Gene Symbol | PECAM1 |
Entrez ID | 5175 |
Uniprot ID | P16284 |
Description | platelet/endothelial cell adhesion molecule 1 |
Chromosomal Location | chr17: 64,319,415-64,413,776 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0002576 |
platelet degranulation |
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. |
TAS |
BP |
GO:0006909 |
phagocytosis |
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
IDA |
BP |
GO:0007155 |
cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
IEA |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
BP |
GO:0008037 |
cell recognition |
The process in which a cell in an organism interprets its surroundings. |
TAS |
BP |
GO:0030198 |
extracellular matrix organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
TAS |
BP |
GO:0050900 |
leukocyte migration |
The movement of a leukocyte within or between different tissues and organs of the body. |
TAS |
BP |
GO:0050904 |
diapedesis |
The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. |
IDA |
BP |
GO:0072011 |
glomerular endothelium development |
The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus. |
IEP |
CC |
GO:0005615 |
extracellular space |
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
IDA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA|TAS |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
CC |
GO:0030054 |
cell junction |
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. |
IEA |
CC |
GO:0031092 |
platelet alpha granule membrane |
The lipid bilayer surrounding the platelet alpha granule. |
TAS |
CC |
GO:0045121 |
membrane raft |
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
IEA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
Domain ID | Description |
---|---|
IPR003598 |
Immunoglobulin subtype 2 |
IPR003599 |
Immunoglobulin subtype |
IPR007110 |
Immunoglobulin-like domain |
IPR013783 |
Immunoglobulin-like fold |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04514 |
Cell adhesion molecules (CAMs) |
KEGG |
hsa04670 |
Leukocyte transendothelial migration |
KEGG |
hsa05144 |
Malaria |
KEGG |
hsa05418 |
Fluid shear stress and atherosclerosis |
KEGG |
h_granulocytesPathway |
Adhesion and Diapedesis of Granulocytes |
BioCarta |
h_lympathway |
Adhesion and Diapedesis of Lymphocytes |
BioCarta |
h_lymphocytePathway |
Adhesion Molecules on Lymphocyte |
BioCarta |
h_cell2cellPathway |
Cell to Cell Adhesion Signaling |
BioCarta |
h_monocytePathway |
Monocyte and its Surface Molecules |
BioCarta |
h_neutrophilPathway |
Neutrophil and Its Surface Molecules |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0004352 |
Autistic Disorder |
C0004364 |
Autoimmune Diseases |
C0010068 |
Coronary Heart Disease |
C0040034 |
Thrombocytopenia |
Tissue | Cell Type |
---|---|
colon |
endothelial cells |
kidney |
cells in glomeruli |
smooth muscle |
smooth muscle cells |
spleen |
cells in red pulp |
Database Name |
---|
DGA |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
SDC1 |
6382 |
P18827 |
0.49 |
CXCR4 |
7852 |
P61073 |
0.49 |
CD38 |
952 |
P28907 |
0.52 |
ITGA5 |
3678 |
P08648 |
0.52 |
VIM |
7431 |
P08670 |
0.52 |
XRCC6 |
2547 |
P12956 |
0.63 |
CSK |
1445 |
P41240 |
0.67 |
LCK |
3932 |
P06239 |
0.67 |
MAPK1 |
5594 |
P28482 |
0.72 |
PIK3R1 |
5295 |
P27986 |
0.73 |
PRPF40A |
55660 |
O75400 |
0.73 |
HCK |
3055 |
P08631 |
0.74 |
LYN |
4067 |
P07948 |
0.74 |
YES1 |
7525 |
P07947 |
0.74 |
DSP |
1832 |
P15924 |
0.77 |
JUP |
3728 |
P14923 |
0.78 |
PLCG1 |
5335 |
P19174 |
0.78 |
FYN |
2534 |
P06241 |
0.84 |
PECAM1 |
5175 |
P16284 |
0.85 |
CTNNB1 |
1499 |
P35222 |
0.87 |
BCAR1 |
9564 |
P56945 |
0.00 |
GPC1 |
2817 |
P35052 |
0.49 |
SDC4 |
6385 |
P31431 |
0.49 |
ACKR3 |
57007 |
P25106 |
0.49 |
EFNB2 |
1948 |
P52799 |
0.52 |
ABL2 |
27 |
P42684 |
0.56 |
SH2D1B |
117157 |
O14796 |
0.56 |
ITGB3 |
3690 |
P05106 |
0.58 |
GNAQ |
2776 |
P50148 |
0.63 |
PRKCE |
5581 |
Q02156 |
0.70 |
INPP5D |
3635 |
Q92835 |
0.78 |
PTPN6 |
5777 |
P29350 |
0.89 |
SRC |
6714 |
P12931 |
0.89 |
PTPN11 |
5781 |
Q06124 |
0.90 |