Gene Symbol | PPARG |
Entrez ID | 5468 |
Uniprot ID | P37231 |
Description | peroxisome proliferator-activated receptor gamma |
Chromosomal Location | chr3: 12,287,368-12,434,356 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA|ISS |
BP |
GO:0001890 |
placenta development |
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. |
ISS |
BP |
GO:0002674 |
negative regulation of acute inflammatory response |
Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. |
IEA |
BP |
GO:0006367 |
transcription initiation from RNA polymerase II promoter |
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. |
TAS |
BP |
GO:0006629 |
lipid metabolic process |
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
TAS |
BP |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. |
IDA |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
IDA |
BP |
GO:0007186 |
G-protein coupled receptor signaling pathway |
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). |
IEA |
BP |
GO:0007507 |
heart development |
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
IEA |
BP |
GO:0007584 |
response to nutrient |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. |
TAS |
BP |
GO:0008217 |
regulation of blood pressure |
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. |
IMP |
BP |
GO:0009409 |
response to cold |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. |
IEA |
BP |
GO:0009612 |
response to mechanical stimulus |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. |
IEA |
BP |
GO:0010742 |
macrophage derived foam cell differentiation |
The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. |
IDA |
BP |
GO:0010745 |
negative regulation of macrophage derived foam cell differentiation |
Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. |
IC|IDA |
BP |
GO:0010871 |
negative regulation of receptor biosynthetic process |
Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
IDA |
BP |
GO:0010887 |
negative regulation of cholesterol storage |
Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
IDA |
BP |
GO:0010891 |
negative regulation of sequestering of triglyceride |
Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. |
IDA |
BP |
GO:0015909 |
long-chain fatty acid transport |
The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
ISS |
BP |
GO:0019395 |
fatty acid oxidation |
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. |
IEA |
BP |
GO:0030224 |
monocyte differentiation |
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. |
IDA |
BP |
GO:0030308 |
negative regulation of cell growth |
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. |
IEA |
BP |
GO:0030855 |
epithelial cell differentiation |
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. |
ISS |
BP |
GO:0031000 |
response to caffeine |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. |
IEA |
BP |
GO:0031100 |
animal organ regeneration |
The regrowth of a lost or destroyed animal organ. |
IEA |
BP |
GO:0032526 |
response to retinoic acid |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. |
IDA |
BP |
GO:0032869 |
cellular response to insulin stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
IMP |
BP |
GO:0032966 |
negative regulation of collagen biosynthetic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. |
