PCOSBase

Protein Description

Gene Symbol	POLR2A
Entrez ID	5430
Uniprot ID	P24928
Description	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Chromosomal Location	chr17: 7,484,366-7,514,616

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000398	mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.	TAS
BP	GO:0001172	transcription, RNA-templated	The cellular synthesis of RNA on a template of RNA.	IEA
BP	GO:0006283	transcription-coupled nucleotide-excision repair	The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.	TAS
BP	GO:0006353	DNA-templated transcription, termination	The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.	IMP
BP	GO:0006355	regulation of transcription, DNA-templated	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.	NAS
BP	GO:0006366	transcription from RNA polymerase II promoter	The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).	IDA\|NAS\|TAS
BP	GO:0006367	transcription initiation from RNA polymerase II promoter	Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.	TAS
BP	GO:0006368	transcription elongation from RNA polymerase II promoter	The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.	TAS
BP	GO:0006370	7-methylguanosine mRNA capping	Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.	TAS
BP	GO:0008543	fibroblast growth factor receptor signaling pathway	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.	TAS
BP	GO:0010467	gene expression	The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	TAS
BP	GO:0031047	gene silencing by RNA	Any process in which RNA molecules inactivate expression of target genes.	TAS
BP	GO:0033120	positive regulation of RNA splicing	Any process that activates or increases the frequency, rate or extent of RNA splicing.	IDA
BP	GO:0035019	somatic stem cell population maintenance	Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.	TAS
BP	GO:0042795	snRNA transcription from RNA polymerase II promoter	The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.	TAS
BP	GO:0050434	positive regulation of viral transcription	Any process that activates or increases the frequency, rate or extent of viral transcription.	TAS
CC	GO:0000974	Prp19 complex	A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.	IDA
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA\|NAS
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA\|TAS
CC	GO:0005665	DNA-directed RNA polymerase II, core complex	RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.	IDA
MF	GO:0001055	RNA polymerase II activity	Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.	IBA
MF	GO:0003677	DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).	NAS
MF	GO:0003899	DNA-directed RNA polymerase activity	Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.	NAS
MF	GO:0003968	RNA-directed RNA polymerase activity	Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template.	IEA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0031625	ubiquitin protein ligase binding	Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.	IPI
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA
MF	GO:0046872	metal ion binding	Interacting selectively and non-covalently with any metal ion.	IEA

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Domain ID	Description
IPR000684	RNA polymerase II, heptapeptide repeat, eukaryotic
IPR000722	RNA polymerase, alpha subunit
IPR006592	RNA polymerase, N-terminal
IPR007066	RNA polymerase Rpb1, domain 3
IPR007073	RNA polymerase Rpb1, domain 7
IPR007075	RNA polymerase Rpb1, domain 6
IPR007080	RNA polymerase Rpb1, domain 1
IPR007081	RNA polymerase Rpb1, domain 5
IPR007083	RNA polymerase Rpb1, domain 4

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Pathway ID	Pathway Term	Pathway Source
hsa00230	Purine metabolism	KEGG
hsa00240	Pyrimidine metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa03020	RNA polymerase	KEGG
hsa05016	Huntington's disease	KEGG
hsa05168	Herpes simplex infection	KEGG
hsa05169	Epstein-Barr virus infection	KEGG
WP405	Eukaryotic Transcription Initiation	WikiPathways
WP411	mRNA Processing	WikiPathways
h_carm-erPathway	CARM1 and Regulation of the Estrogen Receptor	BioCarta
h_hSWI-SNFpathway	Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes	BioCarta
h_rarrxrPathway	Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells	BioCarta
h_dreampathway	Repression of Pain Sensation by the Transcriptional Regulator DREAM	BioCarta
h_telPathway	Telomeres, Telomerase, Cellular Aging, and Immortality	BioCarta
h_pcafpathway	The information-processing pathway at the IFN-beta enhancer	BioCarta

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No diseases found.

