Protein Description

Gene Symbol PKM
Entrez ID 5315
Uniprot ID P14618
Description pyruvate kinase, muscle
Chromosomal Location chr15: 72,199,029-72,231,822
Ontology GO ID GO Term Definition Evidence

BP

GO:0012501

programmed cell death

A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.

IDA

BP

GO:0061621

canonical glycolysis

The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.

TAS

BP

GO:0098609

cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

NAS|TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0005929

cilium

A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.

IEA

CC

GO:0031012

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues.

IDA

CC

GO:0031982

vesicle

Any small, fluid-filled, spherical organelle enclosed by membrane.

IDA

CC

GO:0043209

myelin sheath

An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:1903561

extracellular vesicle

Any vesicle that is part of the extracellular region.

IDA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IEA

MF

GO:0004743

pyruvate kinase activity

Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.

EXP|IDA|TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0016301

kinase activity

Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

IEA

MF

GO:0023026

MHC class II protein complex binding

Interacting selectively and non-covalently with the class II major histocompatibility complex.

IDA

MF

GO:0030955

potassium ion binding

Interacting selectively and non-covalently with potassium (K+) ions.

IEA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA

Domain ID Description

IPR001697

Pyruvate kinase

IPR011037

Pyruvate kinase-like, insert domain

IPR015793

Pyruvate kinase, barrel

IPR015795

Pyruvate kinase, C-terminal

IPR015813

Pyruvate/Phosphoenolpyruvate kinase-like domain

IPR018209

Pyruvate kinase, active site

Pathway ID Pathway Term Pathway Source

hsa00010

Glycolysis / Gluconeogenesis

KEGG

hsa00230

Purine metabolism

KEGG

hsa00620

Pyruvate metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

hsa01200

Carbon metabolism

KEGG

hsa01230

Biosynthesis of amino acids

KEGG

hsa04922

Glucagon signaling pathway

KEGG

hsa04930

Type II diabetes mellitus

KEGG

hsa05203

Viral carcinogenesis

KEGG

hsa05230

Central carbon metabolism in cancer

KEGG

WP534

Glycolysis and Gluconeogenesis

WikiPathways

WP3925

Amino Acid metabolism

WikiPathways

WP3614

Photodynamic therapy-induced HIF-1 survival signaling

WikiPathways

UMLS CUI UMLS Term

C0024667

Animal Mammary Neoplasms

C0024668

Mammary Neoplasms, Experimental

C0027626

Neoplasm Invasiveness

C0029456

Osteoporosis

C2239176

Liver Carcinoma

Tissue Cell Type

soft tissue

chondrocytes

No databases found.

Pubmed ID Author Year Title

17557764

Ma et al.

2007

Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome

19141577

Kim et al.

