BP

GO:0002026

regulation of the force of heart contraction

Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.

IEA

BP

GO:0006984

ER-nucleus signaling pathway

Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.

IEA

BP

GO:0006996

organelle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

IEA

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

TAS

BP

GO:0008544

epidermis development

The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.

TAS

BP

GO:0010460

positive regulation of heart rate

Any process that activates or increases the frequency or rate of heart contraction.

TAS

BP

GO:0010882

regulation of cardiac muscle contraction by calcium ion signaling

Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction.

IEA

BP

GO:0014883

transition between fast and slow fiber

The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.

IEA

BP

GO:0014898

cardiac muscle hypertrophy in response to stress

The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis.

IEA

BP

GO:0032469

endoplasmic reticulum calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.

IDA

BP

GO:0032470

positive regulation of endoplasmic reticulum calcium ion concentration

Any process that increases the concentration of calcium ions in the endoplasmic reticulum.

IDA

BP

GO:0033292

T-tubule organization

A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.

IEA

BP

GO:0034220

ion transmembrane transport

A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

TAS

BP

GO:0034599

cellular response to oxidative stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

IEA

BP

GO:0034976

response to endoplasmic reticulum stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

ISS

BP

GO:0043434

response to peptide hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.

IEA

BP

GO:0045822

negative regulation of heart contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.

IEA

BP

GO:0055119

relaxation of cardiac muscle

The process in which the extent of cardiac muscle contraction is reduced.

IEA

BP

GO:0070296

sarcoplasmic reticulum calcium ion transport

The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.

TAS

BP

GO:0070588

calcium ion transmembrane transport

A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

IDA

BP

GO:0086036

regulation of cardiac muscle cell membrane potential

Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

IC|ISS|TAS

BP

GO:0098909

regulation of cardiac muscle cell action potential involved in regulation of contraction

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction.

ISS

BP

GO:1903233

regulation of calcium ion-dependent exocytosis of neurotransmitter

Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter.

IEA

BP

GO:1903515

calcium ion transport from cytosol to endoplasmic reticulum

The directed movement of calcium ion from cytosol to endoplasmic reticulum.

IDA

BP

GO:1903779

regulation of cardiac conduction

Any process that modulates the frequency, rate or extent of cardiac conduction.

TAS

BP

GO:1990036

calcium ion import into sarcoplasmic reticulum

The directed movement of calcium ions into a sarcoplasmic reticulum.

IC|ISS

CC

GO:0005783

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

IDA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

IDA|TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

CC

GO:0012506

vesicle membrane

The lipid bilayer surrounding any membrane-bounded vesicle in the cell.

IEA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0016529

sarcoplasmic reticulum

A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.

IDA

CC

GO:0031095

platelet dense tubular network membrane

The lipid bilayer surrounding the platelet dense tubular network.

TAS

CC

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.

IEA

CC

GO:0033017

sarcoplasmic reticulum membrane

The lipid bilayer surrounding the sarcoplasmic reticulum.

TAS

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IEA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IEA

CC

GO:0097470

ribbon synapse

Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm.

IEA

MF

GO:0005388

calcium-transporting ATPase activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).

IDA|TAS

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0008022

protein C-terminus binding

Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.

IEA

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0031775

lutropin-choriogonadotropic hormone receptor binding

Interacting selectively and non-covalently with a lutropin-choriogonadotropic hormone receptor.

IEA

MF

GO:0044548

S100 protein binding

Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.

IPI

MF

GO:0086039

calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential

Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell plasma membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). The transfer contributes to the regulation of the plasma membrane potential.

IC|ISS|TAS