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Tissue	Cell Type
appendix	glandular cells
bone marrow	hematopoietic cells
breast	glandular cells
caudate	neuronal cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	glandular cells
endometrium	cells in endometrial stroma
endometrium	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
heart muscle	myocytes
hippocampus	glial cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	ovarian stroma cells
placenta	decidual cells
placenta	trophoblastic cells
rectum	glandular cells
skin	keratinocytes
skin	epidermal cells
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
ATP6V1B2	526	P21281	0.49
CDK2	1017	P24941	0.49
GTF2A2	2958	P52657	0.49
MCM2	4171	P49736	0.49
SRSF2	6427	Q01130	0.49
SMARCC2	6601	Q8TAQ2	0.49
RUVBL2	10856	Q9Y230	0.49
SRRT	51593	Q9BXP5	0.49
UBE3B	89910	Q7Z3V4	0.49
ABL1	25	P00519	0.52
FUS	2521	P35637	0.52
IRF3	3661	Q14653	0.52
RELA	5970	Q04206	0.52
UPF1	5976	Q92900	0.52
ELL	8178	P55199	0.52
ACTL6A	86	O96019	0.55
CASP10	843	Q92851	0.55
NONO	4841	Q15233	0.55
ELP3	55140	Q9H9T3	0.55
SMN1; SMN2	6606	Q16637	0.55
RPS20	6224	P60866	0.56
SUPT4H1	6827	P63272	0.56
KMT2D	8085	O14686	0.56
U2AF2	11338	P26368	0.56
PRPF19	27339	Q9UMS4	0.56
POLR2A	5430	P24928	0.59
CPSF2	53981	Q9P2I0	0.59
HNRNPF	3185	P52597	0.62
CDKN1A	1026	P38936	0.63
ERCC8	1161	Q13216	0.63
ERCC1	2067	P07992	0.63
ERCC3	2071	P19447	0.63
ERCC4	2072	Q92889	0.63
EWSR1	2130	Q01844	0.63
GPS1	2873	Q13098	0.63
GRB2	2885	P62993	0.63
GTF2I	2969	P78347	0.63
HMGN1	3150	P05114	0.63
MAP4	4134	P27816	0.63
MYO6	4646	Q9UM54	0.63
NF1	4763	P21359	0.63
PCNA	5111	P12004	0.63
HIRA	7290	P54198	0.63
XPA	7507	P23025	0.63
SMC1A	8243	Q14683	0.63
URI1	8725	O94763	0.63
SMC3	9126	Q9UQE7	0.63
PPP4R1	9989	Q8TF05	0.63
YAP1	10413	P46937	0.63
WDHD1	11169	O75717	0.63
C14orf166	51637	Q9Y224	0.63
DDB1	100290337	Q16531	0.63
SAFB	6294	Q15424	0.67
CTDSP1	58190	Q9GZU7	0.67
CSTF2	1478	P33240	0.68
XRCC5	7520	P13010	0.68
NSD1	64324	Q96L73	0.68
CSTF1	1477	Q05048	0.69
CPSF1	29894	Q10570	0.69
CPSF3	51692	Q9UKF6	0.69
KMT2A	4297	Q03164	0.70
RPA1	6117	P27694	0.70
WWP2	11060	O00308	0.70
RTF1	23168	Q92541	0.70
EGLN1	54583	Q9GZT9	0.72
EGLN2	112398	Q96KS0	0.72
MCM7	4176	P33993	0.73
AGO1	26523	Q9UL18	0.73
POLR2B	5431	P30876	0.74
BARD1	580	Q99728	0.75
CREBBP	1387	Q92793	0.75
UBE2L3	7332	P68036	0.75
DHX9	1660	Q08211	0.76
GTF2H4	2968	Q92759	0.76
POLR2D	5433	O15514	0.77
POLR2I	5438	P36954	0.77
LEO1	123169	Q8WVC0	0.78
