| Gene Symbol | PPM1B |
| Entrez ID | 5495 |
| Uniprot ID | O75688 |
| Description | protein phosphatase, Mg2+/Mn2+ dependent 1B |
| Chromosomal Location | chr2: 44,167,969-44,244,384 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006470 | protein dephosphorylation |
The process of removing one or more phosphoric residues from a protein. | IMP |
BP | GO:0006499 | N-terminal protein myristoylation |
The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein. | ISS |
BP | GO:0032688 | negative regulation of interferon-beta production |
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production. | IMP |
BP | GO:0035970 | peptidyl-threonine dephosphorylation |
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. | IDA |
BP | GO:0042347 | negative regulation of NF-kappaB import into nucleus |
Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. | IMP |
BP | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. | IMP |
BP | GO:0050687 | negative regulation of defense response to virus |
Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. | IMP |
CC | GO:0005829 | cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. | ISS|TAS |
CC | GO:0016020 | membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | ISS |
MF | GO:0000287 | magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. | IEA |
MF | GO:0004722 | protein serine/threonine phosphatase activity |
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. | IDA |
MF | GO:0005515 | protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | IPI |
MF | GO:0030145 | manganese ion binding |
Interacting selectively and non-covalently with manganese (Mn) ions. | IEA |
| Domain ID | Description |
|---|---|
IPR000222 | PPM-type phosphatase, divalent cation binding |
IPR001932 | PPM-type phosphatase domain |
IPR012911 | Protein serine/threonine phosphatase 2C, C-terminal |
IPR015655 | Protein phosphatase 2C family |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa04010 | MAPK signaling pathway | KEGG |
WP382 | MAPK Signaling Pathway | WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
C0151744 | Myocardial Ischemia |
| Tissue | Cell Type |
|---|---|
cerebellum | Purkinje cells |
small intestine | glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
CDK1 | 983 | P06493 | 0.49 |
CDK9 | 1025 | P50750 | 0.49 |
FOS | 2353 | P01100 | 0.49 |
NAA10 | 8260 | P41227 | 0.49 |
CASK | 8573 | O14936 | 0.49 |
MAP4K5 | 11183 | Q9Y4K4 | 0.49 |
LRRK1 | 79705 | Q38SD2 | 0.49 |
STK40 | 83931 | Q8N2I9 | 0.49 |
UBL7 | 84993 | Q96S82 | 0.49 |
MSN | 4478 | P26038 | 0.52 |
VAV2 | 7410 | P52735 | 0.63 |
PPARG | 5468 | P37231 | 0.65 |
MARK3 | 4140 | P27448 | 0.68 |
CDK2 | 1017 | P24941 | 0.71 |
ANXA1 | 301 | P04083 | 0.76 |
ANXA2 | 302 | P07355 | 0.76 |
GSN | 2934 | P06396 | 0.76 |
KRT18 | 3875 | P05783 | 0.76 |
S100A8 | 6279 | P05109 | 0.76 |
VIL1 | 7429 | P09327 | 0.76 |
PABPC4 | 8761 | Q13310 | 0.76 |
RASGRP1 | 10125 | O95267 | 0.76 |
IKBKB | 3551 | O14920 | 0.77 |
CDK6 | 1021 | Q00534 | 0.81 |
CHUK | 1147 | O15111 | 0.83 |
IKBKG | 8517 | Q9Y6K9 | 0.83 |
MAP3K7 | 6885 | O43318 | 0.85 |
VCP | 7415 | P55072 | 0.86 |
ABL1 | 25 | P00519 | 0.49 |
CSNK1D | 1453 | P48730 | 0.49 |
CSNK1E | 1454 | P49674 | 0.49 |
GAK | 2580 | O14976 | 0.49 |
PRKCI | 5584 | P41743 | 0.49 |
PKN2 | 5586 | Q16513 | 0.49 |
MAPK8 | 5599 | P45983 | 0.49 |
CDK13 | 8621 | Q14004 | 0.49 |
PAK4 | 10298 | O96013 | 0.49 |
DDX53 | 168400 | Q86TM3 | 0.49 |
PPP2CA | 5515 | P67775 | 0.55 |
ECHS1 | 1892 | P30084 | 0.63 |
FNTB | 2342 | P49356 | 0.63 |
GCH1 | 2643 | P30793 | 0.63 |
GRB2 | 2885 | P62993 | 0.63 |
MAGEA6 | 4105 | P43360 | 0.63 |
MAGOH | 4116 | P61326 | 0.63 |
NOS2 | 4843 | P35228 | 0.63 |
PPM1A | 5494 | P35813 | 0.63 |
SKI | 6497 | P12755 | 0.63 |
SUMO3 | 6612 | P55854 | 0.63 |
SUMO2 | 6613 | P61956 | 0.63 |
BCE1 | 7091 | O60756 | 0.63 |
SUMO1 | 7341 | P63165 | 0.63 |
VHL | 7428 | P40337 | 0.63 |
XPO1 | 7514 | O14980 | 0.63 |
YWHAE | 7531 | P62258 | 0.63 |
HIST1H3A | 8350 | P68431 | 0.63 |
HERC2 | 8924 | O95714 | 0.63 |
AURKB | 9212 | Q96GD4 | 0.63 |
EIF4A3 | 9775 | P38919 | 0.63 |
PAN2 | 9924 | Q504Q3 | 0.63 |
NR1I3 | 9970 | Q14994 | 0.63 |
FBXO6 | 26270 | Q9NRD1 | 0.63 |
FAM63B | 54629 | Q8NBR6 | 0.63 |
ARRB1 | 408 | P49407 | 0.72 |
ARRB2 | 409 | P32121 | 0.83 |
ISG15 | 9636 | P05161 | 0.86 |