	O15371	0.55
EIF3I	8668	Q13347	0.55
FARSB	10056	Q9NSD9	0.55
ACTR1B	10120	P42025	0.55
LRPPRC	10128	P42704	0.55
DHRS2	10202	Q13268	0.55
RACK1	10399	P63244	0.55
EIF3M	10480	Q7L2H7	0.55
MYL12A	10627	P19105	0.55
EIF3K	27335	Q9UBQ5	0.55
TUBB	203068	P07437	0.55
CAD	790	P27708	0.56
CORO1C	23603	Q9ULV4	0.59
POLR1B	84172	Q9H9Y6	0.59
ATP5A1	498	P25705	0.62
HSP90AB1	3326	P08238	0.62
HSPD1	3329	P10809	0.62
RPSA	3921	P08865	0.62
RAN	5901	P62826	0.62
BBS1	582	Q8NFJ9	0.63
BBS4	585	Q96RK4	0.63
CAV1	857	Q03135	0.63
CD81	975	P60033	0.63
CSNK2B	1460	P67870	0.63
EHHADH	1962	Q08426	0.63
EP300	2033	Q09472	0.63
ICAM1	3383	P05362	0.63
ICAM3	3385	P32942	0.63
MTNR1A	4543	P48039	0.63
NCF2	4688	P19878	0.63
RPL10A	4736	P62906	0.63
SHBG	6462	P04278	0.63
TAF11	6882	Q15544	0.63
ACTR3	10096	P61158	0.63
ACTR2	10097	P61160	0.63
KHDRBS1	10657	Q07666	0.63
ATP13A2	23400	Q9NQ11	0.63
FHOD1	29109	Q9Y613	0.63
WDYHV1	55093	Q96HA8	0.63
OTUB1	55611	Q96FW1	0.63
ATF7IP	55729	Q6VMQ6	0.63
ACTC1	70	P68032	0.68
AMOT	154796	Q4VCS5	0.68
BAIAP2	10458	Q9UQB8	0.70
CAP2	10486	P40123	0.70
PPP1CB	5500	P62140	0.72
PROM1	8842	O43490	0.72
SMAD9	4093	O15198	0.73
DSTN	11034	P60981	0.73
NSMAF	8439	Q92636	0.75
HNRNPA1	3178	P09651	0.77
HNRNPD	3184	Q14103	0.77
HSPA8	3312	P11142	0.77
PHB	5245	P35232	0.77
PCYT1B	9468	Q9Y5K3	0.78
CFL1	1072	P23528	0.80
HNRNPU	3192	Q00839	0.81
RPA2	6118	P15927	0.82
MDM2	4193	Q00987	0.83
CFL2	1073	Q9Y281	0.88
ACTB	60	P60709	0.97
CENPA	1058	P49450	0.49
FPR1	2357	P21462	0.49
ANGPTL4	51129	Q9BY76	0.49
CORO1B	57175	Q9BR76	0.49
ALOX5	240	P09917	0.52
CAPZA1	829	P52907	0.52
CNN2	1265	Q99439	0.52
CSNK1A1	1452	P48729	0.52
DNM2	1785	P50570	0.52
DMTN	2039	Q08495	0.52
FLII	2314	Q13045	0.52
GNA12	2768	Q03113	0.52
HNRNPAB	3182	Q99729	0.52
HSD17B4	3295	P51659	0.52
LMNA	4000	P02545	0.52
LYN	4067	P07948	0.52
MAP1B	4131	P46821	0.52
MAPT	4137	P10636	0.52
MMP14	4323	P50281	0.52
MX1	4599	P20591	0.52
NOS2	4843	P35228	0.52
NRAP	4892	Q86VF7	0.52
NT5E	4907	P21589	0.52
PRKCD	5580	Q05655	0.52
SPTAN1	6709	Q13813	0.52
SRPK2	6733	P78362	0.52
STX4	6810	Q12846	0.52
TMSB4X	7114	P62328	0.52
