Protein Description

Gene Symbol PPARG
Entrez ID 5468
Uniprot ID P37231
Description peroxisome proliferator-activated receptor gamma
Chromosomal Location chr3: 12,287,368-12,434,356
Ontology GO ID GO Term Definition Evidence

BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA|ISS

BP

GO:0001890

placenta development

The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

ISS

BP

GO:0002674

negative regulation of acute inflammatory response

Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.

IEA

BP

GO:0006367

transcription initiation from RNA polymerase II promoter

Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.

TAS

BP

GO:0006629

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

TAS

BP

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.

IDA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

IDA

BP

GO:0007186

G-protein coupled receptor signaling pathway

A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).

IEA

BP

GO:0007507

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

IEA

BP

GO:0007584

response to nutrient

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

TAS

BP

GO:0008217

regulation of blood pressure

Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

IMP

BP

GO:0009409

response to cold

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.

IEA

BP

GO:0009612

response to mechanical stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

IEA

BP

GO:0010742

macrophage derived foam cell differentiation

The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

IDA

BP

GO:0010745

negative regulation of macrophage derived foam cell differentiation

Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

IC|IDA

BP

GO:0010871

negative regulation of receptor biosynthetic process

Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IDA

BP

GO:0010887

negative regulation of cholesterol storage

Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

IDA

BP

GO:0010891

negative regulation of sequestering of triglyceride

Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.

IDA

BP

GO:0015909

long-chain fatty acid transport

The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

ISS

BP

GO:0019395

fatty acid oxidation

The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.

IEA

BP

GO:0030224

monocyte differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.

IDA

BP

GO:0030308

negative regulation of cell growth

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

IEA

BP

GO:0030855

epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

ISS

BP

GO:0031000

response to caffeine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.

IEA

BP

GO:0031100

animal organ regeneration

The regrowth of a lost or destroyed animal organ.

IEA

BP

GO:0032526

response to retinoic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.

IDA

BP

GO:0032869

cellular response to insulin stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.

IMP

BP

GO:0032966

negative regulation of collagen biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.

IEA

BP

GO:0033189

response to vitamin A

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.

IEA

BP

GO:0033993

response to lipid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.

ISS

BP

GO:0035357

peroxisome proliferator activated receptor signaling pathway

The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes.

IMP

BP

GO:0035902

response to immobilization stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.

IEA

BP

GO:0042493

response to drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

IEA

BP

GO:0042593

glucose homeostasis

Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.

IMP

BP

GO:0042594

response to starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.

IEA

BP

GO:0042752

regulation of circadian rhythm

Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.

ISS

BP

GO:0042953

lipoprotein transport

The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IDA

BP

GO:0043401

steroid hormone mediated signaling pathway

A series of molecular signals mediated by a steroid hormone binding to a receptor.

IEA

BP

GO:0043627

response to estrogen

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.

IEA

BP

GO:0045087

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

TAS

BP

GO:0045165

cell fate commitment

The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

ISS

BP

GO:0045600

positive regulation of fat cell differentiation

Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.

ISS

BP

GO:0045713

low-density lipoprotein particle receptor biosynthetic process

The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells.

IDA

BP

GO:0045892

negative regulation of transcription, DNA-templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

ISS

BP

GO:0045893

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

ISS

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA|IMP

BP

GO:0046321

positive regulation of fatty acid oxidation

Any process that activates or increases the frequency, rate or extent of fatty acid oxidation.

IEA

BP

GO:0048469

cell maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.

IDA

BP

GO:0048511

rhythmic process

Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.

IEA

BP

GO:0048662

negative regulation of smooth muscle cell proliferation

Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.

IDA

BP

GO:0048714

positive regulation of oligodendrocyte differentiation

Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.

IEA

BP

GO:0050872

white fat cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole.

ISS|TAS

BP

GO:0051091

positive regulation of sequence-specific DNA binding transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

IDA

BP

GO:0051974

negative regulation of telomerase activity

Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

IEA

BP

GO:0055088

lipid homeostasis

Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.

TAS

BP

GO:0055098

response to low-density lipoprotein particle

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.

IDA

BP

GO:0060100

positive regulation of phagocytosis, engulfment

Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.

IEA

BP

GO:0060336

negative regulation of interferon-gamma-mediated signaling pathway

Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.

IMP

BP

GO:0060694

regulation of cholesterol transporter activity

Any process that modulates the rate, frequency, or extent of cholesterol transporter activity.

IC

BP

GO:0060850

regulation of transcription involved in cell fate commitment

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate.