2009

Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

AGL

178

P35573

0.49

ALDOA

226

P04075

0.49

ASS1

445

P00966

0.49

BAX

581

Q07812

0.49

EEF1D

1936

P29692

0.49

FH

2271

P07954

0.49

HNRNPD

3184

Q14103

0.49

HNRNPK

3190

P61978

0.49

HSPB1

3315

P04792

0.49

PGK1

5230

P00558

0.49

RAC1

5879

P63000

0.49

RPN1

6184

P04843

0.49

SLC3A2

6520

P08195

0.49

PRDX2

7001

P32119

0.49

TKT

7086

P29401

0.49

TUBA4A

7277

P68366

0.49

ALDH5A1

7915

P51649

0.49

DNAJA3

9093

Q96EY1

0.49

PRDX6

9588

P30041

0.49

TRAP1

10131

Q12931

0.49

AKR1A1

10327

P14550

0.49

DLC1

10395

Q96QB1

0.49

RAB10

10890

P61026

0.49

LYPLA2

11313

O95372

0.49

DAZAP1

26528

Q96EP5

0.49

UFM1

51569

P61960

0.49

FAM49B

51571

Q9NUQ9

0.49

NANS

54187

Q9NR45

0.49

GNG12

55970

Q9UBI6

0.49

TUBB

203068

P07437

0.49

APP

351

P05067

0.56

ME1

4199

P48163

0.56

PFKM

5213

P08237

0.56

AMDHD2

51005

Q9Y303

0.56

PCBP1

5093

Q15365

0.59

ACAT2

39

Q9BWD1

0.63

CBS

875

P35520

0.63

DDB2

1643

Q92466

0.63

EPAS1

2034

Q99814

0.63

POLE2

5427

P56282

0.63

RAD23B

5887

P54727

0.63

RELA

5970

Q04206

0.63

SHBG

6462

P04278

0.63

SRP14

6727

P37108

0.63

ANP32A

8125

P39687

0.63

UBA2

10054

Q9UBT2

0.63

PLIN3

10226

O60664

0.63

PDLIM5

10611

Q96HC4

0.63

TWF2

11344

Q6IBS0

0.63

NPLOC4

55666

Q8TAT6

0.63

NXT2

55916

Q9NPJ8

0.63

LNX1

84708

Q8TBB1

0.63

OLFM2

93145

O95897

0.63

RAF1

5894

P04049

0.65

PKM

5315

P14618

0.66

FLT1

2321

P17948

0.68

FLT4

2324

P35916

0.68

KDR

3791

P35968

0.68

MST1R

4486

Q04912

0.68

PAK2

5062

Q13177

0.68

PCM1

5108

Q15154

0.68

PDGFRA

5156

P16234

0.68

PDPK1

5170

O15530

0.68

PEPD

5184

P12955

0.68

RET

5979

P07949

0.68

ROS1

6098

P08922

0.68

RXRA

6256

P19793

0.68

SOX5

6660

P35711

0.68

TEK

7010

Q02763

0.68

TFF2

7032

Q03403

0.68

THRA

7067

P10827

0.68

TTN

7273

Q8WZ42

0.68

TYRO3

7301

Q06418

0.68

ZFAND5

7763

O76080

0.68

SOCS3

9021

O14543

0.68

TAOK2

9344

Q9UL54

0.68

SDCCAG3

10807

Q96C92

0.68

PAPOLA

10914

P51003

0.68

R3HDM2

22864

Q9Y2K5

0.68

TSSK2

23617

Q96PF2

0.68

TBK1

29110

Q9UHD2

0.68

WAC

51322

Q9BTA9

0.68

SLC50A1

55974

Q9BRV3

0.68

PAK6

56924

Q9NQU5

0.68

PAK7

57144

Q9P286

0.68

PCIF1

63935

Q9H4Z3

0.68

WNK2

65268

Q9Y3S1

0.68

STK33

65975

Q9BYT3

0.68

PHACTR4

65979

Q8IZ21

0.68

ZXDC

79364

Q2QGD7

0.68

TSC22D4

81628

Q9Y3Q8

0.68

TOX2

84969

Q96NM4

0.68

PROSER2

254427

Q86WR7

0.68

WDR62

284403

O43379

0.68

EIF4A3

9775

P38919

0.70

EPM2A

7957

O95278

0.72

EGLN1

54583

Q9GZT9

0.72

EGLN3

112399

Q9H6Z9

0.75

HIF1A

3091

Q16665

0.77

DAPK1

1612

P53355

0.78

ENO3

2027

P13929

0.79

STK4

6789

Q13043

0.84

CFL1

1072

P23528

0.49

EEF1A1

1915

P68104

0.49

EEF1A2

1917

Q05639

0.49

EWSR1

2130

Q01844

0.49

LDHA

3939

P00338

0.49

LDHB

3945

P07195

0.49

PPID

5481

Q08752

0.49

FUBP1

8880

Q96AE4

0.49

PAICS

10606

P22234

0.49

C9orf64

