Protein Description

Gene Symbol PLXNA1
Entrez ID 5361
Uniprot ID Q9UIW2
Description plexin A1
Chromosomal Location chr3: 126,988,594-127,037,392
Ontology GO ID GO Term Definition Evidence

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

TAS

BP

GO:0014910

regulation of smooth muscle cell migration

Any process that modulates the frequency, rate or extent of smooth muscle cell migration.

IEA

BP

GO:0021785

branchiomotor neuron axon guidance

The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.

IBA

BP

GO:0030334

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

IBA

BP

GO:0048841

regulation of axon extension involved in axon guidance

Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance.

IBA

BP

GO:0060666

dichotomous subdivision of terminal units involved in salivary gland branching

The process in which a salivary epithelial cord bifurcates at its end.

IEA

BP

GO:1902287

semaphorin-plexin signaling pathway involved in axon guidance

Any semaphorin-plexin signaling pathway that is involved in axon guidance.

IBA

BP

GO:1990138

neuron projection extension

Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

IEA

CC

GO:0002116

semaphorin receptor complex

A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

TAS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IBA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0004872

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

TAS

MF

GO:0017154

semaphorin receptor activity

Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

TAS

Domain ID Description

IPR001627

Sema domain

IPR002165

Plexin repeat

IPR002909

IPT domain

IPR008936

Rho GTPase activation protein

IPR013548

Plexin, cytoplasmic RasGAP domain

IPR013783

Immunoglobulin-like fold

IPR014756

Immunoglobulin E-set

IPR015943

WD40/YVTN repeat-like-containing domain

IPR016201

PSI domain

IPR031148

Plexin family

Pathway ID Pathway Term Pathway Source

hsa04360

Axon guidance

KEGG

No diseases found.

Tissue Cell Type

appendix

glandular cells

colon

glandular cells

gallbladder

glandular cells

lung

macrophages

rectum

glandular cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

RAC2

5880

P15153

0.00

FES

2242

P07332

0.52

SEMA6D

80031

Q8NFY4

0.52

NPTX1

4884

Q15818

0.72

PLXNB1

5364

O43157

0.72

RHOD

29984

O00212

0.75

NRP1

8829

O14786

0.77

AKT1

207

P31749

0.78

PLXNA1

5361

Q9UIW2

0.83

RND1

27289

Q92730

0.52

HLA-DRA

3122

P01903

0.63

LGALS9

3965

O00182

0.63

PTCH1

5727

Q13635

0.63

PTPRK

5796

Q15262

0.63

TAZ

6901

Q16635

0.63

GAN

8139

Q9H2C0

0.63

FBXO6

26270

Q9NRD1

0.63

SUSD4

55061

Q5VX71

0.63

TMEM25

84866

Q86YD3

0.63

CANT1

124583

Q8WVQ1

0.63

PDIA3

2923

P30101

0.72

KDR

3791

P35968

0.72