ISS

BP

GO:0071300

cellular response to retinoic acid

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.

IEA

BP

GO:0071306

cellular response to vitamin E

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus.

IEA

BP

GO:0071380

cellular response to prostaglandin E stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.

IEA

BP

GO:0071455

cellular response to hyperoxia

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.

IEA

BP

GO:1901558

response to metformin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus.

IEA

BP

GO:2000230

negative regulation of pancreatic stellate cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

ISS

CC

GO:0043231

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

IDA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IEA

CC

GO:0090575

RNA polymerase II transcription factor complex

A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II.

IDA

MF

GO:0001046

core promoter sequence-specific DNA binding

Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.

ISS

MF

GO:0003677

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

IDA|ISS

MF

GO:0003682

chromatin binding

Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

ISS

MF

GO:0003700

transcription factor activity, sequence-specific DNA binding

Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

IDA|ISS

MF

GO:0003707

steroid hormone receptor activity

Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.

IEA

MF

GO:0004879

RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding

Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.

IDA

MF

GO:0004955

prostaglandin receptor activity

Combining with a prostaglandin (PG) to initiate a change in cell activity.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008134

transcription factor binding

Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.

IPI

MF

GO:0008144

drug binding

Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.

IDA

MF

GO:0008270

zinc ion binding

Interacting selectively and non-covalently with zinc (Zn) ions.

IEA

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0019903

protein phosphatase binding

Interacting selectively and non-covalently with any protein phosphatase.

IEA

MF

GO:0030331

estrogen receptor binding

Interacting selectively and non-covalently with an estrogen receptor.

IEA

MF

GO:0030374

ligand-dependent nuclear receptor transcription coactivator activity

The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.

IDA

MF

GO:0033613

activating transcription factor binding

Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.

IDA

MF

GO:0043565

sequence-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

IDA

MF

GO:0044212

transcription regulatory region DNA binding

Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.

IDA|ISS

MF

GO:0046965

retinoid X receptor binding

Interacting selectively and non-covalently with a retinoid X receptor.

IDA

MF

GO:0050544

arachidonic acid binding

Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.

ISS

MF

GO:0051393

alpha-actinin binding

Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.