84267

Q5T6V5

0.49

LDHAL6A

160287

Q6ZMR3

0.49

SORBS2

8470

O94875

0.55

GRB2

2885

P62993

0.56

PFKL

5211

P17858

0.56

PFKP

5214

Q01813

0.56

PTEN

5728

P60484

0.56

UCHL5

51377

Q9Y5K5

0.56

GAPDH

2597

P04406

0.59

HLA-DRB4

3126

P13762

0.63

ANXA7

310

P20073

0.63

ATP1A1

476

P05023

0.63

CAPZA2

830

P47755

0.63

CD81

975

P60033

0.63

CDK4

1019

P11802

0.63

CDKN1A

1026

P38936

0.63

RCC1

1104

P18754

0.63

CRY1

1407

Q16526

0.63

CSNK1E

1454

P49674

0.63

ESR1

2099

P03372

0.63

ETS1

2113

P14921

0.63

EZH2

2146

Q15910

0.63

FUS

2521

P35637

0.63

GJA1

2697

P17302

0.63

HTT

3064

P42858

0.63

HLA-DRA

3122

P01903

0.63

HLA-DRB1

3123

P04229

0.63

HLA-DRB3

3125

P79483

0.63

HLA-DRB5

3127

Q30154

0.63

HNRNPA1

3178

P09651

0.63

HSP90AA1

3320

P07900

0.63

ITGA4

3676

P13612

0.63

JUN

3725

P05412

0.63

LMO7

4008

Q8WWI1

0.63

MCM2

4171

P49736

0.63

MCM5

4174

P33992

0.63

MGMT

4255

P16455

0.63

MPG

4350

P29372

0.63

MYC

4609

P01106

0.63

MYOC

4653

Q99972

0.63

NFKB1

4790

P19838

0.63

NPM1

4869

P06748

0.63

NTRK1

4914

P04629

0.63

PML

5371

P29590

0.63

PPP1CA

5499

P62136

0.63

PRKCD

5580

Q05655

0.63

MAPK7

5598

Q13164

0.63

PSMA3

5684

P25788

0.63

RAP1B

5908

P61224

0.63

SUMO3

6612

P55854

0.63

STAU1

6780

O95793

0.63

TK1

7083

P04183

0.63

VCAM1

7412

P19320

0.63

VCP

7415

P55072

0.63

PAX8

7849

Q06710

0.63

USP7

7874

Q93009

0.63

CUL5

8065

Q93034

0.63

CUL3

8452

Q13618

0.63

CUL2

8453

Q13617

0.63

CUL1

8454

Q13616

0.63

IKBKAP

8518

O95163

0.63

CAMK1

8536

Q14012

0.63

BANF1

8815

O75531

0.63

IQCB1

9657

Q15051

0.63

KIAA0101

9768

Q15004

0.63

CUL7

9820

Q14999

0.63

PAN2

9924

Q504Q3

0.63

HDAC6

10013

Q9UBN7

0.63

HDAC5

10014

Q9UQL6

0.63

HUWE1

10075

Q7Z6Z7

0.63

COPS5

10987

Q92905

0.63

RPP14

11102

O95059

0.63

GABARAPL2

11345

P60520

0.63

OBSL1

23363

O75147

0.63

SUZ12

23512

Q15022

0.63

GABARAPL1

23710

Q9H0R8

0.63

FBXO6

26270

Q9NRD1

0.63

IPO11

51194

Q9UI26

0.63

PPME1

51400

Q9Y570

0.63

NAGK

55577

Q9UJ70

0.63

OTUB1

55611

Q96FW1

0.63

RIOK2

55781

Q9BVS4

0.63

MAP1LC3B

81631

Q9GZQ8

0.63

CCDC8

83987

Q9H0W5

0.63

MAP1LC3A

84557

Q9H492

0.63

RNF185

91445

Q96GF1

0.63

IGSF8

93185

Q969P0

0.63

LRRK2

120892

Q5S007

0.63

SMN1; SMN2

6606

Q16637

0.63

ABL1

25

P00519

0.68

ABL2

27

P42684

0.68

ADD1

118

P35611

0.68

AKT1

207

P31749

0.68

ALDOC

230

P09972

0.68

ALK

238

Q9UM73

0.68

BIN1

274

O00499

0.68

BLK

640

P51451

0.68

BMI1

648

P35226

0.68

BMX

660

P51813

0.68

CAMK2B

816

Q13554

0.68

CDC25A

993

P30304

0.68

CHEK1

1111

O14757

0.68

CHUK

1147

O15111

0.68

CSF1R

1436

P07333

0.68

EGFR

1956

P00533

0.68

EPHA2

1969

P29317

0.68

MARK2

2011

Q7KZI7

0.68

DMTN

2039

Q08495

0.68

EPHA1

2041

P21709

0.68

EPHA5

2044

P54756

0.68

EPHA8

2046

P29322

0.68

EPHB3

2049

P54753

0.68

EPHB4

2050

P54760

0.68

ERBB2

2064

P04626

