Gene Symbol | PLXNA1 |
Entrez ID | 5361 |
Uniprot ID | Q9UIW2 |
Description | plexin A1 |
Chromosomal Location | chr3: 126,988,594-127,037,392 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007275 |
multicellular organism development |
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). |
TAS |
BP |
GO:0014910 |
regulation of smooth muscle cell migration |
Any process that modulates the frequency, rate or extent of smooth muscle cell migration. |
IEA |
BP |
GO:0021785 |
branchiomotor neuron axon guidance |
The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. |
IBA |
BP |
GO:0030334 |
regulation of cell migration |
Any process that modulates the frequency, rate or extent of cell migration. |
IBA |
BP |
GO:0048841 |
regulation of axon extension involved in axon guidance |
Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance. |
IBA |
BP |
GO:0060666 |
dichotomous subdivision of terminal units involved in salivary gland branching |
The process in which a salivary epithelial cord bifurcates at its end. |
IEA |
BP |
GO:1902287 |
semaphorin-plexin signaling pathway involved in axon guidance |
Any semaphorin-plexin signaling pathway that is involved in axon guidance. |
IBA |
BP |
GO:1990138 |
neuron projection extension |
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
IEA |
CC |
GO:0002116 |
semaphorin receptor complex |
A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. |
TAS |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
CC |
GO:0005887 |
integral component of plasma membrane |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IBA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0004872 |
receptor activity |
Combining with an extracellular or intracellular messenger to initiate a change in cell activity. |
TAS |
MF |
GO:0017154 |
semaphorin receptor activity |
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
TAS |
Domain ID | Description |
---|---|
IPR001627 |
Sema domain |
IPR002165 |
Plexin repeat |
IPR002909 |
IPT domain |
IPR008936 |
Rho GTPase activation protein |
IPR013548 |
Plexin, cytoplasmic RasGAP domain |
IPR013783 |
Immunoglobulin-like fold |
IPR014756 |
Immunoglobulin E-set |
IPR015943 |
WD40/YVTN repeat-like-containing domain |
IPR016201 |
PSI domain |
IPR031148 |
Plexin family |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04360 |
Axon guidance |
KEGG |
Tissue | Cell Type |
---|---|
appendix |
glandular cells |
colon |
glandular cells |
gallbladder |
glandular cells |
lung |
macrophages |
rectum |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
RAC2 |
5880 |
P15153 |
0.00 |
FES |
2242 |
P07332 |
0.52 |
SEMA6D |
80031 |
Q8NFY4 |
0.52 |
NPTX1 |
4884 |
Q15818 |
0.72 |
PLXNB1 |
5364 |
O43157 |
0.72 |
RHOD |
29984 |
O00212 |
0.75 |
NRP1 |
8829 |
O14786 |
0.77 |
AKT1 |
207 |
P31749 |
0.78 |
PLXNA1 |
5361 |
Q9UIW2 |
0.83 |
RND1 |
27289 |
Q92730 |
0.52 |
HLA-DRA |
3122 |
P01903 |
0.63 |
LGALS9 |
3965 |
O00182 |
0.63 |
PTCH1 |
5727 |
Q13635 |
0.63 |
PTPRK |
5796 |
Q15262 |
0.63 |
TAZ |
6901 |
Q16635 |
0.63 |
GAN |
8139 |
Q9H2C0 |
0.63 |
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
SUSD4 |
55061 |
Q5VX71 |
0.63 |
TMEM25 |
84866 |
Q86YD3 |
0.63 |
CANT1 |
124583 |
Q8WVQ1 |
0.63 |
PDIA3 |
2923 |
P30101 |
0.72 |
KDR |
3791 |
P35968 |
0.72 |