PQBP1	10084	O60828	0.79
SND1	27044	Q7KZF4	0.79
ACTB	60	P60709	0.81
UBA1	7317	P22314	0.81
HTATSF1	27336	O43719	0.84
GTF2F2	2963	P13984	0.85
CSTF3	1479	Q12996	0.86
ERCC6	2074	Q03468	0.86
GTF2E1	2960	P29083	0.86
POLR2J	5439	P52435	0.86
BRCA1	672	P38398	0.87
CDK7	1022	P50613	0.87
ZNF74	7625	Q16587	0.87
SUPT6H	6830	Q7KZ85	0.88
TAF11	6882	Q15544	0.88
GTF2F1	2962	P35269	0.90
CTDP1	9150	Q9Y5B0	0.90
PIN1	5300	Q13526	0.91
POLR2L	5441	P62875	0.92
CTR9	9646	Q6PD62	0.93
POLR2E	5434	P19388	0.95
RPRD1B	58490	Q9NQG5	0.95
CDK8	1024	P49336	0.96
POLR2F	5435	P61218	0.96
SUPT5H	6829	O00267	0.97
TCEA1	6917	P23193	0.97
POLR2C	5432	P19387	0.98
TBP	6908	P20226	0.98
POLR2G	5436	P62487	0.99
EEF1A1	1915	P68104	0.49
EEF1A2	1917	Q05639	0.49
ILF3	3609	Q12906	0.49
PSMA6	5687	P60900	0.49
HIST2H2BE	8349	Q16778	0.49
GTF3C3	9330	Q9Y5Q9	0.49
MED23	9439	Q9ULK4	0.49
MED20	9477	Q9H944	0.49
RALBP1	10928	Q15311	0.49
POLR3A	11128	O14802	0.49
TCTN3	26123	Q6NUS6	0.49
MED4	29079	Q9NPJ6	0.49
POLR3B	55703	Q9NW08	0.49
EEFSEC	60678	P57772	0.49
CEP128	145508	Q6ZU80	0.49
CCNT1	904	O60563	0.52
CSNK2A1	1457	P68400	0.52
KLK2	3817	P20151	0.52
NFKB1	4790	P19838	0.52
PPP1CA	5499	P62136	0.52
PSMB9	5698	P28065	0.52
RXRA	6256	P19793	0.52
SRC	6714	P12931	0.52
TFF1	7031	P04155	0.52
TTK	7272	P33981	0.52
CDC14A	8556	Q9UNH5	0.52
TRAM2	9697	Q15035	0.52
USPL1	10208	Q5W0Q7	0.52
TRAK1	22906	Q9UPV9	0.52
SMURF1	57154	Q9HCE7	0.52
CCAR2	57805	Q8N163	0.55
CTD	1283	N/A	0.56
PSMA5	5686	P28066	0.56
SUB1	10923	P53999	0.56
IWS1	55677	Q96ST2	0.56
SNAR-B2	100170217	N/A	0.56
DCTN2	10540	Q13561	0.59
PPP4R3A	55671	Q6IN85	0.59
MNAT1	4331	P51948	0.62
VDR	7421	P11473	0.62
AIRE	326	O43918	0.63
CCNH	902	P51946	0.63
DNMT3A	1788	Q9Y6K1	0.63
DNMT3B	1789	Q9UBC3	0.63
ELAVL1	1994	Q15717	0.63
GTF2H1	2965	P32780	0.63
H2AFX	3014	P16104	0.63
HK2	3099	P52789	0.63
IFI16	3428	Q16666	0.63
ILK	3611	Q13418	0.63
MLLT1	4298	Q03111	0.63
AFF1	4299	P51825	0.63
MOV10	4343	Q9HCE1	0.63
NEDD8	4738	Q15843	0.63
NFKBIA	4792	P25963	0.63
NTRK1	4914	P04629	0.63
RAD52	5893	P43351	0.63
SUMO2	6613	P61956	0.63
XPO1	7514	O14980	0.63
TAF15	8148	Q92804	0.63
CUL2	8453	Q13617	0.63
EED	8726	O75530	0.63
MBD2	8932	Q9UBB5	0.63
MTA2	9219	O94776	0.63
TRIP4	9325	Q15650	0.63
QKI	9444	Q96PU8	0.63
SETD1A	9739	O15047	0.63
CUL7	9820	Q14999	0.63
MAGI2	9863	Q86UL8	0.63
PTBP3	9991	O95758	0.63
HNRNPR	10236	O43390	0.63
NXF1	10482	Q9UBU9	0.63
IVNS1ABP	10625	Q9Y6Y0	0.63
XRN2	22803	Q9H0D6	0.63