IPI

Domain ID Description

IPR000536

Nuclear hormone receptor, ligand-binding domain

IPR001628

Zinc finger, nuclear hormone receptor-type

IPR001723

Nuclear hormone receptor

IPR003074

Peroxisome proliferator-activated receptor

IPR003077

Peroxisome proliferator-activated receptor, gamma

IPR013088

Zinc finger, NHR/GATA-type

IPR022590

Peroxisome proliferator-activated receptor gamma, N-terminal

Pathway ID Pathway Term Pathway Source

hsa03320

PPAR signaling pathway

KEGG

hsa04152

AMPK signaling pathway

KEGG

hsa04211

Longevity regulating pathway

KEGG

hsa04380

Osteoclast differentiation

KEGG

hsa05016

Huntington's disease

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05202

Transcriptional misregulation in cancer

KEGG

hsa05216

Thyroid cancer

KEGG

WP1982

Sterol Regulatory Element-Binding Proteins (SREBP) signalling

WikiPathways

WP3599

Transcription factor regulation in adipogenesis

WikiPathways

WP3630

NAD metabolism, sirtuins and aging

WikiPathways

WP299

Nuclear Receptors in Lipid Metabolism and Toxicity

WikiPathways

WP236

Adipogenesis

WikiPathways

WP3942

PPAR signaling pathway

WikiPathways

WP3946

White fat cell differentiation

WikiPathways

WP3594

Circadian rythm related genes

WikiPathways

WP170

Nuclear Receptors

WikiPathways

WP2895

Differentiation of white and brown adipocyte

WikiPathways

WP363

Wnt Signaling Pathway Netpath

WikiPathways

h_pparPathway

Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression

BioCarta

h_nuclearRsPathway

Nuclear Receptors in Lipid Metabolism and Toxicity

BioCarta

h_ppargPathway

Role of PPAR-gamma Coactivators in Obesity and Thermogenesis

BioCarta

h_vobesityPathway

Visceral Fat Deposits and the Metabolic Syndrome

BioCarta

UMLS CUI UMLS Term

C0001418

Adenocarcinoma

C0002395

Alzheimer'S Disease

C0004153

Atherosclerosis

C0004763

Barrett Esophagus

C0009375

Colonic Neoplasms

C0009404

Colorectal Neoplasms

C0010346

Crohn Disease

C0011849

Diabetes Mellitus

C0011853

Diabetes Mellitus, Experimental

C0011859

Lipoatrophic Diabetes Mellitus

C0011860

Diabetes Mellitus, Non-Insulin-Dependent

C0017638

Glioma

C0017658

Glomerulonephritis

C0020538

Hypertensive Disease

C0021368

Inflammation

C0021655

Insulin Resistance

C0022116

Ischemia

C0023794

Lipoidosis

C0023903

Liver Neoplasms

C0025202

Melanoma

C0025517

Metabolic Diseases

C0027746

Nerve Degeneration

C0028754

Obesity

C0028756

Obesity, Morbid

C0029408

Degenerative Polyarthritis

C0030297

Pancreatic Neoplasm

C0033860

Psoriasis

C0035126

Reperfusion Injury

C0038356

Stomach Neoplasms

C0040136

Thyroid Neoplasm

C0079772

T-Cell Lymphoma

C0085413

Polycystic Kidney, Autosomal Dominant

C0206726

Gliosarcoma

C0221406

Pituitary-Dependent Cushing'S Disease

C0236811

Chronobiology Disorders

C0242339

Dyslipidemias

C0242488

Acute Lung Injury

C0271694

Familial Partial Lipodystrophy

C0282548

Leukostasis

C0334588

Giant Cell Glioblastoma

C0860207

Drug-Induced Liver Injury

C1720861

Familial Partial Lipodystrophy, Type 3

C2239176

Liver Carcinoma

C2609414

Acute Kidney Injury

Tissue Cell Type

appendix

lymphoid tissue

cervix, uterine

squamous epithelial cells

colon

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

oral mucosa

squamous epithelial cells

placenta

trophoblastic cells

rectum

glandular cells

stomach

glandular cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

Database Name

PhenomicDB

OMIM

DisGeNET

DISEASES

DGA

Pubmed ID Author Year Title

15308691

Jansen et al.