IEA |
BP |
GO:0033189 |
response to vitamin A |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. |
IEA |
BP |
GO:0033993 |
response to lipid |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. |
ISS |
BP |
GO:0035357 |
peroxisome proliferator activated receptor signaling pathway |
The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes. |
IMP |
BP |
GO:0035902 |
response to immobilization stress |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. |
IEA |
BP |
GO:0042493 |
response to drug |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
IEA |
BP |
GO:0042593 |
glucose homeostasis |
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. |
IMP |
BP |
GO:0042594 |
response to starvation |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. |
IEA |
BP |
GO:0042752 |
regulation of circadian rhythm |
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. |
ISS |
BP |
GO:0042953 |
lipoprotein transport |
The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
IDA |
BP |
GO:0043401 |
steroid hormone mediated signaling pathway |
A series of molecular signals mediated by a steroid hormone binding to a receptor. |
IEA |
BP |
GO:0043627 |
response to estrogen |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. |
IEA |
BP |
GO:0045087 |
innate immune response |
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
TAS |
BP |
GO:0045165 |
cell fate commitment |
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. |
ISS |
BP |
GO:0045600 |
positive regulation of fat cell differentiation |
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. |
ISS |
BP |
GO:0045713 |
low-density lipoprotein particle receptor biosynthetic process |
The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells. |
IDA |
BP |
GO:0045892 |
negative regulation of transcription, DNA-templated |
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
ISS |
BP |
GO:0045893 |
positive regulation of transcription, DNA-templated |
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
ISS |
BP |
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA|IMP |
BP |
GO:0046321 |
positive regulation of fatty acid oxidation |
Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. |
IEA |
BP |
GO:0048469 |
cell maturation |
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. |
IDA |
BP |
GO:0048511 |
rhythmic process |
Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. |
IEA |
BP |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. |
IDA |
BP |
GO:0048714 |
positive regulation of oligodendrocyte differentiation |
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. |
IEA |
BP |
GO:0050872 |
white fat cell differentiation |
The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. |
ISS|TAS |
BP |
GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
IDA |
BP |
GO:0051974 |
negative regulation of telomerase activity |
Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
IEA |
BP |
GO:0055088 |
lipid homeostasis |
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. |
TAS |
BP |
GO:0055098 |
response to low-density lipoprotein particle |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. |
IDA |
BP |
GO:0060100 |
positive regulation of phagocytosis, engulfment |