TNNI2	7136	P48788	0.52
TPM2	7169	P07951	0.52
WASF1	8936	Q92558	0.52
CDK5R2	8941	Q13319	0.52
WASF2	10163	Q9Y6W5	0.52
NEBL	10529	O76041	0.52
PDLIM5	10611	Q96HC4	0.52
WASF3	10810	Q9UPY6	0.52
CORO1A	11151	P31146	0.52
LGALS13	29124	Q9UHV8	0.52
SSH3	54961	Q8TE77	0.52
PHACTR4	65979	Q8IZ21	0.52
MYO18B	84700	Q8IUG5	0.52
TANC1	85461	Q9C0D5	0.52
SLC25A5	292	P05141	0.55
ATP6V1B2	526	P21281	0.55
EPB41	2035	P11171	0.55
LASP1	3927	Q14847	0.55
MYC	4609	P01106	0.55
PCYT1A	5130	P49585	0.55
PFDN4	5203	Q9NQP4	0.55
PLD1	5337	Q13393	0.55
PLD2	5338	O14939	0.55
RAB4A	5867	P20338	0.55
TGM2	7052	P21980	0.55
EPB41L3	23136	Q9Y2J2	0.55
LMOD1	25802	P29536	0.55
ABRA	137735	Q8N0Z2	0.55
ABLIM1	3983	O14639	0.56
MAP1A	4130	P78559	0.56
PPP2R2B	5521	Q00005	0.56
UBE3A	7337	Q05086	0.56
YY1	7528	P25490	0.56
COTL1	23406	Q14019	0.56
RUSC1	23623	Q9BVN2	0.56
SAMHD1	25939	Q9Y3Z3	0.56
CORO7	79585	P57737	0.56
GSN	2934	P06396	0.59
MYO1E	4643	Q12965	0.59
DYNLL1	8655	P63167	0.59
P2RX7	5027	Q99572	0.62
PTN	5764	P21246	0.62
TMSB4XP4	7118	N/A	0.62
TPM1	7168	P09493	0.62
TPM3	7170	P06753	0.62
EZR	7430	P15311	0.62
ARPC1B	10095	O15143	0.62
CCT4	10575	P50991	0.62
CCT8	10694	P50990	0.62
XPO6	23214	Q96QU8	0.62
CLIC4	25932	Q9Y696	0.62
SYNJ2BP	55333	P57105	0.62
ADA	100	P00813	0.63
ALK	238	Q9UM73	0.63
ANXA7	310	P20073	0.63
APP	351	P05067	0.63
AR	367	P10275	0.63
ARRB1	408	P49407	0.63
ATF3	467	P18847	0.63
BCL2L1	598	Q07817	0.63
CDC5L	988	Q99459	0.63
CDK2	1017	P24941	0.63
CDKN1A	1026	P38936	0.63
CFTR	1080	P13569	0.63
RCC1	1104	P18754	0.63
AP2M1	1173	Q96CW1	0.63
CLNS1A	1207	P54105	0.63
CRK	1398	P46108	0.63
CYBB	1536	P04839	0.63
DAB2	1601	P98082	0.63
ACE	1636	P12821	0.63
DHX9	1660	Q08211	0.63
DTNA	1837	Q9Y4J8	0.63
ELAVL1	1994	Q15717	0.63
EPS15	2060	P42566	0.63
FABP4	2167	P15090	0.63
FN1	2335	P02751	0.63
NR5A1	2516	Q13285	0.63
FUS	2521	P35637	0.63
GRB2	2885	P62993	0.63
HOXB5	3215	P09067	0.63
HSD17B3	3293	P37058	0.63
HSPB2	3316	Q16082	0.63
HTR7	3363	P34969	0.63
INSR	3643	P06213	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
LGALS3BP	3959	Q08380	0.63
LMX1B	4010	O60663	0.63