2004

Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

ATP6V1C1

528

P21283

0.49

KAT2A

2648

Q92830

0.49

NR4A1

3164

P22736

0.49

IKBKB

3551

O14920

0.49

JUN

3725

P05412

0.49

KIF11

3832

P52732

0.49

STMN1

3925

P16949

0.49

NR4A2

4929

P43354

0.49

PRNP

5621

P04156

0.49

PSMD1

5707

Q99460

0.49

USP11

8237

P51784

0.49

MAP4K4

9448

O95819

0.49

NFE2L3

9603

Q9Y4A8

0.49

OPTN

10133

Q96CV9

0.49

PHB2

11331

Q99623

0.49

CCDC88A

55704

Q3V6T2

0.49

TUBB

203068

P07437

0.49

APP

351

P05067

0.56

IGFBP3

3486

P17936

0.56

JUND

3727

P17535

0.56

TFAP2A

7020

P05549

0.56

SETDB1

9869

Q15047

0.56

CHD7

55636

Q9P2D1

0.56

PDIA2

64714

Q13087

0.56

ALOX15B

247

O15296

0.63

KIF1A

547

Q12756

0.63

ESR1

2099

P03372

0.63

ESR2

2100

Q92731

0.63

SMAD2

4087

Q15796

0.63

SMAD3

4088

P84022

0.63

MDM2

4193

Q00987

0.63

PRKAA1

5562

Q13131

0.63

PRKAA2

5563

P54646

0.63

RBBP5

5929

Q15291

0.63

TCF4

6925

P15884

0.63

XRCC5

7520

P13010

0.63

ZYX

7791

Q15942

0.63

ASH2L

9070

Q9UBL3

0.63

ZBTB5

9925

O15062

0.63

NR2E3

10002

Q9Y5X4

0.63

RANBP9

10048

Q96S59

0.63

COPS5

10987

Q92905

0.63

PAXIP1

22976

Q6ZW49

0.63

KDM4C

23081

Q9H3R0

0.63

MAFF

23764

Q9ULX9

0.63

ZBTB20

26137

Q9HC78

0.63

FHOD1

29109

Q9Y613

0.63

MIF4GD

57409

A9UHW6

0.63

ZBTB3

79842

Q9H5J0

0.63

ZNF496

84838

Q96IT1

0.63

ZBTB9

221504

Q96C00

0.63

ZSCAN1

284312

Q8NBB4

0.63

SERPINH1

871

P50454

0.65

EGFR

1956

P00533

0.65

FOXO1

2308

Q12778

0.65

NFKBIB

4793

Q15653

0.65

USP7

7874

Q93009

0.65

HELZ2

85441

Q9BYK8

0.65

CDC34

997

P49427

0.66

KAT5

10524

Q92993

0.66

STAT6

6778

P42226

0.68

TNP1

7141

P09430

0.68

VDR

7421

P11473

0.68

KCTD13

253980

Q8WZ19

0.68

MUC1

4582

P15941

0.70

SMARCA4

6597

P51532

0.72

PIAS1

8554

O75925

0.72

KLF5

688

Q13887

0.73

FABP1

2168

P07148

0.73

STAT5A

6776

P42229

0.73

SUMO1

7341

P63165

0.74

SFPQ

6421

P23246

0.75

LMO4

8543

P61968

0.75

TRIM24

8805

O15164

0.75

TRIP4

9325

Q15650

0.75

HDAC4

9759

P56524

0.75

JMJD1C

221037

Q15652

0.75

RXRG

6258

P48443

0.76

CEBPB

1051

P17676

0.78

HDAC1

3065

Q13547

0.78

MAP2K1

5604

Q02750

0.78

RB1

5925

P06400

0.78

GRIP1

23426

Q9Y3R0

0.78

SP1

6667

P08047

0.79

ZNHIT3

9326

Q15649

0.80

CAV1

857

Q03135

0.83

NFE2L2

4780

Q16236

0.85

CDK5

1020

Q00535

0.86

CREBBP

1387

Q92793

0.88

PPARG

5468

P37231

0.88

RXRA

6256

P19793

0.90

NCOA1

8648

Q15788

0.90

DUT

1854

P33316

0.49

HSP90AB1

3326

P08238

0.49

MARCH6

10299

O60337

0.49

HNRNPUL1

11100

Q9BUJ2

0.49

CHD8

57680

Q9HCK8

0.49

GADD45B

4616

O75293

0.52

MAPK8

5599

P45983

0.55

ANP32A

8125

P39687

0.56

CEP350

9857

Q5VT06

0.56

BCAS2

10286

O75934

0.56

RAD54L2

23132

Q9Y4B4

0.56

ROBO4

54538

Q8WZ75

0.56

LRIF1

55791

Q5T3J3

0.56

EZH2

2146

Q15910

0.63

XRCC6

2547

P12956

0.63

NR3C1

2908

P04150

0.63

HTT

3064

P42858

0.63

MECP2

4204

P51608

0.63

CIITA

4261

P33076

0.63

MSX2

4488

P35548

0.63

PML

5371

P29590

0.63

RFX5

5993

P48382

0.63

SVIL

6840

O95425

0.63

XPO1

7514

O14980

0.63

YWHAB

7529

P31946

0.63

YWHAG

7532

P61981

0.63

RANBP3

8498

Q9H6Z4

0.63

MED14

9282

O60244

0.63

ZFYVE9

9372

O95405

0.63

CNOT1

23019

A5YKK6

0.63

NSD1

64324

Q96L73

0.63

JAZF1

221895

Q86VZ6

0.63

NEDD4

4734

P46934

0.65

PPM1B

5495

O75688

0.65

SYT1

6857

P21579

0.65

KLF4

9314

O43474

0.65

NFKB1

4790

P19838

0.68

PIN1

5300

Q13526

0.68

NLK

51701

Q9UBE8

0.68

SMARCD3

6604

Q6STE5

0.70

CLU

1191

P10909

0.72

PRKCA

5578

P17252

0.72

BRD8

10902

Q9H0E9

0.73

CTNNB1

1499

P35222

0.74

POU1F1

5449

P28069

0.75

MAPK1

5594

P28482

0.78

UBE2I

7329

P63279

0.84

NCOA6

23054

Q14686

0.84

NR0B1

190

P51843

0.85

HMGA1

3159

P17096

0.85

MED24

9862

O75448

0.85

DNTTIP2

30836

Q5QJE6

0.85

GADD45G

10912

O95257

0.86

RXRB

6257

P28702

0.87

EDF1

8721

O60869

0.88

NCOA4

8031

Q13772

0.89

NCOA3

8202

Q9Y6Q9

0.89

NR0B2

8431

Q15466

0.89

NCOR1

9611

O75376

0.89

EP300

2033

Q09472

0.90

MED1

5469

Q15648

0.90

NRIP1

8204

P48552

0.90

NCOA2

10499

Q15596

0.90

PPARGC1A

10891

Q9UBK2

0.90

RELA

5970

Q04206

0.93

NCOR2

9612

Q9Y618

0.94

HDAC3

8841

O15379

0.96