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. |
IEA |
BP |
GO:0060336 |
negative regulation of interferon-gamma-mediated signaling pathway |
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor. |
IMP |
BP |
GO:0060694 |
regulation of cholesterol transporter activity |
Any process that modulates the rate, frequency, or extent of cholesterol transporter activity. |
IC |
BP |
GO:0060850 |
regulation of transcription involved in cell fate commitment |
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate. |
ISS |
BP |
GO:0071300 |
cellular response to retinoic acid |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. |
IEA |
BP |
GO:0071306 |
cellular response to vitamin E |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. |
IEA |
BP |
GO:0071380 |
cellular response to prostaglandin E stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. |
IEA |
BP |
GO:0071455 |
cellular response to hyperoxia |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. |
IEA |
BP |
GO:1901558 |
response to metformin |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus. |
IEA |
BP |
GO:2000230 |
negative regulation of pancreatic stellate cell proliferation |
Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation. |
IEA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
CC |
GO:0005794 |
Golgi apparatus |
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
ISS |
CC |
GO:0043231 |
intracellular membrane-bounded organelle |
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
IDA |
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
IEA |
CC |
GO:0090575 |
RNA polymerase II transcription factor complex |
A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II. |
IDA |
MF |
GO:0001046 |
core promoter sequence-specific DNA binding |
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. |
ISS |
MF |
GO:0003677 |
DNA binding |
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
IDA|ISS |
MF |
GO:0003682 |
chromatin binding |
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
ISS |
MF |
GO:0003700 |
transcription factor activity, sequence-specific DNA binding |
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
IDA|ISS |
MF |
GO:0003707 |
steroid hormone receptor activity |
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. |
IEA |
MF |
GO:0004879 |
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding |
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
IDA |
MF |
GO:0004955 |
prostaglandin receptor activity |
Combining with a prostaglandin (PG) to initiate a change in cell activity. |
TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0008134 |
transcription factor binding |
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. |
IPI |
MF |
GO:0008144 |
drug binding |
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. |
IDA |
MF |
GO:0008270 |
zinc ion binding |
Interacting selectively and non-covalently with zinc (Zn) ions. |
IEA |
MF |
GO:0019899 |
enzyme binding |
Interacting selectively and non-covalently with any enzyme. |
IPI |
MF |
GO:0019903 |
protein phosphatase binding |
Interacting selectively and non-covalently with any protein phosphatase. |
IEA |
MF |
GO:0030331 |
estrogen receptor binding |
Interacting selectively and non-covalently with an estrogen receptor. |