MAGEA10	4109	P43363	0.63
MAGOH	4116	P61326	0.63
MCL1	4170	Q07820	0.63
MGMT	4255	P16455	0.63
MYBPC3	4607	Q14896	0.63
MYOC	4653	Q99972	0.63
NEDD8	4738	Q15843	0.63
NFKB1	4790	P19838	0.63
PA2G4	5036	Q9UQ80	0.63
PCK1	5105	P35558	0.63
PIK3R2	5296	O00459	0.63
PPID	5481	Q08752	0.63
MAPK7	5598	Q13164	0.63
PSMA3	5684	P25788	0.63
RAD51	5888	Q06609	0.63
SHC1	6464	P29353	0.63
SKI	6497	P12755	0.63
SLC6A2	6530	P23975	0.63
SLC12A3	6559	P55017	0.63
SNCA	6622	P37840	0.63
SS18	6760	Q15532	0.63
SVIL	6840	O95425	0.63
HNF1A	6927	P20823	0.63
TCP1	6950	P17987	0.63
TK1	7083	P04183	0.63
TSC1	7248	Q92574	0.63
TTR	7276	P02766	0.63
TUBG1	7283	P23258	0.63
VSNL1	7447	P62760	0.63
WHSC1	7468	O96028	0.63
AIMP2	7965	Q13155	0.63
CUL5	8065	Q93034	0.63
UBL4A	8266	P11441	0.63
TAGLN2	8407	P37802	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
TPST1	8460	O60507	0.63
KAT2B	8850	Q92831	0.63
PSTPIP1	9051	O43586	0.63
PNMA1	9240	Q8ND90	0.63
BCL7C	9274	Q8WUZ0	0.63
HOMER1	9456	Q86YM7	0.63
ISG15	9636	P05161	0.63
MORF4L2	9643	Q15014	0.63
KIAA0101	9768	Q15004	0.63
EIF4A3	9775	P38919	0.63
PAN2	9924	Q504Q3	0.63
HDAC6	10013	Q9UBN7	0.63
TUBGCP3	10426	Q96CW5	0.63
CARM1	10498	Q86X55	0.63
IVNS1ABP	10625	Q9Y6Y0	0.63
TUBGCP2	10844	Q9BSJ2	0.63
YWHAQ	10971	P27348	0.63
COPS6	10980	Q7L5N1	0.63
COPS5	10987	Q92905	0.63
PRSS23	11098	O95084	0.63
CEP250	11190	Q9BV73	0.63
GABARAP	11337	O95166	0.63
GABARAPL2	11345	P60520	0.63
ZBTB1	22890	Q9Y2K1	0.63
SNW1	22938	Q13573	0.63
UNC13A	23025	Q9UPW8	0.63
CBX5	23468	P45973	0.63
GABARAPL1	23710	Q9H0R8	0.63
OSTF1	26578	Q92882	0.63
UCHL5	51377	Q9Y5K5	0.63
INO80	54617	Q9ULG1	0.63
LGR4	55366	Q9BXB1	0.63
SLC30A6	55676	Q6NXT4	0.63
CAND1	55832	Q86VP6	0.63
SMURF1	57154	Q9HCE7	0.63
MKL1	57591	Q969V6	0.63
NOM1	64434	Q5C9Z4	0.63
USP46	64854	P62068	0.63
FASTKD3	79072	Q14CZ7	0.63
MAP1LC3B	81631	Q9GZQ8	0.63
MAP1LC3A	84557	Q9H492	0.63
UBASH3B	84959	Q8TF42	0.63
UNK	85451	Q9C0B0	0.63
TRIM15	89870	Q9C019	0.63
HAUS1	115106	Q96CS2	0.63
NEDD1	121441	Q8NHV4	0.63
ASB9	140462	Q96DX5	0.63
DUSP19	142679	Q8WTR2	0.63
ASB12	142689	Q8WXK4	0.63
AGO3	192669	Q9H9G7	0.63