0.68

FER

2241

P16591

0.68

FGFR3

2261

P22607

0.68

FGFR2

2263

P21802

0.68

FGFR4

2264

P22455

0.68

GSK3A

2931

P49840

0.68

H3F3A; H3F3B

3020

P84243

0.68

HSF1

3297

Q00613

0.68

IKBKB

3551

O14920

0.68

IL1B

3553

P01584

0.68

JAK2

3717

O60674

0.68

JAK3

3718

P52333

0.68

KIT

3815

P10721

0.68

LTK

4058

P29376

0.68

MEF2A

4205

Q02078

0.68

MEF2D

4209

Q14814

0.68

MAP3K3

4215

Q99759

0.68

MET

4233

P08581

0.68

MAP3K11

4296

Q16584

0.68

NEK1

4750

Q96PY6

0.68

NFIC

4782

P08651

0.68

NFYA

4800

P23511

0.68

NTRK2

4915

Q16620

0.68

NTRK3

4916

Q16288

0.68

PRKAA2

5563

P54646

0.68

PRKCE

5581

Q02156

0.68

PRKD1

5587

Q15139

0.68

PRKCQ

5588

Q04759

0.68

PRKG2

5593

Q13237

0.68

MAPK3

5595

P27361

0.68

MAP2K1

5604

Q02750

0.68

MAP2K2

5605

P36507

0.68

PTK2

5747

Q05397

0.68

MAP4K2

5871

Q12851

0.68

RPS6KA2

6196

Q15349

0.68

RPS6KA3

6197

P51812

0.68

MAPK12

6300

P53778

0.68

MSMO1

6307

Q15800

0.68

SYK

6850

P43405

0.68

YWHAZ

7534

P63104

0.68

MAPKAPK3

7867

Q16644

0.68

CCDC6

8030

Q16204

0.68

HIST1H3A

8350

P68431

0.68

DYRK3

8444

O43781

0.68

MAPKAPK5

8550

Q8IW41

0.68

EIF4G3

8672

O43432

0.68

DYRK1B

9149

Q9Y463

0.68

RPS6KA5

9252

O75582

0.68

MAPKAPK2

9261

P49137

0.68

CYTH1

9267

Q15438

0.68

NR1D1

9572

P20393

0.68

IKBKE

9641

Q14164

0.68

SNAP91

9892

O60641

0.68

AKT3

10000

Q9Y243

0.68

MERTK

10461

Q12866

0.68

CAMKK2

10645

Q96RR4

0.68

MAP3K2

10746

Q9Y2U5

0.68

NEK6

10783

Q9HC98

0.68

YWHAQ

10971

P27348

0.68

CHEK2

11200

O96017

0.68

TRIM35

23087

Q9UPQ4

0.68

PRKD3

23683

O94806

0.68

KIF26A

26153

Q9ULI4

0.68

CASZ1

54897

Q86V15

0.68

CASS4

57091

Q9NQ75

0.68

CYP4F12

66002

Q9HCS2

0.68

FSD1

79187

Q9BTV5

0.68

HMBOX1

79618

Q6NT76

0.68

CARF

79800

Q8N187

0.68

KBTBD7

84078

Q8WVZ9

0.68

BRSK1

84446

Q8TDC3

0.68

DIXDC1

85458

Q155Q3

0.68

FAM122A

116224

Q96E09

0.68

NUP35

129401

Q8NFH5

0.68

BEAN1

146227

Q3B7T3

0.68

KANK4

163782

Q5T7N3

0.68

DCLK2

166614

Q8N568

0.68

HIPK1

204851

Q86Z02

0.68

CBARP

255057

Q8N350

0.68

EP400NL

347918

Q6ZTU2

0.68

CCDC88C

440193

Q9P219

0.68

HIST2H3A; HIST2H3C; HIST2H3D

126961

Q71DI3

0.68

CTPS1

1503

P17812

0.70

HERC1

8925

Q15751

0.71

ARRB1

408

P49407

0.72

ARRB2

409

P32121

0.72

ATF2

1386

P15336

0.72

FN1

2335

P02751

0.72

H2AFX

3014

P16104

0.72

HSP90AB1

3326

P08238

0.72

CDK16

5127

Q00536

0.72

TRAF3IP1

26146

Q8TDR0

0.72

CCDC88A

55704

Q3V6T2

0.72

CDK2

1017

P24941

0.73

EP300

2033

Q09472

0.73

SUMO2

6613

P61956

0.73

TERF1

7013

P54274

0.73

ISG15

9636

P05161

0.73

NDRG1

10397

Q92597

0.73

EXOSC5

56915

Q9NQT4

0.73

TRIM63

84676

Q969Q1

0.73

ARAF

369

P10398

0.75

TINF2

26277

Q9BSI4

0.75

MDM2

4193

Q00987

0.78

FGFR1

2260

P11362

0.84

GRB7

2886

Q14451

0.84

PIN1

5300

Q13526

0.84

MAPK13

5603

O15264

0.84

STK25

10494

O00506

0.84

SUMO1

7341

P63165

0.85

NLK

51701

Q9UBE8

0.87