IEA |
MF |
GO:0030374 |
ligand-dependent nuclear receptor transcription coactivator activity |
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. |
IDA |
MF |
GO:0033613 |
activating transcription factor binding |
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription. |
IDA |
MF |
GO:0043565 |
sequence-specific DNA binding |
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
IDA |
MF |
GO:0044212 |
transcription regulatory region DNA binding |
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
IDA|ISS |
MF |
GO:0046965 |
retinoid X receptor binding |
Interacting selectively and non-covalently with a retinoid X receptor. |
IDA |
MF |
GO:0050544 |
arachidonic acid binding |
Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. |
ISS |
MF |
GO:0051393 |
alpha-actinin binding |
Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. |
IPI |
Domain ID | Description |
---|---|
IPR000536 |
Nuclear hormone receptor, ligand-binding domain |
IPR001628 |
Zinc finger, nuclear hormone receptor-type |
IPR001723 |
Nuclear hormone receptor |
IPR003074 |
Peroxisome proliferator-activated receptor |
IPR003077 |
Peroxisome proliferator-activated receptor, gamma |
IPR013088 |
Zinc finger, NHR/GATA-type |
IPR022590 |
Peroxisome proliferator-activated receptor gamma, N-terminal |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa03320 |
PPAR signaling pathway |
KEGG |
hsa04152 |
AMPK signaling pathway |
KEGG |
hsa04211 |
Longevity regulating pathway |
KEGG |
hsa04380 |
Osteoclast differentiation |
KEGG |
hsa05016 |
Huntington's disease |
KEGG |
hsa05200 |
Pathways in cancer |
KEGG |
hsa05202 |
Transcriptional misregulation in cancer |
KEGG |
hsa05216 |
Thyroid cancer |
KEGG |
WP1982 |
Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
WikiPathways |
WP3599 |
Transcription factor regulation in adipogenesis |
WikiPathways |
WP3630 |
NAD metabolism, sirtuins and aging |
WikiPathways |
WP299 |
Nuclear Receptors in Lipid Metabolism and Toxicity |
WikiPathways |
WP236 |
Adipogenesis |
WikiPathways |
WP3942 |
PPAR signaling pathway |
WikiPathways |
WP3946 |
White fat cell differentiation |
WikiPathways |
WP3594 |
Circadian rythm related genes |
WikiPathways |
WP170 |
Nuclear Receptors |
WikiPathways |
WP2895 |
Differentiation of white and brown adipocyte |
WikiPathways |
WP363 |
Wnt Signaling Pathway Netpath |
WikiPathways |
h_pparPathway |
Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression |
BioCarta |
h_nuclearRsPathway |
Nuclear Receptors in Lipid Metabolism and Toxicity |
BioCarta |
h_ppargPathway |
Role of PPAR-gamma Coactivators in Obesity and Thermogenesis |
BioCarta |
h_vobesityPathway |
Visceral Fat Deposits and the Metabolic Syndrome |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0001418 |
Adenocarcinoma |
C0002395 |
Alzheimer'S Disease |
C0004153 |
Atherosclerosis |
C0004763 |
Barrett Esophagus |
C0009375 |
Colonic Neoplasms |
C0009404 |
Colorectal Neoplasms |
C0010346 |
Crohn Disease |
C0011849 |
Diabetes Mellitus |
C0011853 |
Diabetes Mellitus, Experimental |
C0011859 |
Lipoatrophic Diabetes Mellitus |
C0011860 |
Diabetes Mellitus, Non-Insulin-Dependent |
C0017638 |
Glioma |
C0017658 |
Glomerulonephritis |
C0020538 |
Hypertensive Disease |
C0021368 |
Inflammation |
C0021655 |
