Protein Description

Gene Symbol PPM1B
Entrez ID 5495
Uniprot ID O75688
Description protein phosphatase, Mg2+/Mn2+ dependent 1B
Chromosomal Location chr2: 44,167,969-44,244,384
Ontology GO ID GO Term Definition Evidence

BP

GO:0006470

protein dephosphorylation

The process of removing one or more phosphoric residues from a protein.

IMP

BP

GO:0006499

N-terminal protein myristoylation

The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.

ISS

BP

GO:0032688

negative regulation of interferon-beta production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.

IMP

BP

GO:0035970

peptidyl-threonine dephosphorylation

The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.

IDA

BP

GO:0042347

negative regulation of NF-kappaB import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

IMP

BP

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.

IMP

BP

GO:0050687

negative regulation of defense response to virus

Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.

IMP

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

ISS|TAS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

ISS

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IEA

MF

GO:0004722

protein serine/threonine phosphatase activity

Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0030145

manganese ion binding

Interacting selectively and non-covalently with manganese (Mn) ions.

IEA

Domain ID Description

IPR000222

PPM-type phosphatase, divalent cation binding

IPR001932

PPM-type phosphatase domain

IPR012911

Protein serine/threonine phosphatase 2C, C-terminal

IPR015655

Protein phosphatase 2C family

Pathway ID Pathway Term Pathway Source

hsa04010

MAPK signaling pathway

KEGG

WP382

MAPK Signaling Pathway

WikiPathways

UMLS CUI UMLS Term

C0151744

Myocardial Ischemia

Tissue Cell Type

cerebellum

Purkinje cells

small intestine

glandular cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

CDK1

983

P06493

0.49

CDK9

1025

P50750

0.49

FOS

2353

P01100

0.49

NAA10

8260

P41227

0.49

CASK

8573

O14936

0.49

MAP4K5

11183

Q9Y4K4

0.49

LRRK1

79705

Q38SD2

0.49

STK40

83931

Q8N2I9

0.49

UBL7

84993

Q96S82

0.49

MSN

4478

P26038

0.52

VAV2

7410

P52735

0.63

PPARG

5468

P37231

0.65

MARK3

4140

P27448

0.68

CDK2

1017

P24941

0.71

ANXA1

301

P04083

0.76

ANXA2

302

P07355

0.76

GSN

2934

P06396

0.76

KRT18

3875

P05783

0.76

S100A8

6279

P05109

0.76

VIL1

7429

P09327

0.76

PABPC4

8761

Q13310

0.76

RASGRP1

10125

O95267

0.76

IKBKB

3551

O14920

0.77

CDK6

1021

Q00534

0.81

CHUK

1147

O15111

0.83

IKBKG

8517

Q9Y6K9

0.83

MAP3K7

6885

O43318

0.85

VCP

7415

P55072

0.86

ABL1

25

P00519

0.49

CSNK1D

1453

P48730

0.49

CSNK1E

1454

P49674

0.49

GAK

2580

O14976

0.49

PRKCI

5584

P41743

0.49

PKN2

5586

Q16513

0.49

MAPK8

5599

P45983

0.49

CDK13

8621

Q14004

0.49

PAK4

10298

O96013

0.49

DDX53

168400

Q86TM3

0.49

PPP2CA

5515

P67775

0.55

ECHS1

1892

P30084

0.63

FNTB

2342

P49356

0.63

GCH1

2643

P30793

0.63

GRB2

2885

P62993

0.63

MAGEA6

4105

P43360

0.63

MAGOH

4116

P61326

0.63

NOS2

4843

P35228

0.63

PPM1A

5494

P35813

0.63

SKI

6497

P12755

0.63

SUMO3

6612

P55854

0.63

SUMO2

6613

P61956

0.63

BCE1

7091

O60756

0.63

SUMO1

7341

P63165

0.63

VHL

7428

P40337

0.63

XPO1

7514

O14980

0.63

YWHAE

7531

P62258

0.63

HIST1H3A

8350

P68431

0.63

HERC2

8924

O95714

0.63

AURKB

9212

Q96GD4

0.63

EIF4A3

9775

P38919

0.63

PAN2

9924

Q504Q3

0.63

NR1I3

9970

Q14994

0.63

FBXO6

26270

Q9NRD1

0.63

FAM63B

54629

Q8NBR6

0.63

ARRB1

408

P49407

0.72

ARRB2

409

P32121

0.83

ISG15

9636

P05161

0.86