Protein Description

Gene Symbol PLXNA2
Entrez ID 5362
Uniprot ID O75051
Description plexin A2
Chromosomal Location chr1: 208,022,242-208,244,320
Ontology GO ID GO Term Definition Evidence

BP

GO:0001756

somitogenesis

The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.

IEA

BP

GO:0021785

branchiomotor neuron axon guidance

The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.

IBA

BP

GO:0021915

neural tube development

The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.

IEA

BP

GO:0021935

cerebellar granule cell precursor tangential migration

The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.

IEA

BP

GO:0030334

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

IBA|ISS

BP

GO:0048841

regulation of axon extension involved in axon guidance

Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance.

IBA

BP

GO:0051642

centrosome localization

Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.

IEA

BP

GO:0060037

pharyngeal system development

The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.

IEA

BP

GO:0060174

limb bud formation

The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable.

IEA

BP

GO:0071526

semaphorin-plexin signaling pathway

A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.

ISS

BP

GO:1902287

semaphorin-plexin signaling pathway involved in axon guidance

Any semaphorin-plexin signaling pathway that is involved in axon guidance.

IBA

CC

GO:0002116

semaphorin receptor complex

A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IBA|ISS

MF

GO:0017154

semaphorin receptor activity

Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IBA|ISS

Domain ID Description

IPR001627

Sema domain

IPR002165

Plexin repeat

IPR002909

IPT domain

IPR008936

Rho GTPase activation protein

IPR013548

Plexin, cytoplasmic RasGAP domain

IPR013783

Immunoglobulin-like fold

IPR014756

Immunoglobulin E-set

IPR015943

WD40/YVTN repeat-like-containing domain

IPR016201

PSI domain

IPR031148

Plexin family

Pathway ID Pathway Term Pathway Source

hsa04360

Axon guidance

KEGG

WP2431

Spinal Cord Injury

WikiPathways

WP2858

Ectoderm Differentiation

WikiPathways

UMLS CUI UMLS Term

C0036341

Schizophrenia

No tissues found.

No databases found.

Pubmed ID Author Year Title

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

XAB2

56949

Q9HCS7

0.49

PDCD6IP

10015

Q8WUM4

0.63

PTPRK

5796

Q15262

0.63

TAZ

6901

Q16635

0.63

TNF

7124

P01375

0.63

FNBP4

23360

Q8N3X1

0.63

NUFIP1

26747

Q9UHK0

0.63

SUSD4

55061

Q5VX71

0.63

CEMIP

57214

Q8WUJ3

0.63

HACE1

57531

Q8IYU2

0.63

IFT80

57560

Q9P2H3

0.63

DHX37

57647

Q8IY37

0.63

GPHA2

170589

Q96T91

0.63

UBAP2L

9898

Q14157

0.73