Insulin Resistance |
C0022116 |
Ischemia |
C0023794 |
Lipoidosis |
C0023903 |
Liver Neoplasms |
C0025202 |
Melanoma |
C0025517 |
Metabolic Diseases |
C0027746 |
Nerve Degeneration |
C0028754 |
Obesity |
C0028756 |
Obesity, Morbid |
C0029408 |
Degenerative Polyarthritis |
C0030297 |
Pancreatic Neoplasm |
C0033860 |
Psoriasis |
C0035126 |
Reperfusion Injury |
C0038356 |
Stomach Neoplasms |
C0040136 |
Thyroid Neoplasm |
C0079772 |
T-Cell Lymphoma |
C0085413 |
Polycystic Kidney, Autosomal Dominant |
C0206726 |
Gliosarcoma |
C0221406 |
Pituitary-Dependent Cushing'S Disease |
C0236811 |
Chronobiology Disorders |
C0242339 |
Dyslipidemias |
C0242488 |
Acute Lung Injury |
C0271694 |
Familial Partial Lipodystrophy |
C0282548 |
Leukostasis |
C0334588 |
Giant Cell Glioblastoma |
C0860207 |
Drug-Induced Liver Injury |
C1720861 |
Familial Partial Lipodystrophy, Type 3 |
C2239176 |
Liver Carcinoma |
C2609414 |
Acute Kidney Injury |
Tissue | Cell Type |
---|---|
appendix |
lymphoid tissue |
cervix, uterine |
squamous epithelial cells |
colon |
glandular cells |
epididymis |
glandular cells |
esophagus |
squamous epithelial cells |
oral mucosa |
squamous epithelial cells |
placenta |
trophoblastic cells |
rectum |
glandular cells |
stomach |
glandular cells |
tonsil |
squamous epithelial cells |
urinary bladder |
urothelial cells |
Database Name |
---|
PhenomicDB |
OMIM |
DisGeNET |
DISEASES |
DGA |
Pubmed ID | Author | Year | Title |
---|---|---|---|
15308691 |
Jansen et al. |
2004 |
Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ATP6V1C1 |
528 |
P21283 |
0.49 |
KAT2A |
2648 |
Q92830 |
0.49 |
NR4A1 |
3164 |
P22736 |
0.49 |
IKBKB |
3551 |
O14920 |
0.49 |
JUN |
3725 |
P05412 |
0.49 |
KIF11 |
3832 |
P52732 |
0.49 |
STMN1 |
3925 |
P16949 |
0.49 |
NR4A2 |
4929 |
P43354 |
0.49 |
PRNP |
5621 |
P04156 |
0.49 |
PSMD1 |
5707 |
Q99460 |
0.49 |
USP11 |
8237 |
P51784 |
0.49 |
MAP4K4 |
9448 |
O95819 |
0.49 |
NFE2L3 |
9603 |
Q9Y4A8 |
0.49 |
OPTN |
10133 |
Q96CV9 |
0.49 |
PHB2 |
11331 |
Q99623 |
0.49 |
CCDC88A |
55704 |
Q3V6T2 |
0.49 |
TUBB |
203068 |
P07437 |
0.49 |
APP |
351 |
P05067 |
0.56 |
IGFBP3 |
3486 |
P17936 |
0.56 |
JUND |
3727 |
P17535 |
0.56 |
TFAP2A |
7020 |
P05549 |
0.56 |
SETDB1 |
9869 |
Q15047 |
0.56 |
CHD7 |
55636 |
Q9P2D1 |
0.56 |
PDIA2 |
64714 |
Q13087 |
0.56 |
ALOX15B |
247 |
O15296 |
0.63 |
KIF1A |
547 |
Q12756 |
0.63 |
ESR1 |
2099 |
P03372 |
0.63 |
ESR2 |
2100 |
Q92731 |
0.63 |
SMAD2 |
4087 |
Q15796 |
0.63 |
SMAD3 |
4088 |
P84022 |
0.63 |
MDM2 |
4193 |
Q00987 |
0.63 |
PRKAA1 |
5562 |
Q13131 |
0.63 |
PRKAA2 |
5563 |
P54646 |
0.63 |
RBBP5 |
5929 |
Q15291 |
0.63 |
TCF4 |
6925 |
P15884 |
0.63 |
XRCC5 |
7520 |
P13010 |
0.63 |
ZYX |
7791 |
Q15942 |
0.63 |
ASH2L |
9070 |
Q9UBL3 |
0.63 |
ZBTB5 |
9925 |
O15062 |
0.63 |
NR2E3 |
10002 |
Q9Y5X4 |
0.63 |
RANBP9 |
10048 |
Q96S59 |
0.63 |
COPS5 |
10987 |
Q92905 |
0.63 |
PAXIP1 |
22976 |
Q6ZW49 |
0.63 |
KDM4C |
23081 |
Q9H3R0 |
0.63 |
MAFF |
23764 |
Q9ULX9 |
0.63 |
ZBTB20 |
26137 |
Q9HC78 |
0.63 |
FHOD1 |
29109 |
Q9Y613 |
0.63 |
MIF4GD |
57409 |
A9UHW6 |
0.63 |
ZBTB3 |
79842 |
Q9H5J0 |
0.63 |
ZNF496 |
84838 |
Q96IT1 |
0.63 |
ZBTB9 |
221504 |
Q96C00 |
0.63 |
ZSCAN1 |
284312 |
Q8NBB4 |
0.63 |
SERPINH1 |
871 |
P50454 |
0.65 |
EGFR |
1956 |
P00533 |
0.65 |
FOXO1 |
2308 |