CPNE2	221184	Q96FN4	0.63
PROSER2	254427	Q86WR7	0.63
SCARNA22	677770	N/A	0.63
PFDN1	5201	O60925	0.65
S100A11	6282	P31949	0.65
SCN10A	6336	Q9Y5Y9	0.65
CAP1	10487	Q01518	0.65
MYL12B	103910	O14950	0.65
ESR2	2100	Q92731	0.67
FHL3	2275	Q13643	0.67
CDKN2A	1029	P42771	0.68
CTGF	1490	P29279	0.68
EEF1A1	1915	P68104	0.68
GAPDH	2597	P04406	0.68
NOS3	4846	P29474	0.68
LRRK2	120892	Q5S007	0.68
MAP2	4133	P11137	0.69
H2AFX	3014	P16104	0.70
SMAD3	4088	P84022	0.70
SUMO1	7341	P63165	0.70
MORF4L1	10933	Q9UBU8	0.70
DMAP1	55929	Q9NPF5	0.70
PFN2	5217	P35080	0.71
AKT1	207	P31749	0.72
ARRB2	409	P32121	0.72
FLNA	2316	P21333	0.72
RAB2A	5862	P61019	0.72
RAD52	5893	P43351	0.72
SMARCC2	6601	Q8TAQ2	0.72
ENC1	8507	O14682	0.72
IQCB1	9657	Q15051	0.72
SYNPO	11346	Q8N3V7	0.72
LIMA1	51474	Q9UHB6	0.72
RAB8B	51762	Q92930	0.72
KMT2E	55904	Q8IZD2	0.72
MEPCE	56257	Q7L2J0	0.72
AGO4	192670	Q9HCK5	0.72
MYO18A	399687	Q92614	0.72
CBL	867	P22681	0.73
PARK2	5071	O60260	0.73
PPP1CA	5499	P62136	0.73
TP53	7157	P04637	0.73
VCAM1	7412	P19320	0.73
VCP	7415	P55072	0.73
UBD	10537	O15205	0.73
POT1	25913	Q9NUX5	0.73
TRAF3IP1	26146	Q8TDR0	0.73
ACD	65057	Q96AP0	0.73
ERBB2	2064	P04626	0.74
SUMO2	6613	P61956	0.74
HCK	3055	P08631	0.75
PLG	5340	P00747	0.75
TJP1	7082	Q07157	0.75
CPNE1	8904	Q99829	0.75
FBXO25	26260	Q8TCJ0	0.75
TINF2	26277	Q9BSI4	0.75
SSH1	54434	Q8WYL5	0.75
MRGBP	55257	Q9NV56	0.75
SSH2	85464	Q76I76	0.75
CPNE4	131034	Q96A23	0.75
A2M	2	P01023	0.77
RAC1	5879	P63000	0.77
RAC2	5880	P15153	0.77
ERG	2078	P11308	0.78
VHL	7428	P40337	0.78
CCT5	22948	P48643	0.78
ACTG1	71	P63261	0.80
POLR2A	5430	P24928	0.81
ESR1	2099	P03372	0.82
MYH9	4627	P35579	0.82
PPP1CC	5501	P36873	0.82
RPA1	6117	P27694	0.82
RPA3	6119	P35244	0.82
SMARCE1	6605	Q969G3	0.82
STAU1	6780	O95793	0.82
SMN1; SMN2	6606	Q16637	0.82
NCALD	83988	P61601	0.83
SPTBN2	6712	O15020	0.84
IQGAP1	8826	P46940	0.85
EMD	2010	P50402	0.86
NCF1	653361	P14598	0.86
SMARCA4	6597	P51532	0.88
YWHAZ	7534	P63104	0.88
KAT5	10524	Q92993	0.88
CCT2	10576	P78371	0.88
RUVBL1	8607	Q9Y265	0.89
RUVBL2	10856	Q9Y230	0.89
PFN1	5216	P07737	0.96