BP

GO:0000165

MAPK cascade

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

TAS

BP

GO:0001553

luteinization

The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.

ISS

BP

GO:0001775

cell activation

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

TAS

BP

GO:0007204

positive regulation of cytosolic calcium ion concentration

Any process that increases the concentration of calcium ions in the cytosol.

IMP

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IMP

BP

GO:0010544

negative regulation of platelet activation

Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.

IDA

BP

GO:0010863

positive regulation of phospholipase C activity

Any process that increases the rate of phospholipase C activity.

IMP

BP

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.

TAS

BP

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.

TAS

BP

GO:0016032

viral process

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

IEA

BP

GO:0018108

peptidyl-tyrosine phosphorylation

The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.

IDA

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

IDA|IMP

BP

GO:0034614

cellular response to reactive oxygen species

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.

IDA

BP

GO:0035790

platelet-derived growth factor receptor-alpha signaling pathway

A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IMP

BP

GO:0038091

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation.

IDA

BP

GO:0042060

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

ISS

BP

GO:0043547

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

IEA

BP

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.

IMP

BP

GO:0045740

positive regulation of DNA replication

Any process that activates or increases the frequency, rate or extent of DNA replication.

IDA

BP

GO:0046777

protein autophosphorylation

The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

IDA

BP

GO:0046854

phosphatidylinositol phosphorylation

The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.

IEA

BP

GO:0048008

platelet-derived growth factor receptor signaling pathway

The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.

IDA

BP

GO:0048015

phosphatidylinositol-mediated signaling

A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

IMP|TAS

BP

GO:0048146

positive regulation of fibroblast proliferation

Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.

IDA

BP

GO:0048557

embryonic digestive tract morphogenesis

The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.

ISS

BP

GO:0048701

embryonic cranial skeleton morphogenesis

The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase.

ISS

BP

GO:0048704

embryonic skeletal system morphogenesis

The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.

ISS

BP

GO:0050920

regulation of chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

IMP

BP

GO:0055003

cardiac myofibril assembly

The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.

ISS

BP

GO:0060326

cell chemotaxis

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

IMP

BP

GO:0061298

retina vasculature development in camera-type eye

The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.

ISS

BP

GO:0070374

positive regulation of ERK1 and ERK2 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

IMP

BP

GO:0070527

platelet aggregation

The adhesion of one platelet to one or more other platelets via adhesion molecules.

IMP

BP

GO:0072277

metanephric glomerular capillary formation

The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.

ISS

BP

GO:2000249

regulation of actin cytoskeleton reorganization

Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.

TAS

BP

GO:2000739

regulation of mesenchymal stem cell differentiation

Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation.

IMP

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

ISS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

ISS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0031226

intrinsic component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.

IDA

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IDA

MF

GO:0004672

protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

IDA

MF

GO:0004714

transmembrane receptor protein tyrosine kinase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

IDA

MF

GO:0005018

platelet-derived growth factor alpha-receptor activity

Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity.

IDA|IMP

MF

GO:0005021

vascular endothelial growth factor-activated receptor activity

Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.

IDA

MF

GO:0005088

Ras guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

TAS

MF

GO:0005161

platelet-derived growth factor receptor binding

Interacting selectively and non-covalently with the platelet-derived growth factor receptor.

IPI

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0038085

vascular endothelial growth factor binding

Interacting selectively and non-covalently with a vascular endothelial growth factor.

IPI

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IDA

MF

GO:0046934

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).

TAS

MF

GO:0048407

platelet-derived growth factor binding

Interacting selectively and non-covalently with platelet-derived growth factor.

IDA|IPI