SNW1	22938	Q13573	0.63
SETD1B	23067	Q9UPS6	0.63
ZC3H13	23091	Q5T200	0.63
OBSL1	23363	O75147	0.63
CABIN1	23523	Q9Y6J0	0.63
GABARAPL1	23710	Q9H0R8	0.63
NELFB	25920	Q8WX92	0.63
NSMF	26012	Q6X4W1	0.63
INTS1	26173	Q8N201	0.63
INTS6	26512	Q9UL03	0.63
UBN1	29855	Q9NPG3	0.63
GPN3	51184	Q9UHW5	0.63
SIRT7	51547	Q9NRC8	0.63
DCUN1D1	54165	Q96GG9	0.63
CPSF3L	54973	Q5TA45	0.63
INTS10	55174	Q9NVR2	0.63
LGR4	55366	Q9BXB1	0.63
ATF7IP	55729	Q6VMQ6	0.63
CAND1	55832	Q86VP6	0.63
USE1	55850	Q9NZ43	0.63
INTS3	65123	Q68E01	0.63
OBFC1	79991	Q9H668	0.63
WDR82	80335	Q6UXN9	0.63
INTS5	80789	Q6P9B9	0.63
POLR2M	81488	Q6EEV4	0.63
CCDC8	83987	Q9H0W5	0.63
NEURL4	84461	Q96JN8	0.63
UNK	85451	Q9C0B0	0.63
EHBP1L1	254102	Q8N3D4	0.63
ATM	472	Q13315	0.65
TCEB3	6924	Q14241	0.65
CTDSP2	10106	O14595	0.65
PPIG	9360	Q13427	0.67
ERG	2078	P11308	0.68
HIST1H1C	3006	P16403	0.68
SNF8	11267	Q96H20	0.68
PHF8	23133	Q9UPP1	0.68
SETD2	29072	Q9BYW2	0.68
WAC	51322	Q9BTA9	0.68
SMARCB1	6598	Q12824	0.69
TADA2A	6871	O75478	0.70
SMARCA2	6595	P51531	0.71
IKBKAP	8518	O95163	0.71
ITCH	83737	Q96J02	0.71
CREB1	1385	P16220	0.72
BRINP1	1620	O60477	0.72
MED1	5469	Q15648	0.72
SSRP1	6749	Q08945	0.72
TAF10	6881	Q12962	0.72
NELFE	7936	P18615	0.72
SMYD3	64754	Q9H7B4	0.72
NABP1	64859	Q96AH0	0.72
RPAP3	79657	Q9H6T3	0.72
RPAP2	79871	Q8IXW5	0.72
HDAC11	79885	Q96DB2	0.72
VWA9	81556	Q96SY0	0.72
MED30	90390	Q96HR3	0.72
ZNF326	284695	Q5BKZ1	0.72
CCNK	8812	O75909	0.73
CCNL2	81669	Q96S94	0.73
CSH1\|CSH2	1442	P0DML2\|P0DML3	0.74
MCM3	4172	P25205	0.75
CUL5	8065	Q93034	0.75
NR0B2	8431	Q15466	0.75
MED9	55090	Q9NWA0	0.76
MED29	55588	Q9NX70	0.76
CDK9	1025	P50750	0.78
WWOX	51741	Q9NZC7	0.78
GPN1	11321	Q9HCN4	0.79
CBX3	11335	Q13185	0.79
ERCC5	2073	P28715	0.80
MEN1	4221	O00255	0.80
SSU72	29101	Q9NP77	0.80
ESR1	2099	P03372	0.81
CTCF	10664	P49711	0.81
EP300	2033	Q09472	0.82
GTF2E2	2961	P29084	0.82
VHL	7428	P40337	0.82
MDC1	9656	Q14676	0.82
PIH1D1	55011	Q9NWS0	0.82
MED28	80306	Q9H204	0.82
FCP1	2221	N/A	0.85
HNRNPU	3192	Q00839	0.86
SMARCA4	6597	P51532	0.86
MED21	9412	Q13503	0.86
DDX5	1655	P17844	0.87
RECQL5	9400	O94762	0.87
XAB2	56949	Q9HCS7	0.87
CDC73	79577	Q6P1J9	0.87
MED19	219541	A0JLT2	0.87
NELFA	7469	Q9H3P2	0.88
MED26	9441	O95402	0.88
PAF1	54623	Q8N7H5	0.88
MYC	4609	P01106	0.89
TCERG1	10915	O14776	0.89
PCIF1	63935	Q9H4Z3	0.89
POLR2K	5440	P53803	0.91
KAT2B	8850	Q92831	0.91
NEDD4	4734	P46934	0.95
POLR2H	5437	P52434	0.95
GTF2B	2959	Q00403	0.96
MED10	84246	Q9BTT4	0.97