Protein Description

Gene Symbol SERPINB5
Entrez ID 5268
Uniprot ID P36952
Description serpin peptidase inhibitor, clade B (ovalbumin), member 5
Chromosomal Location chr18: 63,476,761-63,505,085
Ontology GO ID GO Term Definition Evidence

BP

GO:0002009

morphogenesis of an epithelium

The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.

IEA

BP

GO:0006928

movement of cell or subcellular component

The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.

TAS

BP

GO:0010951

negative regulation of endopeptidase activity

Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

IEA

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

IEA

BP

GO:0050678

regulation of epithelial cell proliferation

Any process that modulates the frequency, rate or extent of epithelial cell proliferation.

IEA

BP

GO:0060512

prostate gland morphogenesis

The process in which the anatomical structures of a prostate gland are generated and organized.

IEA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IBA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0004867

serine-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

IBA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

Domain ID Description

IPR000215

Serpin family

IPR000240

Serpin B9/maspin

IPR023795

Serpin, conserved site

IPR023796

Serpin domain

IPR033836

Maspin

Pathway ID Pathway Term Pathway Source

hsa04115

p53 signaling pathway

KEGG

hsa05206

MicroRNAs in cancer

KEGG

UMLS CUI UMLS Term

C0009375

Colonic Neoplasms

C0009404

Colorectal Neoplasms

C0022548

Keloid

C0027627

Neoplasm Metastasis

C1134719

Invasive Ductal Breast Carcinoma

C1458155

Mammary Neoplasms

Tissue Cell Type

esophagus

squamous epithelial cells

skin

keratinocytes

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

17148555

Wood et al.

2007

Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis

Gene Symbol Entrez ID Uniprot ID Score

ITPA

3704

Q9BY32

0.49

TPI1

7167

P60174

0.49

PRDX6

9588

P30041

0.49

PPIL3

53938

Q9H2H8

0.49

AKT1

207

P31749

0.63

ALDH2

217

P05091

0.63

RHOA

387

P61586

0.63

CBFB

865

Q13951

0.63

HDLBP

3069

Q00341

0.63

HMGCS1

3157

Q01581

0.63

SMAD4

4089

Q13485

0.63

NARS

4677

O43776

0.63

PLS1

5357

Q14651

0.63

STK11

6794

Q15831

0.63

VRK1

7443

Q99986

0.63

XRCC3

7517

O43542

0.63

EIF2S2

8894

P20042

0.63

ZRANB2

9406

O95218

0.63

ZC3H11A

9877

O75152

0.63

DDX46

9879

Q7L014

0.63

SF3A1

10291

Q15459

0.63

UBA6

55236

A0AVT1

0.63

NAA50

80218

Q9GZZ1

0.63

EIF2A

83939

Q9BY44

0.63

HDGFRP2

84717

Q7Z4V5

0.63

RAP1BL

643752

A6NIZ1

0.63

KHDRBS3

10656

O75525

0.72

FBXO32

114907

Q969P5

0.72

ADA

100

P00813

0.49

SOD1

6647

P00441

0.49

C11orf54

28970

Q9H0W9

0.49

GLOD4

51031

Q9HC38

0.49

UCHL5

51377

Q9Y5K5

0.56

CASP8

841

Q14790

0.63

ESR1

2099

P03372

0.63

GPR18

2841

Q14330

0.63

KIR3DS1

3813

Q14943

0.63

KRAS

3845

P01116

0.63

MAPK9

5601

P45984

0.63

SUMO2

6613

P61956

0.63

BCAR3

8412

O75815

0.63

RAB11B

9230

Q15907

0.63

ISG15

9636

P05161

0.63

DDX19B

11269

Q9UMR2

0.63

RAB9B

51209

Q9NP90

0.63

WWOX

51741

Q9NZC7

0.63

UGT1A10

54575

Q9HAW8

0.63

PALB2

79728

Q86YC2

0.63

SLX4

84464

Q8IY92

0.63

LACC1

144811

Q8IV20

0.63

PYHIN1

149628

Q6K0P9

0.63

SGO2

151246

Q562F6

0.63

RBM24

221662

Q9BX46

0.63

HDAC1

3065

Q13547

0.68

PRSS21

10942

Q9Y6M0

0.78