| Gene Symbol | PPM1B | 
| Entrez ID | 5495 | 
| Uniprot ID | O75688 | 
| Description | protein phosphatase, Mg2+/Mn2+ dependent 1B | 
| Chromosomal Location | chr2: 44,167,969-44,244,384 | 
| Ontology | GO ID | GO Term | Definition | Evidence | 
|---|---|---|---|---|
| 
             BP  | 
          
             GO:0006470  | 
          
             protein dephosphorylation  | 
          
             The process of removing one or more phosphoric residues from a protein.  | 
          
             IMP  | 
        
| 
             BP  | 
          
             GO:0006499  | 
          
             N-terminal protein myristoylation  | 
          
             The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.  | 
          
             ISS  | 
        
| 
             BP  | 
          
             GO:0032688  | 
          
             negative regulation of interferon-beta production  | 
          
             Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.  | 
          
             IMP  | 
        
| 
             BP  | 
          
             GO:0035970  | 
          
             peptidyl-threonine dephosphorylation  | 
          
             The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.  | 
          
             IDA  | 
        
| 
             BP  | 
          
             GO:0042347  | 
          
             negative regulation of NF-kappaB import into nucleus  | 
          
             Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.  | 
          
             IMP  | 
        
| 
             BP  | 
          
             GO:0043124  | 
          
             negative regulation of I-kappaB kinase/NF-kappaB signaling  | 
          
             Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.  | 
          
             IMP  | 
        
| 
             BP  | 
          
             GO:0050687  | 
          
             negative regulation of defense response to virus  | 
          
             Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.  | 
          
             IMP  | 
        
| 
             CC  | 
          
             GO:0005829  | 
          
             cytosol  | 
          
             The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.  | 
          
             ISS|TAS  | 
        
| 
             CC  | 
          
             GO:0016020  | 
          
             membrane  | 
          
             A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.  | 
          
             ISS  | 
        
| 
             MF  | 
          
             GO:0000287  | 
          
             magnesium ion binding  | 
          
             Interacting selectively and non-covalently with magnesium (Mg) ions.  | 
          
             IEA  | 
        
| 
             MF  | 
          
             GO:0004722  | 
          
             protein serine/threonine phosphatase activity  | 
          
             Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.  | 
          
             IDA  | 
        
| 
             MF  | 
          
             GO:0005515  | 
          
             protein binding  | 
          
             Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).  | 
          
             IPI  | 
        
| 
             MF  | 
          
             GO:0030145  | 
          
             manganese ion binding  | 
          
             Interacting selectively and non-covalently with manganese (Mn) ions.  | 
          
             IEA  | 
        
| Domain ID | Description | 
|---|---|
| 
             IPR000222  | 
          
             PPM-type phosphatase, divalent cation binding  | 
        
| 
             IPR001932  | 
          
             PPM-type phosphatase domain  | 
        
| 
             IPR012911  | 
          
             Protein serine/threonine phosphatase 2C, C-terminal  | 
        
| 
             IPR015655  | 
          
             Protein phosphatase 2C family  | 
        
| Pathway ID | Pathway Term | Pathway Source | 
|---|---|---|
| 
           hsa04010  | 
        
           MAPK signaling pathway  | 
        
           KEGG  | 
      
| 
           WP382  | 
        
           MAPK Signaling Pathway  | 
        
           WikiPathways  | 
      
| UMLS CUI | UMLS Term | 
|---|---|
| 
             C0151744  | 
          
             Myocardial Ischemia  | 
        
| Tissue | Cell Type | 
|---|---|
| 
             cerebellum  | 
          
             Purkinje cells  | 
        
| 
             small intestine  | 
          
             glandular cells  | 
        
| Pubmed ID | Author | Year | Title | 
|---|---|---|---|
| 
                 22951915  | 
              
                 Haozi et al.  | 
              
                 2012  | 
              
                 Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome  | 
            
| Gene Symbol | Entrez ID | Uniprot ID | Score | 
|---|---|---|---|
| 
             CDK1  | 
          
