Gene Symbol | PPM1B |
Entrez ID | 5495 |
Uniprot ID | O75688 |
Description | protein phosphatase, Mg2+/Mn2+ dependent 1B |
Chromosomal Location | chr2: 44,167,969-44,244,384 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006470 |
protein dephosphorylation |
The process of removing one or more phosphoric residues from a protein. |
IMP |
BP |
GO:0006499 |
N-terminal protein myristoylation |
The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein. |
ISS |
BP |
GO:0032688 |
negative regulation of interferon-beta production |
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production. |
IMP |
BP |
GO:0035970 |
peptidyl-threonine dephosphorylation |
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. |
IDA |
BP |
GO:0042347 |
negative regulation of NF-kappaB import into nucleus |
Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. |
IMP |
BP |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. |
IMP |
BP |
GO:0050687 |
negative regulation of defense response to virus |
Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. |
IMP |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
ISS|TAS |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
ISS |
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IEA |
MF |
GO:0004722 |
protein serine/threonine phosphatase activity |
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0030145 |
manganese ion binding |
Interacting selectively and non-covalently with manganese (Mn) ions. |
IEA |
Domain ID | Description |
---|---|
IPR000222 |
PPM-type phosphatase, divalent cation binding |
IPR001932 |
PPM-type phosphatase domain |
IPR012911 |
Protein serine/threonine phosphatase 2C, C-terminal |
IPR015655 |
Protein phosphatase 2C family |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04010 |
MAPK signaling pathway |
KEGG |
WP382 |
MAPK Signaling Pathway |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0151744 |
Myocardial Ischemia |
Tissue | Cell Type |
---|---|
cerebellum |
Purkinje cells |
small intestine |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CDK1 |
983 |
P06493 |
0.49 |
CDK9 |
1025 |
P50750 |
0.49 |
FOS |
2353 |
P01100 |
0.49 |
NAA10 |
8260 |
P41227 |
0.49 |
CASK |
8573 |
O14936 |
0.49 |
MAP4K5 |
11183 |
Q9Y4K4 |
0.49 |
LRRK1 |
79705 |
Q38SD2 |
0.49 |
STK40 |
83931 |
Q8N2I9 |
0.49 |
UBL7 |
84993 |
Q96S82 |
0.49 |
MSN |
4478 |
P26038 |
0.52 |
VAV2 |
7410 |
P52735 |
0.63 |
PPARG |
5468 |
P37231 |
0.65 |
MARK3 |
4140 |
P27448 |
0.68 |
CDK2 |
1017 |
P24941 |
0.71 |
ANXA1 |
301 |
P04083 |
0.76 |
ANXA2 |
302 |
P07355 |
0.76 |
GSN |
2934 |
P06396 |
0.76 |
KRT18 |
3875 |
P05783 |
0.76 |
S100A8 |
6279 |
P05109 |
0.76 |
VIL1 |
7429 |
P09327 |
0.76 |
PABPC4 |
8761 |
Q13310 |
0.76 |
RASGRP1 |
10125 |
O95267 |
0.76 |
IKBKB |
3551 |
O14920 |
0.77 |
CDK6 |
1021 |
Q00534 |
0.81 |
CHUK |
1147 |
O15111 |
0.83 |
IKBKG |
8517 |
Q9Y6K9 |
0.83 |
MAP3K7 |
6885 |
O43318 |
0.85 |
VCP |
7415 |
P55072 |
0.86 |
ABL1 |
25 |
P00519 |
0.49 |
CSNK1D |
1453 |
P48730 |
0.49 |
CSNK1E |
1454 |
P49674 |
0.49 |
GAK |
2580 |
O14976 |
0.49 |
PRKCI |
5584 |
P41743 |
0.49 |
PKN2 |
5586 |
Q16513 |
0.49 |
MAPK8 |
5599 |
P45983 |
0.49 |
CDK13 |
8621 |
Q14004 |
0.49 |
PAK4 |
10298 |
O96013 |
0.49 |
DDX53 |
168400 |
Q86TM3 |
0.49 |
PPP2CA |
5515 |
P67775 |
0.55 |
ECHS1 |
1892 |
P30084 |
0.63 |
FNTB |
2342 |
P49356 |
0.63 |
GCH1 |
2643 |
P30793 |
0.63 |
GRB2 |
2885 |
P62993 |
0.63 |
MAGEA6 |
4105 |
P43360 |
0.63 |
MAGOH |
4116 |
P61326 |
0.63 |
NOS2 |
4843 |
P35228 |
0.63 |
PPM1A |
5494 |
P35813 |
0.63 |
SKI |
6497 |
P12755 |
0.63 |
SUMO3 |
6612 |
P55854 |
0.63 |
SUMO2 |
6613 |
P61956 |
0.63 |
BCE1 |
7091 |
O60756 |
0.63 |
SUMO1 |
7341 |
P63165 |
0.63 |
VHL |
7428 |
P40337 |
0.63 |
XPO1 |
7514 |
O14980 |
0.63 |
YWHAE |
7531 |
P62258 |
0.63 |
HIST1H3A |
8350 |
P68431 |
0.63 |
HERC2 |
8924 |
O95714 |
0.63 |
AURKB |
9212 |
Q96GD4 |
0.63 |
EIF4A3 |
9775 |
P38919 |
0.63 |
PAN2 |
9924 |
Q504Q3 |
0.63 |
NR1I3 |
9970 |
Q14994 |
0.63 |
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
FAM63B |
54629 |
Q8NBR6 |
0.63 |
ARRB1 |
408 |
P49407 |
0.72 |
ARRB2 |
409 |
P32121 |
0.83 |
ISG15 |
9636 |
P05161 |
0.86 |