| Gene Symbol | PLXNA2 |
| Entrez ID | 5362 |
| Uniprot ID | O75051 |
| Description | plexin A2 |
| Chromosomal Location | chr1: 208,022,242-208,244,320 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0001756 |
somitogenesis |
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. |
IEA |
|
BP |
GO:0021785 |
branchiomotor neuron axon guidance |
The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. |
IBA |
|
BP |
GO:0021915 |
neural tube development |
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. |
IEA |
|
BP |
GO:0021935 |
cerebellar granule cell precursor tangential migration |
The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium. |
IEA |
|
BP |
GO:0030334 |
regulation of cell migration |
Any process that modulates the frequency, rate or extent of cell migration. |
IBA|ISS |
|
BP |
GO:0048841 |
regulation of axon extension involved in axon guidance |
Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance. |
IBA |
|
BP |
GO:0051642 |
centrosome localization |
Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. |
IEA |
|
BP |
GO:0060037 |
pharyngeal system development |
The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. |
IEA |
|
BP |
GO:0060174 |
limb bud formation |
The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable. |
IEA |
|
BP |
GO:0071526 |
semaphorin-plexin signaling pathway |
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. |
ISS |
|
BP |
GO:1902287 |
semaphorin-plexin signaling pathway involved in axon guidance |
Any semaphorin-plexin signaling pathway that is involved in axon guidance. |
IBA |
|
CC |
GO:0002116 |
semaphorin receptor complex |
A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. |
TAS |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
|
CC |
GO:0005887 |
integral component of plasma membrane |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IBA|ISS |
|
MF |
GO:0017154 |
semaphorin receptor activity |
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IBA|ISS |
| Domain ID | Description |
|---|---|
|
IPR001627 |
Sema domain |
|
IPR002165 |
Plexin repeat |
|
IPR002909 |
IPT domain |
|
IPR008936 |
Rho GTPase activation protein |
|
IPR013548 |
Plexin, cytoplasmic RasGAP domain |
|
IPR013783 |
Immunoglobulin-like fold |
|
IPR014756 |
Immunoglobulin E-set |
|
IPR015943 |
WD40/YVTN repeat-like-containing domain |
|
IPR016201 |
PSI domain |
|
IPR031148 |
Plexin family |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04360 |
Axon guidance |
KEGG |
|
WP2431 |
Spinal Cord Injury |
WikiPathways |
|
WP2858 |
Ectoderm Differentiation |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0036341 |
Schizophrenia |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
XAB2 |
56949 |
Q9HCS7 |
0.49 |
|
PDCD6IP |
10015 |
Q8WUM4 |
0.63 |
|
PTPRK |
5796 |
Q15262 |
0.63 |
|
TAZ |
6901 |
Q16635 |
0.63 |
|
TNF |
7124 |
P01375 |
0.63 |
|
FNBP4 |
23360 |
Q8N3X1 |
0.63 |
|
NUFIP1 |
26747 |
Q9UHK0 |
0.63 |
|
SUSD4 |
55061 |
Q5VX71 |
0.63 |
|
CEMIP |
57214 |
Q8WUJ3 |
0.63 |
|
HACE1 |
57531 |
Q8IYU2 |
0.63 |
|
IFT80 |
57560 |
Q9P2H3 |
0.63 |
|
DHX37 |
57647 |
Q8IY37 |
0.63 |
|
GPHA2 |
170589 |
Q96T91 |
0.63 |
|
UBAP2L |
9898 |
Q14157 |
0.73 |