             983  | 
          
             P06493  | 
          
             0.49  | 
        
| 
             CDK9  | 
          
             1025  | 
          
             P50750  | 
          
             0.49  | 
        
| 
             FOS  | 
          
             2353  | 
          
             P01100  | 
          
             0.49  | 
        
| 
             NAA10  | 
          
             8260  | 
          
             P41227  | 
          
             0.49  | 
        
| 
             CASK  | 
          
             8573  | 
          
             O14936  | 
          
             0.49  | 
        
| 
             MAP4K5  | 
          
             11183  | 
          
             Q9Y4K4  | 
          
             0.49  | 
        
| 
             LRRK1  | 
          
             79705  | 
          
             Q38SD2  | 
          
             0.49  | 
        
| 
             STK40  | 
          
             83931  | 
          
             Q8N2I9  | 
          
             0.49  | 
        
| 
             UBL7  | 
          
             84993  | 
          
             Q96S82  | 
          
             0.49  | 
        
| 
             MSN  | 
          
             4478  | 
          
             P26038  | 
          
             0.52  | 
        
| 
             VAV2  | 
          
             7410  | 
          
             P52735  | 
          
             0.63  | 
        
| 
             PPARG  | 
          
             5468  | 
          
             P37231  | 
          
             0.65  | 
        
| 
             MARK3  | 
          
             4140  | 
          
             P27448  | 
          
             0.68  | 
        
| 
             CDK2  | 
          
             1017  | 
          
             P24941  | 
          
             0.71  | 
        
| 
             ANXA1  | 
          
             301  | 
          
             P04083  | 
          
             0.76  | 
        
| 
             ANXA2  | 
          
             302  | 
          
             P07355  | 
          
             0.76  | 
        
| 
             GSN  | 
          
             2934  | 
          
             P06396  | 
          
             0.76  | 
        
| 
             KRT18  | 
          
             3875  | 
          
             P05783  | 
          
             0.76  | 
        
| 
             S100A8  | 
          
             6279  | 
          
             P05109  | 
          
             0.76  | 
        
| 
             VIL1  | 
          
             7429  | 
          
             P09327  | 
          
             0.76  | 
        
| 
             PABPC4  | 
          
             8761  | 
          
             Q13310  | 
          
             0.76  | 
        
| 
             RASGRP1  | 
          
             10125  | 
          
             O95267  | 
          
             0.76  | 
        
| 
             IKBKB  | 
          
             3551  | 
          
             O14920  | 
          
             0.77  | 
        
| 
             CDK6  | 
          
             1021  | 
          
             Q00534  | 
          
             0.81  | 
        
| 
             CHUK  | 
          
             1147  | 
          
             O15111  | 
          
             0.83  | 
        
| 
             IKBKG  | 
          
             8517  | 
          
             Q9Y6K9  | 
          
             0.83  | 
        
| 
             MAP3K7  | 
          
             6885  | 
          
             O43318  | 
          
             0.85  | 
        
| 
             VCP  | 
          
             7415  | 
          
             P55072  | 
          
             0.86  | 
        
| 
             ABL1  | 
          
             25  | 
          
             P00519  | 
          
             0.49  | 
        
| 
             CSNK1D  | 
          
             1453  | 
          
             P48730  | 
          
             0.49  | 
        
| 
             CSNK1E  | 
          
             1454  | 
          
             P49674  | 
          
             0.49  | 
        
| 
             GAK  | 
          
             2580  | 
          
             O14976  | 
          
             0.49  | 
        
| 
             PRKCI  | 
          
             5584  | 
          
             P41743  | 
          
             0.49  | 
        
| 
             PKN2  | 
          
             5586  | 
          
             Q16513  | 
          
             0.49  | 
        
| 
             MAPK8  | 
          
             5599  | 
          
             P45983  | 
          
             0.49  | 
        
| 
             CDK13  | 
          
             8621  | 
          
             Q14004  | 
          
             0.49  | 
        
| 
             PAK4  | 
          
             10298  | 
          
             O96013  | 
          
             0.49  | 
        
| 
             DDX53  | 
          
             168400  | 
          
             Q86TM3  | 
          
             0.49  | 
        
| 
             PPP2CA  | 
          
             5515  | 
          
             P67775  | 
          
             0.55  | 
        
| 
             ECHS1  | 
          
             1892  | 
          
             P30084  | 
          
             0.63  | 
        
| 
             FNTB  | 
          
             2342  | 
          
             P49356  | 
          
             0.63  | 
        
| 
             GCH1  | 
          
             2643  | 
          
             P30793  | 
          
             0.63  | 
        
| 
             GRB2  | 
          
             2885  | 
          
             P62993  | 
          
             0.63  | 
        
| 
             MAGEA6  | 
          
             4105  | 
          
             P43360  | 
          
             0.63  | 
        
| 
             MAGOH  | 
          
             4116  | 
          
             P61326  | 
          
             0.63  | 
        
| 
             NOS2  | 
          
             4843  | 
          
             P35228  | 
          
             0.63  | 
        
| 
             PPM1A  | 
          
             5494  | 
          
             P35813  | 
          
             0.63  | 
        
| 
             SKI  | 
          
             6497  | 
          
             P12755  | 
          
             0.63  | 
        
| 
             SUMO3  | 
          
             6612  | 
          
             P55854  | 
          
             0.63  | 
        
| 
             SUMO2  | 
          
             6613  | 
          
             P61956  | 
          
             0.63  | 
        
| 
             BCE1  | 
          
             7091  | 
          
             O60756  | 
          
             0.63  | 
        
| 
             SUMO1  | 
          
             7341  | 
          
             P63165  | 
          
             0.63  | 
        
| 
             VHL  | 
          
             7428  | 
          
             P40337  | 
          
             0.63  | 
        
| 
             XPO1  | 
          
             7514  | 
          
             O14980  | 
          
             0.63  | 
        
| 
             YWHAE  | 
          
             7531  | 
          
             P62258  | 
          
             0.63  | 
        
| 
             HIST1H3A  | 
          
             8350  | 
          
             P68431  | 
          
             0.63  | 
        
| 
             HERC2  | 
          
             8924  | 
          
             O95714  | 
          
             0.63  | 
        
| 
             AURKB  | 
          
             9212  | 
          
             Q96GD4  | 
          
             0.63  | 
        
| 
             EIF4A3  | 
          
             9775  | 
          
             P38919  | 
          
             0.63  | 
        
| 
             PAN2  | 
          
             9924  | 
          
             Q504Q3  | 
          
             0.63  | 
        
| 
             NR1I3  | 
          
             9970  | 
          
             Q14994  | 
          
             0.63  | 
        
| 
             FBXO6  | 
          
             26270  | 
          
             Q9NRD1  | 
          
             0.63  | 
        
| 
             FAM63B  | 
          
             54629  | 
          
             Q8NBR6  | 
          
             0.63  | 
        
| 
             ARRB1  | 
          
             408  | 
          
             P49407  | 
          
             0.72  | 
        
| 
             ARRB2  | 
          
             409  | 
          
             P32121  | 
          
             0.83  | 
        
| 
             ISG15  | 
          
             9636  | 
          
             P05161  | 
          
             0.86  |