Q12778 |
0.65 |
NFKBIB |
4793 |
Q15653 |
0.65 |
USP7 |
7874 |
Q93009 |
0.65 |
HELZ2 |
85441 |
Q9BYK8 |
0.65 |
CDC34 |
997 |
P49427 |
0.66 |
KAT5 |
10524 |
Q92993 |
0.66 |
STAT6 |
6778 |
P42226 |
0.68 |
TNP1 |
7141 |
P09430 |
0.68 |
VDR |
7421 |
P11473 |
0.68 |
KCTD13 |
253980 |
Q8WZ19 |
0.68 |
MUC1 |
4582 |
P15941 |
0.70 |
SMARCA4 |
6597 |
P51532 |
0.72 |
PIAS1 |
8554 |
O75925 |
0.72 |
KLF5 |
688 |
Q13887 |
0.73 |
FABP1 |
2168 |
P07148 |
0.73 |
STAT5A |
6776 |
P42229 |
0.73 |
SUMO1 |
7341 |
P63165 |
0.74 |
SFPQ |
6421 |
P23246 |
0.75 |
LMO4 |
8543 |
P61968 |
0.75 |
TRIM24 |
8805 |
O15164 |
0.75 |
TRIP4 |
9325 |
Q15650 |
0.75 |
HDAC4 |
9759 |
P56524 |
0.75 |
JMJD1C |
221037 |
Q15652 |
0.75 |
RXRG |
6258 |
P48443 |
0.76 |
CEBPB |
1051 |
P17676 |
0.78 |
HDAC1 |
3065 |
Q13547 |
0.78 |
MAP2K1 |
5604 |
Q02750 |
0.78 |
RB1 |
5925 |
P06400 |
0.78 |
GRIP1 |
23426 |
Q9Y3R0 |
0.78 |
SP1 |
6667 |
P08047 |
0.79 |
ZNHIT3 |
9326 |
Q15649 |
0.80 |
CAV1 |
857 |
Q03135 |
0.83 |
NFE2L2 |
4780 |
Q16236 |
0.85 |
CDK5 |
1020 |
Q00535 |
0.86 |
CREBBP |
1387 |
Q92793 |
0.88 |
PPARG |
5468 |
P37231 |
0.88 |
RXRA |
6256 |
P19793 |
0.90 |
NCOA1 |
8648 |
Q15788 |
0.90 |
DUT |
1854 |
P33316 |
0.49 |
HSP90AB1 |
3326 |
P08238 |
0.49 |
MARCH6 |
10299 |
O60337 |
0.49 |
HNRNPUL1 |
11100 |
Q9BUJ2 |
0.49 |
CHD8 |
57680 |
Q9HCK8 |
0.49 |
GADD45B |
4616 |
O75293 |
0.52 |
MAPK8 |
5599 |
P45983 |
0.55 |
ANP32A |
8125 |
P39687 |
0.56 |
CEP350 |
9857 |
Q5VT06 |
0.56 |
BCAS2 |
10286 |
O75934 |
0.56 |
RAD54L2 |
23132 |
Q9Y4B4 |
0.56 |
ROBO4 |
54538 |
Q8WZ75 |
0.56 |
LRIF1 |
55791 |
Q5T3J3 |
0.56 |
EZH2 |
2146 |
Q15910 |
0.63 |
XRCC6 |
2547 |
P12956 |
0.63 |
NR3C1 |
2908 |
P04150 |
0.63 |
HTT |
3064 |
P42858 |
0.63 |
MECP2 |
4204 |
P51608 |
0.63 |
CIITA |
4261 |
P33076 |
0.63 |
MSX2 |
4488 |
P35548 |
0.63 |
PML |
5371 |
P29590 |
0.63 |
RFX5 |
5993 |
P48382 |
0.63 |
SVIL |
6840 |
O95425 |
0.63 |
XPO1 |
7514 |
O14980 |
0.63 |
YWHAB |
7529 |
P31946 |
0.63 |
YWHAG |
7532 |
P61981 |
0.63 |
RANBP3 |
8498 |
Q9H6Z4 |
0.63 |
MED14 |
9282 |
O60244 |
0.63 |
ZFYVE9 |
9372 |
O95405 |
0.63 |
CNOT1 |
23019 |
A5YKK6 |
0.63 |
NSD1 |
64324 |
Q96L73 |
0.63 |
JAZF1 |
221895 |
Q86VZ6 |
0.63 |
NEDD4 |
4734 |
P46934 |
0.65 |
PPM1B |
5495 |
O75688 |
0.65 |
SYT1 |
6857 |
P21579 |
0.65 |
KLF4 |
9314 |
O43474 |
0.65 |
NFKB1 |
4790 |
P19838 |
0.68 |
PIN1 |
5300 |
Q13526 |
0.68 |
NLK |
51701 |
Q9UBE8 |
0.68 |
SMARCD3 |
6604 |
Q6STE5 |
0.70 |
CLU |
1191 |
P10909 |
0.72 |
PRKCA |
5578 |
P17252 |
0.72 |
BRD8 |
10902 |
Q9H0E9 |
0.73 |
CTNNB1 |
1499 |
P35222 |
0.74 |
POU1F1 |
5449 |
P28069 |
0.75 |
MAPK1 |
5594 |
P28482 |
0.78 |
UBE2I |
7329 |
P63279 |
0.84 |
NCOA6 |
23054 |
Q14686 |
0.84 |
NR0B1 |
190 |
P51843 |
0.85 |
HMGA1 |
3159 |
P17096 |
0.85 |
MED24 |
9862 |
O75448 |
0.85 |
DNTTIP2 |
30836 |
Q5QJE6 |
0.85 |
GADD45G |
10912 |
O95257 |
0.86 |
RXRB |
6257 |
P28702 |
0.87 |
EDF1 |
8721 |
O60869 |
0.88 |
NCOA4 |
8031 |
Q13772 |
0.89 |
NCOA3 |
8202 |
Q9Y6Q9 |
0.89 |
NR0B2 |
8431 |
Q15466 |
0.89 |
NCOR1 |
9611 |
O75376 |
0.89 |
EP300 |
2033 |
Q09472 |
0.90 |
MED1 |
5469 |
Q15648 |
0.90 |
NRIP1 |
8204 |
P48552 |
0.90 |
NCOA2 |
10499 |
Q15596 |
0.90 |
PPARGC1A |
10891 |
Q9UBK2 |
0.90 |
RELA |
5970 |
Q04206 |
0.93 |
NCOR2 |
9612 |
Q9Y618 |
0.94 |
HDAC3 |
8841 |
O15379 |
0.96 |