BP

GO:0002159

desmosome assembly

A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.

IMP

BP

GO:0007507

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

ISS

BP

GO:0008285

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

ISS

BP

GO:0010765

positive regulation of sodium ion transport

Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

ISS

BP

GO:0016264

gap junction assembly

Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids.

ISS

BP

GO:0016337

single organismal cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism.

ISS|NAS

BP

GO:0030336

negative regulation of cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.

ISS

BP

GO:0034334

adherens junction maintenance

The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.

ISS

BP

GO:0045110

intermediate filament bundle assembly

The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs.

IMP

BP

GO:0048496

maintenance of animal organ identity

The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized.

IMP

BP

GO:0055010

ventricular cardiac muscle tissue morphogenesis

The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.

IMP

BP

GO:0055088

lipid homeostasis

Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.

ISS

BP

GO:0086001

cardiac muscle cell action potential

An action potential that occurs in a cardiac muscle cell.

ISS

BP

GO:0086002

cardiac muscle cell action potential involved in contraction

An action potential that occurs in a cardiac muscle cell and is involved in its contraction.

IMP

BP

GO:0086005

ventricular cardiac muscle cell action potential

An action potential that occurs in a ventricular cardiac muscle cell.

IMP

BP

GO:0086019

cell-cell signaling involved in cardiac conduction

Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.

IMP

BP

GO:0086064

cell communication by electrical coupling involved in cardiac conduction

The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.

ISS

BP

GO:0086073

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.

IMP

BP

GO:0086091

regulation of heart rate by cardiac conduction

A cardiac conduction process that modulates the frequency or rate of heart contraction.

IMP

BP

GO:0090002

establishment of protein localization to plasma membrane

The directed movement of a protein to a specific location in the plasma membrane.

IMP

BP

GO:0098911

regulation of ventricular cardiac muscle cell action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

IMP

BP

GO:2000810

regulation of bicellular tight junction assembly

Any process that modulates the frequency, rate or extent of tight junction assembly.

ISS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

NAS

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA

CC

GO:0005882

intermediate filament

A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.

ISS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0005911

cell-cell junction

A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.

ISS

CC

GO:0005912

adherens junction

A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.

ISS

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0014704

intercalated disc

A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.

IDA|ISS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

CC

GO:0030054

cell junction

A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

IDA

CC

GO:0030057

desmosome

A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.

ISS|NAS

MF

GO:0003674

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

ND

MF

GO:0005080

protein kinase C binding

Interacting selectively and non-covalently with protein kinase C.

IPI

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0017080

sodium channel regulator activity

Modulates the activity of a sodium channel.

ISS

MF

GO:0019215

intermediate filament binding

Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space.

IDA

MF

GO:0032947

protein complex scaffold

Functions to provide a physical support for the assembly of a multiprotein complex.

IMP

MF

GO:0044325

ion channel binding

Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

ISS

MF

GO:0045294

alpha-catenin binding

Interacting selectively and non-covalently with the alpha subunit of the catenin complex.

IPI

MF

GO:0086083

cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication

Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.

IC

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA