BP

GO:0001504

neurotransmitter uptake

The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.

IEA

BP

GO:0002026

regulation of the force of heart contraction

Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.

IEA

BP

GO:0002087

regulation of respiratory gaseous exchange by neurological system process

A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.

IEA

BP

GO:0006813

potassium ion transport

The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NAS

BP

GO:0006814

sodium ion transport

The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NAS

BP

GO:0006883

cellular sodium ion homeostasis

Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.

IDA

BP

GO:0006940

regulation of smooth muscle contraction

Any process that modulates the frequency, rate or extent of smooth muscle contraction.

IEA

BP

GO:0006942

regulation of striated muscle contraction

Any process that modulates the frequency, rate or extent of striated muscle contraction.

NAS

BP

GO:0008217

regulation of blood pressure

Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

IEA

BP

GO:0008344

adult locomotory behavior

Locomotory behavior in a fully developed and mature organism.

IEA

BP

GO:0008542

visual learning

Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.

IEA

BP

GO:0010107

potassium ion import

The directed movement of potassium ions into a cell or organelle.

IDA

BP

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore.

IEA

BP

GO:0010881

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.

TAS

BP

GO:0015991

ATP hydrolysis coupled proton transport

The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis.

IBA

BP

GO:0019229

regulation of vasoconstriction

Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.

IEA

BP

GO:0030007

cellular potassium ion homeostasis

Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.

IC|IDA

BP

GO:0034220

ion transmembrane transport

A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

TAS

BP

GO:0035094

response to nicotine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.

IEA

BP

GO:0036376

sodium ion export from cell

The directed movement of sodium ions out of a cell.

IDA

BP

GO:0040011

locomotion

Self-propelled movement of a cell or organism from one location to another.

IEA

BP

GO:0045822

negative regulation of heart contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.

IEA

BP

GO:0045988

negative regulation of striated muscle contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.

IEA

BP

GO:0046034

ATP metabolic process

The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.

IMP

BP

GO:0051481

negative regulation of cytosolic calcium ion concentration

Any process that decreases the concentration of calcium ions in the cytosol.

IEA

BP

GO:0051946

regulation of glutamate uptake involved in transmission of nerve impulse

Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell.

NAS

BP

GO:0051966

regulation of synaptic transmission, glutamatergic

Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.

NAS

BP

GO:0055119

relaxation of cardiac muscle

The process in which the extent of cardiac muscle contraction is reduced.

TAS

BP

GO:0060048

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

TAS

BP

GO:0071260

cellular response to mechanical stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

IEA

BP

GO:0071383

cellular response to steroid hormone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.

IDA

BP

GO:0086004

regulation of cardiac muscle cell contraction

Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.

IEA

BP

GO:0086009

membrane repolarization

The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.

TAS

BP

GO:0086012

membrane depolarization during cardiac muscle cell action potential

The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.

TAS

BP

GO:0086064

cell communication by electrical coupling involved in cardiac conduction

The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.

TAS

BP

GO:1903170

negative regulation of calcium ion transmembrane transport

Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport.

ISS

BP

GO:1903280

negative regulation of calcium:sodium antiporter activity

Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity.

ISS

BP

GO:1903416

response to glycoside

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus.

IC|ISS

BP

GO:1903779

regulation of cardiac conduction

Any process that modulates the frequency, rate or extent of cardiac conduction.

TAS

BP

GO:1990573

potassium ion import across plasma membrane

The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.

IC

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005768

endosome

A vacuole to which materials ingested by endocytosis are delivered.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005890

sodium:potassium-exchanging ATPase complex

Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.

IC|IDA

CC

GO:0005901

caveola

A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.

IEA

CC

GO:0014704

intercalated disc

A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.

IEA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0030315

T-tubule

Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.

IEA

CC

GO:0043197

dendritic spine

A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including thin, stubby, mushroom, and branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.

IEA

CC

GO:0043209

myelin sheath

An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.

IEA

CC

GO:0043231

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

IBA

CC

GO:1903561

extracellular vesicle

Any vesicle that is part of the extracellular region.

IDA

MF

GO:0005391

sodium:potassium-exchanging ATPase activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).

IDA|IMP

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IMP

MF

GO:0008144

drug binding

Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.

IPI

MF

GO:0016887

ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.

IMP

MF

GO:0030955

potassium ion binding

Interacting selectively and non-covalently with potassium (K+) ions.

IMP

MF

GO:0031402

sodium ion binding

Interacting selectively and non-covalently with sodium ions (Na+).

IMP

MF

GO:0051087

chaperone binding

Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.

IPI

MF

GO:1990239

steroid hormone binding

Interacting selectively and non-covalently with a steroid hormone.

IDA