Protein Description

Gene Symbol PECAM1
Entrez ID 5175
Uniprot ID P16284
Description platelet/endothelial cell adhesion molecule 1
Chromosomal Location chr17: 64,319,415-64,413,776
Ontology GO ID GO Term Definition Evidence

BP

GO:0002576

platelet degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.

TAS

BP

GO:0006909

phagocytosis

An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.

IDA

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0008037

cell recognition

The process in which a cell in an organism interprets its surroundings.

TAS

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0050900

leukocyte migration

The movement of a leukocyte within or between different tissues and organs of the body.

TAS

BP

GO:0050904

diapedesis

The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.

IDA

BP

GO:0072011

glomerular endothelium development

The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus.

IEP

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0030054

cell junction

A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

IEA

CC

GO:0031092

platelet alpha granule membrane

The lipid bilayer surrounding the platelet alpha granule.

TAS

CC

GO:0045121

membrane raft

Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

Domain ID Description

IPR003598

Immunoglobulin subtype 2

IPR003599

Immunoglobulin subtype

IPR007110

Immunoglobulin-like domain

IPR013783

Immunoglobulin-like fold

Pathway ID Pathway Term Pathway Source

hsa04514

Cell adhesion molecules (CAMs)

KEGG

hsa04670

Leukocyte transendothelial migration

KEGG

hsa05144

Malaria

KEGG

hsa05418

Fluid shear stress and atherosclerosis

KEGG

h_granulocytesPathway

Adhesion and Diapedesis of Granulocytes

BioCarta

h_lympathway

Adhesion and Diapedesis of Lymphocytes

BioCarta

h_lymphocytePathway

Adhesion Molecules on Lymphocyte

BioCarta

h_cell2cellPathway

Cell to Cell Adhesion Signaling

BioCarta

h_monocytePathway

Monocyte and its Surface Molecules

BioCarta

h_neutrophilPathway

Neutrophil and Its Surface Molecules

BioCarta

UMLS CUI UMLS Term

C0004352

Autistic Disorder

C0004364

Autoimmune Diseases

C0010068

Coronary Heart Disease

C0040034

Thrombocytopenia

Tissue Cell Type

colon

endothelial cells

kidney

cells in glomeruli

smooth muscle

smooth muscle cells

spleen

cells in red pulp

Database Name

DGA

Pubmed ID Author Year Title

22904171

Kaur et al.

2012

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

Gene Symbol Entrez ID Uniprot ID Score

SDC1

6382

P18827

0.49

CXCR4

7852

P61073

0.49

CD38

952

P28907

0.52

ITGA5

3678

P08648

0.52

VIM

7431

P08670

0.52

XRCC6

2547

P12956

0.63

CSK

1445

P41240

0.67

LCK

3932

P06239

0.67

MAPK1

5594

P28482

0.72

PIK3R1

5295

P27986

0.73

PRPF40A

55660

O75400

0.73

HCK

3055

P08631

0.74

LYN

4067

P07948

0.74

YES1

7525

P07947

0.74

DSP

1832

P15924

0.77

JUP

3728

P14923

0.78

PLCG1

5335

P19174

0.78

FYN

2534

P06241

0.84

PECAM1

5175

P16284

0.85

CTNNB1

1499

P35222

0.87

BCAR1

9564

P56945

0.00

GPC1

2817

P35052

0.49

SDC4

6385

P31431

0.49

ACKR3

57007

P25106

0.49

EFNB2

1948

P52799

0.52

ABL2

27

P42684

0.56

SH2D1B

117157

O14796

0.56

ITGB3

3690

P05106

0.58

GNAQ

2776

P50148

0.63

PRKCE

5581

Q02156

0.70

INPP5D

3635

Q92835

0.78

PTPN6

5777

P29350

0.89

SRC

6714

P12931

0.89

PTPN11

5781

Q06124

0.90